Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 815 - 815
Опубликована: Июль 7, 2024
Colorectal
cancer
(CRC)
is
a
leading
cause
of
deaths
worldwide.
Despite
significant
advances
in
medical
treatment,
chemotherapy
as
monotherapy
can
lead
to
substantial
side
effects
and
chemoresistance.
This
underscores
the
need
for
therapeutic
approaches
that
are
not
only
pharmacologically
safe
but
also
modulate
multiple
potent
signaling
pathways
sensitize
cells
overcome
resistance
standard
drugs.
In
recent
years,
scientists
have
been
searching
natural
compounds
be
used
chemosensitizers
addition
conventional
medications
synergistic
treatment
CRC.
Polyphenols
represent
diverse
group
target
induce
anti-cancer
effects.
Additionally,
polyphenols
shown
work
synergistically
with
chemotherapeutics
other
cells.
review
aims
provide
comprehensive
insight
into
mechanisms
selected
CRC
Further
research
clinical
trials
warranted
fully
harness
combined
or
improving
outcomes.
Food Science & Nutrition,
Год журнала:
2023,
Номер
11(4), С. 1657 - 1670
Опубликована: Янв. 13, 2023
Abstract
Antioxidants
are
compounds
that
inhibit
the
oxidation
of
other
molecules
and
protect
body
from
effects
free
radicals,
produced
either
by
normal
cell
metabolism
or
as
an
effect
pollution
exposure
to
external
factors
responsible
for
premature
aging
play
a
role
in
cardiovascular
disease.
degenerative
diseases
such
cataracts,
Alzheimer's
disease,
cancer.
While
many
antioxidants
found
nature,
others
obtained
synthetic
form
reduce
oxidative
stress
organisms.
This
review
highlights
pharmacological
relevance
fruits,
plants,
natural
sources
their
beneficial
on
human
health
through
analysis
in‐depth
discussion
studies
included
phytochemistry
effects.
The
information
this
was
collected
several
scientific
databases
(ScienceDirect,
TRIP
database,
PubMed/Medline,
Scopus,
Web
Science),
professional
websites,
traditional
medicine
books.
Current
evidence
have
shown
various
present
some
seeds,
foods,
products
different
health‐promoting
Adopting
functional
foods
with
high
antioxidant
potential
will
improve
effective
affordable
management
radical
while
avoiding
toxicities
unwanted
side
caused
conventional
medication.
Gallic
acid
(GA)
is
a
phenolic
molecule
found
naturally
in
wide
range
of
fruits
as
well
medicinal
plants.
It
has
many
health
benefits
due
to
its
antioxidant
properties.
This
study
focused
on
finding
out
the
neurobiological
effects
and
mechanisms
GA
using
published
data
from
reputed
databases.
For
this,
were
collected
various
sources,
such
PubMed/Medline,
Science
Direct,
Scopus,
Google
Scholar,
SpringerLink,
Web
Science.
The
findings
suggest
that
can
be
used
manage
several
neurological
diseases
disorders,
Alzheimer's
disease,
Parkinson's
strokes,
sedation,
depression,
psychosis,
neuropathic
pain,
anxiety,
memory
loss,
neuroinflammation.
According
database
reports
this
current
literature-based
study,
may
considered
one
potential
lead
compounds
treat
disorders.
More
preclinical
clinical
studies
are
required
establish
neuroprotective
drug.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
158, С. 114145 - 114145
Опубликована: Дек. 29, 2022
The
use
of
plant
secondary
metabolites
has
gained
considerable
attention
among
clinicians
in
the
prevention
and
treatment
cancer.
A
metabolite
isolated
mainly
from
roots
rhizomes
Podophyllum
species
(Berberidaceae)
is
aryltetralin
lignan
-
podophyllotoxin
(PTOX).
purpose
this
review
to
discuss
therapeutic
properties
PTOX
as
an
important
anticancer
compound
natural
origin.
relevant
information
regarding
antitumor
mechanisms
its
derivatives
were
collected
analyzed
scientific
databases.
results
analysis
showed
exhibits
potent
cytotoxic
activity;
however,
it
cannot
be
used
pure
form
due
toxicity
generation
many
side
effects.
Therefore,
practically
remains
clinically
unusable.
Currently,
high
effort
focused
on
attempts
synthesize
analogs
that
have
better
for
e.g.
etoposide
(VP-16),
teniposide,
etopophos.
are
drugs
which
showing
additional
immunosuppressive,
antiviral,
antioxidant,
hypolipemic,
anti-inflammatory
In
review,
paid
potential
usefulness
vitro
cultures
P.
peltatum
can
a
valuable
source
lignans,
including
PTOX.
conclusion,
preclinical
pharmacological
studies
vivo
confirm
chemotherapeutic
derivatives.
future,
clinical
human
subjects
needed
certify
effects
certified
more
detail
validate
experimental
studies.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114687 - 114687
Опубликована: Апрель 14, 2023
Cancer
is
still
the
leading
cause
of
death
worldwide,
burdening
global
medical
system.
Rosmarinic
acid
(RA)
among
first
secondary
metabolites
discovered
and
it
a
bioactive
compound
identified
in
plants
such
as
Boraginaceae
Nepetoideae
subfamilies
Lamiaceae
family,
including
Thymus
masticmasti
chinaythia
koreana,
Ocimum
sanctum,
Hyptis
pectinate.
