Peptides, Год журнала: 2020, Номер 135, С. 170426 - 170426
Опубликована: Окт. 15, 2020
Язык: Английский
British Journal of Pharmacology, Год журнала: 2019, Номер 177(24), С. 5437 - 5458
Опубликована: Июль 26, 2019
Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with ability to make continual adjustments function response moment‐to‐moment changes physiological input. Here, we summarize progress field argue NO‐synthetizing neurons NO signalling provide core hub for integrating sensory‐ homeostatic‐related cues, control bodily functions, potential target new therapeutic opportunities against several neuroendocrine behavioural abnormalities.
Язык: Английский
Процитировано
79
Neuron, Год журнала: 2022, Номер 110(21), С. 3597 - 3626
Опубликована: Ноя. 1, 2022
Язык: Английский
Процитировано
57
The Annual Review of Pharmacology and Toxicology, Год журнала: 2022, Номер 62(1), С. 55 - 84
Опубликована: Янв. 6, 2022
Historically, pancreatic islet beta cells have been viewed as principal regulators of glycemia, with type 2 diabetes (T2D) resulting when insulin secretion fails to compensate for peripheral tissue resistance. However, glycemia is also regulated by insulin-independent mechanisms that are dysregulated in T2D. Based on evidence supporting its role both adaptive coupling changes sensitivity and the regulation glucose disposal, central nervous system (CNS) has emerged a fundamental player homeostasis. Here, we review expand upon an integrative model wherein CNS, together islet, establishes maintains defended level glycemia. We discuss implications this understanding normal homeostasis T2D pathogenesis highlight centrally targeted therapeutic approaches potential restore normoglycemia patients
Язык: Английский
Процитировано
42
Endocrinology, Год журнала: 2021, Номер 162(10)
Опубликована: Июль 15, 2021
Abstract The ventromedial nucleus of the hypothalamus (VMH) is a complex brain structure that integral to many neuroendocrine functions, including glucose regulation, thermogenesis, and appetitive, social, sexual behaviors. As such, it little surprise under intensive investigation decipher mechanisms which underlie these diverse roles. Developments in genetic investigative tools, for example targeting steroidogenic factor-1-expressing neurons, have allowed us take closer look at VMH, its connections, how affects competing In current review, we aim integrate recent findings into literature contemplate conclusions can be drawn.
Язык: Английский
Процитировано
47
Cell & Bioscience, Год журнала: 2022, Номер 12(1)
Опубликована: Май 26, 2022
Abstract The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body homeostasis. However, it is still not fully understood how brain detects responds to changes circulating levels, as well brain-body coordinated control of In this review, we address growing evidence implicating homeostasis, especially contexts hypoglycemia diabetes. addition neurons, emphasize potential roles played by non-neuronal cells, extracellular matrix hypothalamus Further, review ionic mechanisms which glucose-sensing neurons sense fluctuations ambient levels. We also introduce significant implications heterogeneous VMH upon sex difference addressed. Meanwhile, research gaps have identified, necessities further mechanistic studies future.
Язык: Английский
Процитировано
30
Diabetes Care, Год журнала: 2023, Номер 46(2), С. 237 - 244
Опубликована: Янв. 26, 2023
“Relative hypoglycemia” is an often-overlooked complication of diabetes characterized by increase in the glycemic threshold for detecting and responding to hypoglycemia. The clinical relevance this problem linked growing evidence that among patients with critical illness, higher blood glucose intensive care unit associated mortality without but lower preexisting elevated prehospitalization HbA1c. Although additional studies are needed, cardiovascular stress hypoglycemia perception, which can occur at normal or even levels diabetes, offers a plausible explanation difference outcomes. Little known, however, regarding how normally detected brain, much less relative develops diabetes. In article, we explore role detection played glucose-responsive sensory neurons supplying peripheral vascular beds and/or circumventricular organs. These observations support model wherein results from diabetes-associated impairment neuronal glucose-sensing process. By raising may contribute increased risk standard management critically ill
Язык: Английский
Процитировано
23
Cell Metabolism, Год журнала: 2018, Номер 29(1), С. 11 - 17
Опубликована: Дек. 6, 2018
Язык: Английский
Процитировано
55
Journal of Neuroendocrinology, Год журнала: 2019, Номер 32(1)
Опубликована: Июль 22, 2019
Abstract The ventromedial hypothalamus ( VMH ) plays a complex role in glucose and energy homeostasis. is necessary for the counter‐regulatory response to hypoglycaemia CRR that increases hepatic gluconeogenesis restore euglycaemia. On other hand, also restrains production during euglycaemia stimulates peripheral uptake. important ability of oestrogen increase expenditure. This latter function mediated by modulation lateral/perifornical hypothalamic area orexin neurones. Activation AMP ‐activated protein kinase AMPK . By contrast, inhibition favours decreased basal levels required Specialised glucose‐sensing neurones confer sense respond changes blood levels. Glucose‐excited GE glucose‐inhibited GI decrease their activity as rise. neurones, particular, appear be , although cannot discounted. mediates sensing suggesting that, activation these it silence them lower enable In support this, we found reduces low inhibiting this review, present evidence underlying We then discuss mediating effects, with strong emphasis on oestrogenic regulation how may affect
Язык: Английский
Процитировано
47
Diabetologia, Год журнала: 2020, Номер 63(10), С. 2086 - 2094
Опубликована: Сен. 7, 2020
Язык: Английский
Процитировано
47
eLife, Год журнала: 2020, Номер 9
Опубликована: Дек. 15, 2020
To maintain energy homeostasis during cold exposure, the increased demands of thermogenesis must be counterbalanced by intake. investigate neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are activated when animals placed in a environment and, if so, response is required for associated hyperphagia. We report that AgRP neuron activation occurs rapidly upon acute as do increases both expenditure and intake, suggesting mere perception sufficient to engage each these responses. further silencing selectively blocks effect exposure increase food intake but has no on expenditure. Together, findings establish physiologically important role hyperphagic exposure.
Язык: Английский
Процитировано
45