Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(4)
Опубликована: Фев. 1, 2025
ABSTRACT
The
intestinal
flora
has
attracted
much
attention
in
recent
years.
An
imbalance
the
can
cause
not
only
diseases
but
also
a
variety
of
parenteral
diseases,
such
as
endocrine
nervous
system
and
cardiovascular
diseases.
Research
on
mechanism
disease
is
likely
to
be
hampered
by
sample
accessibility,
ethical
issues,
differences
between
cellular
animal
physiological
studies.
However,
advances
stem
cell
culture
have
made
it
possible
reproduce
3D
human
tissues
vitro
that
mimic
cellular,
anatomical
functional
characteristics
real
organs.
Recent
studies
shown
organoids
used
simulate
development
gut
wide
range
applications
physiology
disease.
Intestinal
provide
preeminent
model
for
cultivating
microbiota
influence
GI
physiology,
well
understanding
how
they
encounter
epithelial
cells
mechanistic
details
obtained
from
modelling
may
new
avenues
prevention
treatment
many
gastrointestinal
(GI)
disorders.
Researchers
are
now
starting
take
inspiration
other
fields,
bioengineering,
rise
interdisciplinary
approaches,
including
organoid
chip
technology
microfluidics,
greatly
accelerated
generate
more
physiologically
relevant
suitable
Here,
we
describe
models
biology
application
study
pathophysiology
caused
dysbiosis.
Annals of Microbiology,
Год журнала:
2024,
Номер
74(1)
Опубликована: Янв. 3, 2024
Abstract
Background
The
gut
microbiota
plays
a
crucial
role
in
regulating
the
host’s
immune
responses
during
aging,
which
was
characterized
by
different
abundance
of
bacteria
several
age
groups.
Main
body
Gut
dysbiosis
is
associated
with
antibiotic
exposure,
underlying
diseases,
infections,
hormonal
variations,
circadian
rhythm,
and
malnutrition,
either
singularly
or
combination.
appropriate
use
prebiotics
probiotics
may
be
able
to
prevent
reduce
this
disruption.
Conclusion
current
review
focuses
on
composition
across
life
cycle,
factors
affecting
changes
interventions
modulate
microbiota.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 727 - 727
Опубликована: Янв. 5, 2024
Iron
is
a
vital
trace
element
that
plays
an
important
role
in
humans
and
other
organisms.
It
active
the
growth,
development,
reproduction
of
bacteria,
such
as
Bifidobacteria.
deficiency
or
excess
can
negatively
affect
bacterial
hosts.
Studies
have
reported
major
iron
human
intestine,
which
necessary
for
maintaining
body
homeostasis
intestinal
barrier
function.
Organisms
maintain
their
normal
activities
regulate
some
cancer
cells
by
regulating
excretion
iron-dependent
ferroptosis.
In
addition,
modify
interaction
between
hosts
microorganisms
altering
growth
virulence
affecting
immune
system
host.
Lactic
acid
bacteria
Lactobacillus
acidophilus
(L.
acidophilus),
rhamnosus
rhamnosus),
casei
casei)
were
to
increase
elements,
protect
host
barrier,
mitigate
inflammation,
This
review
article
focuses
on
two
aspects
gut
generally
summarizes
mechanistic
ions
immunity
remodeling
microbiota.
Abstract
Background
Interactions
between
the
gut
microbiota,
diet,
and
host
metabolism
contribute
to
development
of
cardiovascular
disease,
but
a
firm
link
disease-specific
microbiota
alterations
circulating
metabolites
is
lacking.
Methods
We
performed
shot-gun
sequencing
on
235
samples
from
166
HF
patients
69
healthy
control
samples.
Separate
plasma
controls
(
n
=
53)
were
used
for
comparison
imidazole
propionate
(ImP)
levels.
Taxonomy
functional
pathways
shotgun
data
was
assigned
using
MetaPhlAn3
HUMAnN3
pipelines.
Results
Here,
we
show
that
heart
failure
(HF)
associated
with
specific
compositional
shift
linked
levels
microbial
histidine-derived
metabolite
ImP.
Circulating
ImP
are
elevated
in
chronic
compared
HF-related
alterations.
Contrary
composition,
provide
insight
into
etiology
severity
also
associate
markers
intestinal
permeability
systemic
inflammation.
Conclusions
Our
findings
establish
connection
changes
presence,
etiology,
HF,
gut-microbially
produced
While
appears
promising
as
biomarker
reflecting
dysbiosis
related
further
studies
essential
demonstrate
its
causal
or
contributing
role
pathogenesis.
