Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Cancer Medicine, Год журнала: 2019, Номер 8(5), С. 1958 - 1975

Опубликована: Апрель 3, 2019

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment cancer. In this review, we sought to summarize molecular cellular mechanisms underlying chemopreventive therapeutic activity TCM, especially that herbal medicine-derived phytochemicals curcumin, resveratrol, berberine. Numerous genes have reported be involved when using TCM treatments so selectively highlighted role a number oncogene tumor suppressor in therapy. addition, impact on DNA methylation, histone modification, regulation noncoding RNAs discussed. Furthermore, studies therapy modulate microenvironment eliminate cancer stem cells. The information compiled review will serve solid foundation formulate hypotheses future TCM-based

Язык: Английский

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Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

Oncotarget, Год журнала: 2018, Номер 9(24), С. 17181 - 17198

Опубликована: Март 30, 2018

// Carolina Simioni 1 , Giorgio Zauli Alberto M. Martelli 2 Marco Vitale 3, 4 Gianni Sacchetti 5 Arianna Gonelli and Luca Neri Department of Morphology, Surgery Experimental Medicine, University Ferrara, Italy Biomedical Neuromotor Sciences, Bologna, 3 Medicine Surgery, Parma, CoreLab, Azienda Ospedaliero-Universitaria di Life Sciences Biotechnology, Pharmaceutical Biology Laboratory, Correspondence to: Neri, email: [email protected] Keywords: exercise training; nutraceuticals; flavonoids intake; aging; antioxidant supplementation Received: January 26, 2018      Accepted: March 08, Published: 30, 2018 ABSTRACT Physical is considered to be one the beneficial factors a proper lifestyle nowadays seen as an indispensable element for good health, able lower risk disorders cardiovascular, endocrine osteomuscular apparatus, immune system diseases onset potential neoplasms. A moderate programmed physical has often been reported therapeutic both in adulthood aging, since capable promote fitness. Regular alleviates negative effects caused by free radicals offers many health benefits, including reduced all-cause mortality, sarcopenia skeletal muscle, chronic disease, premature death elderly people. However, performance also known induce oxidative stress, inflammation, muscle fatigue. Many efforts have carried out identify micronutrients natural compounds, nutraceuticals, prevent or attenuate exercise-induced stress inflammation. The aim this review discuss benefits deriving from constant activity intake compounds protect body stress. attention will focused mainly on three antioxidants, which are quercetin, resveratrol curcumin. Their properties described, well their expected increase through years can get favorable activity.

Язык: Английский

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A review on the effects of current chemotherapy drugs and natural agents in treating non–small cell lung cancer

Biomedicine, Год журнала: 2017, Номер 7(4), С. 23 - 23

Опубликована: Ноя. 13, 2017

Lung cancer is the leading cause of deaths worldwide, and this makes it an attractive disease to review possibly improve therapeutic treatment options. Surgery, radiation, chemotherapy, targeted treatments, immunotherapy separate or in combination are commonly used treat lung cancer. However, these types may different side effects, chemotherapy-based regimens appear have reached a plateau. Hence, effective, better-tolerated treatments needed address hopefully overcome conundrum. Recent advances enabled biologists better investigate potential use natural compounds for control various cancerous diseases. For past 30 years, been pillar chemotherapy. only few tested patients partial evidence available regarding their clinical effectiveness. Herein, we research on using current chemotherapy drugs (Wortmannin Roscovitine, Cordyceps militaris, Resveratrol, OSU03013, Myricetin, Berberine, Antroquinonol) beneficial effects they cancers including non-small cell Based literature review, propose along with advanced and/or refractory solid tumours.

