Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2023, Номер 1867(10), С. 130440 - 130440
Опубликована: Июль 30, 2023
Язык: Английский
Nano-Micro Letters, Год журнала: 2024, Номер 17(1)
Опубликована: Окт. 17, 2024
The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.
Язык: Английский
Процитировано
15
Molecular Biology of the Cell, Год журнала: 2025, Номер 36(2)
Опубликована: Янв. 28, 2025
The cellular electrical signals of living organisms were discovered more than a century ago and have been extensively investigated in the neuromuscular system. Neuronal depolarization hyperpolarization are essential for our physiological pathological functions. Bioelectricity is being recognized as an ancient, intrinsic, fundamental property all cells, it not limited to Instead, emerging evidence supports view bioelectricity instructional signaling cue physiology, embryonic development, regeneration, human diseases, including cancers. Here, we highlight current understanding share views on challenges perspectives.
Язык: Английский
Процитировано
2
Advanced NanoBiomed Research, Год журнала: 2022, Номер 3(1)
Опубликована: Дек. 1, 2022
Piezoelectric nanomaterials are functional materials that hold a great promise for the nanoscale conversion of mechanical energy and electrical signals. Owing to their excellent electromechanical dependence, catalytic activity, response sensitivity, piezoelectric widely used in harvesting, sensors, actuators, resonators, medical detectors. Nano‐piezoelectric exhibit unique chemical activities field biomedical engineering, such as disease diagnosis treatment. The working principles, device‐design mechanics, classification systematically reviewed. Then, recent advances applications tissue regeneration, antitumor/antibacterial therapy, cell force detection, controlled drug release, pathological/physiological parameter monitoring highlighted. Finally, perspectives on development future smart nanomaterials, how they can serve building block inspire impact novel treatment applications, presented.
Язык: Английский
Процитировано
38
Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10
Опубликована: Май 17, 2022
Pluripotent stem cell-derived organoid models of the central nervous system represent one most exciting areas in vitro tissue engineering. Classically, organoids brain, retina and spinal cord have been generated via recapitulation vivo developmental cues, including biochemical biomechanical. However, a lesser studied cue, bioelectricity, has shown to regulate development function. In particular, electrical stimulation neural cells some important phenotypes relating differentiation. Emerging techniques bioengineering biomaterials utilise using conductive polymers. state-of-the-art pluripotent cell technology not yet merged with this area bioelectricity. Here, we discuss recent findings field bioelectricity system, possible mechanisms, how may be utilised as novel technique engineer "next-generation" organoids.
Язык: Английский
Процитировано
36
Biosemiotics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2022, Номер 12(1)
Опубликована: Июнь 2, 2022
A sound theory of biological organization is clearly missing for a better interpretation observational results and faster progress in understanding life complexity. The availability such represents fundamental explaining both normal pathological organism development. present work introduces computational implementation some principles development, namely that the default state cells proliferation motility, includes principle variation by closure constraints. In model, bioelectric context tissue field responsible organization, as it regulates cell level communication driving system's evolution. Starting from depolarized (proliferative) cell, grows to certain size, limited increasingly polarized after successive events. system reaches homeostasis, with core (proliferative cells) surrounded rim (non-proliferative this condition). This resilient death (random or due injure) depolarization (potentially carcinogenic) Carcinogenesis introduced through localized event (a spot random tissue, which returns their initial proliferative state. normalization condition can reverse out-of-equilibrium new homeostatic one. simplified model embryogenesis, carcinogenesis, based on non-excitable cells' properties, be made more realistic introduction other components, like biochemical fields mechanical interactions, are faithful representation reality. However, even simple give insight approaches complex systems suggest experimental tests, focused its predictions interpreted under paradigm.
Язык: Английский
Процитировано
25
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16464 - 16464
Опубликована: Ноя. 17, 2023
It is well established that cells, tissues, and organisms exposed to low doses of ionizing radiation can induce effects in non-irradiated neighbors (non-targeted or NTE), but the mechanisms remain unclear. This especially true initial steps leading release signaling molecules contained exosomes. Voltage-gated ion channels, photon emissions, calcium fluxes are all involved precise sequence events not yet known. We identified what may be a quantum entanglement type effect this prompted us consider whether aspects biology such as tunneling underlie NTE. review field where it relevant processes. These include NTE, low-dose hyper-radiosensitivity, hormesis, adaptive response. Finally, we present possible biological-based model for
Язык: Английский
Процитировано
15
Physics Reports, Год журнала: 2022, Номер 1004, С. 1 - 31
Опубликована: Дек. 22, 2022
Язык: Английский
Процитировано
22
PLoS Biology, Год журнала: 2024, Номер 22(8), С. e3002762 - e3002762
Опубликована: Авг. 22, 2024
During embryonic development, tissues and organs are gradually shaped into their functional morphologies through a series of spatiotemporally tightly orchestrated cell behaviors. A highly conserved organ shape across metazoans is the epithelial tube. Tube morphogenesis complex multistep process carefully choreographed behaviors such as convergent extension, elongation, lumen formation. The identity signaling molecules that coordinate these intricate morphogenetic steps remains elusive. notochord an essential tubular present in midline region all members chordate phylum. Here, using genome editing, pharmacology quantitative imaging early Ciona intestinalis we show Ano10/Tmem16k, member evolutionarily ancient family transmembrane proteins called Anoctamin/TMEM16 for expansion, connection during morphogenesis. We find Ano10/Tmem16k works concert with plasma membrane (PM) localized Na + /Ca 2+ exchanger (NCX) endoplasmic reticulum (ER) residing SERCA, RyR, IP3R to establish developmental stage specific Ca molecular modules regulate dynamics. In addition, sensors calmodulin (CaM) /calmodulin-dependent protein kinase (CaMK) Ano10/Tmem16k-dependent subcellular localization. Their pharmacological inhibition leads tubulogenesis defects, deranged dynamics, suggesting involved both “encoding” “decoding” signals. Furthermore, mediates cytoskeletal reorganization morphogenesis, likely by altering localization 2 important regulators, small GTPase Ras homolog (RhoA) actin binding Cofilin. Finally, use electrophysiological recordings scramblase assay tissue culture demonstrate acts ion channel but not phospholipid scramblase. Our results novel player prevertebrate toolkit controls scales.
Язык: Английский
Процитировано
4
Опубликована: Ноя. 21, 2024
Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with precise architecture metamaterials. This review provides a comprehensive overview various materials- such as molecular crystals, ceramics, and polymers-known their exceptional performance biocompatibility. We explore advanced engineering approaches, including design, supramolecular packing, 3D assembly, which enable customization targeted applications. Particular attention is given to pivotal role metamaterial structuring in development 0D spheres, 1D fibers tubes, 2D films, scaffolds. Key applications, tissue engineering, drug delivery, wound healing, biosensing, are discussed through illustrative examples. Finally, article addresses critical challenges future directions, aiming drive further innovations biomaterials next-generation healthcare technologies.
Язык: Английский
Процитировано
4