Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation DOI Creative Commons
Megan E. Griffiths, Alice Broos, Juan M. Morales

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Interrupting pathogen transmission between species is a priority strategy to mitigate zoonotic threats. However, avoiding counterproductive interventions requires knowing animal reservoirs of infection and the dynamics within them, neither which are easily ascertained from cross-sectional surveys currently dominate investigations into newly discovered viruses. We used biobanked sera metagenomic data reconstruct recently bat-associated influenza virus (BIV) over 12 years in three zones Peru. Mechanistic models fit under Bayesian framework, enabled joint inference serological molecular data, showed that common vampire bats maintain BIV independently assumed fruit bat reservoir through immune waning seasonal pulses. A large-scale cull targeting rabies incidentally halved transmission, confirming as maintenance hosts. Our results show how combining field studies, perturbation responses multi-data type can elucidate nature reveal pathogen-dependent effects interventions.

Language: Английский

Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission DOI Creative Commons
Elsayed M. Abdelwhab, Mahmoud M. Naguib, Aitor Nogales

et al.

mBio, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Since the emergence of highly pathogenic avian influenza virus (HPAIV) H5N1 clade 2.3.4.4b as a novel reassortant from subtype H5N8, has led to massive number outbreaks worldwide in wild and domestic birds. Compared parental HPAIV H5N8 2.3.4.4b, displayed an increased ability escape species barriers infect multiple mammalian species, including humans. The host range been recently expanded include ruminants, particularly dairy cattle United States, where cattle-to-cattle transmission was reported. As with 2.3.4.4.b viruses, cattle-infecting found transmit other contact animals cats, raccoons, rodents, opossums, poultry. Although replication cows appears be mainly confined mammary tissue, high levels viral loads detected milk, infected cats poultry showed severe respiratory disease, neurologic signs, eventually died. Furthermore, several human infections have also reported farm workers were attributed exposures cattle. This is believed represent first mammalian-to-human report H5N1. Fortunately, infection humans cows, opposed animals, mild most cases. Nevertheless, bovine outbreak represents largest mammal close humans, increasing risk that this already adapted further adapts human-to-human starts pandemic. Herein, we discuss epidemiology, evolution, pathogenesis, potential impact identified States. Eventually, interdisciplinary cooperation under One Health framework required able control ongoing stop it before expansion its geographical distribution.

Language: Английский

Citations

17
The introduction of the SARS-CoV-2 BA.4 lineage into Pakistan DOI
Zaira Rehman,

Katherine Edington,

Zunera Jamal

et al.

Archives of Virology, Journal Year: 2025, Volume and Issue: 170(2)

Published: Jan. 6, 2025

Language: Английский

Citations

0
Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation DOI Creative Commons
Megan E. Griffiths, Alice Broos, Juan M. Morales

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(6)

Published: Feb. 5, 2025

Interrupting pathogen transmission between species is a priority strategy to mitigate zoonotic threats. However, avoiding counterproductive interventions requires knowing animal reservoirs of infection and the dynamics within them, neither which are easily ascertained from cross-sectional surveys that now dominate investigations into newly discovered viruses. We used biobanked sera metagenomic data reconstruct recently bat-associated influenza virus (BIV; H18N11) over 12 years in three zones Peru. Mechanistic models fit under Bayesian framework, enabled joint inference serological molecular data, showed common vampire bats maintain BIV independently assumed fruit bat reservoir through immune waning seasonal pulses. A large-scale cull targeting rabies incidentally halved transmission, confirming as maintenance hosts. Our results show how combining field studies, perturbation responses, multi-data–type can elucidate nature reveal pathogen-dependent effects interventions.

Language: Английский

Citations

0
Mycophenolate mofetil exerts broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2 DOI Creative Commons
Mengyuan Wu, Kun Wang, Huiqiang Wang

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 4, 2025

Language: Английский

Citations

0
Swine Influenza (H1N1) DOI
Aftab Siddique, Sanower Warsi, Anurag Singh

et al.

