Mechanisms of Ageing and Development, Год журнала: 2020, Номер 189, С. 111259 - 111259
Опубликована: Май 23, 2020
Язык: Английский
SAGE Open Medicine, Год журнала: 2021, Номер 9
Опубликована: Янв. 1, 2021
Cancer is a global health problem responsible for one in six deaths worldwide. Treating cancer has been highly complex process. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have use, while significant advances are being made recent times, including stem cell therapy, targeted ablation nanoparticles, natural antioxidants, radionics, chemodynamic sonodynamic ferroptosis-based therapy. Current methods oncology focus on the development of safe efficient nanomedicines. Stem therapy brought promising efficacy regenerating repairing diseased or damaged tissues by targeting both primary metastatic foci, nanoparticles new diagnostic therapeutic options. Targeted possessed breakthrough potential inhibiting growth spread specific cells, causing less damage to healthy cells. Ablation emerged minimally invasive procedure that burns freezes cancers without need open surgery. Natural antioxidants demonstrated tracking down free radicals neutralizing their harmful effects thereby treating preventing cancer. Several technologies currently under research clinical trials, some them already approved. This review presented an update breakthroughs therapies.
Язык: Английский
Процитировано
945
Nanomaterials, Год журнала: 2022, Номер 12(3), С. 457 - 457
Опубликована: Янв. 28, 2022
In the last few decades, vast potential of nanomaterials for biomedical and healthcare applications has been extensively investigated. Several case studies demonstrated that can offer solutions to current challenges raw materials in fields. This review describes different nanoparticles nanostructured material synthesis approaches presents some emerging biomedical, healthcare, agro-food applications. focuses on various nanomaterial types (e.g., spherical, nanorods, nanotubes, nanosheets, nanofibers, core-shell, mesoporous) be synthesized from their bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, agro-foods. Depending morphology size, aspect ratio, geometry, porosity), used as formulation modifiers, moisturizers, nanofillers, additives, membranes, films. As toxicological assessment depends sizes morphologies, stringent regulation is needed testing efficient dosages. The perspectives an industrial breakthrough are related optimization production processing conditions.
Язык: Английский
Процитировано
376
Antioxidants, Год журнала: 2021, Номер 10(2), С. 201 - 201
Опубликована: Янв. 30, 2021
Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of many diseases. The imbalance between production reactive oxygen species (ROS) antioxidant systems has been extensively studied pulmonary, neurodegenerative cardiovascular disorders; however, its contribution is still debated gastrointestinal disorders. Evidence suggests affects motility obesity, post-infectious disorders by favoring smooth muscle phenotypic switch toward a synthetic phenotype. aim this review to gain insight into played pathologies (GIT), involvement ROS signaling underlying muscular alterations tract (GIT). In addition, potential therapeutic strategies based on use antioxidants for treatment inflammatory diseases are reviewed discussed. Although substantial progress made identifying new techniques capable assessing presence humans, biochemical-molecular mechanisms GIT mucosal not yet well defined. Therefore, further studies needed clarify through which stress-related can contribute alteration mucosa order devise effective preventive curative strategies.
Язык: Английский
Процитировано
293
Antioxidants, Год журнала: 2023, Номер 12(3), С. 651 - 651
Опубликована: Март 6, 2023
Aging is a complex biological process accompanied by progressive decline in the physical function of organism and an increased risk age-related chronic diseases such as cardiovascular diseases, cancer, neurodegenerative diseases. Studies have established that there exist nine hallmarks aging process, including (i) telomere shortening, (ii) genomic instability, (iii) epigenetic modifications, (iv) mitochondrial dysfunction, (v) loss proteostasis, (vi) dysregulated nutrient sensing, (vii) stem cell exhaustion, (viii) cellular senescence, (ix) altered communication. All these alterations been linked to sustained systemic inflammation, mechanisms contribute timing not clearly determined yet. Nevertheless, dysfunction one most important contributing process. Mitochondria primary endogenous source reactive oxygen species (ROS). During ATP production elevated ROS together with antioxidant defense. Elevated levels can cause oxidative stress severe damage cell, organelle membranes, DNA, lipids, proteins. This contributes phenotype. In this review, we summarize recent advances emphasis on production.
Язык: Английский
Процитировано
199
Marine Drugs, Год журнала: 2022, Номер 20(1), С. 61 - 61
Опубликована: Янв. 10, 2022
Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these has become increasingly prevalent. used as a biomaterial because it is water soluble, metabolically compatible, highly accessible. Upon review literature, evident marine versatile compound capable healing skin injuries varying severity, well delaying natural human aging process. From vitro to vivo experiments, demonstrated its ability invoke keratinocyte fibroblast migration vascularization skin. Additionally, derivatives have proven beneficial useful for both osteoporosis osteoarthritis prevention treatment. Other bone-related diseases may also targeted by collagen, increasing bone mineral density, deposition, importantly, osteoblast maturation proliferation. In this review, we demonstrate advantages over land animal sources biomedical related damage. Finally, some limitations are briefly discussed.
