Clinical Kidney Journal,
Journal Year:
2024,
Volume and Issue:
17(6)
Published: April 23, 2024
ABSTRACT
Background
There
is
interest
in
identifying
novel
filtration
markers
that
lead
to
more
accurate
GFR
estimates
than
current
(creatinine
and
cystatin
C)
are
consistent
across
demographic
groups.
We
hypothesize
large-scale
metabolomics
can
identify
serum
metabolites
strongly
influenced
by
glomerular
rate
(GFR)
variables
creatinine,
which
would
be
promising
for
future
investigation.
Methods
evaluated
the
consistency
of
associations
between
measured
(mGFR)
887
common,
known
quantified
an
untargeted
chromatography-
spectroscopy-based
platform
(Metabolon)
performed
on
frozen
blood
samples
from
580
participants
Chronic
Kidney
Disease
Children
(CKiD),
674
Modification
Diet
Renal
(MDRD)
Study
962
African
American
Hypertension
(AASK).
metabolite–mGFR
correlation
association
with
metabolite
class,
molecular
weight,
assay
measurement
coefficient
variation
(CV).
Among
strong
negative
correlations
mGFR
(r
<
−0.5),
we
assessed
additional
age
(height
children),
sex,
race
body
mass
index
(BMI).
Results
A
total
561
(63%)
were
negatively
correlated
mGFR.
Correlations
highly
study,
BMI
categories
(correlation
0.88
0.95).
Amino
acids,
carbohydrates
nucleotides
often
compared
lipids,
but
there
was
no
liquid
chromatography/mass
spectrometry
CV.
114
27
consistently
not
associated
sex
or
race.
Conclusions
The
majority
race,
study.
Metabolites
non-association
may
represent
candidate
improve
estimation
GFR.
Experimental Physiology,
Journal Year:
2021,
Volume and Issue:
107(5), P. 410 - 414
Published: Dec. 18, 2021
What
is
the
topic
of
this
review?
In
report,
we
summarize
latest
clinical
evidence
linking
developmental
programming
in
kidney
to
later
life
blood
pressure
and
disease.
advances
does
it
highlight?
Population-level
studies
now
show
convincingly
that
low
birth
weight,
fetal
growth
restriction
preterm
are
associated
with
have
a
synergistic
impact
on
risk
disease
life.
A
new
approach
also
considers
how
evolutionary
selection
might
fail
select
for
long-term
robustness
function.The
global
burden
high
rising.
The
among
individuals
highly
variable,
part
related
genetic
environmental
factors,
but
likely
be
modulated
by
number
nephrons
function
varies
widely
across
population
lower
those
who
were
born
small
or
preterm.
Population
registry
clearly
shows
an
association
between
these
circumstances
later-life
hypertension
disease,
not
only
chronic
acquired
demonstrating
inherent
susceptibility
individuals.
Gestational
stressors
development,
process
layered
upon
history
organ
has
developed
response
support
reproductive
capacity
early
adulthood,
withstand
multiple
stresses
Reducing
future
generations
will
require
both
individual-
population/environment-level
risks
addressed.
ACS Chemical Biology,
Journal Year:
2023,
Volume and Issue:
18(10), P. 2114 - 2127
Published: Aug. 1, 2023
Nucleic
acid
modifications
include
a
wide
range
of
epigenetic
and
epitranscriptomic
factors
impact
nucleic
acids
due
to
their
profound
influence
on
biological
inheritance,
growth,
metabolism.
The
recently
developed
methods
mapping
characterizing
these
have
promoted
discovery
as
well
large-scale
studies
in
eukaryotes,
especially
humans.
Because
pioneering
strategies,
been
shown
great
human
disorders
such
cancer.
Therefore,
whether
could
become
new
type
biomarker
remains
an
open
question.
In
this
review,
we
briefly
look
back
at
classical
then
focus
the
progress
made
investigating
diagnostic
biomarkers
clinical
therapy
present
our
perspective
development
prospects.
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(4), P. 2451 - 2506
Published: March 30, 2023
Chronic
kidney
disease
(CKD)
affects
>10%
of
the
world
population,
with
increasing
prevalence
in
middle
age.
The
risk
for
CKD
is
dependent
on
number
functioning
nephrons
through
life
cycle,
and
50%
are
lost
normal
aging,
revealing
their
vulnerability
to
internal
external
stressors.
Factors
responsible
remain
poorly
understood,
limited
availability
biomarkers
or
effective
therapy
slow
progression.
This
review
draws
disciplines
evolutionary
medicine
bioenergetics
account
heterogeneous
nephron
injury
that
characterizes
progressive
following
episodes
acute
incomplete
recovery.
evolution
symbiosis
eukaryotes
led
efficiencies
oxidative
phosphorylation
rise
metazoa.
Adaptations
ancestral
environments
products
natural
selection
have
shaped
mammalian
its
vulnerabilities
ischemic,
hypoxic,
toxic
injury.
Reproductive
fitness
rather
than
longevity
has
served
as
driver
evolution,
constrained
by
available
energy
allocation
homeostatic
responses
cycle.
