The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 28, 2025

Previous studies found that it is promising to achieve the protective effects of dietary patterns on cardiovascular health through modulation gut microbiota. However, conflicting findings have been reported how impact microbiota in individuals either established or at risk disease (CVD). Our systematic review aimed explore effect composition and factors for CVD these populations. We systematically searched seven databases, including PubMed/MEDLINE, MEDLINE (Ovid), Embase CINHAL (EBSCO), Web Science, CNKI (Chinese), Wanfang covering literature from inception October 2024. Studies were included if they focused adults aged 18 years older with least two factors, implemented pattern interventions, incorporated outcomes related microbiome analysis. The bias was assessed using revised Cochrane tool (RoB2) randomized trials Risk Of Bias In Non-randomised Interventions (ROBINS-I) non-randomized studies. Changes relative abundance summarized various taxonomic levels, phylum, class, order, family, genus, species. Random-effects meta-analysis conducted analyze mean difference cardiometabolic parameters pre- post-intervention. Nineteen identified, 17 RCT self-controlled trails. across mixed but mainly identified as low unclear. most frequently increased taxa Faecalibacterium (N = 8) plant-rich diets, Bacteroides 3) restrictive Ruminococcaceae UCG 005 Alistipes 9) polyphenol-rich diets. decreased Parabacteroides 7) Roseburia Ruminococcus gauvreauii group 6) Plant-rich diets showed a significant decrease total cholesterol (TC) -6.77 (95% CI, -12.36 -2.58; I2 84.7%), while triglycerides (TG) -22.12 -36.05 -8.19; 98.4%). Different distinct impacts composition. promoted proliferation butyrate-producing bacteria, suggesting prospects modulating butyrate production interventions enhance health. Further research warranted investigate long-term clinical endpoints, such events mortality. Registration number: CRD42024507660

Язык: Английский

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The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

Frontiers in Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Янв. 5, 2024

Increasing evidence links the gut microbiome and nervous system in health disease. This narrative review discusses current views on interaction between microbiota, intestinal epithelium, brain, provides an overview of communication routes signals bidirectional interactions microbiota including circulatory, immunological, neuroanatomical, neuroendocrine pathways. Similarities differences healthy humans mice exist that are relevant for translational gap non-human model systems patients. There is increasing spectrum metabolites neurotransmitters released and/or modulated by both homeostatic pathological conditions. Dysbiotic disruptions occur as consequences critical illnesses such cancer, cardiovascular chronic kidney disease but also neurological, mental, pain disorders, well ischemic traumatic brain injury. Changes (dysbiosis) a concomitant imbalance release mediators may be cause or consequence diseases central increasingly emerging to disruption physiological function, alterations nutrition intake, exposure hypoxic conditions others, observed disorders. Despite generally accepted importance microbiome, not fully understood. Elucidating these signaling pathways more detail offers novel mechanistic insight into pathophysiology multifaceted aspects

Язык: Английский

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Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk: a comprehensive review

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 28, 2024

Язык: Английский

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The interaction between Mediterranean diet and intestinal microbiome: relevance for preventive strategies against frailty in older individuals

Aging Clinical and Experimental Research, Год журнала: 2024, Номер 36(1)

Опубликована: Март 6, 2024

Age-related changes in intestinal microbiome composition and function are increasingly recognized as pivotal the pathophysiology of aging associated with phenotype. Diet is a major determinant gut-microbiota throughout entire lifespan, several benefits healthy diet could be mediated by microbiome. Mediterranean (MD) traditional dietary pattern regarded paradigm, large number studies have demonstrated its promoting aging. MD has also positive modulatory effect on microbiome, favoring bacterial taxa involved synthesis bioactive compounds, such short-chain fatty acids (SCFAs), that counteract inflammation, anabolic resistance, tissue degeneration. Intervention conducted older populations suggested individual response subjects to MD, terms reduction frailty scores amelioration cognitive function, significantly functionality. In this context, should considered when designing MD-based interventions tailored needs geriatric patients.

Язык: Английский

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Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort

Nutrients, Год журнала: 2024, Номер 16(6), С. 773 - 773

Опубликована: Март 8, 2024

While polyphenol consumption is often associated with an increased abundance of beneficial microbes and decreased opportunistic pathogens, these relationships are not completely described for polyphenols consumed via habitual diet, including culinary herb spice consumption. This analysis the International Cohort on Lifestyle Determinants Health (INCLD Health) cohort uses a dietary questionnaire 16s microbiome data to examine between gut microbiota in healthy adults (n = 96). In this exploratory analysis, microbial taxa, but diversity measures, differed by levels Taxa identified as biomarkers daily (mg/day) included Lactobacillus, Bacteroides, Enterococcus, Eubacterium ventriosum group, Ruminococcus torques Sutterella. frequency polyphenol-weighted use Lachnospiraceae UCG-001, UCG-004, Methanobrevibacter, Lachnoclostridium, Lachnotalea. Several differentiating taxa carry out activities important human health, although those previously pro-inflammatory qualities certain contexts displayed inverse Our results suggest that higher quantities may support intestinal environment where bacteria represented lower relative compared less potentially virulent qualities.