Язык: Английский
Процитировано
140
Biomolecules, Год журнала: 2022, Номер 12(3), С. 371 - 371
Опубликована: Фев. 25, 2022
Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology these disorders is not well known; however, environmental, molecular, genetic influences play a major role in pathogenesis Using disease (AD) as archetype, pathological findings include aggregation Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), cerebrovascular dysregulation. This review highlights neuroinflammatory neuroprotective epigallocatechin-3-gallate (EGCG): medicinal component green tea, known nutraceutical that has shown promise modulating AD progression due to its antioxidant, anti-inflammatory, anti-aging abilities. report also re-examines current literature provides innovative approaches for EGCG be used preventive measure alleviate other disorders.
Язык: Английский
Процитировано
106
Environmental Research, Год журнала: 2023, Номер 235, С. 116585 - 116585
Опубликована: Июль 10, 2023
Язык: Английский
Процитировано
81
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 4027 - 4027
Опубликована: Апрель 5, 2022
Resveratrol is a polyphenol that has been shown to possess many applications in different fields of medicine. This systematic review drawn attention the axis between resveratrol and human microbiota, which plays key role maintaining an adequate immune response can lead diseases when compromised. also be asset new technologies, such as gene therapy. PubMed, Cochrane Library, Scopus, Web Science, Google Scholar were searched find papers matched our topic dating from 1 January 2017 up 18 2022, with English-language restriction using following Boolean keywords: (“resveratrol” AND “microbio*”). Eighteen studies included relevant matching purpose investigation. Immune response, prevention thrombotic complications, therapy, bone regeneration retrieved main topics. The analyzed mostly involved supplementation its effects on microbiota by trials vitro, vivo, ex vivo. beneficial activity evident analyzing changes host’s genetic expression gastrointestinal microbial community administration. possibility identifying individual families may allow tailor therapeutic plans targeted polyphenolic diets associated dysbiosis, inflammatory tract, degenerative diseases, tumors, obesity, diabetes, tissue regeneration, metabolic syndrome.
Язык: Английский
Процитировано
71
Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151756 - 151756
Опубликована: Апрель 30, 2024
Язык: Английский
Процитировано
17
Scientific Reports, Год журнала: 2021, Номер 11(1)
Опубликована: Авг. 19, 2021
Abstract Flower based nanoparticles has gained a special attention as new sustainable eco-friendly avenue. Rosa floribunda charisma belongs to modern roses with bright yellow, red flowers marvellous rose scent. Different methods were used for the extraction of its floral scent such hexane, microwave, and solid-phase micro-extraction. The latter was most efficient method phenyl ethyl alcohol, unique roses. In current study, magnesium (RcNps) have been synthesized using petals that privileges beyond chemical physical routs. RcNps formation confirmed UV–Visible (UV–Vis) Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), High Resolution-Transmission Electron Microscope (HR-TEM), Field Emission-Scanning (FE-SEM), Energy dispersive X-ray (EDX), Diffractometer (XRD), photoelectron spectroscopy (XPS). HR-TEM images detected polyhedral shape diverse size ranged within 35.25–55.14 nm. resulting exhibited high radical scavenging activity illustrated by inhibition superoxide, nitric oxide, hydroxyl xanthine oxidase IC 50 values 26.2, 52.9, 31.9 15.9 µg/ml respectively compared ascorbic acid. Furthermore, at concentration 100 significantly reduced (15.9 ± 0.61 µg/ml) acid (12.80 0.32 p < 0.05. Moreover, showed an excellent antiaging demonstrated collagenase, elastase, hyaluronidase tyrosinase enzymes in dose-dependent manner 58.7 1.66 µg/ml, 82.5 2.93 191.4 5.68 158.6 5.20 EGCG respectively. also, promising antibacterial against three skin pathogens delineate significant threat public health, Staphylococcus epidermidis , Streptococcus pyogenes Pseudomonas aeruginosa MIC 15.63, 7.81, 31.25 ciprofloxacin (7.81, 3.9 15.63 µg/ml). suppressed biofilms minimum biofilm inhibitory concentrations 1.95, 7.81 fore mentioned strains, Overall, our findings indicate could be leading natural source care cosmetic industry.
Язык: Английский
Процитировано
92