Язык: Английский

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Resveratrol (RV): A pharmacological review and call for further research

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 143, С. 112164 - 112164

Опубликована: Окт. 4, 2021

Resveratrol (RV) is a well-known polyphenolic compound in various plants, including grape, peanut, and berry fruits, which quite famous for its association with several health benefits such as anti-obesity, cardioprotective neuroprotective, antitumor, antidiabetic, antioxidants, anti-age effects, glucose metabolism. Significantly, promising therapeutic properties have been reported cancer, neurodegeneration, atherosclerosis are regulated by synergistic pathways that control oxidative stress, cell death, inflammation. Similarly, RV possesses strong anti-adipogenic effect inhibiting fat accumulation processes activating lipolytic pathways, exhibiting their effects platelet aggregation. The also shows significant antibacterial against food-borne pathogens (Listeria, Campylobacter, Staphylococcus aureus, E. coli) an electron transport chain (ETC) F0F1-ATPase, decreases the production of cellular energy leads to spread pathogens. After collecting analyzing scientific literature, it may be concluded well tolerated favorably affects cardiovascular, neurological, diabetic disorders. As such, possible can considered best nutritional additive complementary drug, especially candidate. Therefore, this review would increase knowledge about blend inspire researchers around world consider pharmaceutical drug combat future crises inhumane diseases. In future, article will aware discoveries potential natural nutraceuticals drugs medicine.

Язык: Английский

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SIRT1 Activation by Natural Phytochemicals: An Overview

Frontiers in Pharmacology, Год журнала: 2020, Номер 11

Опубликована: Авг. 7, 2020

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+ as a cofactor. reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead tissue-specific degenerative events involved in the development several human pathologies, including cancer, neurodegeneration, cardiovascular disease. The most studied member this enzymes sirtuin 1 (SIRT1), associated with increasing insulin sensitivity. SIRT1 has been implicated both tumorigenic anticancer processes, regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders metabolism. Via regulation p53 deacetylation modulation autophagy, cellular response caloric restriction lifespan extension. In recent years, scientific interest focusing identification modulators led discovery novel small molecules targeting activity. This review will examine compounds natural origin recently found upregulate activity, such polyphenolic products fruits, vegetables, plants resveratrol, fisetin, quercetin, curcumin. We also discuss potential therapeutic effects these prevention treatment disorders, particular emphasis impact.

Язык: Английский

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Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition

Frontiers in Pharmacology, Год журнала: 2019, Номер 10

Опубликована: Июль 30, 2019

Epithelial to mesenchymal transition (EMT) is a self-regulated physiological process required for tissue repair that in non-controled conditions may lead fibrosis, angiogenesis, loss of normal organ function or cancer. Although several molecular pathways involved EMT regulation has been described, this does not have any specific treatment. This article introduces systematic review effective natural plant compounds and their extract modulates the pathological its deleterious effects through acting on different cellular signal transduction both vivo vitro. Thereby, cryptotanshinone, resveratrol, oxymatrine, ligustrazine, osthole, codonolactone, betanin, tannic acid, gentiopicroside, curcumin, genistein, paeoniflorin, gambogic acid cinnamomum cassia extracts, inhibit TGF-β/smads signaling pathway. Gedunin, carnosol, celastrol, black rice anthocyanins, duchesnea indica, cordycepin celastrus orbiculatus downregulate vimectin, fibronectin, N-cadherin. Sulforaphane, luteolin, arctigenin β- catenin Salvianolic acid-A plumbagin block oxidative stress, while, honokiol, gallic piperlongumine, brusatol paeoniflorin transcription factors such as SNAIL, TWIST ZEB. Plectranthoic baicalin, polyphyllin I, cairicoside E, berberine, nimbolide, withaferin-A, jatrophone, ginsenoside-Rb1, parthenolide, phoyunnanin-E, epicatechin-3-gallate, gigantol, eupatolide, baicalin baicalein nitidine chloride other (SIRT1, p38 MAPK, NFAT1, SMAD, IL-6, STAT3, AQP5, notch 1, PI3K/Akt, Wnt/β- catenin, NF-kB, FAK/AKT, Hh). Despite huge amount preclinical data regarding modulation by plants compounds, clinical translation poor. Additionally, highlights some relevant examples trials using compound modulate effects. In overall, opens up new therapeutic alternatives cancer, inflammatory fibrosing diseases control process.

