Identification and verification of ferroptosis-related genes in gastric intestinal metaplasia DOI Creative Commons
Biao Song, Tingting Li, Yi Zhang

и другие.

Frontiers in Genetics, Год журнала: 2023, Номер 14

Опубликована: Апрель 18, 2023

Background: Gastric intestinal metaplasia (IM) is the key link of gastric precancerous lesions. Ferroptosis a novel form programmed cell death. However, its impact on IM unclear. The focus this study to identify and verify ferroptosis-related genes (FRGs) that may be involved in by bioinformatics analysis. Materials methods: Differentially expressed (DEGs) were obtained from microarray dataset GSE60427 GSE78523 downloaded Gene Expression Omnibus (GEO) database. (DEFRGs) overlapping DEGs FRGs got FerrDb. DAVID database was used for functional enrichment Protein-protein interaction (PPI) analysis Cytoscape software screen hub gene. In addition, we built receiver operating characteristic (ROC) curve verified relative mRNA expression quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Finally, CIBERSORT algorithm analyze immune infiltration IM. Results: First, total 17 DEFRGs identified. Second, gene module identified considered as gene: PTGS2, HMOX1, IFNG, NOS2. Third, ROC showed HMOX1 NOS2 had good diagnostic characteristics. qRT-PCR experiments confirmed differential normal tissues. immunoassay proportion T cells regulatory (Tregs) macrophages M0 relatively higher, while CD4 memory activated dendritic lower. Conclusion: We found significant associations between IM, biomarkers therapeutic targets These results enhance our understanding contribute treatment.

Язык: Английский

FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis DOI Creative Commons

Liangbo Niu,

Yi Li, Gui‐Xiang Huang

и другие.

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Апрель 2, 2024

Abstract The occurrence of chemoresistance is an inescapable obstacle affecting the clinical efficacy cisplatin in gastric cancer (GC). Exploring regulatory mechanism resistance will help to provide potential effective targets for improving prognosis patients. Here, we find that FAM120A upregulated GC tissues and higher cisplatin-resistant tissues, its high expression positively correlated with poor outcome Functional studies indicate confers cells by inhibiting ferroptosis. Mechanically, METTL3-induced m6A modification YTHDC1-induced stability mRNA enhance expression. inhibits ferroptosis binding SLC7A11 enhancing stability. deficiency enhances sensitivity promoting vivo. These results reveal function chemotherapy tolerance targeting strategy alleviate GC.

Язык: Английский

Процитировано

8
Qizhu Jianwei decoction triggers ferroptosis by exosome-mediated miR-199-3p/ACSL4 signaling pathways DOI
Xinyi Dai, Yanqin Hu, Cheng Sun

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119529 - 119529

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills DOI Creative Commons
Valeria Consoli, Antonino N. Fallica, Valeria Sorrenti

и другие.

Antioxidants and Redox Signaling, Год журнала: 2023, Номер 40(1-3), С. 40 - 85

Опубликована: Май 3, 2023

The multifactorial nature of the mechanisms implicated in cancer development still represents a major issue for success established antitumor therapies. discovery ferroptosis, novel form programmed cell death distinct from apoptosis, along with identification molecular pathways activated during its execution, has led to uncovering molecules characterized by ferroptosis-inducing properties.

Язык: Английский

Процитировано

15
The Role of Cuproptosis Key Factor FDX1 in Gastric Cancer DOI
Qiqi Zhao, Miao Yu,

Xueqin Du

и другие.

Current Pharmaceutical Biotechnology, Год журнала: 2024, Номер 26(1), С. 132 - 142

Опубликована: Июнь 26, 2024

Gastric cancer is a common malignant tumor of the digestive tract, both domestically and internationally. It has high incidence mortality rates, posing significant threat to human health. The levels blood copper are elevated in patients with gastric cancer. However, exact relationship between overload phenotype still unclear. This study aims investigate role Cuproptosis-related factor FDX1 conversion phenotype.

Язык: Английский

Процитировано

5
The role of metal ions in the occurrence, progression, drug resistance, and biological characteristics of gastric cancer DOI Creative Commons

Pengtuo Xiao,

Changfeng Li, Yuanda Liu

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 2, 2024

Metal ions exert pivotal functions within the human body, encompassing essential roles in upholding cell structure, gene expression regulation, and catalytic enzyme activity. Additionally, they significantly influence various pathways implicated divergent mechanisms of death. Among prevailing malignant tumors digestive tract worldwide, gastric cancer stands prominent, exhibiting persistent high mortality rates. A compelling body evidence reveals conspicuous ion irregularities tumor tissues, cancer. Notably, metal have been observed to elicit distinct contributions progression, drug resistance, biological attributes This review consolidates pertinent literature on involvement etiology advancement Particular attention is directed towards ions, namely, Na, K, Mg, Ca, Fe, Cu, Zn, Mn, elucidating their initiation progression cancer, cellular demise processes, resistance phenomena, therapeutic approaches.

