Regional and aging-specific cellular architecture of non-human primate brains

Genome Medicine, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 28, 2025

Язык: Английский

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Live birth of chimeric monkey with high contribution from embryonic stem cells

Cell, Год журнала: 2023, Номер 186(23), С. 4996 - 5014.e24

Опубликована: Ноя. 1, 2023

Язык: Английский

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Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID

Neurology International, Год журнала: 2023, Номер 15(2), С. 725 - 742

Опубликована: Май 31, 2023

Sustained cognitive deficits are a common and debilitating feature of “long COVID”, but currently there no FDA-approved treatments. The functions the dorsolateral prefrontal cortex (dlPFC) most consistently afflicted by long COVID, including in working memory, motivation, executive functioning. COVID-19 infection greatly increases kynurenic acid (KYNA) glutamate carboxypeptidase II (GCPII) brain, both which can be particularly deleterious to PFC function. KYNA blocks NMDA nicotinic-alpha-7 receptors, two receptors required for dlPFC neurotransmission, GCPII reduces mGluR3 regulation cAMP-calcium-potassium channel signaling, weakens network connectivity neuronal firing. Two agents approved other indications may helpful restoring physiology: antioxidant N-acetyl cysteine inhibits production KYNA, α2A-adrenoceptor agonist guanfacine regulates signaling is also anti-inflammatory. Thus, these treating symptoms COVID.

Язык: Английский

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Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis

Virologica Sinica, Год журнала: 2023, Номер 38(6), С. 971 - 974

Опубликована: Сен. 30, 2023

• Establishment of 3D cardiac organoids composed cardiomyocyte and endothelial layers. SARS-CoV-2 infection causes multi-lineage injuries. Cardiovascular health should be greatly concerned in COVID-19 patients.

Язык: Английский

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

动物学研究, Год журнала: 2024, Номер 45(4), С. 877 - 909

Опубликована: Янв. 1, 2024

The tree shrew (Tupaia belangeri) has long been proposed as a suitable alternative to non-human primates (NHPs) in biomedical and laboratory research due its close evolutionary relationship with primates. In recent years, significant advances have facilitated studies, including the determination of genome, genetic manipulation using spermatogonial stem cells, viral vector-mediated gene delivery, mapping brain atlas. However, limited availability shrews globally remains substantial challenge field. Additionally, determining key questions best answered constitutes another difficulty. Tree models historically used study hepatitis B virus (HBV) C (HCV) infection, myopia, psychosocial stress-induced depression, more studies focusing on developing animal for infectious neurodegenerative diseases. Despite these efforts, impact not yet matched that rodent or NHP research. This review summarizes prominent advancements reflects biological addressed this model. We emphasize intensive dedication robust international collaboration are essential achieving breakthroughs studies. use unique resource is expected gain considerable attention application advanced techniques development viable models, meeting increasing demands life science

Язык: Английский

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Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19

Viruses, Год журнала: 2025, Номер 17(1), С. 98 - 98

Опубликована: Янв. 14, 2025

Post-acute sequelae of COVID-19 (PASC) are a diverse set symptoms and syndromes driven by dysfunction multiple organ systems that can persist for years negatively impact the quality life millions individuals. We currently lack specific therapeutics patients with PASC, due in part to an incomplete understanding its pathogenesis, especially non-pulmonary sequelae. Here, we discuss three animal models have been utilized investigate PASC: non-human primates (NHPs), hamsters, mice. focus on neurological, gastrointestinal, cardiovascular PASC highlight advances mechanistic insight made using these models, as well discussing warrant continued intensive research.

Язык: Английский

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Cell atlas of CCl₄-induced progressive liver fibrosis reveals stage-specific responses

动物学研究, Год журнала: 2023, Номер 44(3), С. 451 - 466

Опубликована: Янв. 1, 2023

Chronic liver injury leads to progressive fibrosis and ultimately cirrhosis, a major cause of morbidity mortality worldwide. However, there are currently no effective anti-fibrotic therapies available, especially for late-stage patients, which is partly attributed the knowledge gap regarding cell heterogeneity cell-specific responses in different stages. To reveal multicellular networks regulating mammalian from mild severe phenotypes, we generated single-nucleus transcriptomic atlas encompassing 49 919 nuclei corresponding all main types at stages murine carbon tetrachloride (CCl

Язык: Английский

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Comparative transcriptome analysis between rhesus macaques (<i>Macaca mulatta</i>) and crab-eating macaques (<i>M. fascicularis</i>)

动物学研究, Год журнала: 2023, Номер 45(2), С. 299 - 310

Опубликована: Дек. 28, 2023

Understanding the variations in gene expression between species is pivotal for deciphering evolutionary diversity phenotypes. Rhesus macaques and crab-eating serve as crucial nonhuman primate biomedical models with different phenotypes, but large-scale of comparative transcriptome research these two has yet to be fully elucidated. Here, we conduct systematic comparisons utilizing newly sequenced RNA-seq data from 84 samples (41 Mfa 43 Mmu samples) encompassing 14 common tissues. Our findings reveal that a small fraction genes (~3.7%) show differential macaque species, while ~36.5% tissue-specific both macaques. We also compare humans ~22.6 % orthologous at least 2 Moreover, ~19.41% overlapped macaque-specific structural variants are more likely Of these, FAM220A shows elevated compared because lineage-specific duplication. In summary, our study presents analysis transcriptomes within humans. These insights into will enhance utility contributing broader realm genomic studies.

Язык: Английский

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Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement: insights into COVID-19 pathogenesis

Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2024, Номер 51(6), С. 608 - 616

Опубликована: Март 4, 2024

Язык: Английский

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Ferrets: A powerful model of SARS-CoV-2

动物学研究, Год журнала: 2023, Номер 44(2), С. 323 - 330

Опубликована: Янв. 1, 2023

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent years not only caused a global pandemic but resulted enormous social, economic, and health burdens worldwide. Despite considerable efforts to combat disease 2019 (COVID-19), various SARS-CoV-2 variants have emerged, their underlying mechanisms pathogenicity remain largely unknown. Furthermore, effective therapeutic drugs are still under development. Thus, an ideal animal model is crucial for studying the pathogenesis COVID-19 preclinical evaluation vaccines antivirals against variant infections. Currently, several models, including mice, hamsters, ferrets, non-human primates (NHPs), been established study COVID-19. Among them, ferrets naturally susceptible infection considered suitable study. Here, we summarize developments application ferret models studies on pathogenesis, agents, vaccines, provide perspective role these preventing spread.

Язык: Английский

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