npj Biofilms and Microbiomes,
Год журнала:
2022,
Номер
8(1)
Опубликована: Окт. 20, 2022
The
intestinal
mucus
layer
has
a
dual
role
in
human
health
constituting
well-known
microbial
niche
that
supports
gut
microbiota
maintenance
but
also
acting
as
physical
barrier
against
enteric
pathogens.
Enterotoxigenic
Escherichia
coli
(ETEC),
the
major
agent
responsible
for
traveler's
diarrhea,
is
able
to
bind
and
degrade
mucins,
representing
an
important
understudied
virulent
trait
of
pathogen.
Using
set
complementary
vitro
approaches
simulating
digestive
environment,
this
study
aimed
describe
how
microenvironment
could
shape
different
aspects
ETEC
strain
H10407
pathophysiology,
namely
its
survival,
adhesion,
virulence
gene
expression,
interleukin-8
induction
interactions
with
fecal
microbiota.
TNO
gastrointestinal
model
(TIM-1)
physicochemical
conditions
upper
(GI)
tract,
we
reported
secretion
surface
sustained
probably
by
helping
it
face
GI
stresses.
When
integrating
host
part
Caco2/HT29-MTX
co-culture
model,
demonstrated
secreting-cells
favored
adhesion
did
not
impede
Interleukin-8
(IL-8)
induction.
Furthermore,
proved
mucosal
favor
colonization
complex
background
simulated
batch
experiments.
However,
mucus-specific
was
widely
modified
upon
challenge
suggesting
pathogen
infectious
cycle.
multi-targeted
approaches,
played
opening
avenues
design
new
treatment
strategies.
Reviews in Aquaculture,
Год журнала:
2022,
Номер
15(2), С. 820 - 839
Опубликована: Ноя. 8, 2022
Abstract
The
gut
microbiota
is
currently
one
of
the
most
studied
‘organs’
in
animals,
and
fish
are
no
exception.
A
complex
diversity
microbes,
including
bacteria,
archaea,
yeast
fungus,
constitute
microbiota,
creating
a
interaction
with
their
host
accomplishing
multiple
beneficial
functions,
such
as
food
digestion,
nutrient
absorption,
immune
system,
endocrine
stress
response.
microbiota–pathogen
protects
by
mounting
colonization
resistance,
competing
for
nutrients
space.
Changes
balance
community
could
affect
structure
homeostasis,
inducing
dysbiosis.
In
addition,
invading
pathogens
can
induce
dysbiosis
evading
host's
defence
barriers,
acquiring
from
host,
using
metabolites
produced
producing
toxins.
this
regard,
understanding
interactions
within
essential
to
prevent
pathogen
establishment
host.
Hence,
review
describes
close
indivisible
relationships
between
that
lead
disease.
Current Research in Parasitology and Vector-Borne Diseases,
Год журнала:
2021,
Номер
1, С. 100036 - 100036
Опубликована: Янв. 1, 2021
The
main
importance
of
ticks
resides
in
their
ability
to
harbor
pathogens
that
can
be
transmitted
terrestrial
vertebrates
including
humans.
Recently,
studies
have
focused
on
the
taxonomic
and
functional
composition
tick
microbiome,
its
microbial
diversity
variation
under
different
factors
species,
sex,
environment
among
others.
Of
special
interest
are
interactions
between
tick,
microbiome
since
influence
pathogen
colonization
within
vector,
potentially,
transmission
vertebrate
host.
In
this
review,
we
tackled
a
synthesis
growing
field
microbiomes.
We
focus
current
state
research,
addressing
controversial
hotly
debated
topics
advances
precise
manipulation
microbiome.
Furthermore,
discuss
innovative
anti-tick
microbiota
vaccines
as
possible
tool
for
modulation
thus,
control
tick-borne
diseases.
Deciphering
tick-microbiome
spur
new
strategies
diseases
via
Reviews in Aquaculture,
Год журнала:
2022,
Номер
15(2), С. 579 - 594
Опубликована: Окт. 12, 2022
Abstract
Infectious
diseases
are
a
major
burden
in
aquaculture,
and
represent
significant
yield‐limiting
factor
production
that
is
costly
to
manage
as
well
potential
vector
for
zoonoses.
Over
the
past
decades,
range
of
new
have
emerged,
alongside
increased
levels
antibiotic
resistance,
thus
heightening
need
improved
disease
management
methods
supportive
One
Health
concept.
Simultaneously,
recent
advances
Next‐Generation
Sequencing
increasingly
elucidated
role
microbiome
regulating
metabolism,
immune
function
resilience.
Such
work
has
included
plethora
studies
on
pathogens
through
manipulation
microbiome,
related
mechanisms
behind
host
There
now
an
increasing
robust
body
evidence
recognizing
importance
holistic
framework
aetiology
between
host,
its
environment
colonizing
microorganisms,
with
perturbation
associated
specific
dysbiotic
states
outcomes.
Elucidating
preliminary
step
towards
development
prevention
methods,
main
goal
being
early
identification
dysbiosis‐associated
biomarkers
prior
any
physical
signs
disease.
While
acknowledging
challenges
using
key
microbial
taxa
biomarkers,
we
review
characterization
dysbiosis
signatures
context
development,
emphasis
aquaculture
prevention.
Several
promising
strategies
suggested,
including
use
functional
genes
or
metabolic
pathways
conserved
proxy
homeostasis.
Life,
Год журнала:
2022,
Номер
12(3), С. 456 - 456
Опубликована: Март 19, 2022
Microorganisms
are
an
essential
part
of
life
on
the
earth
and
can
exist
in
association
with
virtually
any
living
thing.
The
environmental
microbiome
is
much
more
diverse
than
human
microbiome.
It
reported
that
most
microbes
existing
environment
difficult
to
culture
laboratory.
Whereas
both
pathogenic
beneficial
may
be
prevailing
environment,
body
have
three
categories
microbes-
beneficial,
pathogenic,
opportunistic
pathogenic.
With
at
least
10-fold
cells
cells,
as
normal
flora
critical
for
survival.
present
play
a
crucial
role
maintaining
health,
influences
makeup.
interaction
between
highly
however
it
poorly
understood.
In
addition,
established
infection
associated
health-seeking
behavior,
large
number
studies
focused
transmission
dynamics
infectious
microorganisms
noninfectious
or
ones.
This
review
will
summarize
how
affects
health
identify
approaches
might
humans
improve
by
being
exposed
natural
environment.
Microorganisms,
Год журнала:
2023,
Номер
11(1), С. 192 - 192
Опубликована: Янв. 12, 2023
Healthcare-associated
infections
(HAIs)
are
still
a
global
public
health
concern,
associated
with
high
mortality
and
increased
by
the
phenomenon
of
antimicrobial
resistance.
Causative
agents
HAIs
commonly
found
in
hospital
environment
monitored
epidemiological
surveillance
programs;
however,
is
potential
reservoir
for
pathogenic
microbial
strains
where
microorganisms
may
persist
on
medical
equipment
surfaces,
surrounding
patients,
corporal
surfaces
patients
healthcare
workers
(HCWs).
The
characterization
microbiota
provide
knowledge
regarding
relatedness
between
commensal
microorganisms,
their
role
development,
environmental
conditions
that
favor
its
proliferation.
This
information
contribute
to
effective
control
dissemination
pathogens
improve
infection
programs.
In
this
review,
we
describe
evidence
contribution
HAI
development
factors,
resistance,
virulence
factors
community
persistence
surfaces.
