Journal of Neuroinflammation,
Год журнала:
2022,
Номер
19(1)
Опубликована: Июнь 17, 2022
Abstract
The
choroid
plexus
is
a
tissue
located
in
the
lateral
ventricles
of
brain
and
composed
mainly
epithelium
cells.
main
function
currently
thought
to
be
secretion
cerebrospinal
fluid
regulation
its
pH,
more
functions
are
gradually
being
demonstrated.
Assistance
removal
metabolic
waste
participation
apoptotic
pathway
also
plexus.
Besides,
it
helps
repair
by
regulating
neuropeptides
delivery
drugs.
It
involved
immune
response
assist
clearance
infections
central
nervous
system.
now
believed
that
an
inflammatory
state
after
damage
brain.
This
state,
along
with
changes
cilia,
abnormal
physiological
plexus,
which
turn
leads
conditions
triggers
hydrocephalus.
review
describes
pathophysiological
mechanism
hydrocephalus
following
cell
abnormalities
based
on
normal
cells,
analyzes
attempts
future
developments
using
cells
as
therapeutic
target
for
Fluids and Barriers of the CNS,
Год журнала:
2022,
Номер
19(1)
Опубликована: Апрель 1, 2022
Intraventricular
hemorrhage
(IVH)
is
a
significant
cause
of
morbidity
and
mortality
in
both
neonatal
adult
populations.
IVH
not
only
causes
immediate
damage
to
surrounding
structures
by
way
mass
effect
elevated
intracranial
pressure;
the
subsequent
inflammation
additional
brain
injury
edema.
Of
those
neonates
who
experience
severe
IVH,
25-30%
will
go
on
develop
post-hemorrhagic
hydrocephalus
(PHH).
PHH
places
adults
at
risk
for
white
matter
injury,
seizures,
death.
Unfortunately,
molecular
determinants
are
well
understood.
Within
past
decade
an
emphasis
has
been
placed
neuroinflammation
PHH.
More
information
come
light
regarding
inflammation-induced
fibrosis
cerebrospinal
fluid
hypersecretion
response
IVH.
The
aim
this
review
discuss
role
involving
clot-derived
neuroinflammatory
factors
including
hemoglobin/iron,
peroxiredoxin-2
thrombin,
as
macrophages/microglia,
cytokines
complement
development
Understanding
mechanisms
after
may
highlight
potential
novel
therapeutic
targets
Cells,
Год журнала:
2024,
Номер
13(11), С. 974 - 974
Опубликована: Июнь 4, 2024
Primary
ciliary
dyskinesia
(PCD)
is
a
rare,
genetically
heterogeneous,
motile
ciliopathy,
characterized
by
neonatal
respiratory
distress,
recurrent
upper
and
lower
tract
infections,
subfertility,
laterality
defects.
Diagnosis
relies
on
combination
of
tests
for
confirmation,
including
nasal
nitric
oxide
(nNO)
measurements,
high-speed
videomicroscopy
analysis
(HSVMA),
immunofluorescent
staining,
axonemal
ultrastructure
via
transmission
electron
microscopy
(TEM),
genetic
testing.
Notably,
there
no
single
gold
standard
confirmatory
or
exclusionary
test.
Currently,
54
causative
genes
involved
in
cilia
assembly,
structure,
function
have
been
linked
to
PCD;
this
rare
disease
has
spectrum
clinical
manifestations
emerging
genotype–phenotype
relationships.
In
review,
we
provide
an
overview
the
structure
cilia,
genetics
pathophysiology
disease,
as
well
features
associated
with
ciliopathies,
novel
diagnostic
tools,
updates
relationships
PCD.
Frontiers in Molecular Neuroscience,
Год журнала:
2022,
Номер
15
Опубликована: Июль 12, 2022
Cerebrospinal
fluid
(CSF),
a
colorless
liquid
that
generally
circulates
from
the
lateral
ventricles
to
third
and
fourth
ventricles,
provides
essential
nutrients
for
brain
homeostasis
growth
factors
during
development.
As
evidenced
by
an
increasing
corpus
of
research,
CSF
serves
range
important
functions.
While
it
is
considered
decreased
flow
associated
development
hydrocephalus,
has
recently
been
postulated
motile
cilia,
which
line
apical
surfaces
ependymal
cells
(ECs),
play
role
in
stimulating
circulation
cilia
beating.
