Biomedicines,
Год журнала:
2023,
Номер
11(5), С. 1436 - 1436
Опубликована: Май 12, 2023
This
study
explores
the
therapeutic
efficacy
of
heparin-based
hydrogel
micropatches
containing
human
adipose-derived
stem
cells
(hASCs)
in
treating
neuropathic
pain
caused
by
nerve
damage.
Our
results
showed
that
hASCs
exhibited
neuroregenerative
and
pain-relieving
effects
when
used
with
animal
model.
The
use
this
combination
also
produced
enhanced
cell
viability
regeneration.
We
conducted
various
neurological
behavioral
tests,
dynamic
plantar
histological
examinations,
neuroelectrophysiological
examinations
to
confirm
effect.
findings
suggest
approach
could
maximize
improve
quality
life
for
patients
suffering
from
pain.
Abstract
Neural
stem
cells
(NSCs)
transplantation
is
an
attractive
and
promising
treatment
strategy
for
spinal
cord
injury
(SCI).
Various
pathological
processes
including
the
severe
inflammatory
cascade
difficulty
in
stable
proliferation
differentiation
of
NSCs
limit
its
application
translation.
Here,
a
novel
physico‐chemical
bifunctional
neural
delivery
system
containing
magnetic
nanoparticles
(MNPs
methylprednisolone
(MP)
designed
to
repair
SCI,
former
regulates
through
mechanical
stimulation
chronic
phase,
while
latter
alleviates
response
acute
phase.
The
releases
MP
promote
microglial
M2
polarization,
inhibit
M1
reduce
neuronal
apoptosis.
Meanwhile,
tend
differentiate
into
functional
neurons
with
generated
by
MNPs
static
field,
which
related
activation
PI3K/AKT/mTOR
pathway.
SCI
mice
achieve
better
recovery
after
receiving
via
system,
has
milder
inflammation,
higher
number
microglia,
more
neurons,
axonal
regeneration.
Together,
this
combined
physical
chemical
drug
therapy
demonstrated
be
effective,
provides
new
insights
clinical
transformation
repair.
Gels,
Год журнала:
2024,
Номер
10(3), С. 190 - 190
Опубликована: Март 9, 2024
The
repair
of
nervous
tissue
is
a
critical
research
field
in
engineering
because
the
degenerative
process
injured
system.
In
this
review,
we
summarize
progress
injectable
hydrogels
using
vitro
and
vivo
studies
for
regeneration
tissue.
Traditional
treatments
have
not
been
favorable
patients,
as
they
are
invasive
inefficient;
therefore,
promising
treatment
damaged
This
review
will
contribute
to
better
understanding
potential
scaffolds
drug
delivery
system
neural
applications.
Spinal
cord
injury
(SCI)
has
no
effective
treatment
modalities.
It
faces
a
significant
global
therapeutical
challenge,
given
its
features
of
poor
axon
regeneration,
progressive
local
inflammation,
and
inefficient
systemic
drug
delivery
due
to
the
blood-spinal
barrier
(BSCB).
To
address
these
challenges,
new
nano
complex
that
achieves
targeted
damaged
spinal
is
proposed,
which
contains
mesoporous
silica
nanoparticle
core
loaded
with
microRNA
cloaking
layer
human
umbilical
mesenchymal
stem
cell
membrane
modified
rabies
virus
glycoprotein
(RVG).
The
more
readily
crosses
BSCB
exosome-resembling
properties,
including
appropriate
size
low-immunogenic
disguise
accumulates
in
center
because
RVG,
where
it
releases
abundant
microRNAs
elicit
sprouting
rehabilitate
inflammatory
microenvironment.
Culturing
complexes
promotes
axonal
growth
neurons
M2
polarization
microglia.
Furthermore,
showed
SCI
mice
treated
this
by
tail
vein
injection
display
improvement
regrowth,
microenvironment
regulation,
functional
restoration.
efficacy
biocompatibility
demonstrate
their
immense
potential
as
noninvasive
for
SCI.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 7305 - 7333
Опубликована: Дек. 1, 2023
Abstract:
Spinal
cord
injury
(SCI)
treatment
represents
a
major
challenge
in
clinical
practice.
In
recent
years,
the
rapid
development
of
neural
tissue
engineering
technology
has
provided
new
therapeutic
approach
for
spinal
repair.
Implanting
functionalized
electroconductive
hydrogels
(ECH)
area
been
shown
to
promote
axonal
regeneration
and
facilitate
generation
neuronal
circuits
by
reshaping
microenvironment
SCI.