Metabolic
plasticity
evolved
parallel
robustness
necessary
preserve
complex
developmental
programs,
adaptations
optimize
survival
reproductive
years
can
become
maladaptive
reflecting
antagonistic
pleiotropy.
Consequently,
environmental
stresses
promote
trade-offs
mismatches
result
cell
fate
decisions
ultimately
lead
loss.
Elucidation
bioenergetic
contemporary
may
development
new
therapies
reduce
global
burden
CKD.
Kidney Research and Clinical Practice,
Journal Year:
2023,
Volume and Issue:
42(5), P. 591 - 605
Published: May 18, 2023
Immunoglobulin
A
nephropathy
(IgAN)
is
the
most
prevalent
form
of
glomerulonephritis
worldwide.
Prediction
disease
progression
in
IgAN
can
help
to
provide
individualized
treatment
based
on
accurate
risk
stratification.We
performed
proton
nuclear
magnetic
resonance-based
metabolomics
analyses
serum
and
urine
samples
from
healthy
controls,
non-progressor
(NP),
progressor
(P)
groups
identify
metabolic
profiles
progression.
Metabolites
that
were
significantly
different
between
NP
P
selected
for
pathway
analysis.
Subsequently,
we
analyzed
multivariate
area
under
receiver
operating
characteristic
(ROC)
curves
evaluate
predictive
power
metabolites
associated
with
progression.We
observed
several
distinct
fingerprints
group
involving
following
pathways:
glycolipid
metabolism;
valine,
leucine,
isoleucine
biosynthesis;
aminoacyl-transfer
RNA
glycine,
serine,
threonine
glyoxylate
dicarboxylate
metabolism.
In
ROC
analyses,
combinations
glycerol,
threonine,
proteinuria
(area
curve
[AUC],
0.923;
95%
confidence
interval
[CI],
0.667-1.000)
urinary
(AUC,
0.912;
CI,
showed
highest
discriminatory
ability
predict
progression.This
study
identified
aid
identification
progressive
proposed
perturbed
pathways
metabolites.
Children,
Journal Year:
2022,
Volume and Issue:
9(1), P. 118 - 118
Published: Jan. 17, 2022
Renal
diseases
in
childhood
form
a
spectrum
of
different
conditions
with
potential
long-term
consequences.
Given
that,
great
effort
has
been
made
by
researchers
to
identify
candidate
biomarkers
that
are
able
influence
diagnosis
and
prognosis,
particular
using
omics
techniques
(e.g.,
metabolomics,
lipidomics,
genomics,
transcriptomics).
Over
the
past
decades,
metabolomics
added
promising
number
‘new’
‘old’
group
through
better
physiopathological
knowledge,
paving
way
for
insightful
perspectives
on
management
renal
diseases.
We
aimed
summarize
most
recent
evidence
main
pediatric
(including
acute
injury,
kidney
transplantation,
chronic
disease,
dysplasia,
vesicoureteral
reflux,
lithiasis)
this
narrative
review.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(12), P. 3934 - 3934
Published: June 8, 2023
Chronic
kidney
disease
(CKD)
in
children
is
a
major
concern
of
medical
care
and
public
health
as
it
related
to
high
morbidity
mortality
due
progression
end-stage
(ESKD).
It
essential
identify
patients
with
risk
developing
CKD
implement
therapeutic
interventions.
Unfortunately,
conventional
markers
CKD,
such
serum
creatinine,
glomerular
filtration
rate
(GFR)
proteinuria,
have
many
limitations
serving
an
early
specific
diagnostic
tool
for
this
condition.
Despite
the
above,
they
are
still
most
frequently
utilized
we
do
not
better.
Studies
from
last
decade
identified
multiple
blood
urine
protein
biomarkers
but
mostly
assessed
adult
population.
This
article
outlines
some
recent
achievements
new
perspectives
finding
set
that
might
improve
our
ability
prognose
children,
monitor
response
treatment,
or
even
become
potential
target.
Children,
Journal Year:
2022,
Volume and Issue:
9(11), P. 1650 - 1650
Published: Oct. 28, 2022
Hypertension
is
the
most
common
complication
of
chronic
kidney
disease
(CKD)
in
children,
having
a
strong
association
with
subsequential
cardiovascular
(CVD).
In
pediatric
CKD,
considerable
percentage
children
hypertension
are
undiagnosed
or
undertreated.
Prior
research
has
evaluated
structural
and
functional
markers
subclinical
CVD
biomarkers
adults
while
ideal
pediatrics
still
insufficiently
studied.
The
ultimate
goal
this
review
to
summarize
what
currently
known
about
state
hypertension,
risk
factors,
potential
markers/biomarkers
pre-dialysis
CKD.
We
discuss
omics-related
pathophysiologic
processes
endothelial
dysfunction,
injury,
oxidative
stress
inflammation
that
classified
by
specific
biomarkers.
Moreover,
we
illustrate
existing
challenges
highlight
paucity
CKD
evaluate
these
for
future
clinical
practice.
Thus,
achieving
utility
use
remains
significant
challenge
requiring
additional
efforts.