This
updated
review
to
highlight
chemopreventive
chemotherapeutic
effects
RA
its
derivatives,
thus
providing
valuable
clues
for
potential
development
some
complementary
drugs
treatment
cancers.
Relevant
information
about
RA's
derivatives
were
collected
from
electronic
scientific
databases,
PubMed/Medline,
Scopus,
TRIP
database,
Web
Science,
Science
Direct.
The
results
studies
showed
numerous
significant
biological
antiviral,
antibacterial,
anti-inflammatory,
anti-tumour,
antioxidant
antiangiogenic
effects.
Most
on
anticancer
with
corresponding
mechanisms
are
experimental
preclinical
stage
missing
evidence
clinical
trials
support
research.
To
open
new
therapeutic
perspectives
future
must
elucidate
molecular
targets
action
more
detail,
human
toxic
adverse
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 1, 2023
Abstract
Cancer
is
a
leading
cause
of
death
worldwide
and
involves
an
oxidative
stress
mechanism.
The
transcription
factor
Nrf2
has
crucial
role
in
cytoprotective
response
against
stress,
including
cancer
growth
progression
therapy
resistance.
For
this
reason,
inhibitors
are
new
targets
to
be
studied.
Traditional
plant-based
remedies
rich
phytochemicals
have
been
used
human
cancers
phenolic
compounds
known
for
their
chemopreventive
properties.
This
comprehensive
review
offers
updated
the
as
anticancer
agents
due
action
on
inhibition.
In
addition,
naturally-occurring
bioactive
covered
clinical
applications
polyphenols
inhibitors.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1680 - 1680
Опубликована: Янв. 14, 2023
Various
literature
data
show
how
a
diet
rich
in
vegetables
could
reduce
the
incidence
of
several
cancers
due
to
contribution
natural
polyphenols
contained
them.
Polyphenols
are
attributed
multiple
pharmacological
actions
such
as
anti-inflammatory,
anti-oxidant,
antibiotic,
antiseptic,
anti-allergic,
cardioprotective
and
even
anti-tumor
properties.
The
mechanisms
involved
their
action
include
signaling
pathways
modulation
associated
with
cell
proliferation,
differentiation,
migration,
angiogenesis,
metastasis
death.
Since
dysregulation
death
processes
is
cancer
etiopathology,
compounds
able
kill
cells
be
used
new
anticancer
agents.
Apoptosis,
programmed
form
death,
most
potent
defense
against
main
mechanism
by
both
chemotherapy
agents
polyphenols.
aim
this
review
provide
an
update
on
apoptotic
molecular
induced
some
representative
polyphenol
family
members
cells.
This
aspect
particularly
important
because
it
may
useful
design
therapeutic
strategies
involving
adjuvants.
Cancer Cell International,
Год журнала:
2022,
Номер
22(1)
Опубликована: Ноя. 15, 2022
Abstract
Recent
technological
advances
in
nanoscience
and
material
designing
have
led
to
the
development
of
point-of-care
devices
for
biomolecule
sensing
cancer
diagnosis.
In
situ
portable
bedside,
diagnosis
can
effectively
improve
patient’s
clinical
outcomes
reduce
mortality
rate.
Detection
exosomal
RNAs
by
immuno-biochip
with
increased
sensitivity
specificity
diagnose
has
raised
understanding
tumor
microenvironment
many
other
technology-based
biosensing
hold
great
promise
innovations
conquer
unbeatable
fort
metastasis.
Electrochemical
biosensors
are
most
sensitive
category
detection
sensors
significantly
low
concentrations
down
atomic
level.
this
sense,
review
addresses
recent
developing
significant
biological
that
believed
better
potential
than
existing
facilities.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32390 - e32390
Опубликована: Июнь 1, 2024
A
form
of
cancer
that
affects
the
rectum
or
colon
(large
intestine)
is
called
colorectal
(CRC).
The
main
risk
factors
for
CRC
include
dietary,
lifestyle,
and
environmental
variables.
Currently
natural
polyphenols
have
demonstrated
impressive
anticarcinogenic
capabilities.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 181 - 181
Опубликована: Март 11, 2025
Cancer
remains
a
leading
cause
of
death
globally,
with
breast
cancer
being
the
most
commonly
diagnosed
in
women.
This
systematic
review
focuses
on
therapeutic
potential
baicalin
and
baicalein,
two
bioactive
flavonoids
derived
from
Scutellaria
baicalensis,
treatment.
These
compounds
exhibit
anticancer
properties
through
mechanisms
such
as
apoptosis
induction,
cell
cycle
arrest,
inhibition
metastasis.
Baicalin
baicalein
modulate
key
signaling
pathways,
including
NF-κB,
PI3K/AKT/mTOR,
Wnt/β-catenin,
have
shown
efficacy
both
vitro
vivo
models.
Their
synergy
chemotherapy
agents
incorporation
into
nanotechnology-based
delivery
systems
highlight
opportunities
to
enhance
outcomes.
However,
current
evidence
is
predominantly
preclinical,
limited
clinical
trials
validate
their
safety
humans.
Challenges
poor
bioavailability
rapid
metabolism
also
underscore
need
for
advanced
formulation
strategies.
synthesizes
molecular
mechanisms,
efficacy,
applications
research.
