Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Background
Vascular
dementia
(VaD)
includes
a
group
of
brain
disorders
that
are
characterized
by
cerebrovascular
pathology.Neuroinflammation,
disruption
the
blood–brain
barrier
(BBB)
permeability,
white
matter
lesions,
and
neuronal
loss
all
significant
pathological
manifestations
VaD
play
key
role
in
disease
progression.
Necroptosis,
also
known
asprogrammed
necrosis,
is
mode
programmed
cell
death
distinct
from
apoptosis
closely
associated
with
ischemic
injury
neurodegenerative
diseases.
Recent
studies
have
shown
necroptosis
exacerbates
BBB
destruction,
activates
neuroinflammation,
promotes
loss,
severely
affects
prognosis.
Results
Conclusions
In
this
review,
we
outline
roles
its
molecular
mechanisms
process
VaD,
particular
focus
on
modulating
neuroinflammation
exacerbating
permeability
elaborate
regulatory
centrally
involved
cells
mediated
tumor
necrosis
factor‐α
VaD.
We
analyze
possibility
specific
strategy
targeting
would
help
inhibit
destruction
With
necroptosis,
study
delved
into
impact
changes
prognosis
to
provide
new
treatment
ideas.
Язык: Английский
Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Язык: Английский
Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
Brain Hemorrhages,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
The use of bioinformatic analysis to study intracerebral hemorrhage
Brain Hemorrhages,
Год журнала:
2024,
Номер
5(4), С. 188 - 196
Опубликована: Май 14, 2024
The
integration
of
bioinformatics
analysis
into
intracerebral
hemorrhage
(ICH)research
represents
a
paradigm
shift
in
our
approach
to
understanding,
diagnosing,
and
treating
this
complex
neurological
disorder.
By
leveraging
the
power
bioinformatics,
scientific
community
is
poised
make
significant
strides
combating
devastating
condition,
ultimately
improving
patient
outcomes
quality
life.
This
study
provides
comprehensive
overview
application
tools
techniques
elucidating
genetic,
molecular,
environmental
underpinnings
ICH.
Through
detailed
examination
genomic
sequencing,
transcriptomics,
proteomics,
machine
learning,
we
explore
how
these
approaches
have
contributed
identifying
genetic
variants,
understanding
molecular
pathways,
discovering
biomarkers
related
Challenges
such
as
data
complexity,
multi-omics
data,
translation
findings
clinical
practice
are
discussed,
alongside
ethical
considerations
surrounding
privacy
consent.
underscores
critical
role
advancing
ICH,
offering
insights
its
pathophysiology,
paving
way
for
personalized
medicine
targeted
therapeutic
interventions.
Язык: Английский
Ultrasensitive Electrochemiluminescence Imaging Detection of Multiple miRNAs in Single Cells with a Closed Bipolar Electrode Array Chip
Analytical Chemistry,
Год журнала:
2024,
Номер
96(29), С. 12112 - 12119
Опубликована: Июль 11, 2024
In
situ
sensitive
detection
of
multiple
biomarkers
in
a
single
cell
was
highly
necessary
for
understanding
the
pathogenesis
mechanism
and
facilitating
disease
diagnosis.
Herein,
bipolar
electrode
(BPE)-electrochemiluminescence
(ECL)
imaging
chip
designed
ultrasensitive
miRNAs
cells
based
on
dual-signal
amplification
strategy.
A
trapped
lysed
within
microtrap
cathode
chamber
an
HCR
process
nanoprobes
(Fc/DNA/Fe
Язык: Английский
GAS6-AS1 drives bladder cancer progression by increasing MMP7 expression in a ceRNA- and RBP-dependent manner
Translational Oncology,
Год журнала:
2024,
Номер
48, С. 102065 - 102065
Опубликована: Июль 24, 2024
Язык: Английский
Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 3, 2024
Periodontitis
is
one
of
the
most
prevalent
oral
diseases
leading
to
tooth
loss
in
adults,
and
characterized
by
destruction
periodontal
supporting
structures.
Traditional
therapies
for
periodontitis
cannot
achieve
ideal
regeneration
tissue.
Mesenchymal
stem
cells
(MSCs)
represent
a
promising
approach
tissue
regeneration.
Recently,
prominent
role
MSCs
this
context
has
been
attributed
microRNAs
(miRNAs),
which
participate
post-transcriptional
regulation
are
crucial
various
physiological
pathological
processes.
Additionally,
they
function
as
indispensable
elements
extracellular
vesicles,
protect
them
from
degradation.
In
periodontitis,
MSCs-derived
miRNAs
play
pivotal
cellular
proliferation
differentiation,
angiogenesis
tissues,
regulating
autophagy,
providing
anti-apoptotic
effects,
mediating
inflammatory
microenvironment.
As
cell-free
strategy,
their
small
size
ability
target
related
sets
genes
regulate
signaling
networks
predispose
become
candidates
This
review
aims
introduce
summarize
potential
functions
mechanisms
repair
Язык: Английский
Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE)
Chinese Neurosurgical Journal,
Год журнала:
2024,
Номер
10(1)
Опубликована: Дек. 16, 2024
Abstract
Background
Precise
diagnosis
and
rapid
treatment
for
acute
complex
intracranial
hemorrhage
(ICH)
are
crucial.
The
neurosurgical
hybrid
operating
platform
integrates
traditional
open
neurosurgery
room
functionalities
with
endovascular
therapy
capabilities
is
developing
in
the
practice.
However,
its
effect
on
emergent
complicated
neurovascular
cases
needs
pilot
exploration.
Methods
In
this
prospective
study,
a
total
of
103
both
spontaneous
non-spontaneous
ICH
were
consecutively
recruited
between
June
2019
2023.
Demographic
data,
including
age,
gender
distribution,
types
hemorrhage,
collected.
Surgical
interventions
tailored
based
DSA,
hemorrhages.
Functional
outcomes
assessed
using
modified
Rankin
Scale
(mRS)
preoperatively
postoperatively.
Results
Over
study
period
from
to
2023,
cohort
underwent
emergency
surgical
utilizing
E-HOPE
platform.
Among
these
cases,
88
classified
as
ICH,
while
15
non-spontaneous.
mean
age
at
entire
was
54.0
±
3.7
years,
slight
predominance
male
patients.
Spontaneous
encompassed
diverse
spectrum
etiologies,
arteriovenous
malformations,
aneurysms,
fistulas,
cavernous
moyamoya
disease,
cryptogenic
address
specific
pathology.
Notably,
improvements
mRS
scores
observed
majority
some
patients
experiencing
stabilization
or
deterioration
Non-spontaneous
(
n
=
15)
primarily
iatrogenic
13)
due
tumors
adjacent
internal
carotid
artery,
necessitating
stent
graft
deployment.
approaches,
deployment
middle
meningeal
artery
embolization,
effective
managing
cases.
Postoperative
functional
varied
depending
nature
subset
demonstrating
improvement
others
showed
no
significant
change.
Conclusions
Emergency
offers
promising
Tailored
approaches
result
favorable
postoperative
outcomes,
highlighting
importance
multidisciplinary
approach
Язык: Английский