Consistency of metabolite associations with measured glomerular filtration rate in children and adults DOI Creative Commons
Taibo Li, Morgan E. Grams, Lesley A. Inker

et al.

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(6)

Published: April 23, 2024

ABSTRACT Background There is interest in identifying novel filtration markers that lead to more accurate GFR estimates than current (creatinine and cystatin C) are consistent across demographic groups. We hypothesize large-scale metabolomics can identify serum metabolites strongly influenced by glomerular rate (GFR) variables creatinine, which would be promising for future investigation. Methods evaluated the consistency of associations between measured (mGFR) 887 common, known quantified an untargeted chromatography- spectroscopy-based platform (Metabolon) performed on frozen blood samples from 580 participants Chronic Kidney Disease Children (CKiD), 674 Modification Diet Renal (MDRD) Study 962 African American Hypertension (AASK). metabolite–mGFR correlation association with metabolite class, molecular weight, assay measurement coefficient variation (CV). Among strong negative correlations mGFR (r < −0.5), we assessed additional age (height children), sex, race body mass index (BMI). Results A total 561 (63%) were negatively correlated mGFR. Correlations highly study, BMI categories (correlation 0.88 0.95). Amino acids, carbohydrates nucleotides often compared lipids, but there was no liquid chromatography/mass spectrometry CV. 114 27 consistently not associated sex or race. Conclusions The majority race, study. Metabolites non-association may represent candidate improve estimation GFR.

Language: Английский

Impact of early life development on later onset chronic kidney disease and hypertension and the role of evolutionary trade‐offs DOI Creative Commons
Valérie A. Luyckx, Robert L. Chevalier

Experimental Physiology, Journal Year: 2021, Volume and Issue: 107(5), P. 410 - 414

Published: Dec. 18, 2021

What is the topic of this review? In report, we summarize latest clinical evidence linking developmental programming in kidney to later life blood pressure and disease. advances does it highlight? Population-level studies now show convincingly that low birth weight, fetal growth restriction preterm are associated with have a synergistic impact on risk disease life. A new approach also considers how evolutionary selection might fail select for long-term robustness function.The global burden high rising. The among individuals highly variable, part related genetic environmental factors, but likely be modulated by number nephrons function varies widely across population lower those who were born small or preterm. Population registry clearly shows an association between these circumstances later-life hypertension disease, not only chronic acquired demonstrating inherent susceptibility individuals. Gestational stressors development, process layered upon history organ has developed response support reproductive capacity early adulthood, withstand multiple stresses Reducing future generations will require both individual- population/environment-level risks addressed.

Language: Английский

Citations

17
Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers DOI Creative Commons
Ruocheng Dong, Diandra N. Denier‐Fields, Qiongshi Lu

et al.

Neurobiology of Aging, Journal Year: 2022, Volume and Issue: 117, P. 12 - 23

Published: May 3, 2022

Language: Английский

Citations

12
Disease Diagnosis Based on Nucleic Acid Modifications DOI

Xiaochen Xue,

Zhiying Wang,

Yafen Wang

et al.

ACS Chemical Biology, Journal Year: 2023, Volume and Issue: 18(10), P. 2114 - 2127

Published: Aug. 1, 2023

Nucleic acid modifications include a wide range of epigenetic and epitranscriptomic factors impact nucleic acids due to their profound influence on biological inheritance, growth, metabolism. The recently developed methods mapping characterizing these have promoted discovery as well large-scale studies in eukaryotes, especially humans. Because pioneering strategies, been shown great human disorders such cancer. Therefore, whether could become new type biomarker remains an open question. In this review, we briefly look back at classical then focus the progress made investigating diagnostic biomarkers clinical therapy present our perspective development prospects.

Language: Английский

Citations

7
Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD DOI
Arthur Lee, Yunwen Xu, Stephen R. Hooper

et al.

Clinical Journal of the American Society of Nephrology, Journal Year: 2023, Volume and Issue: 19(1), P. 13 - 25

Published: Oct. 23, 2023

Children with CKD are at risk for impaired neurocognitive functioning. We investigated metabolomic associations neurocognition in children CKD.

Language: Английский

Citations

7
Bioenergetics: the evolutionary basis of progressive kidney disease DOI
Robert L. Chevalier

Physiological Reviews, Journal Year: 2023, Volume and Issue: 103(4), P. 2451 - 2506

Published: March 30, 2023

Chronic kidney disease (CKD) affects >10% of the world population, with increasing prevalence in middle age. The risk for CKD is dependent on number functioning nephrons through life cycle, and 50% are lost normal aging, revealing their vulnerability to internal external stressors. Factors responsible remain poorly understood, limited availability biomarkers or effective therapy slow progression. This review draws disciplines evolutionary medicine bioenergetics account heterogeneous nephron injury that characterizes progressive following episodes acute incomplete recovery. evolution symbiosis eukaryotes led efficiencies oxidative phosphorylation rise metazoa. Adaptations ancestral environments products natural selection have shaped mammalian its vulnerabilities ischemic, hypoxic, toxic injury. Reproductive fitness rather than longevity has served as driver evolution, constrained by available energy allocation homeostatic responses cycle. Metabolic plasticity evolved parallel robustness necessary preserve complex developmental programs, adaptations optimize survival reproductive years can become maladaptive reflecting antagonistic pleiotropy. Consequently, environmental stresses promote trade-offs mismatches result cell fate decisions ultimately lead loss. Elucidation bioenergetic contemporary may development new therapies reduce global burden CKD.

