Self‐Lubricating, Living Contact Lenses

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Апрель 7, 2024

Abstract The increasing prevalence of dry eye syndrome in aging and digital societies compromises long‐term contact lens (CL) wear forces users to regular drop instillation alleviate discomfort. Here a novel approach with the potential improve extend lubrication properties CLs is presented. This achieved by embedding lubricant‐secreting biofactories within CL material. self‐replenishable reservoirs autonomously produce release hyaluronic acid (HA), natural wetting agent, long term. hydrogel matrix regulates growth HA production, allows diffusion nutrients for at least 3 weeks. continuous sustainably reduces friction coefficient surface. A self‐lubricating prototype presented, where functional are contained ring periphery, outside vision area. device cytocompatible fulfils physicochemical requirements commercial CLs. fabrication process compatible current manufacturing processes correction. It envisioned that durable‐by‐design living could enable comfort minimize need lubricating drops.

Язык: Английский

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BCLA CLEAR Presbyopia: Management with contact lenses and spectacles

Contact Lens and Anterior Eye, Год журнала: 2024, Номер 47(4), С. 102158 - 102158

Опубликована: Апрель 16, 2024

This paper seeks to outline the history, market situation, clinical management and product performance related correction of presbyopia with both contact lenses spectacles. The history development various optical forms presbyopic are reviewed, an overview is presented current status Clinical considerations in fitting aftercare lens spectacle wearers presented, general recommendations for best practice. Current options include soft simultaneous, rigid translating simultaneous designs, addition monovision. Spectacle single vision lenses, bifocal a range progressive lenses. comparative presented. With significant proportion global population now being presbyopic, this particularly timely designed act as guide researchers, industry eyecare practitioners alike.

Язык: Английский

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TFOS Lifestyle: Impact of contact lenses on the ocular surface

The Ocular Surface, Год журнала: 2023, Номер 29, С. 175 - 219

Опубликована: Май 4, 2023

Язык: Английский

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From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors

Critical Reviews in Clinical Laboratory Sciences, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Фев. 1, 2025

Monitoring individuals' laboratory data is essential for assessing their health status, evaluating the effectiveness of treatments, predicting disease prognosis and detecting subclinical conditions. Currently, monitoring performed intermittently, measuring serum, plasma, whole blood, urine occasionally other body fluids at predefined time intervals. The ideal approach entails continuous measurement concentration activity biomolecules in all fluids, including solid tissues. This can be achieved through use biosensors strategically placed various locations on human where measurements are required monitoring. High-tech wearable provide an ideal, noninvasive, esthetically pleasing solution data. However, despite significant advances biosensor technology, capacities number different analytes that continuously monitored patients not yet desired level. In this review, we conducted a literature search examined: (i) overview background personalized medicine, (ii) used individuals, (iii) types methods biomolecules, (iv) statistical algorithms analysis interpretation evaluation.

Язык: Английский

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BCLA CLEAR - Effect of contact lens materials and designs on the anatomy and physiology of the eye

Contact Lens and Anterior Eye, Год журнала: 2021, Номер 44(2), С. 192 - 219

Опубликована: Март 25, 2021

Язык: Английский

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Testing drug release from medicated contact lenses: The missing link to predict in vivo performance

Journal of Controlled Release, Год журнала: 2022, Номер 343, С. 672 - 702

Опубликована: Фев. 14, 2022

Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms, but the feasibility medicated CL development is constrained by numerous scientific, technological, and regulatory challenges. One main difficulty setting release rate specifications for each drug, since at present there are no standardized in vitro models that can appropriately predict performance drug-eluting CLs once placed onto eye. CL-adapted tests may provide knowledge on how drug pattern should perform vivo to trigger maintain therapeutic effects both anterior posterior tissues. Moreover, valuable tools quality assessment during production investigate effect change composition or process variables. This review aims shed light biorelevant ways evaluating from establishing vitro-in correlations (IVIVC) performance. First, general guidelines Pharmacopeia topical ophthalmic formulations well implemented drug-CLs last two decades analyzed. Then, an appropriate method IVIVC attempted few papers simultaneously reporting profiles either response. Finally, key points be considered testing suggested pave way clinical arena.