Trial
registration
NCT02637167,
registered
December
22,
2015.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(13), С. 7476 - 7496
Опубликована: Март 21, 2024
Inflammatory
bowel
disease
is
a
major
health
problem
that
can
lead
to
prolonged
damage
the
digestive
system.
This
study
investigated
effects
of
an
exopolysaccharide
from
genistein-stimulated
Monascus
purpureus
(G-EMP)
in
mouse
model
colitis
clarify
its
molecular
mechanisms
and
identified
structures.
G-EMP
(Mw
=
56.4
kDa)
was
primarily
consisted
→
4)-α-D-Galp-(1
→,
2,6)-α-D-Glcp-(1→
→2)-β-D-Manp-(1
,
with
one
branches
being
α-D-Manp-(1
→.
intervention
reduced
loss
body
weight,
degree
colonic
shortening,
activity
index
scores,
histopathology
while
restoring
goblet
cell
production
oxidative
homeostasis,
repairing
functions,
regulating
inflammatory
cytokines.
RNA
sequencing
Western
blot
analysis
indicated
exerts
anti-inflammatory
properties
by
suppressing
TLR4/MAPK/NF-κB
signaling
pathway.
modulated
gut
microbiota
improving
diversities,
elevating
relative
abundances
beneficial
bacteria,
declining
Firmicutes/Bacteroidota
value,
level
short-chain
fatty
acids
(SCFAs).
Correlation
demonstrated
strong
links
between
SCFAs,
microbiota,
response,
indicating
potential
prevent
colitis.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(18), С. 10355 - 10365
Опубликована: Апрель 15, 2024
The
genus
Bifidobacterium
has
been
widely
used
in
functional
foods
for
health
promotion
due
to
its
beneficial
effects
on
human
health,
especially
the
gastrointestinal
tract
(GIT).
In
this
study,
we
characterize
anti-inflammatory
potential
of
probiotic
strain
pseudocatenulatum
G7,
isolated
from
a
healthy
male
adult.
G7
secretion
inhibited
inflammatory
response
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
macrophages.
Moreover,
oral
administration
bacteria
alleviated
severity
colonic
inflammation
dextran
sulfate
sodium
(DSS)-treated
colitis
mice,
which
was
evidenced
by
decreased
disease
activity
index
(DAI)
and
enhanced
structural
integrity
colon.
16S
rRNA
gene
sequencing
result
illustrated
that
DSS-induced
gut
microbiota
dysbiosis,
accompanied
modulated
bile
acids
short-chain
fatty
acid
(SCFA)
levels.
Overall,
our
results
demonstrated
both
vitro
vivo
models,
provided
solid
foundation
further
development
novel
probiotic.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(5), С. 535 - 535
Опубликована: Май 16, 2024
Psoriasis
is
a
chronic
recurrent
inflammatory
autoimmune
pathology
with
significant
genetic
component
and
several
interferences
of
immunological
cells
their
cytokines.
The
complex
orchestration
psoriasis
pathogenesis
related
to
the
synergic
effect
immune
cells,
polygenic
alterations,
autoantigens,
other
external
factors.
major
act
IL-23/IL-17
axis,
strongly
influencing
pattern
established
during
disease
activity,
visible
as
continuous
perpetuation
pro-inflammatory
response
keratinocyte
activation
proliferation,
leading
development
psoriatic
lesions.
Genome-wide
association
studies
(GWASs)
offer
better
view
pathogenic
pathways,
approximately
one-third
psoriasis’s
impact
on
associated
MHC
region,
loci
located
chromosome
6.
most
eloquent
factor
psoriasis,
PSORS1,
was
identified
in
I
site.
Among
factors
involved
its
etiology,
dysbiosis,
due
or
stimulus,
induces
burst
consequences;
both
cutaneous
gut
microbiome
get
process.
Cutting-edge
research
comprehensive
insights
into
pathogenesis,
fostering
novel
genetic,
epigenetic,
factors,
have
generated
spectacular
improvement
over
past
decades,
securing
path
toward
specific
targeted
immunotherapeutic
approach
delayed
progression
arthritis.
This
review
aimed
insight
various
domains
that
underline
how
they
influence
evolution.
mechanism
multifaceted
involves
an
interplay
cellular
humoral
immunity,
which
affects
susceptible
microbiota
background.
An
in-depth
understanding
role
forms
basis
for
developing
individualized
therapeutic
targets
can
improve
management.
