Extracellular Vesicles: A Review of Their Therapeutic Potentials, Sources, Biodistribution, and Administration Routes DOI Creative Commons

Xiaorong Su,

Hongxiang Wang, Qiubai Li

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3175 - 3199

Опубликована: Март 1, 2025

Extracellular vesicles (EVs) participate in intercellular communication and play an essential role physiological pathological processes. In recent years, EVs have garnered significant attention as cell-free therapeutic alternatives, vectors for drug gene delivery, biomarkers disease diagnosis prognosis, vaccine development, nutraceuticals. The biodistribution of critically influences their efficacy toxicity. Therefore, this review aims to discuss the main factors influencing unmodified EVs, highlighting distribution patterns, advantages, limitations, applications under different routes administration. addition, we provide a comprehensive discussion currently available sources summarize current status potentials EVs. By optimizing administration selecting appropriate EV sources, aim offer valuable insights enhance delivery efficiency target tissues.

Язык: Английский

Exosomes: compositions, biogenesis, and mechanisms in diabetic wound healing DOI Creative Commons

Yichuan Li,

Zhanyong Zhu,

Sicheng Li

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 5, 2024

Abstract Diabetic wounds are characterized by incomplete healing and delayed healing, resulting in a considerable global health care burden. Exosomes lipid bilayer structures secreted nearly all cells express characteristic conserved proteins parent cell-associated proteins. harbor diverse range of biologically active macromolecules small molecules that can act as messengers between different cells, triggering functional changes recipient thus endowing the ability to cure various diseases, including diabetic wounds. accelerate wound regulating cellular function, inhibiting oxidative stress damage, suppressing inflammatory response, promoting vascular regeneration, accelerating epithelial facilitating collagen remodeling, reducing scarring. from tissues or potentially possess functions varying levels promote healing. For example, mesenchymal stem cell-derived exosomes (MSC-exos) have favorable potential field due their superior stability, permeability, biocompatibility, immunomodulatory properties. Exosomes, which derived skin components, modulate inflammation regeneration key turn promotes Therefore, this review mainly emphasizes roles mechanisms sources, represented MSCs improving A deeper understanding therapeutic will yield promising candidates perspectives for management.

Язык: Английский

Процитировано

19
Emerging role of exosomes in cancer therapy: progress and challenges DOI Creative Commons
Jiale Li,

Jiachong Wang,

Zigui Chen

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Язык: Английский

Процитировано

10
Engineering exosomes to reshape the immune microenvironment in breast cancer: Molecular insights and therapeutic opportunities DOI Creative Commons

Jilong Cao,

Gang Lv, Wei Fang

и другие.

Clinical and Translational Medicine, Год журнала: 2024, Номер 14(4)

Опубликована: Апрель 1, 2024

Breast cancer remains a global health challenge, necessitating innovative therapeutic approaches. Immunomodulation and immunotherapy have emerged as promising strategies for breast treatment. Engineered exosomes are the sort of modified with surface decoration internal molecules. Through suitable modifications, engineered exhibit capability to overcome limitations associated traditional This ability opens up novel avenues development more effective, personalized, minimally invasive interventions.

Язык: Английский

Процитировано

14
Nerve Growth Factor and the Role of Inflammation in Tumor Development DOI Creative Commons
Giampiero Ferraguti, Sergio Terracina, Luigi Tarani

и другие.

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(2), С. 965 - 989

Опубликована: Янв. 23, 2024

Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting as pro-inflammatory oncogenic an anti-inflammatory pro-apoptotic mediator context-dependent way based on the signaling networks its interaction with diverse cellular components within microenvironment. This report aims to provide summary subsequent review of literature NGF regulating microenvironment tumor cell growth, survival, death. The inflammation tumorigenesis component system, various respective microenvironments, ability cause epigenetic changes, treatment cancer have been highlighted this paper.

Язык: Английский

Процитировано

13
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency DOI Creative Commons

Xiaofei Zhang,

Linzi Ma, Xiaotong Liu

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101469 - 101469

Опубликована: Янв. 9, 2025

Premature ovarian insufficiency (POI) refers to the severe decline or failure of function in women younger than 40 years age. It is a serious hazard women's physical and mental health, but current treatment options are limited. Mesenchymal stem cell-derived exosomes (MSC-Exo) exhibit promising potential as therapeutic approach for POI. However, their clinical application hindered by instability low long-term retention rate vivo. In this study, miR-21 was identified predominant miRNA with low-expression follicular fluid POI patients shown possess antiapoptotic activity. Next, we loaded agomir MSC-Exo form Agomir21-Exo, which significantly reversed apoptosis granulosa cells vitro. Moreover, successfully developed GelMA hydrogel microspheres encapsulating Agomir21-Exo through microfluidic technology, named GelMA-Ag21Exo, had good injectability enhanced stability mice sustained release. The release from GelMA-Ag21Exo notably alleviated improved reserve fertility mice. Our findings illustrate that activating could improve cells. exosome-based efficacy These provide novel strategy patients.

