BPA and its analogues (BPS and BPF) modify the expression of genes involved in the endocrine pathway and apoptosis and a multi drug resistance gene of the aquatic midge Chironomus riparius (Diptera)

Environmental Pollution, Год журнала: 2020, Номер 265, С. 114806 - 114806

Опубликована: Май 24, 2020

Язык: Английский

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Exposure to heavy metal-contaminated sediments disrupts gene expression, lipid profile, and life history traits in the midge Chironomus riparius

Water Research, Год журнала: 2019, Номер 168, С. 115165 - 115165

Опубликована: Окт. 7, 2019

Язык: Английский

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Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(10), С. 3529 - 3529

Опубликована: Май 16, 2020

The choice of the study objective was affected by numerous controversies and concerns around bisphenol F (BPF) S (BPS)—analogues A (BPA). focused on determination comparison scale BPA, BPF, BPS impact soil microbiome its enzymatic activity. following parameters were determined in uncontaminated contaminated with BPS: count eleven groups microorganisms, colony development (CD) index, microorganism ecophysiological diversity (EP) genetic bacteria activity dehydrogenases (Deh), urease (Ure), catalase (Cat), acid phosphatase (Pac), alkaline (Pal), arylsulphatase (Aryl) β-glucosidase (Glu). Bisphenols A, significantly disrupted homeostasis. BPF is regarded as most toxic, followed BPA. reduced abundance Proteobacteria Acidobacteria increased that Actinobacteria. Unique types identified well characteristics each bisphenol: Lysobacter, Steroidobacter, Variovorax, Mycoplana, for Caldilinea, Arthrobacter, Cellulosimicrobium Promicromonospora Dactylosporangium Geodermatophilus, Sphingopyxis BPS. Considering strength a negative bisphenols biochemical activity, they can be arranged follows: > Urease proved to susceptible least pressure, regardless duration.

Язык: Английский

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The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE‐1 cells: A comparative study

Journal of Applied Toxicology, Год журнала: 2019, Номер 40(5), С. 643 - 654

Опубликована: Дек. 26, 2019

Bisphenol A (BPA) is a well-known endocrine disruptor and it widely used mainly in the plastics industry. Due to recent reports on its possible impact health (particularly male reproductive system), bisphenol F (BPF) S (BPS) are now being as alternatives. In this study, RWPE-1 cells were model compare cytotoxicity, oxidative stress-causing potential genotoxicity of these chemicals. addition, effects derivatives assessed DNA repair proteins. incubated with BPA, BPF, BPS at concentrations 0-600 μM for 24 h. The inhibitory concentration 20 (IC20 , that causes 20% cell viability loss) values 45, 65, 108 μM, respectively. These results indicated cytotoxicity potentials ranked BPA > BPF BPS. We also found alterations superoxide dismutase, glutathione peroxidase reductase activities, total antioxidant capacity all bisphenol-exposed groups. standard modified Comet assay, produced significantly higher levels damage vs control. proteins (OGG1, Ape-1, MyH) involved base excision pathway, well p53 protein down-regulated alternatives cytotoxic genotoxic, changed expressions enzymes. Therefore, further studies needed assess whether they can be safely or not.

Язык: Английский

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BPA and BPS affect the expression of anti-Mullerian hormone (AMH) and its receptor during bovine oocyte maturation and early embryo development

Reproductive Biology and Endocrinology, Год журнала: 2021, Номер 19(1)

Опубликована: Авг. 3, 2021

Exposure to endocrine-disrupting chemicals, such as Bisphenol A (BPA) and S (BPS), is widespread has negative implications on embryonic development. Preliminary evidence revealed that in women undergoing IVF treatment, urinary BPA levels were associated with low serum anti-Mullerian hormone, however a definitive relationship between the two not yet been characterized.This study aimed evaluate BPS effects vitro oocyte maturation early preimplantation embryo development through i) analysis of hormone (AMH) receptor II (AMHRII), ii) investigation developmental parameters, cleavage, blastocyst rates arrest, iii) detection apoptosis iv) assessment possible sex ratio skew. An bovine model was used translational for human We first assessed AMH AMHRII after bisphenol exposure during maturation. Zygotes also analyzed cleavage blastocysts stages. Techniques include fertilization, quantitative polymerase chain reaction (qPCR), western blotting, TUNEL immunofluorescence.Our findings show significantly decreased (p < 0.001), 0.005) overall well increased arrest at 2-4 cell stage 0.05). Additionally, both DNA fragmentation cells, 8-16 cells embryos Furthermore, alter mRNA protein level oocytes blastocysts. BPA, but BPS, skews ratios towards female 0.05).This shows affects expression exerts its greater extent fertilization therefore may be safer alternative BPA. Our data lay foundation future functional studies, kinetics, downstream effectors, promoter activation/inhibition prove bisphenols signalling system.

Язык: Английский

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Bisphenols' occurrence in bivalves as sentinel of environmental contamination

The Science of The Total Environment, Год журнала: 2021, Номер 785, С. 147263 - 147263

Опубликована: Апрель 22, 2021

Язык: Английский

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Chironomus riparius exposure to field-collected contaminated sediments: From subcellular effect to whole-organism response

The Science of The Total Environment, Год журнала: 2019, Номер 671, С. 874 - 882

Опубликована: Март 27, 2019

Язык: Английский

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Occurrence, distribution, and risk assessment of bisphenol analogues in Luoma Lake and its inflow rivers in Jiangsu Province, China

Environmental Science and Pollution Research, Год журнала: 2021, Номер 29(1), С. 1430 - 1445

Опубликована: Авг. 5, 2021

Язык: Английский

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Prenatal bisphenol S exposure induces hepatic lipid deposition in male mice offspring through downregulation of adipose-derived exosomal miR-29a-3p

Journal of Hazardous Materials, Год журнала: 2023, Номер 453, С. 131410 - 131410

Опубликована: Апрель 12, 2023

Язык: Английский

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Chironomus riparius molecular response to polystyrene primary microplastics

The Science of The Total Environment, Год журнала: 2023, Номер 868, С. 161540 - 161540

Опубликована: Янв. 13, 2023

Microplastics are emerging as a central concern for the environment. They can be found worldwide, produced industry and because of plastic debris degradation. The microplastics smaller than 5 mm, but they also range in micro nanometer scales, present soil aquatic ecosystems. Furthermore, have different chemical compositions, including additives with putative toxicity. Chironomus riparius is dipteran larvae used toxicology tests. As benthic organism, it exposed to water sediments, being able ingest some them depending on size shape. However, still poor knowledge effects that invertebrates, especially at molecular level. We analyzed impact 5–5.9 μm spheres polystyrene metabolism C. riparius, studying transcriptional activity eighty genes, twenty-eight described here first time. genes covered endocrine response, detoxification mechanisms, stress DNA repairing hypoxia, oxidative stress, apoptosis, immunity, cholesterol metabolism, energy circadian rhythm, signaling, regulation piRNAs. results showed 24 h, response was most affected, while 48 were slightly affected. Finally, 72 lipid altered. Overall, data suggest an acute involving downregulation, later seems move metabolic alterations, changes hormonal metabolism. It could micrometer confounded food, decreasing availability resources larval development. work shows dynamic microspheres provides new biomarkers analyze several mechanisms involved cellular physiological toxicants.

Язык: Английский

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