Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 116990 - 116990
Опубликована: Июль 17, 2024
Dental
pulp
is
a
valuable
and
accessible
source
of
stem
cells
(DPSCs)
with
characteristics
similar
to
mesenchymal
cells.
DPSCs
can
regenerate
range
tissues
their
potential
for
clinical
application
in
regenerative
medicine
promising.
have
been
found
express
low
levels
Class
II
HLA-DR
(MHC)
molecules,
making
them
candidates
allogeneic
transplantation
without
matching
the
donor's
tissue.
Research
on
correlation
between
non-coding
RNAs
(ncRNAs)
human
dental
provides
promising
insights
into
use
these
settings
wide
medical
conditions.
It
possible
number
ncRNAs
order
restore
functional
role
downregulated
that
are
correlated
osteoblastogenesis,
or
suppress
overexpressed
associated
osteoclast
differentiation
some
cases.
Biomedicines,
Год журнала:
2024,
Номер
12(4), С. 743 - 743
Опубликована: Март 27, 2024
Mesenchymal
stem
cells
(MSCs)
have
been
recognized
as
a
cell
therapy
with
the
potential
to
promote
skin
healing.
MSCs,
their
multipotent
differentiation
ability,
can
generate
various
related
wound
healing,
such
dermal
fibroblasts
(DFs),
endothelial
cells,
and
keratinocytes.
In
addition,
MSCs
neovascularization,
cellular
regeneration,
tissue
healing
through
mechanisms
including
paracrine
autocrine
signaling.
Due
these
characteristics,
extensively
studied
in
context
of
burn
chronic
repair.
Furthermore,
during
investigation
unique
roles
aging
scarless
also
discovered.
this
review,
we
summarize
by
which
discuss
recent
findings
from
preclinical
clinical
studies.
We
explore
strategies
enhance
therapeutic
effects
MSCs.
Moreover,
emerging
trend
combining
engineering
techniques,
leveraging
advantages
materials,
biodegradable
scaffolds
hydrogels,
repair
capacity
Additionally,
highlight
using
characteristics
cell-free
therapies
future
direction
cell-based
treatments,
further
demonstrating
regenerative
aesthetic
applications
regeneration.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3562 - 3562
Опубликована: Март 21, 2024
Exosomes
are
extracellular
vesicles
of
endosomal
origin,
ranging
from
30
to
150
nm
in
diameter,
that
mediate
intercellular
transfer
various
biomolecules,
such
as
proteins,
lipids,
nucleic
acids,
and
metabolites.
They
modulate
the
functions
recipient
cells
participate
diverse
physiological
pathological
processes,
immune
responses,
cell-cell
communication,
carcinogenesis,
viral
infection.
Stem
(SCs)
pluripotent
or
multipotent
can
differentiate
into
cell
types.
SCs
also
secrete
exosomes,
which
exhibit
remarkable
therapeutic
potential
for
diseases,
especially
field
regenerative
medicine.
For
example,
exosomes
derived
mesenchymal
stem
(MSCs)
contain
miRNAs
ameliorate
endocrine
disorders,
diabetes
cancer.
(sc-exos)
may
offer
similar
advantages
SCs,
but
with
reduced
risks
challenges.
Sc-exos
have
lower
tumorigenicity,
immunogenicity,
infectivity.
deliver
drugs
more
efficiently
penetrate
deeper
tissues.
In
this
review,
we
provide
an
overview
recent
advances
sc-exos
their
applications
We
elucidate
how
biological
effects
depend
on
molecular
composition.
address
current
challenges
future
directions
using
sc-exos.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 15, 2024
A
wound
takes
a
long
time
to
heal
and
involves
several
steps.
Following
tissue
injury,
inflammation
is
the
primary
cause
of
regeneration
repair
processes.
As
result,
pathophysiological
processes
involving
skin
damage,
healing,
remodeling
depend
critically
on
control
inflammation.
The
fact
that
it
feasible
target
for
improving
prognosis
healing
has
lately
become
clear.
Mesenchymal
stem
cells
(MSCs)
are
an
innovative
effective
therapeutic
option
due
their
immunomodulatory
paracrine
properties.
By
controlling
inflammatory
milieu
wounds
through
immunomodulation,
transplanted
MSCs
have
been
shown
speed
up
process.
In
addition
other
mechanisms,
including
handling
neutrophil
activity
modifying
macrophage
polarization,
there
may
be
modifications
activation
T
cells,
natural
killer
(NK)
dendritic
(DCs).
Furthermore,
studies
pretreating
improves
ability
modulate
immunity.
this
review,
we
summarize
existing
knowledge
about
how
influence
local
in
by
influencing
immunity
facilitate
We
also
provide
overview
optimizing
techniques
when
used
treat
wounds.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115206 - 115206
Опубликована: Июль 24, 2023
Corneal
epithelial
defects
and
excessive
wound
healing
might
lead
to
severe
complications.
