Jian Yun Qing Hua Decoction inhibits malignant behaviors of gastric carcinoma cells via COL12A1 mediated ferroptosis signal pathway DOI Creative Commons
Baoxinzi Liu, Yu Li, Yuanyuan Xu

et al.

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Sept. 12, 2023

Abstract Background Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction, which has been applied in the treatment of gastric cancer (GC). We attempt to confirm anti-gastric effect JYQHD and explore mechanism JYQHD. Methods Acute toxicity test was used understand studied expression prognostic outcome COL12A1 within GC tissues through network databases. Using several web-based databases, we analyzed major components targets JYQHD, as well known therapeutic cancer. The Venn diagram utilized obtain overlapped genes. Lentiviral vector, shRNAs plasmids, were transfect cells. Cell counting kit-8 (CCK8), sphere formation, malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), Fe 2+ , transmission electron microscopy (TEM), quantitative Real-Time Polymerase Chain Reaction (qRT-PCR), Western-Blot (WB), immunohistochemical (IHC) assays employed investigate role GC. Results results showed that non-toxic safe. inhibited growth formation ability inducing ferroptosis cells, suppressed cells induced subcutaneous xenograft tumor growth. highly expressed tissues, indicating poor prognosis. specifically enhanced cell progression stemness via suppressing ferroptosis. down-regulated order suppress Conclusion development by inhibiting pathway mediated COL12A1.

Language: Английский

FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis DOI Creative Commons

Liangbo Niu,

Yi Li, Gui‐Xiang Huang

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: April 2, 2024

Abstract The occurrence of chemoresistance is an inescapable obstacle affecting the clinical efficacy cisplatin in gastric cancer (GC). Exploring regulatory mechanism resistance will help to provide potential effective targets for improving prognosis patients. Here, we find that FAM120A upregulated GC tissues and higher cisplatin-resistant tissues, its high expression positively correlated with poor outcome Functional studies indicate confers cells by inhibiting ferroptosis. Mechanically, METTL3-induced m6A modification YTHDC1-induced stability mRNA enhance expression. inhibits ferroptosis binding SLC7A11 enhancing stability. deficiency enhances sensitivity promoting vivo. These results reveal function chemotherapy tolerance targeting strategy alleviate GC.

Language: Английский

Citations

8
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills DOI Creative Commons
Valeria Consoli, Antonino N. Fallica, Valeria Sorrenti

et al.

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 40(1-3), P. 40 - 85

Published: May 3, 2023

The multifactorial nature of the mechanisms implicated in cancer development still represents a major issue for success established antitumor therapies. discovery ferroptosis, novel form programmed cell death distinct from apoptosis, along with identification molecular pathways activated during its execution, has led to uncovering molecules characterized by ferroptosis-inducing properties.

Language: Английский

Citations

14
The Role of Cuproptosis Key Factor FDX1 in Gastric Cancer DOI
Qiqi Zhao, Miao Yu,

Xueqin Du

et al.

Current Pharmaceutical Biotechnology, Journal Year: 2024, Volume and Issue: 26(1), P. 132 - 142

Published: June 26, 2024

Gastric cancer is a common malignant tumor of the digestive tract, both domestically and internationally. It has high incidence mortality rates, posing significant threat to human health. The levels blood copper are elevated in patients with gastric cancer. However, exact relationship between overload phenotype still unclear. This study aims investigate role Cuproptosis-related factor FDX1 conversion phenotype.

Language: Английский

Citations

5
The role of metal ions in the occurrence, progression, drug resistance, and biological characteristics of gastric cancer DOI Creative Commons

Pengtuo Xiao,

Changfeng Li, Yuanda Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 2, 2024

Metal ions exert pivotal functions within the human body, encompassing essential roles in upholding cell structure, gene expression regulation, and catalytic enzyme activity. Additionally, they significantly influence various pathways implicated divergent mechanisms of death. Among prevailing malignant tumors digestive tract worldwide, gastric cancer stands prominent, exhibiting persistent high mortality rates. A compelling body evidence reveals conspicuous ion irregularities tumor tissues, cancer. Notably, metal have been observed to elicit distinct contributions progression, drug resistance, biological attributes This review consolidates pertinent literature on involvement etiology advancement Particular attention is directed towards ions, namely, Na, K, Mg, Ca, Fe, Cu, Zn, Mn, elucidating their initiation progression cancer, cellular demise processes, resistance phenomena, therapeutic approaches.

