Extracellular matrix promotes diabetic oral wound healing by modulating the microenvironment
Biomaterials Research,
Год журнала:
2025,
Номер
29
Опубликована: Янв. 1, 2025
Oral
wounds
in
diabetes
mellitus
(DM)
often
delay
healing
due
to
reduced
angiogenesis
and
increased
inflammatory
response
the
local
microenvironment,
even
leading
graft
necrosis
implant
failure.
Therefore,
developing
an
effective
program
promote
is
of
great
clinical
value.
Much
current
research
focused
on
promoting
wound
through
surface
adhesive
materials
that
exert
a
pro-angiogenic,
anti-inflammatory
effect.
However,
application
bonding
oral
cavity
very
limited
humid
friction-prone
environment.
Decellularized
extracellular
adipose
tissue
(DAT)
easily
accessible
biocompatible
material
derived
from
tissue.
To
further
explore
potential
DAT,
we
used
multi-omics
analyze
its
composition
possible
mechanisms.
Proteomic
studies
revealed
DAT
contains
anti-inflammatory,
pro-angiogenic
proteins
DM
regeneration.
adapt
moist
chewing
friction
environment
mouth,
modified
into
temperature-sensitive
hydrogel
can
be
injected
intramucosally.
has
been
verified
effects
macrophage
phenotypic
transformation.
Meanwhile,
transcriptome
analysis
suggested
inhibitory
effect
interleukin
17
signaling
pathway
might
key
factor
healing.
In
conclusion,
after
multi-omic
analysis,
good
adapted
specific
cavity.
This
provides
way
setting.
Язык: Английский
Advanced strategies in 3D bioprinting for vascular tissue engineering and disease modelling using smart bioinks
Joeng Ju Kim,
Dong‐Woo Cho
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Авг. 30, 2024
Advanced
three-dimensional
(3D)
bioprinting
technology
enables
the
precise
production
of
complex
vascular
structures
and
biomimetic
models,
driving
advancements
in
tissue
engineering
disease
mechanism
research.
At
core
this
is
smart
bioink,
which
suitable
for
fabricating
models
that
can
be
vascularised
to
meet
property
requirements
various
tissues.
Examples
bioinks
include
decellularized
extracellular
matrix
(dECM),
photocrosslinkable,
reversible,
microgel-based
biphasic
(MB)
bioinks,
whose
mechanical
properties
tuned
through
external
stimuli.
This
tuning
helps
generate
high-resolution
complex-shaped
networks
essential
cell
survival
functional
maturation.
review
explores
advanced
3D
strategies
using
spatially
controlled
perfusable
vitro
emphasising
reconstruction
within
bioprinted
models.
It
also
discusses
challenges
future
prospects,
suggesting
could
serve
as
alternatives
traditional
animal
modelling
drug
screening.
Язык: Английский
Exploiting the Potential of Decellularized Extracellular Matrix (ECM) in Tissue Engineering: A Review Study
Macromolecular Bioscience,
Год журнала:
2024,
Номер
25(1)
Опубликована: Окт. 16, 2024
Abstract
While
significant
progress
has
been
made
in
creating
polymeric
structures
for
tissue
engineering,
the
therapeutic
application
of
these
scaffolds
remains
challenging
owing
to
intricate
nature
replicating
conditions
native
organs
and
tissues.
The
use
human‐derived
biomaterials
purposes
closely
imitates
properties
natural
tissue,
thereby
assisting
regeneration.
Decellularized
extracellular
matrix
(dECM)
derived
from
tissues
have
become
popular
because
their
unique
biomimetic
properties.
These
dECM
can
enhance
body's
ability
heal
itself
or
be
used
generate
new
restoration,
expanding
beyond
traditional
transfers
transplants.
Enhanced
knowledge
how
ECM
scaffold
materials
affect
microenvironment
at
injury
site
is
expected
improve
clinical
outcomes.
In
this
review,
recent
advancements
are
explored
relevant
perspectives
offered,
highlighting
development
engineering
various
organs,
such
as
skin,
nerve,
bone,
heart,
liver,
lung,
kidney.
Язык: Английский
Current multi-scale biomaterials for tissue regeneration following spinal cord injury
Y Zhang,
Zhonghuan Wu,
Junfeng Wu
и другие.
