Chronobiology and Chronomedicine

Royal Society of Chemistry eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 23, 2024

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for difference between life death response identical stimulus. The partly endogenous nature of circadian has well documented methods their characterisation developed enabling cellular molecular mechanisms understood. Chronobiology Chronomedicine aims provide a review these underlying illustrate role brain’s suprachiasmatic nuclei ‘pace-making’ process effects caused by ‘clock genes’ present almost all cells. Beyond involved, book discusses relationship body systems, disease, proper function; particular, how disruption rhythm is associated with ill health disease status from observations made at organismic level. organised an ideal introduction postgraduate various fields, reviewing developments outlining show depth breadth chronobiology chronomedicine, as invaluable companion researchers healthcare professionals working field interest developing novel therapeutic approaches.

Язык: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5846 - 5846

Опубликована: Май 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Язык: Английский

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Comprehensive integrative analysis of circadian rhythms in human saliva

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Май 10, 2025

Abstract The circadian clock orchestrates vital physiological functions, with its dysregulation implicated in various pathologies. Assessing human status via the measurement of rhythms is crucial for health management and disease treatment. Saliva provides a non-invasive means such analysis. In this study, we examined related parameters 21 healthy individuals ( n = 4 – 19 per experiment), assessing different data types, including saliva gene expression our TimeTeller ® methodology, hormone levels, cell composition, self-assessment tests chronotype evaluation. While substantial individual variability profiles was observed, found significant correlations between acrophases ARNTL1 cortisol, both correlated bedtime on sampling day. Our findings validate robustness reliability method determining peripheral humans, offering potential clinical applications diverse cohorts.

Язык: Английский

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Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effects

EBioMedicine, Год журнала: 2025, Номер unknown, С. 105764 - 105764

Опубликована: Май 1, 2025

Ovarian cancer is among the most lethal malignancies in women. The advent of PARP inhibitors (PARPi) has improved outcomes. However, treatment-related toxicity remains a critical challenge, impacting patient quality life and treatment adherence. In circadian sub-study MAMOC trial-a double-blind, phase III study-42 patients (FIGO stage IIIA-IV) were randomised 2:1 ratio to receive rucaparib or placebo. subset these patients, we performed differential gene expression rhythmicity analysis on up 800 genes, including clock clock-controlled genes. Machine learning algorithms mathematical modelling employed simulate patient-specific profiles explore correlations between patterns side effects. Our revealed significant disruptions rhythms, specifically core genes BMAL1 PER2, following treatment. These strongly correlated with severity frequency effects, nausea fatigue, displaying opposite trends placebo rucaparib-treated groups. K-means clustering successfully distinguished from those receiving based profiles. addition, therapy also altered several SIRT1, BRCA1, BRCA2, TP53. Notably, our data suggest that individual differences rhythms may lead distinct 24-h patients. findings rhythm dysregulation contribute PARPi therapy. Aligning timing could mitigate adverse improve This study was funded by Dr. Rolf Schwiete Stiftung MSH Medical School Hamburg, Germany. trial (ClinicalTrials.gov: NCT04227522) Clovis Oncology, United States.

Язык: Английский

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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

npj Precision Oncology, Год журнала: 2024, Номер 8(1)

Опубликована: Фев. 20, 2024

Abstract Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines necessity to understand glioblastoma biology on other levels and use these learnings for development new concepts. Mounting evidence in field circadian medicine points a tight interplay between disturbances system progression. The clock, an internal biological mechanism governing numerous physiological processes across 24-h cycle, also plays pivotal role regulationg key cellular functions, including DNA repair, cell cycle progression, apoptosis. These are integral tumour response therapy. Disruptions rhythms can influence growth, invasion, treatment patients. In this review, we explore robust association cancer hallmarks within context glioblastoma. We further discuss impact clock eight shown previously link molecular different cancers, summarize putative proteins rhythm chronotherapy By unravelling mechanisms behind intricate connections researchers pave way identification potential targets, innovative strategies personalized approaches. conclusion, review underscores significant advancement understanding future therapies glioblastoma, ultimately leading enhanced outcomes

Язык: Английский

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Circadian regulation in aging: Implications for spaceflight and life on earth

Aging Cell, Год журнала: 2023, Номер 22(9)

