Study on the Nanoaggregate Formation Mechanism and Antipyretic Effect of Maxing Shigan Decoction DOI Creative Commons
Bing Zhao, Yanxu Zhang,

Zhengmin Fan

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(17), P. 19311 - 19319

Published: April 16, 2024

Traditional Chinese medicine (TCM) formula decoctions easily form nanoaggregates due to self-assembly during the decoction process. However, research on in TCM is still its infancy with limited systematic studies. Maxing Shigan Decoction (MXSGT), a formula, has been commonly used for treatment of fever thousands years China. This study MXSGT as an example investigate antipyretic effects (MXSGT-NAs) decoction, shedding light compatibility mechanisms medicine. MXSGT-NAs were isolated by using high-speed centrifugation and dialysis techniques. The morphology, particle size distribution, electrical potential characterized. High-performance liquid chromatography (HPLC) was detect ephedrine pseudoephedrine MXSGT-NAs. mechanism investigated deconstructing prescription. In pharmacodynamic experiments, rat model established through subcutaneous injection dry yeast results showed presence regularly shaped spherical MXSGT. It contains carbon, oxygen (O), sulfur (S), sodium, aluminum (Al), calcium (Ca), iron, magnesium, bismuth (Bi), etc. exerted substantial febrile rats. Furthermore, we found micrometer-sized particles composed Ca, O, S, potassium, Bi Shi gao decoctions. first provide evidence self-assembling property gao, elucidate scientific connotation dispensing MXSGT, novel perspective

Language: Английский

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine DOI
Li Qiao,

Yuan Lianghao,

Gao Shijie

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1662 - 1692

Published: Jan. 1, 2024

In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, potential applications for cancer treatment and future development prospects are also prospected.

Language: Английский

Citations

16
Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023 DOI Creative Commons

Sinan Ai,

Yake Li,

Huijuan Zheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 1, 2024

Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical

Language: Английский

Citations

11
Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

In the past 11 years, there has been a surge in studies exploring regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, significant gap persists comprehensive scientometric analysis and scientific mapping research, especially tracking evolution, primary contributors, emerging research focal points. This study aims to comprehensively update advancements targeting ferroptosis with various TCMs during previous years. The data, covering period from 1 January 2012, 30 November 2023, were retrieved Web Science database. For in-depth visualized analyses, series advanced analytical instruments employed. findings highlight China’s predominant role, accounting for 71.99% total publications significantly shaping this domain. Noteworthy productivity was observed at institutions, including Guangzhou University Medicine, Chengdu Zhejiang University. Thomas Efferth emerged as foremost author within field, while Frontiers Pharmacology boasted highest publication count. pinpointed hepatocellular carcinoma, chemical drug-induced liver injury, mitochondrial diseases, acute kidney failure most critical disorders addressed realm. offers bibliometric evaluation, enhancing our understanding present status TCM therapy managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers newcomers by accelerating access vital information fostering innovative concept extraction specialized field.

Language: Английский

Citations

10
Carrier-free nanoparticles—new strategy of improving druggability of natural products DOI Creative Commons

Youyun Yao,

Zhenghu Xu, Hang Ding

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

There are abundant natural products resources and extensive clinical use experience in China. However, the active components of generally have problems such as poor water solubility low bioavailability, which limit their druggability. Carrier-free nanoparticles, nanocrystals, self-assembled extracellular vesicles derived from both animal plant sources, great application potential improving safety efficacy drugs due to simple flexible preparation methods, high drug loading capacity delivery efficiency, well long half-life blood circulation. It has been widely used biomedical fields anti-tumor, anti-bacterial, anti-inflammatory anti-oxidation. Therefore, based on that clinic, this review focuses advantages carrier-free nanoparticles delivering compounds, order improve process vivo draggability.

