Role of SLC7A11/xCT in Ovarian Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(1), С. 587 - 587

Опубликована: Янв. 2, 2024

Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage disease as well recurrence occurrence chemotherapy resistance. In fact, chemoresistance weakens therapeutic effects, worsening outcome this pathology. Solute Carrier Family 7 Member 11 (SLC7A11, also known xCT) functional subunit Xc− system, anionic L-cystine/L-glutamate antiporter expressed on cell surface. SLC7A11 expression significantly upregulated in several types which it can inhibit ferroptosis favor proliferation, invasion chemoresistance. increased ovarian tissues, suggesting possible role protein target. review, we provide overview current literature regarding new insights modulation evaluate potential

Язык: Английский

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Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116432 - 116432

Опубликована: Март 22, 2024

Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing crucial role the early and sustained phases of DNA damage genomic epigenetic instability, both which are intricately linked to development tumors. The molecular pathways contributing carcinogenesis this context, particularly those related double-strand single-strand breaks DNA, serve as indicators due cancer cases, well factors instability through ectopic expressions. has been considered therapeutic target for many years, an increasing number studies have highlighted promising effectiveness natural products treatment. In regard, we present significant research on targeting oxidative using molecules underscore essential cancer. consequences stress, especially also offer prospects. use epi-drugs capable modulating reorganizing network is beginning emerge remarkably. review, emphasize close connections between tumor transformation, while highlighting substances antioxidants anti-tumoral context.

Язык: Английский

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Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis

Antioxidants, Год журнала: 2024, Номер 13(10), С. 1270 - 1270

Опубликована: Окт. 18, 2024

Periodontitis affects up to 40% of adults over 60 years old and is a consequence gingivitis. characterized by chronic inflammation, periodontal damage, alveolar bone resorption. The nuclear factor erythroid 2-related 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays key role in periodontitis modulating redox balance inflammation the periodontium. However, NRF2 expression decreased gingival tissues patients with while oxidative stress significantly increased this pathology. Oxidative lipopolysaccharide (LPS) produced gram-negative bacteria favor production inflammatory causing favoring bone. In review, we analyzed current literature regarding natural synthetic compounds NRF2/KEAP1 vitro vivo models order evaluate new potential treatments that can improve outcome disease.

Язык: Английский

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The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update

Cells, Год журнала: 2024, Номер 13(17), С. 1469 - 1469

Опубликована: Сен. 1, 2024

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known be longevity regulators, and exerts a key role in prevention of vascular aging. By aging, expression levels Sirt1 decline with severe impact on function, such as rise endothelial dysfunction, which turn promotes development cardiovascular diseases. In this context, activity preventing senescence is particularly important. Given counteracting senescence, great efforts have been made deepen knowledge about intricate cross-talks interactions other molecules, order set up possible strategies boost prevent or treat The aim review provide proper background regulation function endothelium discuss recent advances regarding therapeutic targeting counteract

Язык: Английский

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Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116802 - 116802

Опубликована: Май 24, 2024

Oxidative stress plays a key role in chronic kidney disease (CKD) development and progression, inducing cell damage, inflammation, fibrosis. However, effective therapeutic interventions to slow down CKD advancement are currently lacking. The multifaceted pharmacological effects of molecular hydrogen (H2) have made it promising avenue. H2 is capable capturing harmful •OH ONOO- while maintaining the crucial reactive oxygen species (ROS) involved cellular signaling. NRF2-KEAP1 system, which manages redox balance, could be used treat CKD. activates this pathway, fortifying antioxidant defenses scavenging ROS counteract oxidative stress. can improve NRF2 signaling by using Wnt/β-catenin pathway indirectly activate mitochondria. Additionally, modulates NF-κB activity regulating status, inhibiting MAPK pathways, Trx levels. Treatment with also attenuates HIF neutralizing bolstering HIF-1α function. Furthermore, affects FOXO factors enhances enzymes. Despite encouraging results bench studies, clinical trials still limited require further investigation. focus review on hydrogen's treating renal diseases, specific regulation, discusses its potential applications.