Язык: Английский

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Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions

Metabolites, Год журнала: 2024, Номер 14(6), С. 327 - 327

Опубликована: Июнь 11, 2024

Several hallmarks of metabolic syndrome, such as dysregulation in the glucose and lipid metabolism, endothelial dysfunction, insulin resistance, low-to-medium systemic inflammation, intestinal microbiota dysbiosis, represent a pathological bridge between syndrome diabesity, cardiovascular, neurodegenerative disorders. This review aims to highlight some therapeutic strategies against involving integrative approaches improve lifestyle daily diet. The beneficial effects foods containing antioxidant polyphenols, control, physical activity were also considered. We comprehensively examined large body published articles basic, animal, human studie, well recent guidelines. As result, dietary polyphenols from natural plant-based antioxidants adherence Mediterranean diet, along with exercise, are promising complementary therapies delay or prevent onset counteract diabesity cardiovascular diseases, protect disorders cognitive decline. Modulation reduces risks associated MS, improves diabetes diseases (CVD), exerts neuroprotective action. Despite several studies, estimation polyphenol intake is inconclusive requires further evidence. Lifestyle interventions reduced calorie can outcomes.

Язык: Английский

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Bile salt hydrolase: The complexity behind its mechanism in relation to lowering-cholesterol lactobacilli probiotics

Journal of Functional Foods, Год журнала: 2024, Номер 120, С. 106357 - 106357

Опубликована: Июль 20, 2024

Язык: Английский

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Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics

Biomedicines, Год журнала: 2025, Номер 13(1), С. 179 - 179

Опубликована: Янв. 13, 2025

In the current era, malnutrition is seen as both undernutrition and overweight obesity; conditions are caused by nutrient deficiency or excess improper use imbalance in intake of macro micronutrients. Recent evidence suggests that alters intestinal microbiota, known dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role maintaining increasing beneficial microbiota populations protecting against pathogenic species. Depletion bacterial throughout life also conditioned malnutrition. This review aims to synthesize establishes interrelationship between diet, malnutrition, changes flora, sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, postbiotic administration can restore immune response intestine host’s homeostasis.

Язык: Английский

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Gut microbiota-derived metabolites and chronic inflammatory diseases

Exploration of Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

The gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption this microbial balance, known as dysbiosis, has been increasingly implicated the pathogenesis chronic inflammatory conditions, including cardiovascular, gastrointestinal, autoimmune diseases, well disorders such diabetes obesity. A crucial mechanism through which microbiota exerts its effects on host physiology is via production bioactive metabolites. These metabolites, short-chain fatty acids, bile tryptophan derivatives, are key modulating responses regulating functions. Dysbiosis disrupts function these thereby contributing to dysregulation, inflammation, disease progression. This review examines microbiota-derived metabolites with focus their immunomodulatory effects. deeper understanding mechanisms may open way for novel therapeutic strategies aimed at restoring homeostasis mitigating global burden diseases.

Язык: Английский

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The gut microbiota and its role in the development of cardiovascular disease

Expert Review of Cardiovascular Therapy, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Фев. 7, 2025

The pathophysiology of cardiovascular diseases encompasses a complex interplay genetic and environmental risk factors. Even if traditional factors are treated to target, there remains residual risk. This manuscript reviews the potential role gut microbiota in development disease, as target. A systematic search was conducted until 30 October 2024 on PubMed (MEDLINE), using MeSH terms [Gut microbiota] + [Dysbiosis] [Cardiovascular] [TMAO] [bile acids] [short-chain fatty acids]. term dysbiosis implies changes equilibrium, with modifications composition functionality series additional factors: reduced diversity uniformity microorganisms; short-chain acid-producing bacteria; increased permeability; release metabolites, such trimethylamine N-oxide, betaine, phenylalanine, tryptophan-kynurenine, phenylacetylglutamine, lipopolysaccharides; secondary bile acid excretion, leading inflammation, oxidative stress, endothelial dysfunction facilitating onset pathological conditions, including obesity, hypertension, diabetes, atherosclerosis, heart failure. Attempts restore balance through different interventions, mainly diet, have been shown positively affect individual components metabolites reduce disease. In addition, probiotics prebiotics potentially useful. Fecal transplantation is promising therapy.

Язык: Английский

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