Язык: Английский

Процитировано

4
Ferroptosis and its current progress in gastric cancer DOI Creative Commons

Zhenqi Yue,

Yi‐Wu Yuan,

Qi Zhou

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Фев. 28, 2024

Gastric Cancer (GC) is a prevalent malignancy within the digestive tract, ranking as fifth most common malignant tumor worldwide. It characterized by clinical features such tendency for metastasis and an unfavorable prognosis. Ferroptosis, recently identified form of cell death, represents novel mode cellular demise that diverges from traditional concepts necrosis apoptosis. Numerous studies have found ferroptosis plays significant role in proliferation, metastasis, drug resistance, microenvironment regulation GC. This review summarizes mechanism its occurrence development GC cells. provides examples demonstrating how various anti-tumor drugs can induce Additionally, it potential application value future treatment

Язык: Английский

Процитировано

4
Ferroptosis and its role in gastric and colorectal cancers DOI Open Access
Jinxiu Hou, Bo Wang, Jing Li

и другие.

Korean Journal of Physiology and Pharmacology, Год журнала: 2024, Номер 28(3), С. 183 - 196

Опубликована: Апрель 29, 2024

Ferroptosis is a novel mechanism of programmed cell death, characterized by intracellular iron overload, intensified lipid peroxidation, and abnormal accumulation reactive oxygen species, which ultimately resulting in membrane impairment demise.Research has revealed that cancer cells exhibit greater demand for compared to normal cells, indicating potential susceptibility ferroptosis.Stomach colorectal cancers are common gastrointestinal malignancies, their elevated occurrence mortality rates render them global health concern.Despite significant advancements medical treatments, certain unfavorable consequences drug resistance persist.Consequently, directing attention towards the phenomenon ferroptosis gastric holds promise enhancing therapeutic efficacy.This review aims elucidate intricate cellular metabolism associated with ferroptosis, encompassing amino acid metabolism, as well metabolic processes.Furthermore, significance context thoroughly examined discussed.

Язык: Английский

Процитировано

4
Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage DOI Creative Commons
Yuan Cao, Wenbiao Xiao, Shuzhen Liu

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Фев. 6, 2023

Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high rates of morbidity, mortality, and disability. Optimal treatment ICH major clinical challenge, as the underlying mechanisms remain unclear. Ferroptosis, newly identified form non-apoptotic programmed cell death, characterized by iron-induced accumulation lipid reactive oxygen species (ROS), leading to intracellular oxidative stress. Lipid ROS causes damage nucleic acids, proteins, membranes, eventually resulting in ferroptosis. In past 10 years, ferroptosis has resulted plenty discoveries breakthroughs cancer, neurodegeneration, other diseases. Some studies have also reported that does occur after vitro vivo contribute neuronal death. However, on following are still preliminary stage. this review, we will summarize current evidence mechanism ICH. And review traditional modes death identify crosstalk ICH, including apoptosis, necroptosis, autophagy. Additionally, aim explore promising therapeutic application death-based

Язык: Английский

Процитировано

9
Lipid Metabolism-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Advanced Gastric Cancer DOI Creative Commons
Lijian He, Qiange Ye, Yanmei Zhu

и другие.

Gastroenterology Research and Practice, Год журнала: 2024, Номер 2024, С. 1 - 28

Опубликована: Фев. 26, 2024

Abnormal lipid metabolism is known to influence the malignant behavior of gastric cancer. However, underlying mechanism remains elusive. In this study, we comprehensively analyzed biological significance genes involved in advanced cancer (AGC).

Язык: Английский

Процитировано

3
Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer DOI Creative Commons
Yinghui Li, Cui-Yun Liu, Bo Fang

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 22, 2024

The identification of ferroptosis represents a pivotal advancement in the field cell death research, revealing an entirely novel mechanism cellular demise and offering new insights into initiation, progression, therapeutic management various diseases. Ferroptosis is predominantly induced by intracellular iron accumulation, lipid peroxidation, or impairments antioxidant defense system, culminating membrane rupture consequent death. Studies have associated with wide range diseases, enhancing our comprehension its underlying mechanisms, we can formulate innovative strategies, thereby providing renewed hope for patients.

Язык: Английский

Процитировано

3