Published: Jan. 1, 2024
Language: Английский
Chemical Biology Letters, Journal Year: 2024, Volume and Issue: 11(2), P. 659 - 659
Published: April 18, 2024
Mitogen-activated protein kinases (MAPKs), also known as extracellular signal regulated (ERKs), are found in numerous transduction pathways and triggered by kinase cascades. This article will review the present state of MAPK pathway inhibitors, with an emphasis on characteristics tiny molecule blockers p38, MEK1, MEK2 kinases. Many these inhibitors have showed potential experimental animal models disease, they now being investigated people for inflammatory cancer diseases. Clinical trials currently evaluating targeting a subset cellular signaling cascades that control pleiotropic activity. These activities far-reaching consequences management wide range disorders. The Ras-Raf-MEK-ERK (ERK) pathway, other hand, is clear therapeutic target because it common downstream route critical growth factor tyrosine receptors frequently changed or overexpressed human malignancies. Several new medicines this been discovered tested clinical studies. BAY 43-9006 one most intriguing agents. Although was initially created Raf inhibitor, has ability to Flt-3, c-Kit, VEGFR-2, which helps explain its antiproliferative antiangiogenic characteristics. ERK system normal malignant tissue be discussed paper, focus emerging treatments cascade at level.
Language: Английский
Citations
6
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(14)
Published: July 1, 2024
Abstract Polycystic ovarian syndrome (PCOS) is related to pro‐apoptotic and pro‐inflammatory conditions generated by Endoplasmic reticulum (ER) stress. This study aimed determine the effect of Astaxanthin (ASX), as carotenoid with potent antioxidant anti‐inflammatory properties, on serum inflammatory markers, apoptotic factors ER stress‐apoptotic genes in peripheral blood mononuclear cells (PBMCs) women PCOS. randomized, double‐blind clinical trial included 56 PCOS patients aged 18–40. For 8 weeks, subjects were randomly assigned one two groups: either 12 mg ASX ( n = 28) or placebo 28). Real‐time PCR was used quantify gene expression associated stress‐apoptosis women's PBMCs. The levels TNF‐α, IL18, IL6 CRP determined obtaining samples from all before after intervention using Enzyme‐linked immunosorbent assay (ELISA). Also, active caspase‐3 caspase‐8 detected PBMC ELISA kit. Furthermore, we evaluated efficacy disease symptoms. Following 8‐week intervention, supplementation able reduce GRP78 p 0.051), CHOP 0.008), XBP1 0.002), ATF4 (0.038), ATF6 (0.157) DR5 (0.016) when compared placebo. However, this decrease not statistically significant for 0.067) marginally 0.051). TNF‐α 0.009), IL‐18 0.003), IL‐6 0.013) 0.012) also lower therapy group. there no difference 0.177) 0.491) between treatment control groups. In our study, had positive BMI, hirsutism, hair loss regularity menstrual cycle. It appears that may benefit changing pathway reducing markers; however, additional research required compound's potential relevance.
Language: Английский
Citations
5
BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 26, 2025
Salvia.officinalis (S. officinalis), is recognized for its antihyperlipidemic, metabolism-regulating, and antioxidant properties in diabetic hyperlipidemic disorders. This study examining effects on lipid oxidative stress (OS) markers patients with Polycystic Ovary Syndrome (PCOS), thereby substantiating role managing metabolic In this randomized placebo-controlled trial was performed gynecology clinics affiliated to Iran University of Medical Sciences. Accordingly, 70 Iranian married women aged 15–40 years newly diagnosed PCOS were included. They receive either 330 mg S. officinalis extract or placebo daily eight weeks. The outcomes included profile OS markers. found a significantly lower triglyceride levels malondialdehyde after weeks intake compared placebo. Also, the mean change triglyceride, high-density lipoprotein cholesterol, malondialdehyde, total capacity statistically significant intervention group. demonstrates that can reduce PCOS, suggesting potential as an adjunctive natural therapy imbalances associated condition. While did not alter other markers, observed improvements highlight therapeutic promise officinalis. These findings support further investigation into clinical applications benefits health. IRCT201504146917N2 2015–10-03 (registered while recruiting).
Language: Английский
Citations
0
Endocrine and Metabolic Science, Journal Year: 2025, Volume and Issue: 18, P. 100245 - 100245
Published: May 3, 2025
Language: Английский
Citations
0
Journal of Basic and Clinical Physiology and Pharmacology, Journal Year: 2024, Volume and Issue: 35(3), P. 153 - 168
Published: May 1, 2024
Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which often triggered an entire or relative inadequacy of insulin production resistance. As result resistance to (IR) and overall lack in the body, type (T2DM) metabolic illness that hyperglycaemia. Notably, occurrence vascular complications advancement IR T2DM are accompanied dysbiosis gut microbiota. Due difficulties managing disease dangers multiple accompanying complications, chronic, progressive immune-mediated condition plays significant clinical health burden on patients. The frequency incidence among young people have been rising worldwide. relationship between microbiota composition physio-pathological characteristics proposes novel way monitor enhance effectiveness therapies. Our knowledge how it affects has changed over last 20 years. Species genus Eubacterium, make up portion core animal microbiome, some recently discovered 'generation' possibly helpful bacteria. In this article, we focused pathogenesis therapeutic approaches towards T2DM, with special reference bacteria from ancient times present day.