As
stem
cells
can
self-renew
infinitely,
they
are
a
promising
solution
for
regenerating
the
corneal
epithelium
treating
injury.
The
chemical
biophysical
properties
of
biological
scaffolds,
such
as
amniotic
membrane,
fibrin,
hydrogels,
provide
necessary
signals
cell
proliferation
differentiation.
Multiple
researchers
have
conducted
investigations
on
these
scaffolds
evaluated
them
potential
therapeutic
interventions
disorders.
These
studies
identified
various
inherent
benefits
drawbacks
associated
with
scaffolds.
In
this
study,
we
provided
comprehensive
overview
history
use
in
repair.
We
mainly
discussed
that
used
transplantation
innovative
materials
under
investigation.
Stem Cell Research & Therapy,
Год журнала:
2023,
Номер
14(1)
Опубликована: Сен. 23, 2023
Abstract
Rheumatoid
arthritis
(RA)
is
a
chronic
and
systemic
autoimmune
disease
of
unknown
etiology.
The
most
common
form
this
inflammatory
arthritis,
which
begins
with
inflammation
the
synovial
membrane
affected
joints
eventually
leads
to
disability
limb.
Despite
significant
advances
in
RA
pharmaceutical
therapies
availability
variety
medicines
on
market,
none
available
medicinal
has
been
able
completely
cure
disease.
In
addition,
percentage
(30–40%)
patients
do
not
respond
appropriately
any
medicines.
Recently,
mesenchymal
stromal
cells
(MSCs)
have
shown
promising
results
controlling
diseases,
including
RA.
Experimental
studies
clinical
trials
demonstrated
high
power
MSCs
modulating
immune
system.
article,
we
first
examine
mechanism
disease,
role
cytokines
existing
therapies.
We
then
discuss
immunomodulatory
function
from
different
perspectives.
Our
understanding
how
work
suppressing
system
will
lead
better
utilization
these
as
tool
treatment
diseases.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 707 - 707
Опубликована: Май 30, 2024
Mesenchymal
stem
cells
(MSCs)
have
emerged
as
a
promising
approach
for
drug
delivery
strategies
because
of
their
unique
properties.
These
include
cell
membrane-coated
nanoparticles,
cell-derived
extracellular
vesicles,
immunomodulatory
effects,
cell-laden
scaffolds,
and
scaffold-free
sheets.
MSCs
offer
advantages
such
low
immunogenicity,
homing
ability,
tumor
tropism,
making
them
ideal
targeted
systems.
Stem
vesicles
gained
attention
immune
properties
tumor-homing
abilities,
presenting
potential
solution
challenges.
The
relationship
between
MSC-based
the
self-renewal
differentiation
capabilities
lies
in
engineered
to
serve
effective
carriers
therapeutic
agents
while
maintaining
intrinsic
exhibit
potent
immunosuppressive
functions
strategies.
EVs
immunogenicity
strong
tissue
repair
regeneration.
Scaffold-free
sheets
represent
cutting-edge
regenerative
medicine,
offering
versatile
platform
engineering
regeneration
across
different
medical
specialties.
shown
great
clinical
applications
medicine
ability
differentiate
into
various
types,
secrete
bioactive
factors,
modulate
responses.
Researchers
are
exploring
these
innovative
approaches
enhance
efficiency
effectiveness
treating
diseases.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 792 - 792
Опубликована: Июль 3, 2024
The
vast
regenerative
potential
of
stem
cells
has
laid
the
foundation
for
cell-based
therapies.
However,
certain
challenges
limit
application
therapeutic
use
cell-free
therapy
can
avoid
limitations
associated
with
Acellular
therapies
rely
on
biological
factors
released
by
cells,
including
growth
and
extracellular
vesicles
such
as
exosomes.
Due
to
their
comparable
potential,
acellular
may
provide
a
feasible
scalable
alternative
Exosomes
are
small
secreted
various
types
cells.
contain
parent
cell-derived
nucleic
acids,
proteins,
lipids,
other
bioactive
molecules.
They
play
an
important
role
in
intra-cellular
communication
influence
characteristics
inherit
properties
cells;
therefore,
exosomes
particular
interest
applications
medicine.
In
comparison
therapy,
exosome
offers
several
benefits,
easy
transport
storage,
no
risk
immunological
rejection,
few
ethical
dilemmas.
Unlike
be
lyophilized
stored
off-the-shelf,
making
standardized
more
accessible
while
reducing
overall
treatment
costs.
Exosome-based
treatments
therefore
readily
available
patients
at
time
care.
current
review
discusses
therapy.
explores
molecular
mechanism
biogenesis,
methods
isolation,
characterization.
addition,
latest
advancements
bioengineering
techniques
enhance
have
been
discussed.
well
diverse
diagnosis
diseases
reviewed
detail.
