Fundamental Research,
Год журнала:
2023,
Номер
3(5), С. 692 - 706
Опубликована: Июнь 12, 2023
Tumorigenesis
is
a
complicated
process
in
which
numerous
modulators
are
involved
different
ways.
Previous
studies
have
focused
primarily
on
tumor-associated
protein-coding
genes
such
as
oncogenes
and
tumor
suppressor
genes,
well
their
associated
oncogenic
pathways.
However,
noncoding
RNAs
(ncRNAs),
rising
stars
diverse
physiological
pathological
processes,
recently
emerged
additional
tumorigenesis.
In
this
review,
we
focus
two
typical
kinds
of
ncRNAs:
long
(lncRNAs)
circular
(circRNAs).
We
describe
the
molecular
patterns
ncRNAs
roles
cancer
stem
cells
(CSCs),
cells,
environmental
cells.
CSCs
small
subset
generally
considered
to
be
that
initiate
tumorigenesis,
dozens
been
defined
critical
CSC
maintenance
oncogenesis.
Moreover,
widely
oncogenetic
including
sustaining
proliferation,
resisting
cell
death,
genome
instability,
metabolic
disorders,
immune
escape
metastasis.
also
discuss
potential
applications
diagnosis
therapy.
The
progress
ncRNA
research
greatly
improves
our
understanding
oncogenesis
provides
new
targets
for
future
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 9, 2023
Abstract
According
to
a
paper
released
and
submitted
WHO
by
IARC
scientists,
there
would
be
905,700
new
cases
of
liver
cancer
diagnosed
globally
in
2020,
with
830,200
deaths
expected
as
direct
result.
Hepatitis
B
virus
(HBV)
hepatitis
C
(HCV),
D
(HDV)
all
play
critical
roles
the
pathogenesis
hepatocellular
carcinoma
(HCC),
despite
rising
prevalence
HCC
due
non-infectious
causes.
Liver
cirrhosis
are
devastating
consequences
HBV
HCV
infections,
which
widespread
worldwide.
Associated
high
mortality
rate,
these
infections
cause
about
1.3
million
annually
primary
globally.
In
addition
causing
insertional
mutations
viral
gene
integration,
epigenetic
alterations
inducing
chronic
immunological
dysfunction
methods
viruses
turn
hepatocytes
into
cancerous
ones.
While
expanding
our
knowledge
illness,
identifying
pathways
also
give
possibilities
for
novel
diagnostic
treatment
methods.
Nuclear
factor
erythroid
2-related
2
(NRF2)
activation
is
gaining
popularity
option
oxidative
stress
(OS),
inflammation,
metabolic
abnormalities.
Numerous
studies
have
shown
that
elevated
Nrf2
expression
linked
HCC,
providing
more
evidence
HCC.
This
aberrant
signaling
drives
cell
proliferation,
initiates
angiogenesis
invasion,
imparts
drug
resistance.
As
result,
this
master
regulator
may
promising
target
addition,
common
effect
contributes
pathogenesis,
development,
chronicity
infection.
However,
certain
suppress
activity,
helpful
maintaining
cellular
homeostasis.
paper,
we
discussed
influence
deregulation
on
life
cycle
associated
HCV.
We
summed
up
mechanisms
modulation
deregulated
viruses.
Moreover,
describe
molecular
mechanism
modulated
cancer,
stem
cells
(LCSCs),
caused
Cancer Biology and Medicine,
Год журнала:
2024,
Номер
20(12), С. 985 - 1020
Опубликована: Янв. 2, 2024
Cancer
stem
cells
(CSCs)
are
a
small
subset
of
in
cancers
that
thought
to
initiate
tumorous
transformation
and
promote
metastasis,
recurrence,
resistance
treatment.
Growing
evidence
has
revealed
the
existence
CSCs
various
types
suggested
differentiate
into
diverse
lineage
contribute
tumor
progression.
We
may
be
able
overcome
limitations
cancer
treatment
with
comprehensive
understanding
biological
features
mechanisms
underlying
therapeutic
CSCs.
This
review
provides
an
overview
properties,
biomarkers,
shown
by
Recent
findings
on
metabolic
features,
especially
fatty
acid
metabolism
ferroptosis
CSCs,
highlighted,
along
promising
targeting
strategies.
Targeting
is
potential
plan
conquer
prevent
relapse
Journal of Functional Foods,
Год журнала:
2024,
Номер
116, С. 106224 - 106224
Опубликована: Май 1, 2024
Oleic
acid,
found
in
a
variety
of
food
sources,
is
beneficial
to
health.
However,
studies
on
its
anticancer
effects
cancer
stem
cells
resistant
conventional
treatments
and
the
mechanisms
underlying
such
are
scarce.
