Metabolites,
Год журнала:
2023,
Номер
13(10), С. 1072 - 1072
Опубликована: Окт. 12, 2023
Tannic
acid
(TA)
is
an
organic
compound
belonging
to
the
tannin
group.
Like
other
tannins,
it
has
affinity
for
endogenous
proteins,
including
digestive
enzymes,
which
can
result
in
reduced
digestibility
and
absorption
of
nutrients.
It
also
form
complexes
with
mineral
components,
reducing
their
absorption.
In
some
cases,
this
be
beneficial,
such
as
case
toxic
metals,
but
sometimes
may
have
a
detrimental
effect
on
body
when
involves
essential
components
like
Ca,
P,
Mg,
Na,
K,
or
Fe.
Therefore,
impact
TA
bone
health
should
considered
from
both
perspectives.
This
relatively
short
review
summarizes
available
information
research
findings
TA,
particular
focus
its
potential
health.
worth
noting
that
future
clinical
studies
provide
more
detailed
precise
topic,
allowing
better
understanding
role
maintaining
integrity
musculoskeletal
system.
Despite
brevity,
paper
represents
valuable
contribution
analysis
benefits
challenges
associated
context
We
anticipate
will
continue
along
important
line,
expanding
our
knowledge
influence
skeletal
system
therapeutic
applications.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(5), С. 1436 - 1436
Опубликована: Март 1, 2024
A
growing
number
of
probiotic-containing
products
are
on
the
market,
and
their
use
is
increasing.
Probiotics
thought
to
support
health
gut
microbiota,
which
in
turn
might
prevent
or
delay
onset
gastrointestinal
tract
disorders.
Obesity,
type
2
diabetes,
autism,
osteoporosis,
some
immunological
illnesses
among
conditions
that
have
been
shown
possibly
benefit
from
probiotics.
In
addition
ability
favorably
affect
diseases,
probiotics
represent
a
defense
system
enhancing
intestinal,
nutritional,
oral
health.
Depending
microbial
strain
utilized,
can
variable
beneficial
properties.
Although
many
species
available,
most
widely
employed
ones
lactic
acid
bacteria
bifidobacteria.
The
usefulness
these
dependent
both
origin
capacity
promote
valuable
clinical
tool
supporting
health,
immune
function,
metabolic
balance.
When
used
appropriately,
may
provide
benefits
such
as
reduced
risk
disorders,
enhanced
immunity,
improved
Most
popular
probiotics,
advantages,
mode
action
topic
this
narrative
review
article,
aimed
reader
with
comprehensive
reappraisal
matter.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(9), С. 4726 - 4736
Опубликована: Янв. 31, 2024
Milk-derived
extracellular
vesicles
can
improve
intestinal
health
and
have
antiosteoporosis
potential.
In
this
paper,
we
explored
the
effects
of
bovine
raw
milk-derived
(mEVs)
on
ovariectomized
(OVX)
osteoporotic
mice
from
perspective
gut-bone
axis.
mEVs
could
inhibit
osteoclast
differentiation
microarchitecture.
The
level
biomarkers
in
OVX
was
restored
after
intervened.
Compared
with
mice,
enhance
permeability,
reduce
endotoxin
levels,
expression
TNF-α,
IL-17,
IL-10.
16S
rDNA
sequencing
indicated
that
altered
composition
gut
microbiota,
specifically
for
Bacteroides
associated
short-chain
fatty
acids
(SCFAs).
In-depth
analysis
SCFAs
demonstrated
restore
acetic
acid,
propionic
valeric
isovaleric
acid
levels
mice.
Correlation
revealed
changed
microbiota
were
significantly
inflammation
biomarkers.
This
study
osteoporosis
by
reshaping
increasing
SCFAs,
decreasing
pro-inflammatory
cytokines
differentiation-related
factors
These
findings
provide
evidence
use
as
a
food
supplement
osteoporosis.
Annals of Nutrition and Metabolism,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Янв. 23, 2025
Knowledge
of
the
complex
interplay
between
gut
microbiota
and
human
health
is
gradually
increasing
as
it
has
just
recently
been
a
field
such
great
interest.
Recent
studies
have
reported
that
communities
microorganisms
inhabiting
influence
immune
system
through
cellular
responses
shape
many
physiological
pathophysiological
aspects
body,
including
muscle
bone
metabolism
(formation
resorption).
Specifically,
affects
skeletal
homeostasis
changes
in
host
metabolism,
system,
hormone
secretion,
gut-brain
axis.
The
major
role
on
gut-bone
axis
due
to
short-chain
fatty
acids
(SCFAs).
They
ability
regulatory
T-cell
(Tregs)
development
activate
action
Wnt10.
SCFA
production
may
be
mechanism
by
which
microbial
community,
serum
level
insulin-like
growth
factor
1
(IGF-1),
leads
regulation
homeostasis.
A
specific
SCFA,
butyrate,
diffuses
into
marrow
where
expands
Tregs.
Tregs
induce
Wnt
ligand
Wnt10b
CD8+
T
cells,
leading
activation
signaling
stimulation
formation.
At
hormonal
level,
effect
expressed
biphasic
serotonin.
Some
microbiota,
spore-forming
microbes,
regulate
serotonin
gut,
serum,
feces.
