Curcumin in Cancer Therapy: Mechanisms, Delivery Systems, and Clinical Potential DOI
Lubiao Liang, Yajin Zhao

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Curcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has garnered significant attention for its potential anticancer properties due to ability modulate multiple molecular targets involved in cancer development and progression. This chapter provides comprehensive overview of curcumin’s mechanisms action therapy, focusing on effects cell proliferation, apoptosis, metastasis, inflammation. Curcumin exerts through various signaling pathways, including suppression NF-κB, JAK/STAT3, PI3K/Akt, modulation cycle regulators. Despite promising potential, curcumin faces challenges clinical applications poor bioavailability, low solubility, rapid metabolism. To overcome these limitations, innovative drug delivery systems, such as nanoparticles, liposomes, polymer-based formulations, have been developed enhance therapeutic efficacy stability. These systems improve targeted delivery, controlled release curcumin, thereby maximizing while minimizing systemic toxicity. Moreover, preclinical studies assessing combination with other chemotherapeutic agents role an adjuvant treatment shown results. The concludes by discussing future directions curcumin-based therapies, need further trials establish optimal dosage, formulation, regimens be integrated into personalized treatments.

Язык: Английский

Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies DOI
Elena Azzini, Sheila I. Peña‐Corona,

Héctor Hernández‐Parra

и другие.

Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 3169 - 3189

Опубликована: Апрель 14, 2024

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid‐beta plaques and neurofibrillary tangles, leading to neuronal loss. Curcumin, polyphenolic compound derived from Curcuma longa , has shown potential neuroprotective effects due its anti‐inflammatory antioxidant properties. This review aims synthesize current preclinical data on anti‐neuroinflammatory mechanisms curcumin in context AD, addressing pharmacokinetics, bioavailability, as therapeutic adjunct. An exhaustive literature search was conducted, focusing recent studies within last 10 years related curcumin's impact neuroinflammation role AD. The methodology included sourcing articles specialized databases using specific medical subject headings terms ensure precision relevance. Curcumin demonstrates significant properties modulating neuroinflammatory pathways, scavenging reactive oxygen species, inhibiting production pro‐inflammatory cytokines. Despite potential, challenges remain regarding limited bioavailability scarcity comprehensive human clinical trials. emerges promising adjunct AD multimodal benefits. However, further research required overcome establish effective dosing regimens subjects. Developing novel delivery systems formulations may enhance treatment.

Язык: Английский

Процитировано

28
Unveiling Interindividual Variability in Gut Microbiota-Mediated Curcumin Metabolism DOI
Minna Luo, Siu Ling Wong, Xu Chen

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105941 - 105941

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Co-delivery of paclitaxel and curcumin loaded solid lipid nanoparticles for improved targeting of lung cancer: In vitro and in vivo investigation DOI Creative Commons

Mao Li,

Gang Fang, Fatima Zahid

и другие.

Heliyon, Год журнала: 2024, Номер 10(9), С. e30290 - e30290

Опубликована: Апрель 26, 2024

Язык: Английский

Процитировано

13
Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study DOI Creative Commons
Viljemka Bučević‐Popović,

Esma Karahmet Farhat,

Ines Banjari

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(2), С. 164 - 164

Опубликована: Янв. 28, 2024

Curcumin is a natural compound found in turmeric that exhibits diverse biological activities. However, its poor bioavailability limits therapeutic application, which has led to the development of various bioavailability-improved formulations. In this methodological study, we analyzed whether systematic reviews on curcumin considered systemic oral formulations when synthesizing evidence from human clinical trials. A total 171 published between 2003 and 2022 were included study. From studies, extracted data study characteristics; type curcumin; methods; reporting regarding bioavailability, funding, conflict interest. Our results show rarely consider variable tested Relevant statistical subgroup and/or sensitivity analyses reported methods only 3.5% 6.4% reviews, respectively. more mentioned their discussion (57%) or conclusion (13%). The detailed analysis suggests there broad recognition product as crucial factor affecting health effects curcumin, not accompanied by adequate synthesis. Therefore, most orally administered should be taken with caution.