Ependymal
protrude
ECs,
their
synchronous
pulsing
transports
ventricle
then
subarachnoid
cavity
absorption.
result,
we
malfunctioning
could
disrupt
normal
flow,
raising
risk
hydrocephalus.
This
review
aims
demonstrate
physiological
functions
as
well
how
immobility
or
disorientation
causes
problems.
We
also
conclude
conceivable
ways
treatment
hydrocephalus
currently
clinical
application
provide
theoretical
support
regimen
improvements
investigating
relationship
between
Cells,
Год журнала:
2022,
Номер
11(3), С. 341 - 341
Опубликована: Янв. 20, 2022
Cilia
are
microtubule-based
hair-like
organelles
on
the
cell
surface.
have
been
implicated
in
various
biological
processes
ranging
from
mechanosensation
to
fluid
movement.
Ciliary
dysfunction
leads
a
plethora
of
human
diseases,
known
as
ciliopathies.
Although
non-motile
primary
cilia
ubiquitous,
motile
multicilia
found
restricted
locations
body,
such
respiratory
tract,
oviduct,
efferent
duct,
and
brain
ventricles.
Multicilia
beat
whip-like
motion
generate
flow
over
apical
surface
an
epithelium.
The
concerted
ciliary
provides
driving
force
critical
for
clearing
airway
mucus
debris,
transporting
ova
ovary
uterus,
maintaining
sperm
suspension,
circulating
cerebrospinal
brain.
In
male
reproductive
multiciliated
cells
(MCCs)
were
first
described
mid-1800s,
but
their
importance
fertility
remained
elusive
until
recently.
MCCs
exist
ducts,
which
small,
highly
convoluted
tubules
that
connect
testis
epididymis
play
essential
role
fertility.
this
review,
we
will
introduce
multiciliogenesis,
discuss
mouse
models
infertility
with
defective
multicilia,
summarize
our
current
knowledge
function
tract.
Brain Communications,
Год журнала:
2022,
Номер
4(6)
Опубликована: Ноя. 1, 2022
Within
the
central
nervous
system,
ependymal
cells
form
critical
components
of
blood-cerebrospinal
fluid
barrier
and
cerebrospinal
fluid-brain
barrier.
These
barriers
provide
biochemical,
immunological
physical
protection
against
entry
molecules
foreign
substances
into
while
also
regulating
dynamics,
such
as
composition,
flow
removal
waste
from
fluid.
Previous
research
has
demonstrated
that
several
neurodegenerative
diseases,
Alzheimer's
disease
multiple
sclerosis,
display
irregularities
in
cell
function,
morphology,
gene
expression
metabolism.
Despite
playing
key
roles
maintaining
overall
brain
health,
are
largely
overlooked
understudied
context
disease,
thus
limiting
development
novel
diagnostic
treatment
options.
Therefore,
this
review
explores
anatomical
properties,
functions
structures
define
healthy
brain,
well
ways
which
dysregulation
manifests
across
diseases.
Specifically,
we
will
address
potential
mechanisms,
causes
consequences
dysfunction
describe
how
compromising
integrity
may
initiate,
contribute
to,
or
drive
widespread
neurodegeneration
brain.
Frontiers in Molecular Neuroscience,
Год журнала:
2022,
Номер
15
Опубликована: Окт. 21, 2022
Choroid
plexus
epithelial
cells
can
secrete
cerebrospinal
fluid
into
the
ventricles,
serving
as
major
structural
basis
of
selective
barrier
between
neurological
system
and
blood
in
brain.
In
fact,
choroid
release
majority
fluid,
which
is
connected
with
particular
ion
channels
cells.
also
produce
a
number
essential
growth
factors
peptides
that
help
injured
cerebrovascular
heal.
The
pathophysiology
neurodegenerative
disorders
like
Alzheimer's
disease,
Parkinson's
well
minor
brain
damage
diseases
hydrocephalus
stroke
still
unknown.
Few
studies
have
previously
to
etiology
these
serious
disorders.
Therefore,
hopes
discovering
novel
treatment
options
for
linked
conditions,
this
review
extensively
analyzes
association
such
disease
hydrocephalus.
Finally,
we
CPE
based
immunotherapy,
cauterization,
transplantation,
gene
therapy.