Опубликована: Июль 26, 2023

Abstract Alterations in the circadian system are characteristic of aging on Earth. With decline physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise elderly populations. Similar risks reported as “red flag” among astronauts during after a long‐term Space exploration journey. However, little is known about common molecular alterations underlying terrestrial space‐related astronauts, controversial conclusions have been recently reported. In light regulatory role clock maintenance human health, we review here overlapping both Earth spaceflight with focus four most affected systems: visual, cardiovascular, central nervous, musculoskeletal systems. this review, briefly introduce specific cellular followed by those aging. We next summarize associated spaceflight, highlighting involved clock‐regulated genes space flown Drosophila , nematodes, small mammals, astronauts. Finally, discuss that altered terms their expression spaceflight. Altogether, data elaborated strengthen our hypothesis regarding timely need include dysregulation an emerging hallmark beyond.

Язык: Английский

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Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment

Current Opinion in Systems Biology, Год журнала: 2024, Номер 37, С. 100506 - 100506

Опубликована: Фев. 29, 2024

The growing numbers of cancer cases represent a medical and societal burden worldwide. More than half all patients are treated with chemotherapy. Yet, chemotherapeutic drugs kill not only cells, but also healthy tissue, causing massive adverse side effects. Recent research on circadian medicine suggests that side-effects can be reduced, treatment efficacy increased, by considering the biological clock patients. Integrating profiles molecular markers in personalized mathematical models simulate individual dynamics drug uptake, action cellular response to This requires advanced computational tools balance prediction quality overfitting. Personalized will eventually lead an optimal alignment timing inner patient, reducing effects, increasing enhancing patient well-being.

Язык: Английский

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Circadian dysfunction and cardio-metabolic disorders in humans

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Апрель 29, 2024

The topic of human circadian rhythms is not only attracting the attention clinical researchers from various fields but also sparking a growing public interest. system comprises central clock, located in suprachiasmatic nucleus hypothalamus, and peripheral clocks tissues that are interconnected; together they coordinate many daily activities, including sleep wakefulness, physical activity, food intake, glucose sensitivity cardiovascular functions. Disruption regulation seems to be associated with metabolic disorders (particularly impaired tolerance) disease. Previous trials revealed disturbance system, specifically due shift work, an increased risk type 2 diabetes mellitus. This review intended provide clinicians who wish implement knowledge disruption diagnosis strategies avoid cardio-metabolic disease general overview this topic.

Язык: Английский

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Timing Matters: Time of Day Impacts the Ergogenic Effects of Caffeine—A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(10), С. 1421 - 1421

Опубликована: Май 8, 2024

Caffeine has attracted significant attention from researchers in the sports field due to its well-documented ergogenic effects across various athletic disciplines. As research on caffeine continues progress, there been a growing emphasis evaluating dosage and administration methods. However, investigations into optimal timing of intake remain limited. Therefore, this narrative review aimed assess at different times during morning (06:00 10:00) evening (16:00 21:00). The findings suggest that circadian rhythms play substantial role influencing performance, potentially contributing decline performance. demonstrated effectiveness mitigating phenomenon, resulting performance enhancement, even comparable nighttime levels. While specific mechanisms by which regulates influences unclear, also explores underlying caffeine’s effects, including adenosine receptor blockade, increased muscle calcium release, modulation catecholamines. Additionally, underscores indirect impact enhancing responsiveness light-induced phase shifts. Although precise through improves declines via rhythm regulation necessitate further investigations, it is noteworthy significantly affects exercise. This emphasizes importance considering future endeavors optimize potential elucidate mechanisms.

Язык: Английский

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Optimizing Chronotherapy in Psychiatric Care: The Impact of Circadian Rhythms on Medication Timing and Efficacy

Clocks & Sleep, Год журнала: 2024, Номер 6(4), С. 635 - 655

Опубликована: Ноя. 5, 2024

In many medical settings, medications are typically administered in the morning or evening, aligning with patients' daily routines. This practice does not stem from chronotherapy, which involves scheduling drug administration to enhance its effectiveness, but rather way clinical operations structured. The timing of can significantly affect a medication's effectiveness and side effects, impact varying by up ten times based on circadian rhythms. Disorders such as major depression, bipolar disorder, schizophrenia linked disruptions these Recent studies have found that dysfunctions, including genetic neurohumoral changes, underlie psychiatric conditions. Issues an altered glucocorticoid rhythm due impaired HPA axis function, disturbed melatonin balance, sleep disturbances been noted psychotic disorders. Furthermore, mood disorders associated changes expression genes

Язык: Английский

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