Language: Английский

Citations

4
Ferroptosis and its current progress in gastric cancer DOI Creative Commons

Zhenqi Yue,

Yi‐Wu Yuan,

Qi Zhou

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 28, 2024

Gastric Cancer (GC) is a prevalent malignancy within the digestive tract, ranking as fifth most common malignant tumor worldwide. It characterized by clinical features such tendency for metastasis and an unfavorable prognosis. Ferroptosis, recently identified form of cell death, represents novel mode cellular demise that diverges from traditional concepts necrosis apoptosis. Numerous studies have found ferroptosis plays significant role in proliferation, metastasis, drug resistance, microenvironment regulation GC. This review summarizes mechanism its occurrence development GC cells. provides examples demonstrating how various anti-tumor drugs can induce Additionally, it potential application value future treatment

Language: Английский

Citations

4
Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer DOI Creative Commons
Xiang Pan, Kaiwen Chen, Wei Gao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Association between stable angina pectoris and gastric cancer: two-sample bidirectional mendelian randomization study DOI
Hong Zhao,

Xue-Song Ye,

Chuying Yu

et al.

Journal of Thrombosis and Thrombolysis, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Comprehensive analysis of ferroptosis-related long non-coding RNA and its association with tumor progression and ferroptosis in gastric cancer DOI Creative Commons
Shenglan Huang,

Kan Liu,

Queling Liu

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 8, 2025

Gastric cancer (GC) is one of the most common malignant tumors with a poor prognosis. Ferroptosis an distinct type non-apoptotic cell death that closely associated tumor Thus, we aimed to develop novel prognosis risk model based on ferroptosis-related lncRNAs and excavate diagnostic markers. In this study, eight were obtained for constructing in GC TCGA database. The patients high-risk group had worse survival than those low-risk group, risk-grouping could be used as independent prognostic factor OS. Receiver operating characteristic curve analysis demonstrated was superior traditional clinicopathological features predicting GSEA revealed these mainly involved adhesion, pathways, immune function regulation. key gene HAGLR signature up-regulated tissues cells. Function assays showed knockdown effectively inhibit cells proliferation migration, whereas silencing accelerated apoptosis ferroptosis process. conclusion, established including lncRNAs, which may improve predictive accuracy GC.

Language: Английский

Citations

0
Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage DOI Creative Commons
Yuan Cao, Wenbiao Xiao, Shuzhen Liu

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 6, 2023

Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high rates of morbidity, mortality, and disability. Optimal treatment ICH major clinical challenge, as the underlying mechanisms remain unclear. Ferroptosis, newly identified form non-apoptotic programmed cell death, characterized by iron-induced accumulation lipid reactive oxygen species (ROS), leading to intracellular oxidative stress. Lipid ROS causes damage nucleic acids, proteins, membranes, eventually resulting in ferroptosis. In past 10 years, ferroptosis has resulted plenty discoveries breakthroughs cancer, neurodegeneration, other diseases. Some studies have also reported that does occur after vitro vivo contribute neuronal death. However, on following are still preliminary stage. this review, we will summarize current evidence mechanism ICH. And review traditional modes death identify crosstalk ICH, including apoptosis, necroptosis, autophagy. Additionally, aim explore promising therapeutic application death-based

Language: Английский

Citations

9
Lipid Metabolism-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Advanced Gastric Cancer DOI Creative Commons
Lijian He, Qiange Ye, Yanmei Zhu

et al.

Gastroenterology Research and Practice, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 28

Published: Feb. 26, 2024

Abnormal lipid metabolism is known to influence the malignant behavior of gastric cancer. However, underlying mechanism remains elusive. In this study, we comprehensively analyzed biological significance genes involved in advanced cancer (AGC).

Language: Английский

Citations

3