Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3849 - 3849
Опубликована: Март 29, 2024
This
state-of-the-art
review
explores
the
emerging
field
of
regenerative
hydrogels
and
their
profound
impact
on
treatment
skin
wounds.
Regenerative
hydrogels,
composed
mainly
water-absorbing
polymers,
have
garnered
attention
in
wound
healing,
particularly
for
Their
unique
properties
make
them
well
suited
tissue
regeneration.
Notable
benefits
include
excellent
water
retention,
creating
a
crucially
moist
environment
optimal
facilitating
cell
migration,
proliferation.
Biocompatibility
is
key
feature,
minimizing
adverse
reactions
promoting
natural
healing
process.
Acting
as
supportive
scaffold
growth,
mimic
extracellular
matrix,
aiding
attachment
proliferation
cells
like
fibroblasts
keratinocytes.
Engineered
controlled
drug
release,
enhance
by
angiogenesis,
reducing
inflammation,
preventing
infection.
The
demonstrated
acceleration
process,
beneficial
chronic
or
impaired
wounds,
adds
to
appeal.
Easy
application
conformity
various
shapes
practical,
including
irregular
challenging
areas.
Scar
minimization
through
regeneration
crucial,
especially
cosmetic
functional
regions.
Hydrogels
contribute
pain
management
protective
barrier,
friction,
fostering
soothing
environment.
Some
with
inherent
antimicrobial
properties,
aid
infection
prevention,
which
crucial
aspect
successful
healing.
flexibility
ability
conform
contours
ensure
contact,
enhancing
overall
effectiveness.
In
summary,
present
promising
approach
improving
outcomes
across
diverse
clinical
scenarios.
provides
comprehensive
analysis
benefits,
mechanisms,
challenges
associated
use
this
review,
authors
likely
delve
into
rational
design
principles
efficacy
performance
Through
an
exploration
methodologies
approaches,
paper
poised
highlight
how
these
been
instrumental
refining
potentially
revolutionizing
therapeutic
potential
addressing
By
synthesizing
current
knowledge
highlighting
avenues
future
research,
aims
advancement
medicine
ultimately
improve
patients
Язык: Английский
Research progress of injectable hydrogels in the treatment of bone tissue diseases
Chemical Engineering Journal,
Год журнала:
2024,
Номер
498, С. 155139 - 155139
Опубликована: Авг. 24, 2024
Язык: Английский
Hydrogels for Neural Regeneration: Exploring New Horizons
Materials,
Год журнала:
2024,
Номер
17(14), С. 3472 - 3472
Опубликована: Июль 13, 2024
Nerve
injury
can
significantly
impair
motor,
sensory,
and
autonomic
functions.
Understanding
nerve
degeneration,
particularly
Wallerian
the
mechanisms
of
regeneration
is
crucial
for
developing
effective
treatments.
This
manuscript
reviews
use
advanced
hydrogels
that
have
been
researched
to
enhance
regeneration.
Hydrogels,
due
their
biocompatibility,
tunable
properties,
ability
create
a
supportive
microenvironment,
are
being
explored
effectiveness
in
repair.
Various
types
hydrogels,
such
as
chitosan-,
alginate-,
collagen-,
hyaluronic
acid-,
peptide-based
discussed
roles
promoting
axonal
growth,
functional
recovery,
myelination.
Advanced
formulations
incorporating
growth
factors,
bioactive
molecules,
stem
cells
show
significant
promise
overcoming
limitations
traditional
therapies.
Despite
these
advancements,
challenges
achieving
robust
reliable
remain,
necessitating
ongoing
research
optimize
hydrogel-based
interventions
neural
Язык: Английский
Hydrogel-Based Therapies for Ischemic and Hemorrhagic Stroke: A Comprehensive Review
Gels,
Год журнала:
2024,
Номер
10(7), С. 476 - 476
Опубликована: Июль 18, 2024
Stroke
remains
the
second
leading
cause
of
death
and
a
major
disability
worldwide,
significantly
impacting
individuals,
families,
healthcare
systems.
This
neurological
emergency
can
be
triggered
by
ischemic
events,
including
small
vessel
arteriolosclerosis,
cardioembolism,
large
artery
atherothromboembolism,
as
well
hemorrhagic
incidents
resulting
from
macrovascular
lesions,
venous
sinus
thrombosis,
or
vascular
malformations,
to
significant
neuronal
damage.
The
resultant
motor
impairment,
cognitive
dysfunction,
emotional
disturbances
underscore
urgent
need
for
effective
therapeutic
interventions.
Recent
advancements
in
biomaterials,
particularly
hydrogels,
offer
promising
new
avenues
stroke
management.
Hydrogels,
composed
three-dimensional
networks
hydrophilic
polymers,
are
notable
their
ability
absorb
retain
substantial
amounts
water.
Commonly
used
polymers
hydrogel
formulations
include
natural
like
alginate,
chitosan,
collagen,
synthetic
such
polyethylene
glycol
(PEG),
polyvinyl
alcohol
(PVA),
polyacrylamide.
Their
customizable
characteristics—such
porosity,
swelling
behavior,
mechanical
strength,
degradation
rates—make
hydrogels
ideal
biomedical
applications,
drug
delivery,
cell
tissue
engineering,
controlled
release
agents.
review
comprehensively
explores
hydrogel-based
approaches
both
therapy,
elucidating
mechanisms
which
provide
neuroprotection.
