Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems

Polymers, Год журнала: 2023, Номер 15(7), С. 1596 - 1596

Опубликована: Март 23, 2023

In the last four decades, nanotechnology has gained momentum with no sign of slowing down. The application inventions or products from revolutionised all aspects everyday life ranging medical applications to its impact on food industry. Nanoparticles have made it possible significantly extend shelf lives product, improve intracellular delivery hydrophobic drugs and efficacy specific therapeutics such as anticancer agents. As a consequence, not only impacted global standard living but also economy. this review, characteristics nanoparticles that confers them suitable potentially toxic biological effects, well their in different fields nanoparticle-based systems biomedicine including nano-based currently approved by U.S. Food Drug Administration (FDA) are discussed. consequence continuous exposure due increased use solution is highlighted.

Язык: Английский

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Liposomes containing nanoparticles: preparation and applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2022, Номер 218, С. 112737 - 112737

Опубликована: Июль 28, 2022

Язык: Английский

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Natural and Synthetic Polymers for Biomedical and Environmental Applications

Polymers, Год журнала: 2024, Номер 16(8), С. 1159 - 1159

Опубликована: Апрель 20, 2024

Natural and synthetic polymers are a versatile platform for developing biomaterials in the biomedical environmental fields. organic compounds that found nature. The most common natural include polysaccharides, such as alginate, hyaluronic acid, starch, proteins, e.g., collagen, silk, fibrin, bacterial polyesters. have already been applied numerous sectors, carriers drug delivery, tissue engineering, stem cell morphogenesis, wound healing, regenerative medicine, food packaging, etc. Various polymers, including poly(lactic acid), poly(acrylic poly(vinyl alcohol), polyethylene glycol, etc., biocompatible biodegradable; therefore, they studied controlled release systems, nano-carriers, dispersion of biofilms, gene delivery bio-ink 3D-printing, textiles agriculture, heavy metals removal, packaging. In following review, recent advancements polymer chemistry, which enable imparting specific functions will be discussed detail, antiviral, anticancer, antimicrobial activities. This work contains authors’ experimental contributions to applications. review is vast overview used fields, synthesis, isolation methods, critically assessessing their advantages, limitations, prospects.

Язык: Английский

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Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis

ACS Nano, Год журнала: 2022, Номер 16(12), С. 19665 - 19690

Опубликована: Дек. 13, 2022

Joint diseases are one of the most common causes morbidity and disability worldwide. The main that affect joint cartilage osteoarthritis rheumatoid arthritis, which require chronic treatment focused on symptomatic relief. Conventional drugs administered through systemic or intra-articular routes have low accumulation and/or retention in articular cartilage, causing dose-limiting toxicities reduced efficacy. Therefore, there is an urgent need to develop improved strategies for drug delivery, particular, use micro- nanotechnology-based methods. Encapsulation therapeutic agents delivery systems reduces efflux from protects against rapid cellular enzymatic clearance following injection. Consequently, decreases side effects increases efficacy due enhanced space. Additionally, frequency administration reduced, as enable sustained release. This review summarizes various advanced systems, such nano- microcarriers, developed diseases.

Язык: Английский

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Chitosan as an Outstanding Polysaccharide Improving Health-Commodities of Humans and Environmental Protection

Polymers, Год журнала: 2023, Номер 15(3), С. 526 - 526

Опубликована: Янв. 19, 2023

Public health, production and preservation of food, development environmentally friendly (cosmeto-)textiles plastics, synthesis processes using green technology, improvement water quality, among other domains, can be controlled with the help chitosan. It has been demonstrated that this biopolymer exhibits advantageous properties, such as biocompatibility, biodegradability, antimicrobial effect, mucoadhesive film-forming capacity, elicitor plant defenses, coagulant-flocculant ability, synergistic effect adjuvant along substances materials. In part, its versatility is attributed to presence ionizable reactive primary amino groups provide strong chemical interactions small inorganic organic substances, macromolecules, ions, cell membranes/walls. Hence, chitosan used either create new materials or modify properties conventional applied on an industrial scale. Considering relevance strategic topics around world, review integrates recent studies key background information constructed by different researchers designing chitosan-based potential applications in aforementioned concerns.

Язык: Английский

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Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

Antioxidants, Год журнала: 2023, Номер 12(3), С. 633 - 633

Опубликована: Март 3, 2023

Various active compounds are easily damaged, so they need protection and must be absorbed targeted. This problem can overcome by encapsulating in the form of solid lipid nanoparticles (SLNs). Initially, SLNs were widely used to encapsulate hydrophobic (non-polar) because their matched affinity interactions. Currently, being for encapsulation hydrophilic (polar) semipolar compounds, but there challenges, including increasing entrapment efficiency. review provides information on current research delivery systems antioxidant which includes various synthesis methods applications fields utilization. developed starting from selection matrices, emulsifiers/surfactants, types or antioxidants, methods, The type determines crystal formation, control compound release, SLN fabrication hydrophilic/hydrophobic have advantages disadvantages. Fabrication design, surfactants, characteristics SLNs. High-shear homogenization combined with ultrasonication is recommended method has been ease preparation good results. Appropriate design produce stable antioxidants that become suitable uses.

Язык: Английский

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Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies

Biomedicines, Год журнала: 2023, Номер 11(7), С. 2078 - 2078

Опубликована: Июль 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Язык: Английский

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Overview of Recent Advances in Nano-Based Ocular Drug Delivery

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15352 - 15352

Опубликована: Окт. 19, 2023

Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology biomaterial science, primarily due to the intricate anatomical physiological barriers unique eye. In this comprehensive review, we aim shed light on features eye, emphasizing natural it administration. Our goal is provide a thorough overview various characteristics inherent each nano-based system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, innovative gene therapy approaches employing techniques. We delve into biology methodology these systems, introducing their applications over past decade. Furthermore, discuss advantages illuminated by recent studies. While systems for ophthalmic formulations are gaining increasing attention, further research imperative address potential safety toxicity concerns.

Язык: Английский

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Navigating regulatory challenges in molecularly tailored nanomedicine

Опубликована: Апрель 25, 2024

Nanomedicine, a convergence of nanotechnology and medical sciences, has unleashed transformative potential in healthcare. However, harnessing the benefits nanomedicine requires thorough understanding its regulatory landscape. An in-depth discussion considerations, including molecular safety assessment, harmonization landscape, shaping future innovation, is presented this discourse. The assessment entails evaluating interactions between nanoparticles biomolecules, ensuring compatibility at level. Harmonization involves developing international standards guidelines for consistent approach, while innovations emphasizes integrating assessments into early stages development. Challenges encompass need standardized methods, balancing innovation with safety, addressing unique features novel designs. As landscape evolves, effective strategies must navigate intricate interplay molecules technologies, both patient access product safety.

Язык: Английский

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Transethosomes: A Comprehensive Review of Ultra-Deformable Vesicular Systems for Enhanced Transdermal Drug Delivery

AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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