Язык: Английский

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The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

Ageing Research Reviews, Год журнала: 2021, Номер 67, С. 101271 - 101271

Опубликована: Фев. 9, 2021

While the elderly segment of population continues growing in importance, neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, Central Nervous System (CNS) can benefit from nutritional strategies dietary interventions that prevent signs senescence, cognitive decline or Alzheimer's disease Parkinson's Disease. The polyphenol Resveratrol (RV) possesses antioxidant cytoprotective effects, producing neuroprotection several organisms. oxidative stress (OS) occurs because Reactive oxygen species (ROS) accumulation has been proposed to explain cause ageing. One most harmful effects ROS cell is DNA damage. Nevertheless, there also evidence demonstrating OS produce other molecular changes mitochondrial dysfunction, inflammation, apoptosis, epigenetic modifications, others. Interestingly, RV a potent pleiotropic actions, exerting its activity through various pathways. In addition, recent shown mediates involved function CNS persists across generations. Furthermore, it demonstrated interacts with gut microbiota, showing modifications bacterial composition associated beneficial effects. this review, we give comprehensive overview main mechanisms action different experimental models, including clinical trials discuss how interconnection these events could neuroprotective induced by RV.

Язык: Английский

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Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Molecules, Год журнала: 2021, Номер 26(9), С. 2540 - 2540

Опубликована: Апрель 27, 2021

Nutraceuticals are essential food constituents that provide nutritional benefits as well medicinal effects. The of these foods due to the presence active compounds such carotenoids, collagen hydrolysate, and dietary fibers. have been found positively affect cardiovascular immune system health a role in infection cancer prevention. can be categorized into different classes based on their nature mode action. In this review, classifications nutraceuticals potential therapeutic activity, anti-cancer, antioxidant, anti-inflammatory anti-lipid activity disease will reviewed. Moreover, mechanisms action products, applications, safety upon consumers including current trends future prospect included.

Язык: Английский

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Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Acta Pharmaceutica Sinica B, Год журнала: 2020, Номер 10(12), С. 2299 - 2312

Опубликована: Июнь 30, 2020

Programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) blocking therapy has become a major pillar of cancer immunotherapy. Compared with antibodies targeting, small-molecule checkpoint inhibitors which have favorable pharmacokinetics are urgently needed. Here we identified berberine (BBR), proven anti-inflammation drug, as negative regulator PD-L1 from set traditional Chinese medicine (TCM) chemical monomers. BBR enhanced the sensitivity tumour cells to co-cultured T-cells by decreasing level in cells. In addition, exerted its antitumor effect Lewis tumor xenograft mice through enhancing tumor-infiltrating T-cell immunity and attenuating activation immunosuppressive myeloid-derived suppressor (MDSCs) regulatory (Tregs). triggered degradation ubiquitin (Ub)/proteasome-dependent pathway. Remarkably, selectively bound glutamic acid 76 constitutive photomorphogenic-9 signalosome 5 (CSN5) inhibited PD-1/PD-L1 axis deubiquitination activity, resulting ubiquitination PD-L1. Our data reveals previously unrecognized mechanism BBR, suggesting is immune inhibitor for treatment.

Язык: Английский

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Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases

Molecules, Год журнала: 2020, Номер 25(20), С. 4649 - 4649

Опубликована: Окт. 12, 2020

Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. Cancer, type 2 diabetes mellitus, cardiovascular disease, neurological disorders are commonly classified as diseases that can affect lifespan health individuals. is a complicated sophisticated process involving damage to biochemical macromolecules including DNA, proteins, organelles such mitochondria. causes multiple alterations in processes energy metabolism nutrient sensing, thus reducing cell proliferation causing senescence. Among polyphenolic phytochemicals, resveratrol believed reduce negative effects aging through its activities. Resveratrol several model organisms by regulating oxidative stress, metabolism, epigenetics, primarily activating sirtuin 1. This review summarizes most important mechanisms aging, ability prevent

Язык: Английский

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