ECH
not
only
intercellular
electrical
signaling
but,
when
combined
with
stimulation,
enable
transmission
signals
electroactive
activate
bioelectric
pathways,
thereby
promoting
Therefore,
implantation
into
damaged
tissues
can
effectively
restore
physiological
functions
related
conduction.
This
article
focuses
on
dynamic
pathophysiological
changes
SCI
discusses
mechanisms
stimulation/signal
process
By
examining
activity
during
nerve
repair,
we
provide
insights
behind
stimulation
We
classify
conductive
biomaterials,
offer
an
overview
current
applications
research
progress
repair
regeneration,
aiming
reference
future
explorations
developments
strategies.
Keywords:
engineering,
signal,
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Май 16, 2023
Tissue
defects
can
be
accompanied
by
functional
impairments
that
affect
the
health
and
quality
of
life
patients.
Hydrogels
are
three-dimensional
(3D)
hydrophilic
polymer
networks
used
as
bionic
tissues
to
fill
or
repair
damaged
tissue
a
promising
therapeutic
strategy
in
field
engineering
regenerative
medicine.
This
paper
summarises
discusses
four
outstanding
advantages
hydrogels
their
applications
advances
regeneration
defects.
First,
have
physicochemical
properties
similar
extracellular
matrix
natural
tissues,
providing
good
microenvironment
for
cell
proliferation,
migration
differentiation.
Second,
excellent
shape
adaptation
adhesion
properties,
allowing
them
applied
wide
range
irregularly
shaped
adhere
well
defect
sustained
efficient
function.
Third,
hydrogel
is
an
intelligent
delivery
system
capable
releasing
agents
on
demand.
delivering
reagents
substances
with
temporal
spatial
precision
depending
site
state
defect.
Fourth,
self-healing
maintain
integrity
when
damaged.
We
then
describe
application
research
progress
bone,
cartilage,
skin,
muscle
nerve
tissues.
Finally,
we
discuss
challenges
faced
provide
outlook
future
trends.
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 643 - 643
Опубликована: Март 13, 2024
Traumatic
injury
to
the
brain
and
spinal
cord
(neurotrauma)
is
a
common
event
across
populations
often
causes
profound
irreversible
disability.
Pathophysiological
responses
trauma
exacerbate
damage
of
an
index
injury,
propagating
loss
function
that
central
nervous
system
(CNS)
cannot
repair
after
initial
resolved.
The
way
in
which
lost
consequence
complex
array
mechanisms
continue
chronic
phase
post-injury
prevent
effective
neural
repair.
This
review
summarises
events
traumatic
(TBI)
(SCI),
comprising
description
current
clinical
management
strategies,
summary
known
cellular
molecular
secondary
their
role
prevention
A
discussion
emerging
approaches
promote
neuroregeneration
CNS
presented.
barriers
promoting
neurotrauma
are
pathways
cell
types
occur
on
level.
presents
challenge
traditional
pharmacological
targeting
single
pathways.
It
suggested
novel
multiple
or
using
combinatorial
therapies
may
yield
sought-after
recovery
for
future
patients.
Biofabrication,
Год журнала:
2024,
Номер
16(3), С. 032003 - 032003
Опубликована: Апрель 3, 2024
Abstract
Regenerative
healing
of
spinal
cord
injury
(SCI)
poses
an
ongoing
medical
challenge
by
causing
persistent
neurological
impairment
and
a
significant
socioeconomic
burden.
The
complexity
tissue
presents
hurdles
to
successful
regeneration
following
injury,
due
the
difficulty
forming
biomimetic
structure
that
faithfully
replicates
native
using
conventional
engineering
scaffolds.
3D
bioprinting
is
rapidly
evolving
technology
with
unmatched
potential
create
biological
tissues
complicated
hierarchical
composition.
With
addition
additives
such
as
cells
biomolecules,
can
fabricate
preclinical
implants,
or
organ-like
constructs,
in
vitro
models
through
precise
control
over
deposition
biomaterials
other
building
blocks.
This
review
highlights
characteristics
advantages
for
scaffold
fabrication
enable
SCI
repair,
including
bottom–up
manufacturing,
mechanical
customization,
spatial
heterogeneity.
also
critically
discusses
impact
various
parameters
on
efficacy
repair
bioprinted
scaffolds,
choice
printing
method,
shape,
biomaterials,
supplements
growth
factors.
High-quality
studies
are
required
accelerate
translation
into
clinical
practice
repair.
Meanwhile,
technological
advances
will
continue
improve
regenerative
capability
incorporation
nanoscale
particles
development
4D
printing.