Published: Feb. 28, 2025

Citations

0
Challenges and Opportunities for Wastewater Monitoring of Influenza Viruses During the Multistate Outbreak of Highly Pathogenic Avian Influenza A(H5N1) Virus in Dairy Cattle and Poultry DOI
Margaret A. Honein, Sonja J. Olsen, Daniel B. Jernigan

et al.

American Journal of Public Health, Journal Year: 2024, Volume and Issue: unknown, P. e1 - e4

Published: Sept. 19, 2024

Language: Английский

Citations

2
Mosquito bloodmeals can be used to determine vertebrate diversity, host preference, and pathogen exposure in humans and wildlife DOI Creative Commons
Carla Júlia da Silva Pessoa Vieira, Narayan Gyawali, Michael B. Onn

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 21, 2024

Abstract The surveillance and detection of zoonotic pathogens in animals is essential for predicting disease transmission pathways the risks spillover, but challenges include costs, ethics technical expertise required vertebrate trapping, serum sampling antibody or virus screening. Surveillance using haematophagous arthropods as a tool offers unique opportunity to obtain blood samples from wide range species, allowing study host-mosquito associations, host exposure pathogens. We explored diversity potential Ross River (RRV) by analysing blood-fed mosquitoes collected Brisbane, Australia. Host origins were identified barcode sequencing, RRV was assessed modified plaque reduction neutralisation test. In total, 480 between February 2021 May 2022. 346 (72%) bloodmeals identified, with humans (73%) cattle (9%) comprising dominant hosts. seroprevalence high both species evidence 70% (21/30) 52% (132/253) humans. This novel, non-invasive method estimating populations. Our results highlight provide species-specific insights into pathogen dynamics.

Language: Английский

Citations

1
Mosquito bloodmeals can be used to determine vertebrate diversity, host preference, and pathogen exposure in humans and wildlife DOI Creative Commons
Carla Júlia da Silva Pessoa Vieira, Narayan Gyawali, Michael B. Onn

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 5, 2024

The surveillance and detection of zoonotic pathogens in animals is essential for predicting disease transmission pathways the risks spillover, but challenges include costs, ethics technical expertise required vertebrate trapping, serum sampling antibody or virus screening. Surveillance using haematophagous arthropods as a tool offers unique opportunity to obtain blood samples from wide range species, allowing study host-mosquito associations, host exposure pathogens. We explored diversity potential Ross River (RRV) by analysing blood-fed mosquitoes collected Brisbane, Australia. Host origins were identified barcode sequencing, RRV was assessed modified plaque reduction neutralisation test. In total, 480 between February 2021 May 2022. 346 (72%) bloodmeals identified, with humans (73%) cattle (9%) comprising dominant hosts. seroprevalence high both species evidence 70% (21/30) 52% (132/253) humans. This novel, non-invasive method estimating populations. Our results highlight provide species-specific insights into pathogen dynamics.

Language: Английский

Citations

1
Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation DOI Creative Commons
Megan E. Griffiths, Alice Broos, Juan M. Morales

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Interrupting pathogen transmission between species is a priority strategy to mitigate zoonotic threats. However, avoiding counterproductive interventions requires knowing animal reservoirs of infection and the dynamics within them, neither which are easily ascertained from cross-sectional surveys currently dominate investigations into newly discovered viruses. We used biobanked sera metagenomic data reconstruct recently bat-associated influenza virus (BIV) over 12 years in three zones Peru. Mechanistic models fit under Bayesian framework, enabled joint inference serological molecular data, showed that common vampire bats maintain BIV independently assumed fruit bat reservoir through immune waning seasonal pulses. A large-scale cull targeting rabies incidentally halved transmission, confirming as maintenance hosts. Our results show how combining field studies, perturbation responses multi-data type can elucidate nature reveal pathogen-dependent effects interventions.

Language: Английский

Citations

0