Hereditas, Год журнала: 2024, Номер 161(1)
Опубликована: Дек. 20, 2024
Язык: Английский
Experimental Physiology, Год журнала: 2021, Номер 107(5), С. 410 - 414
Опубликована: Дек. 18, 2021
What is the topic of this review? In report, we summarize latest clinical evidence linking developmental programming in kidney to later life blood pressure and disease. advances does it highlight? Population-level studies now show convincingly that low birth weight, fetal growth restriction preterm are associated with have a synergistic impact on risk disease life. A new approach also considers how evolutionary selection might fail select for long-term robustness function.The global burden high rising. The among individuals highly variable, part related genetic environmental factors, but likely be modulated by number nephrons function varies widely across population lower those who were born small or preterm. Population registry clearly shows an association between these circumstances later-life hypertension disease, not only chronic acquired demonstrating inherent susceptibility individuals. Gestational stressors development, process layered upon history organ has developed response support reproductive capacity early adulthood, withstand multiple stresses Reducing future generations will require both individual- population/environment-level risks addressed.
Язык: Английский
Процитировано
17
Neurobiology of Aging, Год журнала: 2022, Номер 117, С. 12 - 23
Опубликована: Май 3, 2022
Язык: Английский
Процитировано
12
ACS Chemical Biology, Год журнала: 2023, Номер 18(10), С. 2114 - 2127
Опубликована: Авг. 1, 2023
Nucleic acid modifications include a wide range of epigenetic and epitranscriptomic factors impact nucleic acids due to their profound influence on biological inheritance, growth, metabolism. The recently developed methods mapping characterizing these have promoted discovery as well large-scale studies in eukaryotes, especially humans. Because pioneering strategies, been shown great human disorders such cancer. Therefore, whether could become new type biomarker remains an open question. In this review, we briefly look back at classical then focus the progress made investigating diagnostic biomarkers clinical therapy present our perspective development prospects.
Язык: Английский
Процитировано
7
Clinical Journal of the American Society of Nephrology, Год журнала: 2023, Номер 19(1), С. 13 - 25
Опубликована: Окт. 23, 2023
Children with CKD are at risk for impaired neurocognitive functioning. We investigated metabolomic associations neurocognition in children CKD.
Язык: Английский
Процитировано
7
Physiological Reviews, Год журнала: 2023, Номер 103(4), С. 2451 - 2506
Опубликована: Март 30, 2023
Chronic kidney disease (CKD) affects >10% of the world population, with increasing prevalence in middle age. The risk for CKD is dependent on number functioning nephrons through life cycle, and 50% are lost normal aging, revealing their vulnerability to internal external stressors. Factors responsible remain poorly understood, limited availability biomarkers or effective therapy slow progression. This review draws disciplines evolutionary medicine bioenergetics account heterogeneous nephron injury that characterizes progressive following episodes acute incomplete recovery. evolution symbiosis eukaryotes led efficiencies oxidative phosphorylation rise metazoa. Adaptations ancestral environments products natural selection have shaped mammalian its vulnerabilities ischemic, hypoxic, toxic injury. Reproductive fitness rather than longevity has served as driver evolution, constrained by available energy allocation homeostatic responses cycle. Metabolic plasticity evolved parallel robustness necessary preserve complex developmental programs, adaptations optimize survival reproductive years can become maladaptive reflecting antagonistic pleiotropy. Consequently, environmental stresses promote trade-offs mismatches result cell fate decisions ultimately lead loss. Elucidation bioenergetic contemporary may development new therapies reduce global burden CKD.
Язык: Английский
Процитировано
6
Kidney Research and Clinical Practice, Год журнала: 2023, Номер 42(5), С. 591 - 605
Опубликована: Май 18, 2023
Immunoglobulin A nephropathy (IgAN) is the most prevalent form of glomerulonephritis worldwide. Prediction disease progression in IgAN can help to provide individualized treatment based on accurate risk stratification.We performed proton nuclear magnetic resonance-based metabolomics analyses serum and urine samples from healthy controls, non-progressor (NP), progressor (P) groups identify metabolic profiles progression. Metabolites that were significantly different between NP P selected for pathway analysis. Subsequently, we analyzed multivariate area under receiver operating characteristic (ROC) curves evaluate predictive power metabolites associated with progression.We observed several distinct fingerprints group involving following pathways: glycolipid metabolism; valine, leucine, isoleucine biosynthesis; aminoacyl-transfer RNA glycine, serine, threonine glyoxylate dicarboxylate metabolism. In ROC analyses, combinations glycerol, threonine, proteinuria (area curve [AUC], 0.923; 95% confidence interval [CI], 0.667-1.000) urinary (AUC, 0.912; CI, showed highest discriminatory ability predict progression.This study identified aid identification progressive proposed perturbed pathways metabolites.
Язык: Английский
Процитировано
6
Journal of Molecular and Cellular Cardiology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
Children, Год журнала: 2022, Номер 9(1), С. 118 - 118
Опубликована: Янв. 17, 2022
Renal diseases in childhood form a spectrum of different conditions with potential long-term consequences. Given that, great effort has been made by researchers to identify candidate biomarkers that are able influence diagnosis and prognosis, particular using omics techniques (e.g., metabolomics, lipidomics, genomics, transcriptomics). Over the past decades, metabolomics added promising number ‘new’ ‘old’ group through better physiopathological knowledge, paving way for insightful perspectives on management renal diseases. We aimed summarize most recent evidence main pediatric (including acute injury, kidney transplantation, chronic disease, dysplasia, vesicoureteral reflux, lithiasis) this narrative review.
Язык: Английский
Процитировано
9
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(12), С. 3934 - 3934
Опубликована: Июнь 8, 2023
Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it related to high morbidity mortality due progression end-stage (ESKD). It essential identify patients with risk developing CKD implement therapeutic interventions. Unfortunately, conventional markers CKD, such serum creatinine, glomerular filtration rate (GFR) proteinuria, have many limitations serving an early specific diagnostic tool for this condition. Despite the above, they are still most frequently utilized we do not better. Studies from last decade identified multiple blood urine protein biomarkers but mostly assessed adult population. This article outlines some recent achievements new perspectives finding set that might improve our ability prognose children, monitor response treatment, or even become potential target.
Язык: Английский
Процитировано
5
Children, Год журнала: 2022, Номер 9(11), С. 1650 - 1650
Опубликована: Окт. 28, 2022
Hypertension is the most common complication of chronic kidney disease (CKD) in children, having a strong association with subsequential cardiovascular (CVD). In pediatric CKD, considerable percentage children hypertension are undiagnosed or undertreated. Prior research has evaluated structural and functional markers subclinical CVD biomarkers adults while ideal pediatrics still insufficiently studied. The ultimate goal this review to summarize what currently known about state hypertension, risk factors, potential markers/biomarkers pre-dialysis CKD. We discuss omics-related pathophysiologic processes endothelial dysfunction, injury, oxidative stress inflammation that classified by specific biomarkers. Moreover, we illustrate existing challenges highlight paucity CKD evaluate these for future clinical practice. Thus, achieving utility use remains significant challenge requiring additional efforts.
Язык: Английский
Процитировано
7