International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 1001 - 1001
Published: Jan. 13, 2024
Globally,
cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
death
and
disability.
While
there
many
therapeutic
alternatives
available
for
management
CVDs,
majority
classic
strategies
were
found
to
be
ineffective
at
stopping
or
significantly/additionally
slowing
progression
these
diseases,
they
had
unfavorable
side
effects.
Numerous
metal-based
nanoparticles
(NPs)
have
been
created
overcome
limitations,
demonstrating
encouraging
possibilities
in
treatment
CVDs
due
advancements
nanotechnology.
Metallic
nanomaterials,
including
gold,
silver,
iron,
come
various
shapes,
sizes,
geometries.
NPs
generally
smaller
more
specialized
physical,
chemical,
biological
properties.
Metal-based
may
forms,
such
as
nanoshells,
nanorods,
nanospheres,
studied
most.
Massive
potential
applications
metal
nanomaterial
structures
include
supporting
molecular
imaging,
serving
drug
delivery
systems,
enhancing
radiation-based
anticancer
therapy,
supplying
photothermal
transforming
effects
thermal
being
compounds
with
bactericidal,
fungicidal,
antiviral
qualities
that
helpful
diseases.
In
this
context,
present
paper
aims
review
relevant
oxide
creating
an
up-to-date
framework
aids
researchers
developing
efficient
strategies.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(17)
Published: Feb. 17, 2024
Abstract
Atherosclerosis,
a
multifaceted
chronic
inflammatory
disease,
has
profound
impact
on
cardiovascular
health.
However,
the
critical
limitations
of
atherosclerosis
management
include
delayed
detection
advanced
stages,
intricate
assessment
plaque
stability,
and
absence
efficacious
therapeutic
strategies.
Nanotheranostic
based
nanotechnology
offers
novel
paradigm
for
addressing
these
challenges
by
amalgamating
imaging
capabilities
with
targeted
interventions.
Meanwhile,
iron
oxide
nanoparticles
have
emerged
as
compelling
candidates
theranostic
applications
in
due
to
their
magnetic
resonance
capability
biosafety.
This
review
delineates
current
state
prospects
nanoparticle‐based
nanotheranostics
realm
atherosclerosis,
including
pivotal
aspects
development,
pertinent
targeting
strategies
involved
disease
pathogenesis,
diagnostic
roles
nanoparticles.
Furthermore,
this
provides
comprehensive
overview
nanomedicine
approaches
employing
nanoparticles,
encompassing
chemical
therapy,
physical
stimulation
biological
therapy.
Finally,
proposes
discusses
associated
translating
innovative
into
clinically
viable
anti‐atherosclerosis
In
conclusion,
new
insights
future
theranostic,
showcasing
remarkable
potential
oxide‐based
versatile
tools
battle
against
atherosclerosis.
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1030 - 1030
Published: Feb. 27, 2024
The
use
of
conventional
methods
for
the
treatment
cancer,
such
as
chemotherapy
or
radiotherapy,
and
approaches
brachytherapy
in
conjunction
with
unique
properties
nanoparticles
could
enable
development
novel
theranostic
agents.
aim
our
current
study
was
to
evaluate
potential
iron
oxide
nanoparticles,
coated
alginic
acid
polyethylene
glycol,
functionalized
chemotherapeutic
agent
doxorubicin
monoclonal
antibody
bevacizumab,
serve
a
nanoradiopharmaceutical
against
breast
cancer.
Direct
radiolabeling
therapeutic
isotope
Lutetium-177
(177Lu)
resulted
an
additional
effect.
Functionalization
accomplished
at
high
percentages
robust.
cytotoxic
effect
radiolabeled
non-radiolabeled
nanostructures
proven
vitro
five
different
cancer
cell
lines.
ex
vivo
biodistribution
tumor-bearing
mice
investigated
three
ways
administration.
intratumoral
administration
radionanoconjugates
showed
tumor
accumulation
retention
site.
Finally,
efficacy
performed
over
50-day
period
aggressive
triple-negative
line
(4T1)
demonstrated
enhanced
growth
retention,
thus
identifying
developed
promising
nanobrachytherapy
