Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2905 - 2917
Опубликована: Июль 1, 2024
Our previous studies in vitro and vivo have shown anti-severe acute respiratory syndrome coronavirus 2 activity of fingerroot extract (
Язык: Английский
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Март 27, 2024
Abstract Parkinson's disease (PD) is a progressive neurodegenerative as result of the degeneration dopaminergic neurons in substantia nigra pars compacta (SNpc). The fundamental features PD are motor and non-motor symptoms. symptoms develop due to disruption neurotransmitters other such γ-aminobutyric acid (GABA). potential role GABA neuropathology concerning was not precisely discussed. Therefore, this review intended illustrate possible regarding pathway essential regulating inhibitory tone prevent excessive stimulation cerebral cortex. Degeneration linked with reducing GABAergic neurotransmission. Decreasing activity promotes mitochondrial dysfunction oxidative stress, which highly related neuropathology. Hence, restoring by agonists may attenuate progression dysregulation SNpc contributes developing Besides, also pathway, amelioration reduce In conclusion, deregulation might be intricate Improving novel, beneficial approach control
Язык: Английский
Процитировано
16
Heliyon, Год журнала: 2025, Номер 11(2), С. e41980 - e41980
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Inflammopharmacology, Год журнала: 2022, Номер 31(1), С. 37 - 56
Опубликована: Дек. 29, 2022
Abstract Silent information regulator (SIRT) has distinctive enzymatic activities and physiological functions to control cell-cycle progression, gene expression, DNA stability by targeting histone non-histone proteins. SIRT1 enhances synaptic formation activity, therefore, can reduce the progression of various degenerative brain diseases including Parkinson’s disease (PD). activity is decreased aging with a subsequent increased risk for development diseases. Inhibition promotes inflammatory reactions since inhibits transcription nuclear factor kappa B (NF-κB) which also activation via microRNA miR-34a NAD synthesis. highly expressed in microglia as well neurons, antioxidant anti-inflammatory effects. Therefore, this review aimed find possible role PD neuropathology. neuroprotective effects; downregulation during p53 expression may increase vulnerability neuronal cell deaths. neuropathology linked sequence changes release pro-inflammatory cytokines due signaling pathways. In addition, oxidative stress, disorders, mitochondrial dysfunction, apoptosis contribute mutually Thus, activators play crucial mitigation through amelioration apoptosis,
Язык: Английский
Процитировано
68
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Апрель 12, 2023
A novel coronavirus strain (COVID-19) caused severe illness and mortality worldwide from 31 December 2019 to 21 March 2023. As of this writing, 761,071,826 million cases have been diagnosed worldwide, with 6,879,677 deaths accorded by WHO organization has spread 228 countries. The number is closely connected the growth innate immune cells in lungs, mainly macrophages, which generate inflammatory cytokines (especially IL-6 IL-1β) that induce "cytokine storm syndrome" (CSS), multi-organ failure, death. We focus on promising natural products their biologically active chemical constituents as potential phytopharmaceuticals target virus-induced pro-inflammatory cytokines. Successful therapy for condition currently rare, introduction an effective vaccine might take months. Blocking viral entrance replication regulating humoral cellular immunity uninfected population are most often employed treatment approaches infections. Unfortunately, no presently FDA-approved medicine can prevent or reduce SARS-CoV-2 access reproduction. Until now, important element disease severity host's response activation suppression. Several medicines adapted COVID-19 patients, including arbidol, favipiravir, ribavirin, lopinavir, ritonavir, hydroxychloroquine, chloroquine, dexamethasone, anti-inflammatory pharmaceutical drugs, such tocilizumab, glucocorticoids, anakinra (IL-1β cytokine inhibition), siltuximab (IL-6 inhibition). However, these synthetic medications therapies several side effects, heart permanent retinal damage case hydroxyl-chloroquine, liver destruction remdesivir. This review summarizes four strategies fighting storms immunomodulatory deficiency induced using product a therapeutic measure control storms.
Язык: Английский
Процитировано
23
Pharmacological Reports, Год журнала: 2023, Номер 75(4), С. 923 - 936
Опубликована: Июнь 3, 2023
Язык: Английский
Процитировано
23
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Фев. 9, 2024
Abstract Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of central nervous system (CNS). The underlying pathophysiology MS destruction myelin sheath by immune cells. formation plaques, inflammation, injury neuronal characterizes its neuropathology. plaques are multiple focal regions demyelination disseminated in brain's white matter, spinal cords, deep grey cerebral cortex. Fenofibrate a peroxisome proliferative activated receptor alpha (PPAR-α) that attenuates reactions MS. inhibits differentiation Th17 inhibiting expression pro-inflammatory signaling. According to these findings, this review intended illuminate mechanistic immunoinflammatory role fenofibrate mitigating In conclusion, can attenuate neuropathology modulating different pathways, including oxidative stress, autophagy, mitochondrial dysfunction, inflammatory-signaling neuroinflammation.
Язык: Английский
Процитировано
9
Heliyon, Год журнала: 2025, Номер 11(4), С. e42739 - e42739
Опубликована: Фев. 1, 2025
This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2022, Номер 396(3), С. 453 - 468
Опубликована: Дек. 3, 2022
Язык: Английский
Процитировано
28
Mathematics, Год журнала: 2023, Номер 11(5), С. 1274 - 1274
Опубликована: Март 6, 2023
The novel coronavirus pandemic is a major global public health emergency, and has presented new challenges requirements for the timely response operational stability of emergency logistics that were required to address events outbreak in China. Based on problems insufficient timeliness high total system cost distribution epidemic situations, this paper takes minimum vehicle travel cost, time early/late punishment fixed as target, soft window receiving goods at each demand point, rated load vehicle, volume, maximum single delivery constraints, an routing problem optimization model epidemics was constructed. convergence speed improvement strategy, particle search elite retention strategy introduced improve swarm (PSO) algorithm it be suitable solving problems. simulation results prove improved PSO solve medical supplies can reach optimal results. Compared with basic algorithm, reduced by 20.09%.
Язык: Английский
Процитировано
17
Phytotherapy Research, Год журнала: 2024, Номер 38(2), С. 1071 - 1088
Опубликована: Янв. 2, 2024
Abstract A sudden outbreak of the COVID‐19 pandemic was a big blow to world community on every level. Created by novel coronavirus, SARS‐CoV‐2, which previously unknown human immune system. The expert opinion almost immediately united fact that most effective way fighting would be building immunity artificially via mass immunization program. However, it took about year for approval first vaccine against COVID‐19. In meantime, part general population started adapting nutritious diet plans and dietary supplements boost natural as potential prophylactic strategy SARS‐CoV‐2 infection. Whether they originate from mainstream medicine, such synthetic supplements, or traditional herbal remedies in form single poly‐herbs, these may comprise various components exhibit immunomodulatory, anti‐inflammatory, antioxidant, antimicrobial characteristics. There is substantial body predictions opinions suggesting enhancing one's with containing additional nutrients bioactive compounds like vitamins, minerals, amino acids, fatty phytochemicals, probiotics can enhance system's ability develop resistance COVID‐19, although none them have any conclusive evidence nor officially recommended World Health Organization (WHO). current review critically acclaims gap between public perception‐based preference real evidence‐based study weigh actual benefit relation prevention management.
Язык: Английский
Процитировано
7