Язык: Английский

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The Cancer Antioxidant Regulation System in Therapeutic Resistance

Antioxidants, Год журнала: 2024, Номер 13(7), С. 778 - 778

Опубликована: Июнь 27, 2024

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cells adeptly maintain elevated levels both ROS and antioxidants through process termed "redox reprogramming". This balance optimizes proliferative influence while simultaneously reducing potential for cause damage cell. some cases, adapted antioxidant machinery can hamper efficacy treatments neoplastic diseases, representing significant facet resistance mechanisms observed therapy. this review, we outline contribution systems therapeutic resistance. We detail fundamental constituents these systems, encompassing central regulatory involving transcription factors (of particular importance is KEAP1/NRF2 signaling axis), molecular effectors antioxidants, auxiliary responsible NADPH generation. Furthermore, present recent clinical trials based on targeted treatment cancer, assessing as well challenges strategy Additionally, summarize pressing issues field, with aim illuminating path toward emergence novel anticancer approaches by orchestrating redox signaling.

Язык: Английский

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NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway

Theranostics, Год журнала: 2024, Номер 14(2), С. 681 - 698

Опубликована: Янв. 1, 2024

Radiation resistance is the main limitation of application radiotherapy. Ionizing radiation (IR) kills cancer cells mainly by causing DNA damage, particularly double-strand breaks (DSBs). Radioresistant have developed robust capability damage repair to survive IR. Nuclear factor erythroid 2-related 2 (NRF2) has been correlated with resistance. We previously reported a novel function NRF2 as an ATR activator in response DSBs. However, little known about mechanism that how regulates and

Язык: Английский

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EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2024, Номер 1871(3), С. 119659 - 119659

Опубликована: Янв. 11, 2024

Язык: Английский

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Unraveling the Role of Reactive Oxygen Species in T Lymphocyte Signaling

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6114 - 6114

Опубликована: Июнь 1, 2024

Reactive oxygen species (ROS) are central to inter- and intracellular signaling. Their localized transient effects due their short half-life, especially when generated in controlled amounts. Upon T cell receptor (TCR) activation, regulated ROS signaling is primarily initiated by complexes I III of the electron transport chain (ETC). Subsequent production triggers activation nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH 2), prolonging oxidative signal. This signal then engages kinase cascades such as mitogen-activated protein (MAPK) pathway increases activity REDOX-sensitive transcription factors nuclear factor-kappa B (NF-κB) activator protein-1 (AP-1). To limit overproduction prevent stress, factor erythroid 2-related (Nrf2) antioxidant proteins superoxide dismutases (SODs) finely regulate intensity capable terminating needed. Thus, signals, well-controlled critical for cellular communication.

Язык: Английский

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Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response—Toward an Actionable Strategy for Anti-Aging

Biomolecules, Год журнала: 2023, Номер 13(10), С. 1544 - 1544

Опубликована: Окт. 19, 2023

Reactive oxygen species (ROS) are produced mainly by mitochondrial respiration and function as signaling molecules in the physiological range. However, ROS production is also associated with pathogenesis of various diseases, including insulin resistance (IR) type 2 diabetes (T2D). This review focuses on etiology IR early events, especially (mtROS) insulin-sensitive tissues. Importantly, and/or defective adipogenesis white adipose tissues (WAT) thought to increase free fatty acid ectopic lipid deposition develop into systemic IR. Fatty ceramide accumulation mediate coenzyme Q reduction mtROS skeletal muscle, while synthesis downregulation involved WAT. Obesity-related catabolism branched-chain amino acids (BCAAs) WAT, BCAA its metabolites biomarkers blood could reliably indicate future T2D. Transcription factor NF-E2-related (Nrf2), which regulates antioxidant enzyme expression response oxidative stress, downregulated insulin-resistant Nrf2 inducers, such sulforaphane, restore target gene attenuate multiple tissues,

Язык: Английский

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