The Impact of Tannic Acid Consumption on Bone Mineralization DOI Creative Commons

Anna Winiarska‐Mieczan,

Siemowit Muszyński, Ewa Tomaszewska

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1072 - 1072

Published: Oct. 12, 2023

Tannic acid (TA) is an organic compound belonging to the tannin group. Like other tannins, it has affinity for endogenous proteins, including digestive enzymes, which can result in reduced digestibility and absorption of nutrients. It also form complexes with mineral components, reducing their absorption. In some cases, this be beneficial, such as case toxic metals, but sometimes may have a detrimental effect on body when involves essential components like Ca, P, Mg, Na, K, or Fe. Therefore, impact TA bone health should considered from both perspectives. This relatively short review summarizes available information research findings TA, particular focus its potential health. worth noting that future clinical studies provide more detailed precise topic, allowing better understanding role maintaining integrity musculoskeletal system. Despite brevity, paper represents valuable contribution analysis benefits challenges associated context We anticipate will continue along important line, expanding our knowledge influence skeletal system therapeutic applications.

Language: Английский

Unraveling the Puzzle: Health Benefits of Probiotics—A Comprehensive Review DOI Open Access

Sabiha Gul,

Emanuele Durante‐Mangoni

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1436 - 1436

Published: March 1, 2024

A growing number of probiotic-containing products are on the market, and their use is increasing. Probiotics thought to support health gut microbiota, which in turn might prevent or delay onset gastrointestinal tract disorders. Obesity, type 2 diabetes, autism, osteoporosis, some immunological illnesses among conditions that have been shown possibly benefit from probiotics. In addition ability favorably affect diseases, probiotics represent a defense system enhancing intestinal, nutritional, oral health. Depending microbial strain utilized, can variable beneficial properties. Although many species available, most widely employed ones lactic acid bacteria bifidobacteria. The usefulness these dependent both origin capacity promote valuable clinical tool supporting health, immune function, metabolic balance. When used appropriately, may provide benefits such as reduced risk disorders, enhanced immunity, improved Most popular probiotics, advantages, mode action topic this narrative review article, aimed reader with comprehensive reappraisal matter.

Language: Английский

Citations

23
Oral Milk-Derived Extracellular Vesicles Inhibit Osteoclastogenesis and Ameliorate Bone Loss in Ovariectomized Mice by Improving Gut Microbiota DOI

Haining Hao,

Qiqi Liu, Ting Zheng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(9), P. 4726 - 4736

Published: Jan. 31, 2024

Milk-derived extracellular vesicles can improve intestinal health and have antiosteoporosis potential. In this paper, we explored the effects of bovine raw milk-derived (mEVs) on ovariectomized (OVX) osteoporotic mice from perspective gut-bone axis. mEVs could inhibit osteoclast differentiation microarchitecture. The level biomarkers in OVX was restored after intervened. Compared with mice, enhance permeability, reduce endotoxin levels, expression TNF-α, IL-17, IL-10. 16S rDNA sequencing indicated that altered composition gut microbiota, specifically for Bacteroides associated short-chain fatty acids (SCFAs). In-depth analysis SCFAs demonstrated restore acetic acid, propionic valeric isovaleric acid levels mice. Correlation revealed changed microbiota were significantly inflammation biomarkers. This study osteoporosis by reshaping increasing SCFAs, decreasing pro-inflammatory cytokines differentiation-related factors These findings provide evidence use as a food supplement osteoporosis.

Language: Английский

Citations

17
Gut Microbiota-Bone Axis DOI Creative Commons
Flavia Indrio,

Alessia Salatto

Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 23, 2025

Knowledge of the complex interplay between gut microbiota and human health is gradually increasing as it has just recently been a field such great interest. Recent studies have reported that communities microorganisms inhabiting influence immune system through cellular responses shape many physiological pathophysiological aspects body, including muscle bone metabolism (formation resorption). Specifically, affects skeletal homeostasis changes in host metabolism, system, hormone secretion, gut-brain axis. The major role on gut-bone axis due to short-chain fatty acids (SCFAs). They ability regulatory T-cell (Tregs) development activate action Wnt10. SCFA production may be mechanism by which microbial community, serum level insulin-like growth factor 1 (IGF-1), leads regulation homeostasis. A specific SCFA, butyrate, diffuses into marrow where expands Tregs. Tregs induce Wnt ligand Wnt10b CD8+ T cells, leading activation signaling stimulation formation. At hormonal level, effect expressed biphasic serotonin. Some microbiota, spore-forming microbes, regulate serotonin gut, serum, feces. Another group bacterial species (Lactococcus, Mucispirillum, Lactobacillus, Bifidobacterium) can increase peripheral/vascular leptin, turn manages brain

