Опубликована: Янв. 1, 2025
Язык: Английский
Processes, Год журнала: 2023, Номер 11(3), С. 688 - 688
Опубликована: Фев. 24, 2023
Lactic acid (LA) has broad applications in the food, chemical, pharmaceutical, and cosmetics industries. LA production demand rises due to increasing for polylactic since is a precursor production. Fermentative using renewable resources, such as lignocellulosic materials, reduces greenhouse gas emissions offers cheaper alternative feedstock than refined sugars. Suitable pretreatment methods must be selected minimize cost production, successful hydrolysis of lignocellulose results sugar-rich feedstocks fermentation. This review broadly focused on fermentative from lignocellulose. Aspects discussed include (i). low-cost materials (ii). methods, (iii). enzymatic cellulose hemicellulose, (iv). lactic acid-producing microorganisms, including fungi, bacteria, genetically modified their pathways, (v). fermentation modes methods. Industrial purification, difficulties possible strategies circumvent challenges were discussed. A promising option industrial purification that contains enzyme cell recycling continuous simultaneous saccharification coupled with membrane-based separation was proposed. proposed system can eliminate substrate-, feedback-, end-product inhibition, thereby concentration, productivity, yield.
Язык: Английский
Процитировано
64
Journal of Biological Engineering, Год журнала: 2023, Номер 17(1)
Опубликована: Март 20, 2023
Abstract As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs tissues enhancing the cellular capacity proliferate, migrate differentiate into different cell types specific tissues. Renewable resources have been used develop new materials, resulting in attempts produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known be biodegradable it produced from fermentation of carbohydrates. PLA can combined with other polymers biomaterials suitable physicochemical properties for applications. Here, advances modified as are discussed light its drawbacks, such biological inertness, low adhesion, degradation rate, efforts conducted address these challenges toward design enhanced alternative
Язык: Английский
Процитировано
53
Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)
Опубликована: Янв. 20, 2024
Abstract Agri-food residues offer significant potential as a raw material for the production of L -lactic acid through microbial fermentation. Weizmannia coagulans , previously known Bacillus is spore-forming, lactic acid-producing, gram-positive, with probiotic and prebiotic properties. This study aimed to evaluate feasibility utilizing untreated citrus waste sustainable feedstock in one-step process, by using strain W. MA-13. By employing thermophilic enzymatic cocktail (Cellic CTec2) conjunction hydrolytic capabilities MA-13, biomass degradation was enhanced up 62%. Moreover, batch fed-batch fermentation experiments demonstrated complete glucose into acid, achieving concentration 44.8 g/L. These results point MA-13 cell factory combining cost-effective saccharification fermentative performance, on agri-food wastes. this approach valorization agricultural streams successfully proven. Key points • Valorization waste, an abundant residue Mediterranean countries. Sustainable L-( +)-lactic process. Enzymatic pretreatment valuable alternative use chemical. Graphical
Язык: Английский
Процитировано
18
Process Safety and Environmental Protection, Год журнала: 2024, Номер 188, С. 834 - 859
Опубликована: Июнь 2, 2024
Biogas is a resource of renewable energy with the highest significance to development in many countries due great accessibility biomass. It mostly produced by anaerobic digestion various feedstocks, but technologies such as landfilling, aerobic composting and incineration are also being used. The current novel review aimed present emerging for biogas pretreatment, production upgrading process. Furthermore, applications future perspectives have been covered. was found that pretreatment chemical, physical, thermochemical oxidative increasing biomethane yield. Hence, extrusion has increased 190%. upgrading, photosynthetic biofixation CO2 microalgae shown upgraded CH4 maximum content ranging from 2 6%. Microbial electrolysis cell technology sustainable effective low requirement energy. Thus, it bioelectromethanogenesis leads uptake 13.2 gCO2/d. In addition, nanobubble recent studies extensively investigated improvement methane Europe around 70% plants utilising feedstocks agriculture sectors. 2022 global combined reached more than 1.6 EJ which an increase 17% last five years. Fossil fuels primary source 85% world's supply. wider use could ensure goals implementation
Язык: Английский
Процитировано
17
Biotechnology Advances, Год журнала: 2022, Номер 60, С. 108027 - 108027
Опубликована: Авг. 8, 2022
The non-conventional yeast Kluyveromyces marxianus is widely used for several biotechnological applications, mainly due to its thermotolerance, high growth rate, and ability metabolise a wide range of sugars. These cell traits are strategic lignocellulosic biomass valorisation strain diversity prompts the development robust chassis, either with improved tolerance inhibitors or ethanol. This review summarises bioethanol value-added chemicals production by K. from different biomasses. Moreover, metabolic engineering process optimization strategies developed expand potential also compiled, as well studies reporting mechanisms cope lignocellulosic-derived inhibitors. main lignocellulosic-based products bioethanol, representing 71% reports, xylitol, 17% reports. proved be good chassis lactic acid volatile compounds biomass, although literature on this matter still scarce. increasing advances in genome editing tools will widen marxianus-based portfolio products.