Language: Английский
Citations
2
Reproductive health of woman, Journal Year: 2024, Volume and Issue: 2, P. 75 - 80
Published: March 9, 2024
Polycystic ovary syndrome (PCOS) is one of the neuroendocrine syndromes in women reproductive age. In pathogenesis its development a great importance paid to hormonal disbalance, metabolic changes, overweight and obesity, diabetes mellitus, insulin resistance, genetic factors, etc. Very often, PCOS accompanied by infertility, cardiovascular risks, mellitus.The article devoted review modern scientific literature about last researches mechanisms disorders which are connected with also, psychological disturbance stress. The describes specific conditions patients. On basis analyzed publications connection between disorders, overweight, obesity lipidogram parameters presented.Also, gut vaginal microbiota described this paper. studies demonstrate significant changes human microbiome course polycystic syndrome. presents concepts difference composition vagina syndrome.The pathogenetic role processes pathogenesis, namely, regulation immune response inflammation pathology, described. It has been shown that there differences microflora intestines, manifested decreased concentration Lactobacillus presence variety other microorganisms compared healthy women.Thus, main links closely each other. That why multimodal approaches for study management patients extremely important.
Language: Английский
Citations
2
Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 28, 2024
Language: Английский
Citations
2
Research Journal of Pharmacy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 3505 - 3513
Published: July 24, 2024
Abiotic stressors inhibit growth and development, which ultimately leads to low productivity yield of the plants. Reactive oxygen species (ROS) signaling pathway has been demonstrated be a crucial component plants’ acclimatization responses metal toxicity, salinity stressors, etc. Stressed plants experience oxidative stress, is defined by rise in intracellular extracellular ROS specific organelles. Through enhanced synthesis at apoplast various respiratory burst oxidase homolog (RBOH) proteins, it used actively relay variety signals. It also utilized identify stress brought on elevated generation as result metabolic abnormalities. Under intricately entwined with networks, including calcium, hormone, protein phosphorylation that control plant acclimation. Although division antioxidant activities into distinct compartments well understood, further research needed understand how recognize, respond to, balance activity. We can infer, generally, from many conducted over past 20 years cross-talk between abscisic acid (ABA), Ca2+, several other hormones molecules necessary for equilibrium. Furthermore, activates gene cascades support abiotic tolerance acting signal transducer ROS-dependent manner. Genes like kinases transcription factors are important upstream elements facilitate activation additional downstream genes involved reducing toxicity. The current review work tried give summary mechanisms, both non-oxidative, contribute adaptation decrease damage.
Language: Английский
Citations
0
Clinical Physiology and Functional Imaging, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 25, 2024
Abstract Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder with profound implications for the reproductive and metabolic health of women. The utilization anthropometric measures in diagnosis management PCOS has gained increasing attention due to their practicality predictive capacity associated conditions such as obesity insulin resistance. This review rigorously explores application various indices, including body mass index, waist‐to‐hip ratio, advanced metrics shape index roundness wrist circumference, neck circumference. These indices offer critical insights into fat distribution its association hormonal perturbations characteristic PCOS. underscores necessity addressing obesity, prevalent comorbidity PCOS, through lifestyle modifications personalized therapeutic approaches. By incorporating evaluations routine clinical practice, healthcare professionals can enhance diagnostic precision, optimize treatment strategies, ultimately improve patient outcomes. integrative approach not only facilitates challenges inherent but also contributes development more individualized interventions, thereby enhancing overall quality life women affected by
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 14, 2024
Polycystic ovarian syndrome (PCOS) is a common gynaecological and endocrine illness that causes irregular menstruation, inadequate follicular development, interrupted ovulation, decreased conception rates in women of reproductive age. The aetiology available treatments for these symptoms are still restricted, although they can be controlled with the appropriate medicine lifestyle changes. two main characteristics PCOS elevated androgen levels (hyperandrogenism) luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio. excess, synthesis, receptor (AR) signalling mediate negative features examined this review, along role adrenal-derived 11-oxygenated androgens pathogenesis PCOS. It also offers treatment plans specifically address hyperandrogenism PCOS, emphasising how crucial it to comprehend processes involved conversion, metabolism
Language: Английский
Citations
0