Язык: Английский

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Use of refractive aids among adults in a general population

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Spectacles and contact lenses are important for conducting a normal life in large part of the general population. The purpose this study was to estimate use these refractive aids adult population, identify characteristics persons who should be targeted order improve uncorrected refraction. In FORSYN study, 10,350 citizens representative Danish population were invited non-cycloplegic eye examination. examination completed 3,384 persons, data adjusted represent frequencies originally on basis age, sex socio-economic factors. projected estimates absolute numbers total Refractive used by 72.6%, 95% CI: 71.7-73.5% Distance correction 55.7% (95% 54.8-56.7%), alone or alternating with spectacles 11.2% 10.6-11.8%) reading glasses 18.8% 18.0-19.5%). Uncorrected error resulted reduction distance visual acuity 2.99 ETDRS letters per diopter hyperopia 10.3 myopia (p < 0.0001 both regressions). reduced significantly using single vision spectacle progressive addition that had been prescribed more than 3 years previously. approximately 72% checked when have passed since last visit dispensing optometrist.

Язык: Английский

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Performance of a Toric, Monthly, Soft Contact Lens in Digital Device Users

Clinical Optometry, Год журнала: 2025, Номер Volume 17, С. 11 - 20

Опубликована: Янв. 1, 2025

To determine the performance of TOTAL30 for Astigmatism (T30fA; Alcon; Fort Worth, TX, USA) contact lenses (CLs) in existing CL wearers who are also frequent digital device users. This 1-month, 3-visit study recruited adult, 18- to 40-year-old subjects were required use daily devices at least 8 hours per day. All refit into T30fA CLs. A text message visual analog scale (VAS) (±50 scale; positive being comfortable) evaluate at-home eye comfort across day 1 day, week, and month. Subjects evaluated month with Computer Vision Syndrome Questionnaire (CVS-Q), Impact Dry Eye on Everyday Life (IDEEL) Quality questionnaire, a custom questionnaire. total 48 analyzed (mean age = 28.8 ± 6.3 years; 75% female). At month, IDEEL activities, feelings, work domains scores 96.7 6.6, 96.4 6.2, 94.8 8.6, respectively. CVS-Q 3.48 3.73. Most indicated that they satisfied overall CLs (81.3%) their level strain (87.3%). When evaluating VAS, did not differ each time point (all p-value ≥ 0.16), yet decrease minimally wear < 0.001). These data suggest monthly can provide an excellent wearing experience those use.

Язык: Английский

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The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study

The Ocular Surface, Год журнала: 2025, Номер 36, С. 190 - 197

Опубликована: Янв. 31, 2025

Язык: Английский

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The Impact of Comfort Eluting Agents and Replacement Frequency on Enhancing Contact Lens Performance

Clinical ophthalmology, Год журнала: 2025, Номер Volume 19, С. 857 - 873

Опубликована: Март 1, 2025

Abstract: This review explores the development and clinical implications of soft contact lenses designed to elute comfort agents, emphasizing their role in enhancing user experience ocular health. As discomfort remains one primary reasons for discontinuation lens wear, this concept aims address challenge by gradually releasing these agents over period use. also effectiveness, safety, satisfaction associated with frequent replacement schedules lenses. Clinical trials demonstrate that eluting significantly reduce dryness irritation, leading improved wear-time overall comfort. The findings suggest not only enhances hygiene but maximizes therapeutic benefits eluted promoting a healthier environment. practice highlight shift towards more patient-centered approaches design management, aiming improve adherence among users. research paves way future innovations technology, focusing on personalized solutions cater individual needs. Keywords: comfort, lens, frequency, wettability

Язык: Английский

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