Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes DOI
Javier Cervera, Michael Levin, Salvador Mafé

и другие.

Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2023, Номер 1867(10), С. 130440 - 130440

Опубликована: Июль 30, 2023

Язык: Английский

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics DOI Creative Commons
Shichang Liu, Farid Manshaii, Jinmiao Chen

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 17(1)

Опубликована: Окт. 17, 2024

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.

Язык: Английский

Процитировано

15

Bioelectricity is a universal multifaced signaling cue in living organisms DOI
Guangjun Zhang, Michael Levin

Molecular Biology of the Cell, Год журнала: 2025, Номер 36(2)

Опубликована: Янв. 28, 2025

The cellular electrical signals of living organisms were discovered more than a century ago and have been extensively investigated in the neuromuscular system. Neuronal depolarization hyperpolarization are essential for our physiological pathological functions. Bioelectricity is being recognized as an ancient, intrinsic, fundamental property all cells, it not limited to Instead, emerging evidence supports view bioelectricity instructional signaling cue physiology, embryonic development, regeneration, human diseases, including cancers. Here, we highlight current understanding share views on challenges perspectives.

Язык: Английский

Процитировано

2

Developmental Bioelectricity as an Explanatory Framework for Cognition and Meaning DOI Creative Commons
Ahti‐Veikko Pietarinen, Majid Davoody Beni, Vera Shumilina

и другие.

Biosemiotics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

1

Research Trends of Piezoelectric Nanomaterials in Biomedical Engineering DOI Creative Commons

Jianying Ji,

Chunyu Yang,

Yizhu Shan

и другие.

Advanced NanoBiomed Research, Год журнала: 2022, Номер 3(1)

Опубликована: Дек. 1, 2022

Piezoelectric nanomaterials are functional materials that hold a great promise for the nanoscale conversion of mechanical energy and electrical signals. Owing to their excellent electromechanical dependence, catalytic activity, response sensitivity, piezoelectric widely used in harvesting, sensors, actuators, resonators, medical detectors. Nano‐piezoelectric exhibit unique chemical activities field biomedical engineering, such as disease diagnosis treatment. The working principles, device‐design mechanics, classification systematically reviewed. Then, recent advances applications tissue regeneration, antitumor/antibacterial therapy, cell force detection, controlled drug release, pathological/physiological parameter monitoring highlighted. Finally, perspectives on development future smart nanomaterials, how they can serve building block inspire impact novel treatment applications, presented.

Язык: Английский

Процитировано

37

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System DOI Creative Commons
Michelle O’Hara-Wright, Sahba Mobini, Anai Gonzalez-Cordero

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Май 17, 2022

Pluripotent stem cell-derived organoid models of the central nervous system represent one most exciting areas in vitro tissue engineering. Classically, organoids brain, retina and spinal cord have been generated via recapitulation vivo developmental cues, including biochemical biomechanical. However, a lesser studied cue, bioelectricity, has shown to regulate development function. In particular, electrical stimulation neural cells some important phenotypes relating differentiation. Emerging techniques bioengineering biomaterials utilise using conductive polymers. state-of-the-art pluripotent cell technology not yet merged with this area bioelectricity. Here, we discuss recent findings field bioelectricity system, possible mechanisms, how may be utilised as novel technique engineer "next-generation" organoids.

Язык: Английский

Процитировано

36

A computational model of organism development and carcinogenesis resulting from cells’ bioelectric properties and communication DOI Creative Commons
J. Carvalho

