Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113765 - 113765
Опубликована: Дек. 1, 2024
Язык: Английский
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Авг. 3, 2024
Within the scope of this investigation, we carried out experiments to investigate potential Vision Transformer (ViT) in field medical image analysis. The diagnosis osteoporosis through inspection X-ray radio-images is a substantial classification problem that were able address with assistance models. In order provide basis for comparison, conducted parallel analysis which sought solve same by employing traditional convolutional neural networks (CNNs), are well-known and commonly used techniques solution categorization issues. findings our research led us conclude ViT capable achieving superior outcomes compared CNN. Furthermore, provided methods have access sufficient quantity training data, probability increases both arrive at more appropriate solutions critical
Язык: Английский
Процитировано
23
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Язык: Английский
Процитировано
12
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
7
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117357 - 117357
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
7
Critical Reviews in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 25
Опубликована: Сен. 17, 2024
This comprehensive review delves into the advancements and challenges in biosensing, with a strong emphasis on transformative potential of CRISPR technology for early rapid detection infectious diseases. It underscores versatility CRISPR/Cas systems, highlighting their ability to detect both nucleic acids non-nucleic acid targets, seamless integration isothermal amplification techniques. The provides thorough examination latest developments CRISPR-based biosensors, detailing unique properties such as high specificity programmability, which make them particularly effective detecting disease-associated acids. While focuses due its critical role diagnosing diseases, it also explores broader applications thereby acknowledging technology's potential. Additionally, identifies existing challenges, need improved signal real-world applicability, offers future perspectives aimed at overcoming these hurdles. ultimate goal is advance development highly sensitive specific biosensors that can be used widely improving human health, point-of-care settings resource-limited environments.
Язык: Английский
Процитировано
16
Deleted Journal, Год журнала: 2024, Номер 6(8)
Опубликована: Июль 29, 2024
Abstract Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs possess immunomodulatory regenerative capabilities. We discuss recent advances in NP-based delivery systems tailored AS treatment highlight MSCs’ roles modulating inflammation promoting vascular repair. Additionally, we examine synergistic effects combining enhanced outcomes. Furthermore, this paper provides insights into targeting endothelial cells, T-cells, macrophages, lipid levels, plaques using MSCs. It also reviews various types metal-based non-metallic utilized therapy. comprehensive overview underscores synergies between cardiovascular disease therapy, emphasizing need further research to fully realize their implications. Graphical
Язык: Английский
Процитировано
14
Biomedical Physics & Engineering Express, Год журнала: 2024, Номер 10(5), С. 052002 - 052002
Опубликована: Авг. 14, 2024
Abstract Purpose . This review aims to highlight current improvements in microfluidic devices designed for digestive cancer simulation. The emphasizes the use of multicellular 3D tissue engineering models understand complicated biology tumor microenvironment (TME) and progression. purpose is develop oncology research improve patients’ lives. Methods analyzes recent on mimicking cancer. It uses tissue-engineered devices, notably organs a chip (OOC), simulate human organ function lab. Cell cultivation modern three-dimensional hydrogel platforms allows precise geometry, biological components, physiological qualities. novel methodologies, key findings, technical progress explain this field’s advances. Results study discusses advances Micro systems with are emphasized. These capture complex biochemical gradients, niche variables, dynamic cell–cell interactions (TME). reveal stomach progression by duplicating TME. Recent discoveries technology have improved our understanding gut biology, as shown review. Conclusion Microfluidic play crucial role modeling furthering research. could transform drug development treatment revealing provides complete summary suggests future field professionals. review’s major goal further medical
Язык: Английский
Процитировано
14
Life Sciences, Год журнала: 2024, Номер unknown, С. 123120 - 123120
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
12
International Communications in Heat and Mass Transfer, Год журнала: 2025, Номер 164, С. 108895 - 108895
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
1
Nanotechnology, Год журнала: 2024, Номер 35(39), С. 392002 - 392002
Опубликована: Июнь 28, 2024
Tissue engineering is a multidisciplinary field that merges engineering, material science, and medical biology in order to develop biological alternatives for repairing, replacing, maintaining, or boosting the functionality of tissues organs. The ultimate goal tissue create enhancing However, current landscape techniques presents several challenges, including lack suitable biomaterials, inadequate cell proliferation, limited methodologies replicating desired physiological structures, unstable insufficient production growth factors, which are essential facilitating communication appropriate cellular responses. Despite these there has been significant progress made recent years. Nanoparticles hold major role within realm nanotechnology due their unique qualities change with size. These particles, provide potential solutions issues met have helped propel its state prominence. substantial breakthroughs utilization nanoparticles over past two decades, full range addressing difficulties remains largely untapped. This fact advancements occurred relatively isolated pockets. In purpose this research conduct an in-depth investigation ways various types might be put use. addition this, it sheds light on challenges need conquered unlock maximum area.
Язык: Английский
Процитировано
9