Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 8, 2024
Abstract
Mitochondria
occupy
a
central
role
in
the
biology
of
most
eukaryotic
cells,
functioning
as
hub
oxidative
metabolism
where
sugars,
fats,
and
amino
acids
are
ultimately
oxidized
to
release
energy.
This
crucial
function
fuels
variety
cellular
activities.
Disruption
mitochondrial
is
common
feature
many
diseases,
including
cancer,
neurodegenerative
conditions
cardiovascular
diseases.
Targeting
tumor
cell
with
multifunctional
nanosystems
emerges
promising
strategy
for
enhancing
therapeutic
efficacy
against
cancer.
review
comprehensively
outlines
pathways
metabolism,
emphasizing
their
critical
roles
energy
production
metabolic
regulation.
The
associations
between
aberrant
initiation
progression
cancer
highlighted,
illustrating
how
these
disruptions
contribute
oncogenesis
sustainability.
More
importantly,
innovative
strategies
employing
nanomedicines
precisely
target
therapy
fully
explored.
Furthermore,
key
challenges
future
directions
this
field
identified
discussed.
Collectively,
provides
comprehensive
understanding
current
state
potential
nanomedicine
targeting
offering
insights
developing
more
effective
therapies.
Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 967 - 967
Опубликована: Апрель 20, 2023
Inflammatory
bowel
disease
(IBD)
is
a
long-term,
progressive,
and
recurrent
intestinal
inflammatory
disorder.
The
pathogenic
mechanisms
of
IBD
are
multifaceted
associated
with
oxidative
stress,
unbalanced
gut
microbiota,
aberrant
immune
response.
Indeed,
stress
can
affect
the
progression
development
by
regulating
homeostasis
microbiota
Therefore,
redox-targeted
therapy
promising
treatment
option
for
IBD.
Recent
evidence
has
verified
that
Chinese
herbal
medicine
(CHM)-derived
polyphenols,
natural
antioxidants,
able
to
maintain
redox
equilibrium
in
tract
prevent
abnormal
radical
responses.
Here,
we
provide
comprehensive
perspective
implementing
antioxidants
as
potential
candidate
medications.
In
addition,
demonstrate
novel
technologies
stratagems
promoting
antioxidative
properties
CHM-derived
including
delivery
systems,
chemical
modifications,
combination
strategies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(10), С. 8848 - 8848
Опубликована: Май 16, 2023
Mitochondrial
dysfunction
is
a
hallmark
of
numerous
diseases,
including
neurodegenerative
disorders,
metabolic
and
cancer.
transfer,
the
transfer
mitochondria
from
one
cell
to
another,
has
recently
emerged
as
potential
therapeutic
approach
for
restoring
mitochondrial
function
in
diseased
cells.
In
this
review,
we
summarize
current
understanding
its
mechanisms,
applications,
impact
on
death
pathways.
We
also
discuss
future
directions
challenges
field
novel
disease
diagnosis
treatment.
Experimental Hematology and Oncology,
Год журнала:
2023,
Номер
12(1)
Опубликована: Окт. 12, 2023
Abstract
Circular
RNAs
(circRNAs)
are
a
class
of
covalently
closed,
endogenous
ncRNAs.
Most
circRNAs
derived
from
exonic
or
intronic
sequences
by
precursor
RNA
back-splicing.
Advanced
high-throughput
sequencing
and
experimental
technologies
have
enabled
the
extensive
identification
characterization
circRNAs,
such
as
novel
types
biogenesis,
tissue-specific
cell-specific
expression
patterns,
epigenetic
regulation,
translation
potential,
localization
metabolism.
Increasing
evidence
has
revealed
that
participate
in
diverse
cellular
processes,
their
dysregulation
is
involved
pathogenesis
various
diseases,
particularly
cancer.
In
this
review,
we
systematically
discuss
databases,
challenges
for
circRNA
discovery,
new
insight
into
strategies
used
studies
biomedical
applications.
Although
recent
advanced
understanding
knowledge
approaches
annotation,
functional
applications
continuously
needed
to
provide
insights
circRNAs.
The
emergence
circRNA-based
protein
strategy
will
be
promising
direction
field
biomedicine.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
15(1), С. 452 - 468
Опубликована: Дек. 20, 2022
Pyroptosis,
as
a
novel
mode
of
cell
death,
has
been
proven
to
have
impressive
antitumor
effects.
Dying
cells
undergoing
pyroptosis
can
elicit
immunity
by
the
release
tumor-associated
antigens
(TAAs)
and
damage-associated
molecular
patterns
(DAMPs).
Accordingly,
developing
an
effective,
stable,
controllable
nanoplatform
that
promote
these
two
side
effects
is
promising
option
for
cancer
therapy.