Here,
we
evaluated
oleic
acid
against
breast
with
stemness
characteristics.
inhibited
proliferation
stem-like
more
significantly
than
that
their
respective
parental
cells,
reduced
expression
cell
markers
migration
invasion
propensity.
It
also
repressed
phosphorylation
FAK,
AKT,
NF-κB,
proteins
involved
invasion.
acid-induced
increase
reactive
oxygen
species
levels
mediated
inhibition
FAK/AKT/NF-κB
signaling
axis.
Our
study
demonstrates
oxidative
stress
plays
an
important
role
inhibiting
metastatic
behavior
characteristics
relevant
for
management
treatment-resistant
cancer.
Biomedicines,
Год журнала:
2023,
Номер
11(1), С. 189 - 189
Опубликована: Янв. 11, 2023
Inflammatory
processes
and
cancer
stem
cells
(CSCs)
are
increasingly
recognized
as
factors
in
the
development
of
tumors.
Emerging
evidence
indicates
that
CSCs
associated
with
properties
such
metastasis,
treatment
resistance,
disease
recurrence.
However,
precise
interaction
between
immune
microenvironment
remains
unexplored.
Although
evasion
system
by
has
been
extensively
studied,
new
research
demonstrates
can
also
control
even
profit
from
response.
This
review
provides
an
overview
reciprocal
interplay
tumor-infiltrating
cells,
collecting
pertinent
data
about
how
stimulate
leukocyte
reprogramming,
resulting
pro-tumor
promote
chemoresistance,
tumorigenicity,
a
rise
number
CSCs.
Tumor-associated
macrophages,
neutrophils,
Th17
regulatory
T
mesenchymal
cancer-associated
fibroblasts,
well
signaling
pathways
involved
these
activities,
among
studied.
cytotoxic
leukocytes
have
potential
to
eliminate
CSCs,
mechanisms
their
clinical
implications
known.
We
intended
compile
experimental
findings
provide
direct
interactions
inflammatory
milieu.
In
addition,
we
aimed
summarize
key
concepts
order
comprehend
cross-talk
tumor
crucial
process
for
effective
design
anti-CSC
therapies.
Cancer Cell International,
Год журнала:
2023,
Номер
23(1)
Опубликована: Окт. 25, 2023
Cancer
Stem
Cells
(CSCs)
are
the
main
"seeds"
for
initiation,
growth,
metastasis,
and
recurrence
of
tumors.
According
to
many
studies,
several
viral
infections,
including
human
papillomaviruses,
hepatitis
B
virus,
Epstein-Barr
C
promote
aggressiveness
cancer
by
encouraging
development
CSC
features.
Therefore,
a
better
method
targeted
elimination
CSCs
knowledge
their
regulatory
mechanisms
in
carcinogenesis
may
lead
future
tool
management
treatment
cancer.
Oncolytic
viruses
(OVs),
which
include
herpes
adenovirus,
vaccinia,
reovirus,
also
new
class
therapeutics
that
have
favorable
properties
such
as
selective
replication
tumor
cells,
delivery
numerous
eukaryotic
transgene
payloads,
induction
immunogenic
cell
death
promotion
antitumor
immunity,
well
tolerable
safety
profile
essentially
differs
from
other
therapeutics.
The
effects
infection
on
suppression
OV
therapy
were
examined
this
paper.
purpose
review
is
investigate
dual
role
(oncolytic
virotherapy
oncogenes).
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3903 - 3903
Опубликована: Март 31, 2024
Cancers
remain
the
second
leading
cause
of
mortality
in
world.
Preclinical
and
clinical
studies
point
an
important
role
cancer/leukaemia
stem
cells
(CSCs/LSCs)
colonisation
at
secondary
organ
sites
upon
metastatic
spreading,
although
precise
mechanisms
for
specific
actions
are
still
not
fully
understood.
Reviewing
present
knowledge
on
crucial
CSCs/LSCs,
their
plasticity,
population
heterogeneity
treatment
failures
cancer
patients
is
timely.
Standard
chemotherapy,
which
acts
mainly
rapidly
dividing
cells,
unable
to
adequately
affect
CSCs
with
a
low
proliferation
rate.
One
proposed
CSC
resistance
anticancer
agents
fact
that
these
can
easily
shift
between
different
phases
cell
cycle
response
typical
stimuli
induced
by
drugs.
In
this
work,
we
reviewed
recent
CSC/LSC
alterations
associated
disease
recurrence,
systematised
functional
assays,
markers,
novel
methods
screening.
This
review
emphasises
CSCs’
involvement
progression
metastasis,
as
well
targeting
synthetic
natural
compounds
aiming
elimination
or
modulation
stemness
properties.
