Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration DOI Creative Commons

Farhad Sanaeifar,

Sina Pourranjbar,

Mohammad Pourranjbar

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 195, P. 112539 - 112539

Published: Aug. 8, 2024

Neurodegenerative diseases (NDDs) are a class of neurological disorders marked by the progressive loss neurons that afflict millions people worldwide. These illnesses affect brain connection, impairing memory, cognition, behavior, sensory perception, and motor function. Alzheimer's, Parkinson's, Huntington's examples common NDDs, which frequently include buildup misfolded proteins. Cognitive-behavioral impairments early markers neurodevelopmental disorders, emphasizing importance detection intervention. Neurotrophins such as brain-derived neurotrophic factor (BDNF) critical for neuron survival synaptic plasticity, is required learning memory. NDDs have been associated with decreased BDNF levels. Physical exercise, non-pharmacological intervention, benefits health increasing levels, lowering cognitive deficits, slowing degradation. Exercise advantages increased well-being, reduced depression, improved skills, neuroprotection amyloid accumulation, oxidative stress, neuroinflammation. This study examines effects physical exercise on cognitive-behavioral deficits levels in limbic system impacted neurodegeneration. The findings highlight necessity including into NDD treatment to improve structure, function, total As research advances, becoming increasingly acknowledged an important technique treating decline neurodegenerative disorders.

Language: Английский

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend? DOI Creative Commons
Cheng‐Liang Kuo,

Ananth Ponneri Babuharisankar,

Ying‐Chen Lin

et al.

Journal of Biomedical Science, Journal Year: 2022, Volume and Issue: 29(1)

Published: Sept. 26, 2022

The major concept of "oxidative stress" is an excess elevated level reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption oxygen. precise harmonization oxidative stresses between mitochondria other organelles in the cell absolutely vital to survival. Under stress, ROS produced mediator for tumorigenesis different aspects, such as proliferation, migration/invasion, angiogenesis, inflammation, immunoescape allow cancer cells adapt rigorous environment. Accordingly, dynamic balance not only orchestrate complex signaling events but also affect components tumor microenvironment (TME). Immune cells, M2 macrophages, dendritic T immunosuppressive TME ROS-induced inflammation. Based on this notion, numerous strategies mitigate tumors have been tested prevention or therapies; however, these manipulations devised sources mechanisms without established effectiveness. Herein, we integrate current progress regarding impact mitochondrial TME, immune discuss combination emerging ROS-modulating with immunotherapies achieve antitumor effects.

Language: Английский

Citations

184
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome DOI Creative Commons
Renjun Lv, Xueying Liu, Yue Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 25, 2023

Abstract Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in which the airways narrow or collapse during sleep, causing obstructive apnea. The prevalence of OSAS continues to rise worldwide, particularly middle-aged and elderly individuals. mechanism upper airway incompletely understood but associated with several factors, including obesity, craniofacial changes, altered muscle function airway, pharyngeal neuropathy, fluid shifts neck. main characteristics are recurrent pauses respiration, lead intermittent hypoxia (IH) hypercapnia, accompanied by blood oxygen desaturation arousal sharply increases risk diseases. This paper first briefly describes epidemiology, incidence, pathophysiological mechanisms OSAS. Next, alterations relevant signaling pathways induced IH systematically reviewed discussed. For example, can induce gut microbiota (GM) dysbiosis, impair intestinal barrier, alter metabolites. These ultimately secondary oxidative stress, systemic inflammation, sympathetic activation. We then summarize effects on disease pathogenesis, cardiocerebrovascular disorders, neurological metabolic diseases, cancer, reproductive COVID-19. Finally, different therapeutic strategies for caused causes proposed. Multidisciplinary approaches shared decision-making necessary successful treatment future, more randomized controlled trials needed further evaluation define what treatments best specific patients.

