Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Апрель 5, 2025
ObjectiveNanomedicine
is
the
application
of
nanotechnology
to
medicine
and,
therefore,
a
potentially
transformative
approach
healthcare.
This
new
and
interdisciplinary
field
has
three
main
applications
in
diagnostics,
controlled/targeted
drug
delivery,
regenerative
medicine.
Nanomedicine
great
potential
change
human
health
by
advancing
diagnosis,
prevention
treatment
for
wide
variety
diseases,
including
cancer,
cardiovascular
conditions,
neurological
disorders.
Despite
overwhelming
potential,
there
are
some
issues
impeding
complete
integration
nanomedicines
into
healthcare
systems.SignificanceThis
policy
brief
addresses
such
critical
inform
guide
decision-making
on
effectively
deploying
nanomedicine
improve
patient
outcomes
advance
important
public
initiatives.
In
addition,
prospects
were
also
presented
future.Key
findingsThese
brand-new
nanosystems
have
serious
drawbacks
regard
safety,
efficacy,
regulatory
compliance,
not
mention
acceptance.
Nanomaterials
can
be
so
complex
that
their
manufacturing
processes
become
complex,
which
may
bring
question
long-term
effects
environment.
It
discusses
current
barriers
application,
particularly
regarding
hurdles
production
robust
clinical
evidence.ConclusionsThis
identifies
key
considerations
policymakers
stakeholders,
highlighting
requirement
among
researchers,
clinicians,
bodies.
To
facilitate
safe
successful
care,
continued
collaboration
imperative.
Priority
future
should
given
developing
comprehensive
frameworks,
raising
awareness,
promoting
research
resolve
existing
challenges
unlock
sector.
Materials Today Bio,
Год журнала:
2025,
Номер
30, С. 101436 - 101436
Опубликована: Янв. 5, 2025
Well-designed
artificial
scaffolds
are
urgently
needed
due
to
the
limited
self-repair
capacity
of
bone,
which
hampers
effective
regeneration
in
critical
defects.
Optimal
must
provide
physical
guidance
recruit
cells
and
immune
regulation
improve
regenerative
microenvironment.
This
study
presents
a
novel
scaffold
composed
dual-sided
centripetal
microgrooved
poly(D,L-lactide-co-caprolactone)
(PLCL)
film
combined
with
dynamic
hydrogel
containing
prednisolone
(PLS)-loaded
Prussian
blue
nanoparticles
(PB@PLS).
The
microgrooves
on
surface
PLCL
were
imprinted
using
micropatterned
polydimethylsiloxane
(PDMS)
template.
Following
aminolysis,
was
covalently
grafted
EM-7
peptide
via
glutaraldehyde.
Functional
group
analysis,
morphology
hydrophilicity
evaluated
X-ray
photoelectron
spectroscopy
(XPS),
scanning
electron
microscopy
(SEM),
an
optical
contact
angle
measuring
instrument,
respectively.
Bone
regeneration-related
(e.g.,
bone
marrow
mesenchymal
stem
cells,
macrophages,
Schwann
endothelial
cells)
cultured
films
tended
align
along
stripes
migrate
from
periphery
toward
center
region
vitro.
Subsequently,
encapsulated
immune-regulating
synthesized
thiol-modified
gelatin
Cu2+
presence
PB@PLS
nanoparticles,
demonstrated
excellent
antioxidant
properties.
significantly
accelerated
critical-sized
regeneration,
as
evidenced
by
increase
volume
newly
formed
histological
images
vivo.
innovative
approach
holds
substantial
promise
for
clinical
applications
broader
tissue
repair.
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 7, 2025
Ferroptosis
is
a
distinct
form
of
regulated
cell
death
characterized
by
iron-dependent
lipid
peroxidation,
playing
critical
role
in
various
diseases,
including
cancer,
neurodegeneration,
and
tissue
damage.
This
study
reviews
the
intricate
relationship
between
ferroptosis
Janus
kinase/signal
transducer
activator
transcription
(JAK/STAT)
signaling
pathway,
highlighting
its
regulatory
functions
across
multiple
biological
processes.