Another
group
bacterial
species
(Lactococcus,
Mucispirillum,
Lactobacillus,
Bifidobacterium)
can
increase
peripheral/vascular
leptin,
turn
manages
brain
Heliyon,
Год журнала:
2024,
Номер
10(7), С. e28435 - e28435
Опубликована: Март 21, 2024
The
intricate
interplay
between
the
gut
microbiota
and
bone
health
has
become
increasingly
recognized
as
a
fundamental
determinant
of
skeletal
well-being.
Microbiota-derived
metabolites
play
crucial
role
in
dynamic
interaction,
specifically
homeostasis.
In
this
sense,
short-chain
fatty
acids
(SCFAs),
including
acetate,
propionate,
butyrate,
indirectly
promote
formation
by
regulating
insulin-like
growth
factor-1
(IGF-1).
Trimethylamine
N-oxide
(TMAO)
been
found
to
increase
expression
osteoblast
genes,
such
Runt-related
transcription
factor
2
(RUNX2)
morphogenetic
protein-2
(BMP2),
thus
enhancing
osteogenic
differentiation
quality
through
BMP/SMADs
Wnt
signaling
pathways.
Remarkably,
context
infections,
immune
modulation
host
defense
mechanisms
potentially
affects
susceptibility
infections
osteomyelitis.
Furthermore,
ongoing
research
elucidates
precise
which
microbiota-derived
influence
cells,
osteoblasts
osteoclasts.
Understanding
multifaceted
on
bone,
from
homeostasis
modulating
potential
revolutionize
our
approach
disease
management.
This
review
offers
comprehensive
exploration
evolving
field,
providing
holistic
perspective
impact
diseases.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2024,
Номер
23(4)
Опубликована: Июнь 7, 2024
Abstract
Dairy
is
recognized
as
a
good
source
of
calcium,
which
important
for
preventing
osteoporosis.
However,
the
relationship
between
milk
and
bone
health
more
complex
than
just
calcium
supplementation.
It
unwise
to
focus
solely
on
observing
effects
single
nutrient.
Lactose,
proteins,
vitamins
in
milk,
well
fatty
acids,
oligosaccharides,
exosomes,
all
work
together
with
enhance
its
bioavailability
utilization
efficiency
through
various
mechanisms.
We
evaluate
roles
dairy
nutrients
active
ingredients
maintaining
homeostasis
from
perspective
matrix
effects.
Special
attention
given
threshold
effects,
synergistic
associations
gut–bone
axis.
also
summarize
probiotic/prebiotic
low‐fat/high‐fat
lactose‐free
fortified
reduced
risk
osteoporosis
discuss
potential
benefits
controversies
these
products.
Moreover,
we
examine
role
products
increasing
peak
mass
during
adolescence
reducing
loss
old
age.
provides
theoretical
reference
use
accurate
prevention
management
related
chronic
diseases
offers
personalized
dietary
recommendations
different
populations.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 15, 2024
Objective
Osteoporosis,
characterized
by
reduced
bone
density
and
heightened
fracture
risk,
is
influenced
genetic
environmental
factors.
This
study
investigates
the
interplay
between
gut
microbiota,
plasma
metabolomics,
osteoporosis,
identifying
potential
causal
relationships
mediated
metabolites.
Methods
Utilizing
aggregated
genome-wide
association
studies
(GWAS)
data,
a
comprehensive
two-sample
Mendelian
Randomization
(MR)
analysis
was
performed
involving
196
microbiota
taxa,
1,400
metabolites,
osteoporosis
indicators.
Causal
were
explored.
Results
The
MR
analyses
revealed
ten
taxa
associated
with
five
positively
linked
to
increased
risk
negatively
associated.
Additionally,
96
metabolites
exhibited
49
showing
positive
associations
47
displaying
negative
associations.
Mediation
identified
six
pathways
connecting
through
mediating
seven
distinct
two
of
which
demonstrated
suppression
effects.
Conclusion
provides
suggestive
evidence
correlations
links
osteoporosis.
findings
underscore
complex,
multifactorial
nature
suggest
metabolite
profiles
as
biomarkers
or
therapeutic
targets
in
management
Zeitschrift für Naturforschung C,
Год журнала:
2024,
Номер
79(11-12), С. 405 - 411
Опубликована: Июль 5, 2024
Abstract
Osteoporosis
(OP)
is
a
systemic
skeletal
disease
that
characterized
by
low
bone
mass
and
increased
fracture
risk.
This
article
explores
the
potential
of
probiotics
as
an
adjunctive
approach
for
prevention
management
OP.
It
has
been
well
established
gut
microbiota
(GM),
complex
community
microbes,
plays
important
role
in
health.
The
dysbiosis
linked
with
higher
risk
However,
consumption
adequate
amounts
restores
health
thus
improving
Probiotics
may
influence
metabolism
through
enhanced
calcium
absorption,
reduced
inflammation,
formation.
animal
human
studies
demonstrate
positive
effects
on
parameters
like
osteoclastogenesis,
resorption
markers,
osteoblast,
osteocyte
apoptosis,
mineral
density
expression
osteoprotegerin.
current
evidence
suggests
can
be
used
along
existing
therapies