Language: Английский

Citations

175
Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts DOI Open Access
D. Averbeck, Claire Rodriguez‐Lafrasse

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(20), P. 11047 - 11047

Published: Oct. 13, 2021

Until recently, radiation effects have been considered to be mainly due nuclear DNA damage and their management by repair mechanisms. However, molecular biology studies reveal that the outcomes of exposures ionizing (IR) highly depend on activation regulation through other components organelles determine cell survival proliferation capacities. As typical epigenetic-regulated central power stations cells, mitochondria play an important pivotal role in those responses. They direct cellular metabolism, energy supply homeostasis as well radiation-induced signaling, death, immunological This review is focused how energy, dose quality IR affect mitochondria-dependent epigenetic functional control at tissue level. Low-dose appear associated with non-targeted involved genomic instability adaptive responses, whereas high-dose (>1 Gy) concern therapeutic long-term involving mitochondria-mediated innate immune Both quality. For example, increased efficacy high linear transfer particle radiotherapy, e.g., C-ion relies reduction anastasis, enhanced apoptosis immunogenic (antitumor)

Language: Английский

Citations

149
Mitochondrial dysfunction in aging DOI
Ying Guo, Teng Guan,

Kashfia Shafiq

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101955 - 101955

Published: May 15, 2023

Language: Английский

Citations

148
The impact of air pollution on respiratory diseases in an era of climate change: A review of the current evidence DOI
Huan Minh Tran, Feng‐Jen Tsai, Yueh‐Lun Lee

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 898, P. 166340 - 166340

Published: Aug. 15, 2023

Language: Английский

Citations

147
From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration DOI Creative Commons
Sheryar Afzal, Aimi Syamima Abdul Manap, Ali Attiq

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.

Language: Английский

Citations

138
The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds DOI Creative Commons

Nitish Kumar Bhol,

Madhabi M. Bhanjadeo,

Anup K. Singh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117177 - 117177

Published: July 24, 2024

Cytokines regulate immune responses essential for maintaining homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge promising therapeutic agents because they mitigate oxidative stress and modulate pathways. Antioxidants potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated responses. A comprehensive understanding of pathways the interplay with is paramount developing natural targeting helping improve clinical outcomes enhance quality life patients. Among these antioxidants, curcumin, vitamin C, D, propolis, allicin, cinnamaldehyde have garnered attention their anti-inflammatory properties potential benefits. This review highlights interrelationship between cytokines-mediated in various diseases approaches involving antioxidants.

Language: Английский

Citations

112
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies DOI
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma

et al.

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

Citations

87
Oxidative stress response pathways in fungi DOI
Hajar Yaakoub, Sara Mina,

Alphonse Calenda

et al.

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(6)

Published: June 1, 2022

Language: Английский

Citations

79
Targeting Oxidative Stress Involved in Endometriosis and Its Pain DOI Creative Commons

Lauren Clower,

Taylor Fleshman, Werner J. Geldenhuys

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(8), P. 1055 - 1055

Published: July 29, 2022

Endometriosis is a common gynecological disorder seen in women and characterized by chronic pelvic pain infertility. This becoming more prevalent with increased morbidity. The etiology of endometriosis remains to be fully elucidated, which will lead improved therapeutic options. In this review, we evaluate the biochemical mechanisms leading oxidative stress their implication pathophysiology endometriosis, as well potential treatments that target these processes. A comprehensive exploration previous research revealed associated elevated reactive oxygen species oxidation products, decreased antioxidants detoxification enzymes, dysregulated iron metabolism. High levels contributed inflammation, extracellular matrix degradation, angiogenesis, cell proliferation, may explain its role endometriosis. Endometriosis-associated was attributed neurogenic inflammation feed-forward mechanism involving macrophages, pro-inflammatory cytokines, pain-inducing prostaglandins. N-acetylcysteine, curcumin, melatonin, combined vitamin C E supplementation displayed promising results for treatment but further needed use population.

Language: Английский

Citations

74