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Июнь 2, 2022

A sound theory of biological organization is clearly missing for a better interpretation observational results and faster progress in understanding life complexity. The availability such represents fundamental explaining both normal pathological organism development. present work introduces computational implementation some principles development, namely that the default state cells proliferation motility, includes principle variation by closure constraints. In model, bioelectric context tissue field responsible organization, as it regulates cell level communication driving system's evolution. Starting from depolarized (proliferative) cell, grows to certain size, limited increasingly polarized after successive events. system reaches homeostasis, with core (proliferative cells) surrounded rim (non-proliferative this condition). This resilient death (random or due injure) depolarization (potentially carcinogenic) Carcinogenesis introduced through localized event (a spot random tissue, which returns their initial proliferative state. normalization condition can reverse out-of-equilibrium new homeostatic one. simplified model embryogenesis, carcinogenesis, based on non-excitable cells' properties, be made more realistic introduction other components, like biochemical fields mechanical interactions, are faithful representation reality. However, even simple give insight approaches complex systems suggest experimental tests, focused its predictions interpreted under paradigm.

Язык: Английский

Процитировано

25

Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model DOI Open Access
Bruno F. E. Matarèse,

Andrej Rusin,

Colin Seymour

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16464 - 16464

Опубликована: Ноя. 17, 2023

It is well established that cells, tissues, and organisms exposed to low doses of ionizing radiation can induce effects in non-irradiated neighbors (non-targeted or NTE), but the mechanisms remain unclear. This especially true initial steps leading release signaling molecules contained exosomes. Voltage-gated ion channels, photon emissions, calcium fluxes are all involved precise sequence events not yet known. We identified what may be a quantum entanglement type effect this prompted us consider whether aspects biology such as tunneling underlie NTE. review field where it relevant processes. These include NTE, low-dose hyper-radiosensitivity, hormesis, adaptive response. Finally, we present possible biological-based model for

Язык: Английский

Процитировано

15

Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling DOI
Javier Cervera, Michael Levin, Salvador Mafé

и другие.

Physics Reports, Год журнала: 2022, Номер 1004, С. 1 - 31

Опубликована: Дек. 22, 2022

Язык: Английский

Процитировано

22

Emerging Piezoelectric Metamaterials for Biomedical Applications DOI Creative Commons

Zishuo Yan,

Huy Quang Tran, Dongxin Ma

и другие.

Опубликована: Ноя. 21, 2024

Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with precise architecture metamaterials. This review provides a comprehensive overview various materials- such as molecular crystals, ceramics, and polymers-known their exceptional performance biocompatibility. We explore advanced engineering approaches, including design, supramolecular packing, 3D assembly, which enable customization targeted applications. Particular attention is given to pivotal role metamaterial structuring in development 0D spheres, 1D fibers tubes, 2D films, scaffolds. Key applications, tissue engineering, drug delivery, wound healing, biosensing, are discussed through illustrative examples. Finally, article addresses critical challenges future directions, aiming drive further innovations biomaterials next-generation healthcare technologies.

Язык: Английский

Процитировано

4

An Ultrasensitive Genetically Encoded Voltage Indicator Uncovers the Electrical Activity of Non‐Excitable Cells DOI Creative Commons
Philipp Rühl,

Anagha G. Nair,

Namrata Gawande

и другие.

Advanced Science, Год журнала: 2024, Номер 11(20)

Опубликована: Март 25, 2024

Abstract Most animal cell types are classified as non‐excitable because they do not generate action potentials observed in excitable cells, such neurons and muscle cells. Thus, resolving voltage signals cells demands sensors with exceptionally high sensitivity. In this study, the ultrabright, ultrasensitive, calibratable genetically encoded sensor rEstus is developed using structure‐guided engineering. most sensitive resting range of offers a 3.6‐fold improvement brightness change for fast spikes over its precursor ASAP3. Using rEstus, it uncovered that membrane several lines (A375, HEK293T, MCF7) undergoes spontaneous endogenous alterations on second to millisecond timescale. Correlation analysis these optically recorded provides direct, real‐time readout electrical cell–cell coupling, showing visually connected A375 HEK293T also largely electrically connected, while MCF7 only weakly coupled. The presented work enhanced tools methods non‐invasive imaging living demonstrates limited but occur variety types.

Язык: Английский

Процитировано

3