Язык: Английский
Процитировано
45
Fermentation, Год журнала: 2023, Номер 9(11), С. 990 - 990
Опубликована: Ноя. 20, 2023
Lignocellulose consists of cellulose, hemicellulose, and lignin is a sustainable feedstock for biorefinery to generate marketable biomaterials like biofuels platform chemicals. Enormous tons lignocellulose are obtained from agricultural waste, but few utilized due lack awareness the biotechnological importance lignocellulose. Underutilizing could also be linked incomplete use cellulose hemicellulose in biotransformation into new products. Utilizing producing value-added products alleviates waste disposal management challenges. It reduces emission toxic substances environment, which promotes development goal contributes circular economy economic growth. This review broadly focused on production high-value The aspects that were discussed included: (i) sources lignocellulosic biomass; (ii) conversion biomass products; (iii) various bio-based Additionally, several challenges upcycling alleviation strategies discussed. suggested prospects using replace polystyrene packaging with lignin-based products, crafts interior decorations lignin, nanolignin environmental biosensors biomimetic sensors, processing addition nutritional supplements meet dietary requirements animal feeding.
Язык: Английский
Процитировано
25
Industrial Crops and Products, Год журнала: 2022, Номер 193, С. 116132 - 116132
Опубликована: Дек. 20, 2022
India is the largest producer of sugarcane in Asia and its sugar industry represents second agro-based industry. Sugarcane bagasse (SCB), a major waste from industries, indisputably lignocellulosic biomass (LCB) embedding ∼60 % carbohydrates, making it renewable source fermentable sugars. Despite unique chemical composition, SCB primarily used for co-generation. The enormous potential can be unleashed, if platform created using biochemical route. Sugars serve as feedstock fermentative production several fuels chemicals, considered key drivers rapid industrialization. US Department Energy has projected lactic acid (LA) one top biomass-derived chemicals owing to diverse applications multi-billion-dollar market. Currently, industrial LA predominated by microbial fermentation (∼90 %) which principally uses starchy or sugar-rich edible feedstocks. If low-cost manufacturing relying on LCB enabled, boon emerging economies like India, strategically strengthening their socio-economic status. present review showcases technical advances made exploiting route towards commercial realization with feedstock. It comprehensively discusses strategies developed area pretreatment, saccharification fermentation, bridging gap between lab-scale production. gives glimpse downstream processing SCB-derived LA, still nascent stage briefly talks about our perspective preferred choice scale-up "sugar industry" over other bio-based chemicals.
Язык: Английский
Процитировано
34
Bioresource Technology, Год журнала: 2022, Номер 369, С. 128471 - 128471
Опубликована: Дек. 12, 2022
Язык: Английский
Процитировано
32
Molecules, Год журнала: 2022, Номер 27(23), С. 8410 - 8410
Опубликована: Дек. 1, 2022
Food waste has been widely valorized in the past years order to develop eco-friendly materials. Among others, bread is currently of increasing interest, as it considered a huge global issue with serious environmental impacts and significant economic losses that have become even greater post-pandemic due an increase cereal prices, which led higher production costs prices. Owing its richness polysaccharides, previously studied for physico-chemical characteristics numerous biotechnological applications. The present review highlights re-use valorization valuable resource by making value-added products through technological processes efficiency at all stages. Many research studies reporting several transformation methods surplus into ethanol, lactic acid, succinic biohydrogen, hydroxymethylfurfural, proteins pigments, glucose–fructose syrup, aroma compounds, enzymes are discussed. wide variety suggested applications recycling provides insights role technology development potentially maximizing recovery consequently contributing performance reducing amount landfills.
Язык: Английский
Процитировано
29
Metabolic Engineering, Год журнала: 2024, Номер 84, С. 23 - 33
Опубликована: Май 23, 2024
Metabolic engineering for high productivity and increased robustness is needed to enable sustainable biomanufacturing of lactic acid from lignocellulosic biomass. Lactic an important commodity chemical used instance as a monomer production polylactic acid, biodegradable polymer. Here, rational model-based optimization was engineer diploid, xylose fermenting Saccharomyces cerevisiae strain produce L-lactic acid. The metabolic flux steered towards through the introduction multiple lactate dehydrogenase encoding genes while deleting ERF2, GPD1, CYB2. A 93 g/L with yield 0.84 g/g achieved using carbon source. To increase utilization reduce acetic synthesis, PHO13 ALD6 were also deleted strain. Finally, CDC19 pyruvate kinase overexpressed, resulting in 0.75 g /g sugars consumed, when substrate synthetic hydrolysate medium, containing hexoses, pentoses inhibitors such acetate furfural. Notably, modeling provided leads understanding influence oxygen production. High xylose, at oxygen-limitation could be explained by reduced oxidative phosphorylation pathway. On contrast, higher levels beneficial likely ATP concentrations are tolerating therein. work highlights potential S. industrial
Язык: Английский
Процитировано
7