Language: Английский

Citations

1
A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids DOI Creative Commons
Bing Yang,

Xiaochun Wu,

Jingqi Zeng

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6705 - 6724

Published: Nov. 1, 2023

Enhancing the dissolution, permeation and absorption of active components with low solubility poor permeability is crucial for maximizing therapeutic efficacy optimizing functionality. The objective this study to investigate potential natural polysaccharides as carriers improve biopharmaceutical properties components.In study, we employed four representative flavonoids in Astragali Radix, namely Calycosin-7-O-β-D-glucoside (CAG), Ononin (ON), Calycosin (CA) Formononetin (FMN), a demonstration evaluate Astragalus (APS) properties, sush solubility, permeability, vivo. In addition, microstructure flavonoids-APS complexes was characterized, interaction mechanism between APS investigated using multispectral technique molecular dynamics simulation.The results showed that can self-assemble into aggregates porous structure large surface area aqueous solutions. These be loaded through weak intermolecular interactions, such hydrogen bonding, thereby improving their gastrointestinal stability, vivo.We discovered self-assembly its carriers. Compared introducing external excipients, utilization plants may have unique advantage enhancing absorption.

Language: Английский

Citations

20
A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure DOI Creative Commons
Ruibing Feng, Yu Fan, Xinya Zhang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 31, 2024

Acute liver failure (ALF) is a rare and serious condition characterized by major hepatocyte death dysfunction. Owing to the limited therapeutic options, this disease generally has poor prognosis high mortality rate. When ALF cannot be reversed medications, transplantation often needed. However, transplant rejection shortage of donor organs still remain challenges. Most recently, stem cell therapy emerged as promising alternative for treatment diseases. delivery routes stability live products have greatly hindered feasibility efficacy therapy. Inspired functions mesenchymal cells (MSCs) primarily through secretion several factors, we developed an MSC-inspired biomimetic multifunctional nanoframework (MBN) that encapsulates growth-promoting factors secreted MSCs via combination with hydrophilic or hydrophobic drugs. The red blood (RBC) membrane was coated MBN enhance its immunological tolerance prolong circulation time in blood. Importantly, can respond oxidative microenvironment, where it accumulates degrades release payload. In work, two nanoparticles, namely, rhein-encapsulated (RMBN) N-acetylcysteine (NAC)-encapsulated (NMBN), were designed synthesized. lipopolysaccharide (LPS)/d-galactosamine (D-GalN)-induced acetaminophen (APAP)-induced mouse models, RMBN NMBN could effectively target lesions, relieve acute symptoms ALF, promote regeneration virtue their strong antioxidative, anti-inflammatory, regenerative activities. This study demonstrated use treating ALF.

Language: Английский

Citations

8
The development of nanocarriers for natural products DOI
Liying Huang, Shicui Luo, Sen Tong

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems

Language: Английский

Citations

8
Cancer statistics and trends in China: the potential of natural product application DOI
Ting Li,

Mu‐Yang Huang,

Jin‐Jian Lu

et al.

Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(8), P. 673 - 675

Published: Aug. 1, 2024

Language: Английский

Citations

6
Primary study on the effects and mechanisms of separate and combined decoctions of Scutellaria baicalensis Georgi - Coptis chinensis Franch extracts in relieving acute alcoholic liver injury in rats DOI

Yingyan Shen,

Yixin Zhao, Chengyong Zhong

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117790 - 117790

Published: Jan. 20, 2024

Language: Английский

Citations

5
Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine DOI Creative Commons
Jingqi Zeng, Xiao‐Bin Jia

Engineering, Journal Year: 2024, Volume and Issue: 40, P. 28 - 50

Published: April 26, 2024

This research introduces a systems theory-driven framework to integration artificial intelligence (AI) into traditional Chinese medicine (TCM) research, enhancing the understanding of TCM's holistic material basis while adhering evidence-based principles. Utilizing System Function Decoding Model (SFDM), progresses through define, quantify, infer, and validate phases systematically explore basis. It employs dual analytical approach that combines top-down, theory-guided perspectives with bottom-up, elements–structure–function methodologies, provides comprehensive insights Moreover, examines AI's role in quantitative assessment predictive analysis components, proposing two specific AI-driven technical applications. interdisciplinary effort underscores potential enhance our establishes foundation for future at intersection wisdom modern technology.

Language: Английский

Citations

5