Language: Английский

Citations

6
Serum and urine metabolomic biomarkers for predicting prognosis in patients with immunoglobulin A nephropathy DOI Creative Commons
You Hyun Jeon, Sujin Lee, Da Woon Kim

et al.

Kidney Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 42(5), P. 591 - 605

Published: May 18, 2023

Immunoglobulin A nephropathy (IgAN) is the most prevalent form of glomerulonephritis worldwide. Prediction disease progression in IgAN can help to provide individualized treatment based on accurate risk stratification.We performed proton nuclear magnetic resonance-based metabolomics analyses serum and urine samples from healthy controls, non-progressor (NP), progressor (P) groups identify metabolic profiles progression. Metabolites that were significantly different between NP P selected for pathway analysis. Subsequently, we analyzed multivariate area under receiver operating characteristic (ROC) curves evaluate predictive power metabolites associated with progression.We observed several distinct fingerprints group involving following pathways: glycolipid metabolism; valine, leucine, isoleucine biosynthesis; aminoacyl-transfer RNA glycine, serine, threonine glyoxylate dicarboxylate metabolism. In ROC analyses, combinations glycerol, threonine, proteinuria (area curve [AUC], 0.923; 95% confidence interval [CI], 0.667-1.000) urinary (AUC, 0.912; CI, showed highest discriminatory ability predict progression.This study identified aid identification progressive proposed perturbed pathways metabolites.

Language: Английский

Citations

6
Metabolomics in atrial fibrillation - A review and meta-analysis of blood, tissue and animal models DOI Creative Commons

Leonoor F.J. Wijdeveld,

Amelie C. T. Collinet, Fabries G. Huiskes

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

2
New Insights from Metabolomics in Pediatric Renal Diseases DOI Creative Commons
Simona Riccio, Maria Sole Valentino,

Antonio Paride Passaro

et al.

Children, Journal Year: 2022, Volume and Issue: 9(1), P. 118 - 118

Published: Jan. 17, 2022

Renal diseases in childhood form a spectrum of different conditions with potential long-term consequences. Given that, great effort has been made by researchers to identify candidate biomarkers that are able influence diagnosis and prognosis, particular using omics techniques (e.g., metabolomics, lipidomics, genomics, transcriptomics). Over the past decades, metabolomics added promising number ‘new’ ‘old’ group through better physiopathological knowledge, paving way for insightful perspectives on management renal diseases. We aimed summarize most recent evidence main pediatric (including acute injury, kidney transplantation, chronic disease, dysplasia, vesicoureteral reflux, lithiasis) this narrative review.

Language: Английский

Citations

9
Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far? DOI Open Access
Agnieszka Rybi–Szumińska, Anna Wasilewska,

Monika Kamianowska

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 3934 - 3934

Published: June 8, 2023

Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it related to high morbidity mortality due progression end-stage (ESKD). It essential identify patients with risk developing CKD implement therapeutic interventions. Unfortunately, conventional markers CKD, such serum creatinine, glomerular filtration rate (GFR) proteinuria, have many limitations serving an early specific diagnostic tool for this condition. Despite the above, they are still most frequently utilized we do not better. Studies from last decade identified multiple blood urine protein biomarkers but mostly assessed adult population. This article outlines some recent achievements new perspectives finding set that might improve our ability prognose children, monitor response treatment, or even become potential target.

Language: Английский

Citations

5
Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease DOI Creative Commons
You‐Lin Tain, Chien‐Ning Hsu

Children, Journal Year: 2022, Volume and Issue: 9(11), P. 1650 - 1650

Published: Oct. 28, 2022

Hypertension is the most common complication of chronic kidney disease (CKD) in children, having a strong association with subsequential cardiovascular (CVD). In pediatric CKD, considerable percentage children hypertension are undiagnosed or undertreated. Prior research has evaluated structural and functional markers subclinical CVD biomarkers adults while ideal pediatrics still insufficiently studied. The ultimate goal this review to summarize what currently known about state hypertension, risk factors, potential markers/biomarkers pre-dialysis CKD. We discuss omics-related pathophysiologic processes endothelial dysfunction, injury, oxidative stress inflammation that classified by specific biomarkers. Moreover, we illustrate existing challenges highlight paucity CKD evaluate these for future clinical practice. Thus, achieving utility use remains significant challenge requiring additional efforts.

Language: Английский

Citations

7