Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Sept. 12, 2023
Abstract
Background
Jian
Yun
Qing
Hua
Decoction
(JYQHD),
a
traditional
Chinese
medicine
decoction,
which
has
been
applied
in
the
treatment
of
gastric
cancer
(GC).
We
attempt
to
confirm
anti-gastric
effect
JYQHD
and
explore
mechanism
JYQHD.
Methods
Acute
toxicity
test
was
used
understand
studied
expression
prognostic
outcome
COL12A1
within
GC
tissues
through
network
databases.
Using
several
web-based
databases,
we
analyzed
major
components
targets
JYQHD,
as
well
known
therapeutic
cancer.
The
Venn
diagram
utilized
obtain
overlapped
genes.
Lentiviral
vector,
shRNAs
plasmids,
were
transfect
cells.
Cell
counting
kit-8
(CCK8),
sphere
formation,
malondialdehyde
(MDA),
glutathione
(GSH),
reactive
oxygen
species
(ROS),
Fe
2+
,
transmission
electron
microscopy
(TEM),
quantitative
Real-Time
Polymerase
Chain
Reaction
(qRT-PCR),
Western-Blot
(WB),
immunohistochemical
(IHC)
assays
employed
investigate
role
GC.
Results
results
showed
that
non-toxic
safe.
inhibited
growth
formation
ability
inducing
ferroptosis
cells,
suppressed
cells
induced
subcutaneous
xenograft
tumor
growth.
highly
expressed
tissues,
indicating
poor
prognosis.
specifically
enhanced
cell
progression
stemness
via
suppressing
ferroptosis.
down-regulated
order
suppress
Conclusion
development
by
inhibiting
pathway
mediated
COL12A1.
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: April 2, 2024
Abstract
The
occurrence
of
chemoresistance
is
an
inescapable
obstacle
affecting
the
clinical
efficacy
cisplatin
in
gastric
cancer
(GC).
Exploring
regulatory
mechanism
resistance
will
help
to
provide
potential
effective
targets
for
improving
prognosis
patients.
Here,
we
find
that
FAM120A
upregulated
GC
tissues
and
higher
cisplatin-resistant
tissues,
its
high
expression
positively
correlated
with
poor
outcome
Functional
studies
indicate
confers
cells
by
inhibiting
ferroptosis.
Mechanically,
METTL3-induced
m6A
modification
YTHDC1-induced
stability
mRNA
enhance
expression.
inhibits
ferroptosis
binding
SLC7A11
enhancing
stability.
deficiency
enhances
sensitivity
promoting
vivo.
These
results
reveal
function
chemotherapy
tolerance
targeting
strategy
alleviate
GC.
Antioxidants and Redox Signaling,
Journal Year:
2023,
Volume and Issue:
40(1-3), P. 40 - 85
Published: May 3, 2023
The
multifactorial
nature
of
the
mechanisms
implicated
in
cancer
development
still
represents
a
major
issue
for
success
established
antitumor
therapies.
discovery
ferroptosis,
novel
form
programmed
cell
death
distinct
from
apoptosis,
along
with
identification
molecular
pathways
activated
during
its
execution,
has
led
to
uncovering
molecules
characterized
by
ferroptosis-inducing
properties.
Current Pharmaceutical Biotechnology,
Journal Year:
2024,
Volume and Issue:
26(1), P. 132 - 142
Published: June 26, 2024
Gastric
cancer
is
a
common
malignant
tumor
of
the
digestive
tract,
both
domestically
and
internationally.
It
has
high
incidence
mortality
rates,
posing
significant
threat
to
human
health.
The
levels
blood
copper
are
elevated
in
patients
with
gastric
cancer.
However,
exact
relationship
between
overload
phenotype
still
unclear.
This
study
aims
investigate
role
Cuproptosis-related
factor
FDX1
conversion
phenotype.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 2, 2024
Metal
ions
exert
pivotal
functions
within
the
human
body,
encompassing
essential
roles
in
upholding
cell
structure,
gene
expression
regulation,
and
catalytic
enzyme
activity.
Additionally,
they
significantly
influence
various
pathways
implicated
divergent
mechanisms
of
death.
Among
prevailing
malignant
tumors
digestive
tract
worldwide,
gastric
cancer
stands
prominent,
exhibiting
persistent
high
mortality
rates.
