Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

Journal of Biomedical Science, Год журнала: 2022, Номер 29(1)

Опубликована: Сен. 26, 2022

The major concept of "oxidative stress" is an excess elevated level reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption oxygen. precise harmonization oxidative stresses between mitochondria other organelles in the cell absolutely vital to survival. Under stress, ROS produced mediator for tumorigenesis different aspects, such as proliferation, migration/invasion, angiogenesis, inflammation, immunoescape allow cancer cells adapt rigorous environment. Accordingly, dynamic balance not only orchestrate complex signaling events but also affect components tumor microenvironment (TME). Immune cells, M2 macrophages, dendritic T immunosuppressive TME ROS-induced inflammation. Based on this notion, numerous strategies mitigate tumors have been tested prevention or therapies; however, these manipulations devised sources mechanisms without established effectiveness. Herein, we integrate current progress regarding impact mitochondrial TME, immune discuss combination emerging ROS-modulating with immunotherapies achieve antitumor effects.

Язык: Английский

---

Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 25, 2023

Abstract Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in which the airways narrow or collapse during sleep, causing obstructive apnea. The prevalence of OSAS continues to rise worldwide, particularly middle-aged and elderly individuals. mechanism upper airway incompletely understood but associated with several factors, including obesity, craniofacial changes, altered muscle function airway, pharyngeal neuropathy, fluid shifts neck. main characteristics are recurrent pauses respiration, lead intermittent hypoxia (IH) hypercapnia, accompanied by blood oxygen desaturation arousal sharply increases risk diseases. This paper first briefly describes epidemiology, incidence, pathophysiological mechanisms OSAS. Next, alterations relevant signaling pathways induced IH systematically reviewed discussed. For example, can induce gut microbiota (GM) dysbiosis, impair intestinal barrier, alter metabolites. These ultimately secondary oxidative stress, systemic inflammation, sympathetic activation. We then summarize effects on disease pathogenesis, cardiocerebrovascular disorders, neurological metabolic diseases, cancer, reproductive COVID-19. Finally, different therapeutic strategies for caused causes proposed. Multidisciplinary approaches shared decision-making necessary successful treatment future, more randomized controlled trials needed further evaluation define what treatments best specific patients.

Язык: Английский

---

Mitochondrial dysfunction in aging

Ageing Research Reviews, Год журнала: 2023, Номер 88, С. 101955 - 101955

Опубликована: Май 15, 2023

Язык: Английский

---

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(20), С. 11047 - 11047

Опубликована: Окт. 13, 2021

Until recently, radiation effects have been considered to be mainly due nuclear DNA damage and their management by repair mechanisms. However, molecular biology studies reveal that the outcomes of exposures ionizing (IR) highly depend on activation regulation through other components organelles determine cell survival proliferation capacities. As typical epigenetic-regulated central power stations cells, mitochondria play an important pivotal role in those responses. They direct cellular metabolism, energy supply homeostasis as well radiation-induced signaling, death, immunological This review is focused how energy, dose quality IR affect mitochondria-dependent epigenetic functional control at tissue level. Low-dose appear associated with non-targeted involved genomic instability adaptive responses, whereas high-dose (>1 Gy) concern therapeutic long-term involving mitochondria-mediated innate immune Both quality. For example, increased efficacy high linear transfer particle radiotherapy, e.g., C-ion relies reduction anastasis, enhanced apoptosis immunogenic (antitumor)

Язык: Английский

---

The impact of air pollution on respiratory diseases in an era of climate change: A review of the current evidence

The Science of The Total Environment, Год журнала: 2023, Номер 898, С. 166340 - 166340

Опубликована: Авг. 15, 2023

Язык: Английский

---

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Окт. 18, 2023

Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.

Язык: Английский

---

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Год журнала: 2023, Номер 24(5), С. 609 - 662

Опубликована: Июль 30, 2023

Язык: Английский

---

Oxidative stress response pathways in fungi

Cellular and Molecular Life Sciences, Год журнала: 2022, Номер 79(6)

Опубликована: Июнь 1, 2022

Язык: Английский

---

Targeting Oxidative Stress Involved in Endometriosis and Its Pain

Biomolecules, Год журнала: 2022, Номер 12(8), С. 1055 - 1055

Опубликована: Июль 29, 2022

Endometriosis is a common gynecological disorder seen in women and characterized by chronic pelvic pain infertility. This becoming more prevalent with increased morbidity. The etiology of endometriosis remains to be fully elucidated, which will lead improved therapeutic options. In this review, we evaluate the biochemical mechanisms leading oxidative stress their implication pathophysiology endometriosis, as well potential treatments that target these processes. A comprehensive exploration previous research revealed associated elevated reactive oxygen species oxidation products, decreased antioxidants detoxification enzymes, dysregulated iron metabolism. High levels contributed inflammation, extracellular matrix degradation, angiogenesis, cell proliferation, may explain its role endometriosis. Endometriosis-associated was attributed neurogenic inflammation feed-forward mechanism involving macrophages, pro-inflammatory cytokines, pain-inducing prostaglandins. N-acetylcysteine, curcumin, melatonin, combined vitamin C E supplementation displayed promising results for treatment but further needed use population.

Язык: Английский

---

The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117177 - 117177

Опубликована: Июль 24, 2024

Cytokines regulate immune responses essential for maintaining homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge promising therapeutic agents because they mitigate oxidative stress and modulate pathways. Antioxidants potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated responses. A comprehensive understanding of pathways the interplay with is paramount developing natural targeting helping improve clinical outcomes enhance quality life patients. Among these antioxidants, curcumin, vitamin C, D, propolis, allicin, cinnamaldehyde have garnered attention their anti-inflammatory properties potential benefits. This review highlights interrelationship between cytokines-mediated in various diseases approaches involving antioxidants.

Язык: Английский

---