It
covers
application
delivery
systems,
role
reducing
inflammation
secondary
injury,
potential
support
neurogenesis
angiogenesis.
also
discusses
current
technology
challenges
translating
these
innovations
research
into
clinical
practice.
Additionally,
it
emphasizes
limited
number
trials
utilizing
therapies
addresses
associated
limitations
constraints,
underscoring
further
this
field.
Язык: Английский
Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps
Gels,
Год журнала:
2025,
Номер
11(1), С. 52 - 52
Опубликована: Янв. 9, 2025
Carpal
Tunnel
Syndrome
(CTS)
is
a
prevalent
neuropathic
disorder
caused
by
chronic
compression
of
the
median
nerve,
leading
to
sensory
and
motor
impairments.
Conventional
treatments,
such
as
corticosteroid
injections,
wrist
splinting,
surgical
decompression,
often
fail
provide
adequate
outcomes
for
or
recurrent
cases,
emphasizing
need
innovative
therapies.
Hydrogels,
highly
biocompatible
three-dimensional
biomaterials
with
customizable
properties,
hold
significant
potential
CTS
management.
Their
ability
mimic
extracellular
matrix
facilitates
localized
drug
delivery,
anti-adhesion
barrier
formation,
tissue
regeneration.
Advances
in
hydrogel
engineering
have
introduced
stimuli-responsive
systems
tailored
biomechanical
environment
carpal
tunnel,
enabling
sustained
therapeutic
release
improved
integration.
Despite
these
promising
developments,
applications
remain
underexplored.
Key
challenges
include
absence
CTS-specific
preclinical
models
rigorous
clinical
validation.
Addressing
gaps
could
unlock
full
hydrogel-based
interventions,
which
offer
minimally
invasive,
solutions
that
improve
long-term
reduce
recurrence
rates.
This
review
highlights
hydrogels
transformative
approach
therapy,
advocating
continued
research
address
translational
barriers.
These
innovations
redefine
treatment
landscape,
significantly
enhancing
patient
care
quality
life.
Язык: Английский
Nanomedicines for treatment of full-thickness wound
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 417 - 438
Опубликована: Янв. 1, 2025
Язык: Английский
Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Severe
spinal
cord
injuries
(SCI)
lead
to
loss
of
functional
activity
the
body
below
injury
site,
affect
a
person’s
ability
self-care
and
have
direct
impact
on
performance.
Due
structural
features
role
in
body,
consequences
SCI
cannot
be
completely
overcome
at
expense
endogenous
regenerative
potential
and,
developing
over
time,
severe
complications
years
after
injury.
Thus,
primary
task
this
type
treatment
is
create
artificial
conditions
for
growth
damaged
nerve
fibers
through
area
SCI.
Solving
problem
possible
using
tissue
neuroengineering
involving
technology
replacing
natural
environment
with
synthetic
matrices
(for
example,
hydrogels)
combination
stem
cells,
particular,
neural/progenitor
cells
(NSPCs).
This
approach
can
provide
maximum
stimulation
support
axons
neurons
their
myelination.
In
review,
we
consider
currently
available
options
improving
condition
(use
NSC
transplantation
or/and
replacement
matrix,
specifically
hydrogel).
We
emphasise
expediency
effectiveness
hydrogel
matrix
+
NSCs
complex
system
used
reconstruction
Since
such
(a
engineering
cell
therapy),
our
opinion,
allows
not
only
creation
supporting
regeneration
or
mechanical
cord,
but
also
strengthen
regeneration,
prevent
spread
inflammatory
process,
promote
restoration
lost
reflex,
motor
sensory
functions
injured
cord.
Язык: Английский
Physical chitosan hydrogels loaded with TiO2 nanoparticles/resveratrol hydroalcoholic extract: Hemocompatibility, swelling, microstructural, and EDX mapping analysis
Materials Letters,
Год журнала:
2024,
Номер
374, С. 137180 - 137180
Опубликована: Авг. 10, 2024
Язык: Английский
Marine biopolymers in drug delivery applications
Paulina Elizabeth Rodríguez-Jiménez,
Paulo Oropeza García de Quevedo,
Rogelio Rodríguez Rodríguez
и другие.
Elsevier eBooks,
Год журнала:
2024,
Номер
unknown, С. 639 - 676
Опубликована: Окт. 4, 2024
Язык: Английский
A Comprehensive Review on the Utilization of Biomaterials for Bio-Based Hydrogel in Therapeutic Applications
Deleted Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
A
bio-based
hydrogel
is
a
complex
compound
that
consists
of
natural
biomaterials
and
widely
applied
for
various
therapeutic
purposes.
The
modification
from
traditional
to
reformulated
hydrogels
has
gained
place
at
biomedical
field
due
the
growth
benefits
such
as
drug
delivery,
tissue
engineering,
regenerative
medicine.
Moreover,
increasing
global
demand
resulted
in
worldwide
shortage
mass
formulations
raised
environmental
awareness.
By
using
instead
synthetic
ones,
these
minimize
their
negative
effects
on
environment
while
simultaneously
maximizing
successful
execution
product.
However,
mechanisms
governing
degradation
bioactivity
hydrogels,
which
dictate
release
profiles,
stability,
effectiveness,
are
not
yet
comprehensively
understood.
Therefore,
by
analyzing
recent
progress
ongoing
challenges,
this
review
will
reveal
how
advanced
quietly
transforming
future
healthcare
offering
novel
solutions
pressing
health
problems.
Язык: Английский