A
compelling
body
evidence
reveals
conspicuous
ion
irregularities
tumor
tissues,
cancer.
Notably,
metal
have
been
observed
to
elicit
distinct
contributions
progression,
drug
resistance,
biological
attributes
This
review
consolidates
pertinent
literature
on
involvement
etiology
advancement
Particular
attention
is
directed
towards
ions,
namely,
Na,
K,
Mg,
Ca,
Fe,
Cu,
Zn,
Mn,
elucidating
their
initiation
progression
cancer,
cellular
demise
processes,
resistance
phenomena,
therapeutic
approaches.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 28, 2024
Gastric
Cancer
(GC)
is
a
prevalent
malignancy
within
the
digestive
tract,
ranking
as
fifth
most
common
malignant
tumor
worldwide.
It
characterized
by
clinical
features
such
tendency
for
metastasis
and
an
unfavorable
prognosis.
Ferroptosis,
recently
identified
form
of
cell
death,
represents
novel
mode
cellular
demise
that
diverges
from
traditional
concepts
necrosis
apoptosis.
Numerous
studies
have
found
ferroptosis
plays
significant
role
in
proliferation,
metastasis,
drug
resistance,
microenvironment
regulation
GC.
This
review
summarizes
mechanism
its
occurrence
development
GC
cells.
provides
examples
demonstrating
how
various
anti-tumor
drugs
can
induce
Additionally,
it
potential
application
value
future
treatment
BMC Gastroenterology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: May 8, 2025
Gastric
cancer
(GC)
is
one
of
the
most
common
malignant
tumors
with
a
poor
prognosis.
Ferroptosis
an
distinct
type
non-apoptotic
cell
death
that
closely
associated
tumor
Thus,
we
aimed
to
develop
novel
prognosis
risk
model
based
on
ferroptosis-related
lncRNAs
and
excavate
diagnostic
markers.
In
this
study,
eight
were
obtained
for
constructing
in
GC
TCGA
database.
The
patients
high-risk
group
had
worse
survival
than
those
low-risk
group,
risk-grouping
could
be
used
as
independent
prognostic
factor
OS.
Receiver
operating
characteristic
curve
analysis
demonstrated
was
superior
traditional
clinicopathological
features
predicting
GSEA
revealed
these
mainly
involved
adhesion,
pathways,
immune
function
regulation.
key
gene
HAGLR
signature
up-regulated
tissues
cells.
Function
assays
showed
knockdown
effectively
inhibit
cells
proliferation
migration,
whereas
silencing
accelerated
apoptosis
ferroptosis
process.
conclusion,
established
including
lncRNAs,
which
may
improve
predictive
accuracy
GC.
Frontiers in Cellular Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Feb. 6, 2023
Intracerebral
hemorrhage
(ICH)
is
a
serious
cerebrovascular
disease
with
high
rates
of
morbidity,
mortality,
and
disability.
Optimal
treatment
ICH
major
clinical
challenge,
as
the
underlying
mechanisms
remain
unclear.
Ferroptosis,
newly
identified
form
non-apoptotic
programmed
cell
death,
characterized
by
iron-induced
accumulation
lipid
reactive
oxygen
species
(ROS),
leading
to
intracellular
oxidative
stress.
Lipid
ROS
causes
damage
nucleic
acids,
proteins,
membranes,
eventually
resulting
in
ferroptosis.
In
past
10
years,
ferroptosis
has
resulted
plenty
discoveries
breakthroughs
cancer,
neurodegeneration,
other
diseases.
Some
studies
have
also
reported
that
does
occur
after
vitro
vivo
contribute
neuronal
death.
However,
on
following
are
still
preliminary
stage.
this
review,
we
will
summarize
current
evidence
mechanism
ICH.
And
review
traditional
modes
death
identify
crosstalk
ICH,
including
apoptosis,
necroptosis,
autophagy.
Additionally,
aim
explore
promising
therapeutic
application
death-based
Gastroenterology Research and Practice,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 28
Published: Feb. 26, 2024
Abnormal
lipid
metabolism
is
known
to
influence
the
malignant
behavior
of
gastric
cancer.
However,
underlying
mechanism
remains
elusive.
In
this
study,
we
comprehensively
analyzed
biological
significance
genes
involved
in
advanced
cancer
(AGC).