Язык: Английский

Процитировано

12
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review DOI
Jinjin Pei, Chella Perumal Palanisamy, Prabhu Manickam Natarajan

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102393 - 102393

Опубликована: Июнь 24, 2024

Язык: Английский

Процитировано

8
Transition Metal Oxide‐Decorated MXenes as Drugless Nanoarchitectonics for Enriched Nanocatalytic Chemodynamic Treatment DOI

Hong‐Ying Xia,

Bo‐Yi Li,

Ying‐Tong Ye

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(10)

Опубликована: Дек. 31, 2023

Despite their unique characteristics, 2D MXenes with sole photothermal conversion ability are required to explore superfluous abilities in biomedicine. The small-molecule-based chemotherapeutics suffer from various shortcomings of time-consuming and expensiveness concerning theoretical performance (preclinical/clinical) checks. This study demonstrates the fabrication Ti

Язык: Английский

Процитировано

22
Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy DOI Creative Commons

Peiyi Qin,

Qingchen Li,

Qi Zu

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Апрель 2, 2024

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung (NSCLC) being predominant type. The roles autophagy and apoptosis in NSCLC present a dual intricate nature. Additionally, interconnect through diverse crosstalk molecules. Owing to their multitargeting nature, safety, efficacy, natural products have emerged as principal sources for therapeutic candidates. This review begins an exploration mechanisms apoptosis, proceeds examine molecules between these processes, outlines implications interactions NSCLC. Finally, paper reviews that been intensively studied against targeting summarizes detail four most retrieved representative drugs. clarifies good effects by aims promote greater consideration researchers candidates anti-NSCLC drug discovery.

Язык: Английский

Процитировано

7
Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment DOI Open Access
Gladys Maribel Hidalgo-Lozada, Angélica Villarruel‐López, Karla Nuño

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2671 - 2671

Опубликована: Фев. 25, 2024

The prevalence and incidence of obesity the comorbidities linked to it are increasing worldwide. Current therapies for associated pathologies have proven cause a broad number adverse effects, often, they overpriced or not affordable all patients. Among alternatives currently available, natural bioactive compounds stand out. These frequently contained in pharmaceutical presentations, nutraceutical products, supplements, functional foods. clinical evidence these molecules is increasingly solid, among which epigallocatechin-3-gallate, ellagic acid, resveratrol, berberine, anthocyanins, probiotics, carotenoids, curcumin, silymarin, hydroxy citric α-lipoic acid molecular mechanisms signaling pathways been shown interact with endocrine, nervous, gastroenteric systems. They can regulate expression multiple genes proteins involved starvation–satiety processes, activate brown adipose tissue, decrease lipogenesis inflammation, increase lipolysis, improve insulin sensitivity. This review provides comprehensive view nature-based therapeutic options address obesity. It offers valuable perspective future research subsequent practice, addressing everything from molecular, genetic, physiological bases study compounds.

Язык: Английский

Процитировано

5
Curcumin@Fe/Tannic Acid Complex Nanoparticles for Inflammatory Bowel Disease Treatment DOI Creative Commons

Jiman Jin,

Xiuzhi Ye,

Zhenfeng Huang

и другие.

ACS Omega, Год журнала: 2024, Номер 9(12), С. 14316 - 14322

Опубликована: Март 14, 2024

Inflammatory bowel disease (IBD) is a serious public health issue because of its chronic and incurable nature. Common IBD drugs have limited efficacy produce adverse effects, leading to an urgent need develop new drug delivery systems. Curcumin (Cur) natural nontoxic that increasingly used in the treatment owing anti-inflammatory antioxidant effects. Metal–polyphenol networks constructed from metal ions polyphenols exhibit biological functionality while acting as adhesive nanomaterial encapsulate nano-Cur, thereby improving solubility release behavior. In this study, we prepared Cur@Fe&TA nanodrug system by constructing Fe3+/tannic acid (TA) metal–polyphenol network with encapsulated Cur. The exhibited good stability, behavior, biocompatibility. Based on effects Cur@Fe&TA, gastrointestinal cytopathology mouse model was effectively improved. proposed nanomedicine has promising application research value for regulating levels antioxidants inflammatory cytokines.

Язык: Английский

Процитировано

5
Ferroptosis as an emerging target in sickle cell disease DOI Creative Commons
Vitor Fortuna, Jaqueline Costa Lima,

Gabriel F. Oliveira

и другие.

Current Research in Toxicology, Год журнала: 2024, Номер 7, С. 100181 - 100181

Опубликована: Янв. 1, 2024

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of death characterized reactive oxygen species (ROS) lipid peroxide accumulation, leading to damage impairments. The intricate interplay between iron, inflammation, oxidative stress SCD underscores the necessity thoroughly understanding these processes for development innovative therapeutic strategies. This review highlights importance balancing complex interactions among various factors exploitation knowledge developing novel therapeutics this devastating disease.

Язык: Английский

Процитировано

5