Neurochemistry International,
Год журнала:
2024,
Номер
178, С. 105801 - 105801
Опубликована: Июль 5, 2024
Язык: Английский
Extracellular matrix hydrogels with fibroblast growth factor 2 containing exosomes for reconstructing skin microstructures
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 26, 2024
Abstract
Decellularized
extracellular
matrix
hydrogel
(ECM
hydrogel),
a
natural
material
derived
from
normal
tissue
with
unique
biocompatibility
properties,
is
widely
used
for
repair.
However,
there
are
still
problems
such
as
poor
biological
activity
and
insufficient
antimicrobial
property.
To
overcome
these
drawbacks,
fibroblast
growth
factor
2
(FGF
2)
containing
exosome
(exo
FGF
)
was
prepared
to
increase
the
activity.
Furthermore,
capacity
of
ECM
optimised
by
using
copper
ions
ligand-bonded
cross-linking
agent.
The
decellularized
hydrogel,
intricately
cross-linked
through
ligand
bonds
loaded
@ECM/Cu
2+
has
demonstrated
exceptional
properties.
In
vitro,
exo
effectively
promoted
cell
proliferation,
migration,
antioxidant
inhibited
bacterial
growth.
vivo,
wound
area
rat
treated
hydrogels
were
significantly
smaller
than
that
other
groups
at
Day
5
(45.24%
±
3.15%),
10
(92.20%
2.31%)
15
(95.22%
1.28%).
Histological
examination
showed
angiogenesis
collagen
deposition.
Overall,
this
potential
inhibit
promote
healing
in
variety
clinical
applications.
Язык: Английский
Engineered Liver-derived Decellularized Extracellular Matrix-based Three-Dimensional Tumor Constructs for Enhanced Drug Screening Efficiency
Shengchang Luo,
Qingqing Wang,
Miaoting Li
и другие.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
The
decellularized
extracellular
matrix
(dECM)
has
emerged
as
an
effective
medium
for
replicating
the
Язык: Английский
Multi‐Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk
Small Science,
Год журнала:
2024,
Номер
4(11)
Опубликована: Сен. 19, 2024
Various
systemic
metabolic
diseases
arise
from
prolonged
crosstalk
across
multiple
organs,
triggering
serious
impairments
in
various
physiological
systems.
These
are
intricate
pathologies
characterized
by
complex
mechanisms
and
an
unclear
etiology,
making
the
treatment
challenging.
Efforts
have
been
made
to
develop
vitro
models
understand
these
devise
new
treatments.
However,
there
limitations
reconstructing
causal
relationships
between
interorgan
crosstalk,
including
tissue-specific
microenvironment.
Alternatively,
multi-organ
microphysiological
systems
(MOMPS)
present
possibilities
for
capturing
complexity
of
replicating
human
microphysiology
simulating
diverse
crosstalk.
Controlled
interactions
scalable
representations
biological
MOMPS
offer
a
more
accurate
portrayal
organ
interactions,
enabling
identification
novel
metabolism,
immunity.
This,
turn,
can
yield
valuable
insights
into
disease
drug
development
research
enhance
efficiency
preclinical
studies.
In
this
review,
examples
technical
capabilities
pathological
modeling
discussed,
leveraging
state-of-the-art
biofabrication
technology
MOMPS.
It
evaluates
current
opportunities
challenges
field.
Язык: Английский
Decellularized extracellular matrix-based disease models for drug screening
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101280 - 101280
Опубликована: Сен. 28, 2024
Язык: Английский
Decellularized Extracellular Matrix Scaffolds: Recent Advances and Emerging Strategies in Bone Tissue Engineering
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Bone
tissue
engineering
(BTE)
is
a
complex
biological
process
involving
the
repair
of
bone
with
proper
neuronal
network
and
vasculature
as
well
surrounding
soft
tissue.
Synthetic
biomaterials
used
for
BTE
should
be
biocompatible,
support
regeneration,
eventually
degraded
in
situ
replaced
newly
generated
Recently,
various
forms
graft
materials
such
hydrogel,
nanofiber
scaffolds,
3D
printed
composite
scaffolds
have
been
developed
application.
Decellularized
extracellular
matrix
(DECM),
kind
natural
material
obtained
from
specific
tissues
organs,
has
certain
advantages
over
synthetic
exogenous
biomaterial-derived
grafts.
Moreover,
DECM
can
wide
range
sources
possesses
strong
molding
abilities,
structures,
bioactive
factors.
Although
shown
robust
osteogenic,
proangiogenic,
immunomodulatory,
defect
healing
potential,
rapid
degradation
limited
mechanical
properties
improved
bench-to-bed
translation
BTE.
This
review
summarizes
recent
advances
DECM-based
discusses
emerging
strategies
Язык: Английский