Dysregulation
JAK/STAT
pathway
implicated
promoting
or
inhibiting
ferroptosis,
depending
on
context.
JAK2
promotes
activating
STAT
proteins,
modulating
expression
key
regulators
like
SLC7A11
GPX4,
influencing
iron
homeostasis
through
pathways
such
as
ferritinophagy
hepcidin
regulation.
STAT1
activation
primarily
enhances
suppression
cystine-glutamate
antiporter
(System
Xc-),
leading
to
glutathione
depletion
contributing
conditions
Sjogren's
syndrome
age-related
macular
degeneration.
In
contrast,
STAT3
plays
protective
upregulating
which
inhibits
survival,
particularly
cancers
hepatocellular
carcinoma,
prostate
renal
carcinoma.
also
discusses
STAT6's
involvement
diseases
asthma
lung
injury
regulating
antioxidant
defenses.
Furthermore,
review
explores
potential
therapeutic
strategies
targeting
manipulate
for
disease
treatment.
cancer
therapy,
this
can
enhance
effectiveness
inducers,
offering
promising
avenues
overcome
drug
resistance.
Additionally,
interplay
immune
responses,
oxidative
stress,
metabolism
underscores
significance
progression
intervention.
By
exploring
these
mechanisms,
provides
insights
into
development
novel
treatments
modulation,
with
implications
inflammatory
neurodegenerative
conditions.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2678 - 2678
Опубликована: Март 16, 2025
Despite
the
substantial
advances
in
cancer
therapies,
developing
safe
and
effective
treatment
methodologies
is
critical.
Natural
(plant-derived
compounds),
such
as
flavonoids,
might
be
crucial
a
methodology
without
toxicity
toward
healthy
tissues.
Prunin
flavonoid
with
potential
to
used
biomedical
applications.
has
yet
undergo
thorough
scientific
research,
its
precise
molecular
mechanisms
of
action
remain
largely
unexplored.
This
review
summarizes
therapeutic
prunin
for
first
time,
focusing
on
underlying
an
anticancer
compound.
gained
significant
attention
due
antioxidant,
anti-inflammatory,
effects.
aims
unlock
how
functions
at
level
exert
effects,
primarily
modulating
key
cellular
pathways.
Furthermore,
we
have
discussed
prunin’s
adjunctive
therapy
conventional
treatments,
highlighting
ability
strengthen
responses
while
decreasing
drug
resistance.
Moreover,
discussion
probes
into
innovative
delivery
methods,
particularly
nanoformulations,
that
address
bioavailability,
solubility,
stability
limitations
optimize
application.
By
providing
comprehensive
analysis
properties,
this
stimulate
further
exploration
using
agent,
thereby
progressing
development
targeted,
selective,
safe,
methods.
Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 341 - 341
Опубликована: Март 26, 2025
Cancer
treatment
has
historically
depended
on
conventional
methods
like
chemotherapy,
radiation,
and
surgery;
however,
these
strategies
frequently
present
considerable
limitations,
including
toxicity,
resistance,
negative
impacts
healthy
tissues.
In
addressing
challenges,
drug-free
cancer
therapies
have
developed
as
viable
alternatives,
utilizing
advanced
physical
biological
to
specifically
target
tumor
cells
while
reducing
damage
normal
This
review
examines
several
strategies,
such
high-intensity
focused
energy
beams,
nanosecond
pulsed
electric
fields,
photothermal
therapy
well
the
use
of
inorganic
nanoparticles
promote
selective
apoptosis.
We
also
investigate
significance
targeting
microenvironment,
precision
medicine,
immunotherapy
in
progression
personalized
therapies.
Although
approaches
demonstrate
significant
promise,
challenges
scalability,
safety,
regulatory
obstacles
must
be
resolved
for
clinical
application.
paper
presents
an
overview
current
research
therapies,
emphasizing
recent
advancements,
underlying
scientific
principles,
steps
required
implementation.
