Cancers,
Год журнала:
2022,
Номер
14(2), С. 280 - 280
Опубликована: Янв. 7, 2022
Though
heterogeneity
of
cancers
is
recognized
and
has
been
much
discussed
in
recent
years,
the
concept
often
remains
overlooked
different
routine
examinations.
Indeed,
clinical
or
biological
articles,
reviews,
textbooks,
cancer
cells
are
generally
presented
as
evolving
distinct
entities
rather
than
an
independent
heterogeneous
cooperative
cell
population
with
its
self-oriented
biology.
There
are,
therefore,
conceptual
gaps
which
can
mislead
interpretations/diagnostic
therapeutic
approaches.
In
this
short
review,
we
wish
to
summarize
discuss
various
aspects
dynamic
biological,
pathological,
clinical,
diagnostic,
implications,
using
thyroid
carcinoma
illustrative
example.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Май 29, 2021
Abstract
In
this
article,
we
will
describe
the
properties
of
albumin
and
its
biological
functions,
types
sources
that
can
be
used
to
produce
nanoparticles,
methods
producing
therapeutic
applications
importance
nanoparticles
in
production
pharmaceutical
formulations.
view
increasing
use
Abraxane
approval
for
treatment
several
cancer
during
final
stages
clinical
trials
other
cancers,
evaluate
it
compare
effectiveness
with
conventional
non
formulations
chemotherapy
Paclitaxel
is
paid.
examine
role
animal
proteins
Nano
medicine
various
benefits
these
biomolecules
preparation
drug
delivery
carriers
characteristics
plant
protein
cages
their
potentials
diagnosis
treatment.
Finally,
advantages
disadvantages
are
mentioned,
as
well
Molecular Oncology,
Год журнала:
2021,
Номер
15(12), С. 3527 - 3544
Опубликована: Авг. 14, 2021
Cancer
cells
reprogram
their
copper
metabolism
to
adapt
adverse
microenvironments,
such
as
oxidative
stress.
The
chelator
elesclomol
has
been
reported
have
considerable
anticancer
efficacy,
but
the
underlying
mechanisms
remain
largely
unknown.
In
this
study,
we
found
that
elesclomol-mediated
overload
inhibits
colorectal
cancer
(CRC)
both
in
vitro
and
vivo.
Elesclomol
alone
promotes
degradation
of
transporter
copper-transporting
ATPase
1
(ATP7A),
which
retards
proliferation
CRC
cells.
This
property
distinguishes
it
from
several
other
chelators.
Combinational
treatment
leads
retention
within
mitochondria
due
ATP7A
loss,
leading
reactive
oxygen
species
accumulation,
turn
SLC7A11,
thus
further
enhancing
stress
consequent
ferroptosis
effect
accounts
for
robust
antitumour
activity
against
CRC,
can
be
reversed
by
administration
antioxidants
inhibitors,
well
overexpression
ATP7A.
summary,
our
findings
indicate
elesclomol-induced
chelation
targeting
regulating
ferroptosis.
International Journal of Nanomedicine,
Год журнала:
2021,
Номер
Volume 16, С. 6983 - 7022
Опубликована: Окт. 1, 2021
Nowadays,
medicinal
herbs
and
their
phytochemicals
have
emerged
as
a
great
therapeutic
option
for
many
disorders.
However,
poor
bioavailability
selectivity
might
limit
clinical
application.
Therefore,
is
considered
notable
challenge
to
improve
bio-efficacy
in
transporting
dietary
phytochemicals.
Different
methods
been
proposed
generating
effective
carrier
systems
enhance
the
of
Among
them,
nano-vesicles
introduced
promising
candidates
delivery
insoluble
Due
easy
preparation
bilayer
vesicles
adaptability,
they
widely
used
approved
by
scientific
literature.
The
first
part
review
focused
on
introducing
phytosome
technology
well
its
applications,
with
emphasis
principles
formulations
characterization.
second
provides
wide
overview
biological
activities
commercial
non-commercial
phytosomes,
divided
related
pathologies.
These
results
confirm
greater
effectiveness
both
terms
activity
or
reduced
dosage,
highlighting
curcumin
silymarin
most
formulated
compounds.
Finally,
we
describe
experimental
findings
regarding
applications
phytosomes.
conclusion
this
study
encourages
researchers
transfer
knowledge
from
laboratories
market,
further
development
these
products.
Resistance
to
cancer
therapies
has
been
a
commonly
observed
phenomenon
in
clinical
practice,
which
is
one
of
the
major
causes
treatment
failure
and
poor
patient
survival.
The
reduced
responsiveness
cells
multifaceted
that
can
arise
from
genetic,
epigenetic,
microenvironmental
factors.
Various
mechanisms
have
discovered
extensively
studied,
including
drug
inactivation,
intracellular
accumulation
by
uptake
or
increased
efflux,
target
alteration,
activation
compensatory
pathways
for
cell
survival,
regulation
DNA
repair
death,
tumor
plasticity,
microenvironments
(TMEs).
To
overcome
resistance,
variety
strategies
proposed,
are
designed
enhance
effectiveness
reduce
resistance.
These
include
identifying
biomarkers
predict
response
new
targets,
developing
targeted
drugs,
combination
targeting
multiple
signaling
pathways,
modulating
TME.
present
article
focuses
on
different
resistance
corresponding
tackling
approaches
with
recent
updates.
Perspectives
polytherapy
mechanisms,
novel
nanoparticle
delivery
systems,
advanced
design
tools
overcoming
also
reviewed.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2023,
Номер
1869(6), С. 166746 - 166746
Опубликована: Май 7, 2023
Cellular
and
stromal
components
including
tumor
cells,
immune
mesenchymal
cancer-linked
fibroblasts,
extracellular
matrix,
constituent
microenvironment
(TME).
TME
plays
a
crucial
role
in
reprogramming
initiation,
uncontrolled
proliferation,
invasion
metastasis
as
well
response
to
therapeutic
modalities.
In
recent
years
targeting
the
has
developed
potential
strategy
for
treatment
of
cancer
because
its
life-threatening
functions
restricting
development
modulating
responses
standard-of-care
medicines.
Cold
atmospheric
plasma,
oncolytic
viral
therapy,
bacterial
nano-vaccine,
repurposed
pharmaceuticals
with
combination
antiangiogenic
drugs,
immunotherapies
are
among
most
effective
therapies
directed
by
that
have
either
been
clinically
authorized
or
currently
being
studied.
This
article
discusses
above-mentioned
light
TME.
We
also
cover
problems
related
TME-targeted
therapies,
future
insights
practical
uses
this
rapidly
growing
field.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