Language: Английский

Citations

2
Microbiota metabolites in bone: Shaping health and Confronting disease DOI Creative Commons

Dong Han,

Weijiao Wang,

Jinpeng Gong

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28435 - e28435

Published: March 21, 2024

The intricate interplay between the gut microbiota and bone health has become increasingly recognized as a fundamental determinant of skeletal well-being. Microbiota-derived metabolites play crucial role in dynamic interaction, specifically homeostasis. In this sense, short-chain fatty acids (SCFAs), including acetate, propionate, butyrate, indirectly promote formation by regulating insulin-like growth factor-1 (IGF-1). Trimethylamine N-oxide (TMAO) been found to increase expression osteoblast genes, such Runt-related transcription factor 2 (RUNX2) morphogenetic protein-2 (BMP2), thus enhancing osteogenic differentiation quality through BMP/SMADs Wnt signaling pathways. Remarkably, context infections, immune modulation host defense mechanisms potentially affects susceptibility infections osteomyelitis. Furthermore, ongoing research elucidates precise which microbiota-derived influence cells, osteoblasts osteoclasts. Understanding multifaceted on bone, from homeostasis modulating potential revolutionize our approach disease management. This review offers comprehensive exploration evolving field, providing holistic perspective impact diseases.

Language: Английский

Citations

9
New insights into dairy management and the prevention and treatment of osteoporosis: The shift from single nutrient to dairy matrix effects—A review DOI
Kaili Wang,

Xu Zhao,

Sijia Yang

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(4)

Published: June 7, 2024

Abstract Dairy is recognized as a good source of calcium, which important for preventing osteoporosis. However, the relationship between milk and bone health more complex than just calcium supplementation. It unwise to focus solely on observing effects single nutrient. Lactose, proteins, vitamins in milk, well fatty acids, oligosaccharides, exosomes, all work together with enhance its bioavailability utilization efficiency through various mechanisms. We evaluate roles dairy nutrients active ingredients maintaining homeostasis from perspective matrix effects. Special attention given threshold effects, synergistic associations gut–bone axis. also summarize probiotic/prebiotic low‐fat/high‐fat lactose‐free fortified reduced risk osteoporosis discuss potential benefits controversies these products. Moreover, we examine role products increasing peak mass during adolescence reducing loss old age. provides theoretical reference use accurate prevention management related chronic diseases offers personalized dietary recommendations different populations.

Language: Английский

Citations

5
AMP1-1 alleviates bone loss in weightless rats by reducing peripheral 5-HT content via the microbiota-gut-bone axis DOI
Fan Yang,

Qiuxin Yan,

Yunhao Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156447 - 156447

Published: Jan. 1, 2025

Language: Английский

Citations

0
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health DOI
Lei Chen,

Songyi Lin,

Xueqing He

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141634 - 141634

Published: March 2, 2025

Language: Английский

Citations

0
Cross-talks between osteoporosis and gut microbiome DOI
Shiva Shankar Jha, Naveen Jeyaraman,

Madhan Jeyaraman

et al.

World Journal of Orthopedics, Journal Year: 2025, Volume and Issue: 16(3)

Published: March 12, 2025

Language: Английский

Citations

0
Gut microbiota, plasma metabolites, and osteoporosis: unraveling links via Mendelian randomization DOI Creative Commons

Yi Lu,

Xiaobing Cai,

Shi Bao-hua

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Objective Osteoporosis, characterized by reduced bone density and heightened fracture risk, is influenced genetic environmental factors. This study investigates the interplay between gut microbiota, plasma metabolomics, osteoporosis, identifying potential causal relationships mediated metabolites. Methods Utilizing aggregated genome-wide association studies (GWAS) data, a comprehensive two-sample Mendelian Randomization (MR) analysis was performed involving 196 microbiota taxa, 1,400 metabolites, osteoporosis indicators. Causal were explored. Results The MR analyses revealed ten taxa associated with five positively linked to increased risk negatively associated. Additionally, 96 metabolites exhibited 49 showing positive associations 47 displaying negative associations. Mediation identified six pathways connecting through mediating seven distinct two of which demonstrated suppression effects. Conclusion provides suggestive evidence correlations links osteoporosis. findings underscore complex, multifactorial nature suggest metabolite profiles as biomarkers or therapeutic targets in management

Language: Английский

Citations

2
Probiotics: a promising intervention for osteoporosis prevention and management DOI
Lakshay Panchal,

Shivam Arora,

Jhilam Pramanik

et al.

Zeitschrift für Naturforschung C, Journal Year: 2024, Volume and Issue: 79(11-12), P. 405 - 411

Published: July 5, 2024

Abstract Osteoporosis (OP) is a systemic skeletal disease that characterized by low bone mass and increased fracture risk. This article explores the potential of probiotics as an adjunctive approach for prevention management OP. It has been well established gut microbiota (GM), complex community microbes, plays important role in health. The dysbiosis linked with higher risk However, consumption adequate amounts restores health thus improving Probiotics may influence metabolism through enhanced calcium absorption, reduced inflammation, formation. animal human studies demonstrate positive effects on parameters like osteoclastogenesis, resorption markers, osteoblast, osteocyte apoptosis, mineral density expression osteoprotegerin. current evidence suggests can be used along existing therapies

Language: Английский

Citations

2