iMeta, Год журнала: 2024, Номер 3(6)
Опубликована: Дек. 1, 2024
Polyploidization promotes the functional diversification of autophagy in plants, expanding autophagy-associated genes (AAGs) to support processes like chloroplast division and flowering. Analysis 92,967 AAGs
Язык: Английский
Medicinska istrazivanja, Год журнала: 2025, Номер 58(1), С. 61 - 73
Опубликована: Янв. 1, 2025
Cell death emerges during embryonic development, and is preserved after the birth as an important process for maintaining homeostasis by removing damaged or aged cells. Two forms of cell deaths exist: accidental regulated death. Necrosis accidental, unregulated, passive form that occurs due to collapse cellular homeostatic mechanisms under extreme non-physiological conditions. Regulated active, energy-dependent functions a physiological mechanism in numerous pathological conditions when it provides selective elimination potentially dangerous infected There are many types death: intrinsic extrinsic apoptosis, autophagy dependent death, necroptosis, pyroptosis, ferroptosis, parthanatos, mitochondrial permeability transition-driven necrosis, lysosome-dependent immunogenic entosis NET-osis. Different interconnected. Abnormal activation different can cause diseases. Dysregulation apoptotic program lead hyperplasia, autoimmune diseases tumorigenesis, pyroptosis associated with bacterial infection necroptosis human inflammatory skin carcinogenesis. Understanding regulatory apoptosis led discovery BH3 mimetics, drugs used treatment some B malignancies. Drugs target investigation could be future therapies various diseases, including cancer. The aim this review summarize new knowledge about processes emphasize importance newly discovered molecular pathways regulating enhancing our comprehension health disease.
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 154899 - 154899
Опубликована: Окт. 20, 2023
Язык: Английский
Процитировано
10
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 25, 2024
Colorectal cancer is a common malignant tumor of the digestive system. Its morbidity and mortality rank among highest in world. Cancer development associated with aberrant signaling pathways. Autophagy process cell self-digestion that maintains intracellular environment has bidirectional regulatory role cancer. Apoptosis one important death programs cells able to inhibit development. Studies have shown variety substances can regulate autophagy apoptosis colorectal through pathways, participate regulation on apoptosis. In this paper, we focus relevant research based involvement related pathways order provide new ideas therapeutic directions for treatment
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9703 - 9703
Опубликована: Сен. 7, 2024
Breast cancer (BC) has become the most life-threatening to women worldwide, with multiple subtypes, poor prognosis, and rising mortality. The molecular heterogeneity of BC limits efficacy represents challenges for existing therapies, mainly due unpredictable clinical response, reason which probably lies in interactions alterations diverse cell death pathways. However, studies drugs have focused on a single type death, while therapeutic opportunities related other pathways are often neglected. Therefore, it is critical identify predominant transition different patterns during treatment, underlying regulatory mechanisms BC. In this review, we summarize characteristics various forms including PANoptosis (pyroptosis, apoptosis, necroptosis), autophagy, ferroptosis, cuproptosis, discuss their triggers signaling cascades BC, may provide reference future pathogenesis research allow development novel targeted therapeutics
Язык: Английский
Процитировано
3
iMeta, Год журнала: 2024, Номер 3(6)
Опубликована: Дек. 1, 2024
Polyploidization promotes the functional diversification of autophagy in plants, expanding autophagy-associated genes (AAGs) to support processes like chloroplast division and flowering. Analysis 92,967 AAGs
Язык: Английский
Процитировано
3