Язык: Английский

Процитировано

1
Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems DOI
Waleed Y. Rizg, Majed Alghamdi, Sherif El Saadany

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер 106, С. 106696 - 106696

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

1
LncRNA BCYRN1 as a Potential Therapeutic Target and Diagnostic Marker in Serum Exosomes in Bladder Cancer DOI Open Access
Junya Arima, Hirofumi Yoshino,

Wataru Fukumoto

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5955 - 5955

Опубликована: Май 29, 2024

Bladder cancer (BC) is a common genitourinary malignancy that exhibits silent morbidity and high mortality rates because of lack diagnostic markers limited effective treatments. Here, we evaluated the role lncRNA brain cytoplasmic RNA 1 (BCYRN1) in BC. We performed loss-of-function assays to examine effects BCYRN1 downregulation T24 BOY BC cells. found significantly inhibited proliferation, migration, invasion, three-dimensional spheroid formation ability induced apoptosis Additionally, gene set enrichment analysis (GSEA) using sequences from tumor fractions showed decreased expression mRNAs associated with cell cycle. These findings were supported by observations G2/M arrest flow cytometry assays. Finally, examined serum exosomal as biomarker. Clinically, exosomes patients (n = 31) was higher than healthy donors 19; mean difference: 4.1-fold higher, p < 0.01). Moreover, who had undergone complete resection BC, levels 8). Thus, may be promising marker therapeutic target

Язык: Английский

Процитировано

7
Exosome-based nanoparticles and cancer immunotherapy DOI Open Access
Jiarong Ye, Danni Li,

Yiting Jie

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117296 - 117296

Опубликована: Авг. 20, 2024

Over the past decades, cancer immunotherapy has encountered challenges such as immunogenicity, inefficiency, and cytotoxicity. Consequently, exosome-based gained rapid traction a promising alternative. Exosomes, type of extracellular vesicles (EVs) ranging from 50 to 150 nm, are self-originating exhibit fewer side effects compared traditional therapies. Exosome-based encompasses three significant areas: vaccination, co-inhibitory checkpoints, adoptive T-cell therapy. Each these fields leverages inherent advantages exosomes, demonstrating substantial potential for individualized tumor therapy precision medicine. This review aims elucidate reasons behind promise nanoparticles therapies by examining their characteristics summarizing latest research advancements in immunotherapy.

Язык: Английский

Процитировано

7
Mesenchymal stem cell–derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms DOI Creative Commons

Jinhui Wu,

Jiangyi Wu, Zheng Liu

и другие.

Journal of Orthopaedic Translation, Год журнала: 2024, Номер 48, С. 53 - 69

Опубликована: Июль 27, 2024

Joint diseases greatly impact the daily lives and occupational functioning of patients globally. However, conventional treatments for joint have several limitations, such as unsatisfatory efficacy side effects, necessitating exploration more efficacious therapeutic strategies. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) demonstrated high efficacyin tissue repair regeneration, with low immunogenicity tumorigenicity. Recent studies reported that EVs-based therapy has considerable effects against diseases, including osteoarthritis, tendon ligament injuries, femoral head osteonecrosis, rheumatoid arthritis. Herein, we review potential various types MSC-EVs in aforementioned summarise mechanisms underlying specific biological MSC-EVs, discuss future prospects basic research on MSC-EV-based modalities their clinical translation. In general, this provides an in-depth understanding well mechanisms, which may be beneficial to translation treatment. The translational article: cell-free can effectively promote regeneration repair. When used treat desirable preclinical research. This supplement further treatment its

Язык: Английский

Процитировано

6
CAR-T cell-derived exosomes: a new perspective for cancer therapy DOI Creative Commons
Farnaz Sani,

Shabnam Shojaei,

Seyed Amirhossein Tabatabaei

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 18, 2024

Abstract Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack tumors. However, this therapy can have some adverse effects. CAR-T cell-derived exosomes are potential alternative may overcome limitations. Exosomes small vesicles released by and carry variety of molecules, including proteins, RNA, DNA. They play an important role in intercellular communication be used deliver therapeutic agents cells. The application could make more clinically controllable effective. cell-free, which means they less likely cause reactions than combination effective way treat either alone. where cannot reach. appropriate both cellular exosomal platforms practicable for cancer. This offer safe cancers.

Язык: Английский

Процитировано

5