In
this
study,
we
designed
carrier-free
chemo-photodynamic
(A-C/NPs)
using
co-assembly
strategy
with
cytarabine
(Ara-C)
chlorin
e6
(Ce6)
induce
subsequent
immune
response
against
breast
cancer.
Mechanistically,
A-C/NPs
trigger
GSDME-mediated
in
manner
through
reactive
oxygen
species
(ROS)
accumulation,
causing
immunogenic
death
(ICD),
which
dying
high-mobility
group
box
1
(HMGB1),
adenosine
triphosphate
(ATP),
calcitonin
(CRT).
Additionally,
Ara-C
stimulate
maturation
cytotoxic
T
lymphocytes
act
synergistically
Ce6-mediated
collectively
augmenting
anticancer
effect
A-C/NPs.
The
showed
excellent
suppressive
on
growth
orthotopic,
abscopal,
recurrent
tumors
mouse
model.
therapy
(PDT)
proposed
nanomedicine
could
be
triggering
improving
global
response.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115036 - 115036
Опубликована: Июнь 23, 2023
Drug
resistance
is
the
main
obstacle
to
achieving
a
cure
in
many
cancer
patients.
Reactive
oxygen
species
(ROS)
are
master
regulators
of
development
that
act
through
complex
mechanisms.
Remarkably,
ROS
levels
and
antioxidant
content
typically
higher
drug-resistant
cells
than
non-resistant
normal
cells,
have
been
shown
play
central
role
modulating
drug
resistance.
Therefore,
determining
underlying
functions
modulation
will
contribute
develop
therapies
sensitize
resistant
by
leveraging
modulation.
In
this
review,
we
summarize
notable
literature
on
sources
regulation
production
highlight
roles
chemoresistance,
encompassing
transcription
factor-mediated
maintenance
stem
their
impact
tumor
microenvironment.
We
also
discuss
potential
ROS-targeted
overcoming
therapeutic
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 19, 2023
A
large
body
of
evidence
indicates
the
existence
a
complex
pathophysiological
relationship
between
cardiovascular
diseases
and
cancer.
Mitochondria
are
crucial
organelles
whose
optimal
activity
is
determined
by
quality
control
systems,
which
regulate
critical
cellular
events,
ranging
from
intermediary
metabolism
calcium
signaling
to
mitochondrial
dynamics,
cell
death
mitophagy.
Emerging
data
indicate
that
impaired
drives
myocardial
dysfunction
occurring
in
several
heart
diseases,
including
cardiac
hypertrophy,
infarction,
ischaemia/reperfusion
damage
metabolic
cardiomyopathies.
On
other
hand,
diverse
human
cancers
also
dysregulate
promote
their
initiation
progression,
suggesting
modulating
homeostasis
may
represent
promising
therapeutic
strategy
both
cardiology
oncology.
In
this
review,
first
we
briefly
introduce
physiological
mechanisms
underlying
system,
then
summarize
current
understanding
about
impact
dysregulated
functions
We
discuss
key
increased
risk
complications
secondary
main
anticancer
strategies,
highlighting
potential
strategies
aimed
at
alleviating
impairment-related
tumorigenesis.
It
hoped
summary
can
provide
novel
insights
into
precision
medicine
approaches
reduce
cancer
morbidities
mortalities.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Янв. 24, 2023
Abstract
Despite
significant
progress
in
clinical
management,
drug
resistance
remains
a
major
obstacle.
Recent
research
based
on
protein
degradation
to
restrain
has
attracted
wide
attention,
and
several
therapeutic
strategies
such
as
inhibition
of
proteasome
with
bortezomib
proteolysis-targeting
chimeric
have
been
developed.
Compared
intervention
at
the
transcriptional
level,
targeting
process
seems
be
more
rapid
direct
strategy.
Proteasomal
proteolysis
lysosomal
are
most
critical
quality
control
systems
responsible
for
proteins
or
organelles.
Although
proteasomal
inhibitors
(e.g.,
chloroquine)
achieved
certain
improvements
some
application
scenarios,
their
routine
practice
is
still
long
way
off,
which
due
lack
precise
capabilities
inevitable
side
effects.
In-depth
studies
regulatory
mechanism
regulators,
including
E3
ubiquitin
ligases,
deubiquitylating
enzymes
(DUBs),
chaperones,
expected
provide
clues
developing
reducing
Here,
we
discuss
underlying
mechanisms
regulating
efflux,
metabolism,
DNA
repair,
target
alteration,
downstream
bypass
signaling,
sustaining
stemness,
tumor
microenvironment
remodeling
delineate
functional
roles
resistance.
We
also
highlight
specific
DUBs,
discussing
possible
modulating
cancer
A
systematic
summary
molecular
basis
by
regulates
will
help
facilitate
development
appropriate
strategies.
