Chronobiology and Chronomedicine

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for difference between life death response identical stimulus. The partly endogenous nature of circadian has well documented methods their characterisation developed enabling cellular molecular mechanisms understood. Chronobiology Chronomedicine aims provide a review these underlying illustrate role brain’s suprachiasmatic nuclei ‘pace-making’ process effects caused by ‘clock genes’ present almost all cells. Beyond involved, book discusses relationship body systems, disease, proper function; particular, how disruption rhythm is associated with ill health disease status from observations made at organismic level. organised an ideal introduction postgraduate various fields, reviewing developments outlining show depth breadth chronobiology chronomedicine, as invaluable companion researchers healthcare professionals working field interest developing novel therapeutic approaches.

Language: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 20, 2024

Abstract Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines necessity to understand glioblastoma biology on other levels and use these learnings for development new concepts. Mounting evidence in field circadian medicine points a tight interplay between disturbances system progression. The clock, an internal biological mechanism governing numerous physiological processes across 24-h cycle, also plays pivotal role regulationg key cellular functions, including DNA repair, cell cycle progression, apoptosis. These are integral tumour response therapy. Disruptions rhythms can influence growth, invasion, treatment patients. In this review, we explore robust association cancer hallmarks within context glioblastoma. We further discuss impact clock eight shown previously link molecular different cancers, summarize putative proteins rhythm chronotherapy By unravelling mechanisms behind intricate connections researchers pave way identification potential targets, innovative strategies personalized approaches. conclusion, review underscores significant advancement understanding future therapies glioblastoma, ultimately leading enhanced outcomes

Language: Английский

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Circadian regulation in aging: Implications for spaceflight and life on earth

Aging Cell, Journal Year: 2023, Volume and Issue: 22(9)

Published: July 26, 2023

Abstract Alterations in the circadian system are characteristic of aging on Earth. With decline physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise elderly populations. Similar risks reported as “red flag” among astronauts during after a long‐term Space exploration journey. However, little is known about common molecular alterations underlying terrestrial space‐related astronauts, controversial conclusions have been recently reported. In light regulatory role clock maintenance human health, we review here overlapping both Earth spaceflight with focus four most affected systems: visual, cardiovascular, central nervous, musculoskeletal systems. this review, briefly introduce specific cellular followed by those aging. We next summarize associated spaceflight, highlighting involved clock‐regulated genes space flown Drosophila , nematodes, small mammals, astronauts. Finally, discuss that altered terms their expression spaceflight. Altogether, data elaborated strengthen our hypothesis regarding timely need include dysregulation an emerging hallmark beyond.

Language: Английский

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Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment

Current Opinion in Systems Biology, Journal Year: 2024, Volume and Issue: 37, P. 100506 - 100506

Published: Feb. 29, 2024

The growing numbers of cancer cases represent a medical and societal burden worldwide. More than half all patients are treated with chemotherapy. Yet, chemotherapeutic drugs kill not only cells, but also healthy tissue, causing massive adverse side effects. Recent research on circadian medicine suggests that side-effects can be reduced, treatment efficacy increased, by considering the biological clock patients. Integrating profiles molecular markers in personalized mathematical models simulate individual dynamics drug uptake, action cellular response to This requires advanced computational tools balance prediction quality overfitting. Personalized will eventually lead an optimal alignment timing inner patient, reducing effects, increasing enhancing patient well-being.

Language: Английский

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Chronobiologie in der Onkologie: Onkologische Therapien am besten zur individuell optimalen Tageszeit

Deutsches Ärzteblatt, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

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Time matters: chrono-pharmacotherapy as precision medicine

Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

The circadian clock and its inherent rhythms serve as the foundation for regulating many of body’s vital processes. Recent advances in medicine have leveraged these natural cycles through chronotherapy, practice timing drug administration to align with body's internal clock, enhance treatment outcomes. Endogenous clocks not only dictate physiological but also influence how drugs are absorbed, distributed, metabolized, excreted, thereby affecting both their therapeutic efficacy potential toxicity. When disrupted, resulting imbalance has been linked a range disorders, such cancer cardiovascular diseases, highlighting growing need time-sensitive strategies. Technological breakthroughs, including wearable sensors, digital health platforms, sophisticated machine learning techniques, now allow continuous, real-time monitoring biomarkers, which turn helps optimize regimens. In oncology, example, synchronizing chemotherapy, therapy, immunotherapy anti-inflammatory patient’s cycle shown effectiveness improve tolerability. Moreover, observed sex-based differences responses emphasize importance tailoring individual patient profiles. Emerging research is focusing on directly targeting molecular components, showing treating metabolic oncological conditions. However, fully integrating chronopharmacology into clinical will require development standardized protocols, regulatory backing, large-scale trials that incorporate biomarkers. Ultimately, merging biology strategies promises efficacy, minimize side effects, Future studies must address inter-individual variability, sex differences, misalignment harness chronotherapy’s personalized medicine.

Language: Английский

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A prospective study to investigate circadian rhythms as health indicator in women’s aging

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 28, 2025

Abstract The circadian clock plays a crucial role in regulating the timing of numerous physiological processes. Its dysregulation has severe implications for organism’s homeostasis and is among main characteristics aging. As women age transition through menopause, disruptions rhythms may occur, leading to symptoms such as insomnia, mood changes, or altered energy levels. In this prospective non-randomized cohort study, we seek characterize better understand alterations across various stages their reproductive cycle, both with without daily routine (e.g., specific diet, light exposure). Understanding intricate relationship between female health during aging process essential developing targeted interventions mitigate promote overall well-being menopausal women. Findings from study will be used devise tailored rhythm assessments women, facilitating alleviation menopause-related promoting healthy

Language: Английский

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Circadian Rhythm Desynchrony and Its Correlation with Insulin Resistance in Type 2 Diabetes

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Timing Matters: Time of Day Impacts the Ergogenic Effects of Caffeine—A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1421 - 1421

Published: May 8, 2024

Caffeine has attracted significant attention from researchers in the sports field due to its well-documented ergogenic effects across various athletic disciplines. As research on caffeine continues progress, there been a growing emphasis evaluating dosage and administration methods. However, investigations into optimal timing of intake remain limited. Therefore, this narrative review aimed assess at different times during morning (06:00 10:00) evening (16:00 21:00). The findings suggest that circadian rhythms play substantial role influencing performance, potentially contributing decline performance. demonstrated effectiveness mitigating phenomenon, resulting performance enhancement, even comparable nighttime levels. While specific mechanisms by which regulates influences unclear, also explores underlying caffeine’s effects, including adenosine receptor blockade, increased muscle calcium release, modulation catecholamines. Additionally, underscores indirect impact enhancing responsiveness light-induced phase shifts. Although precise through improves declines via rhythm regulation necessitate further investigations, it is noteworthy significantly affects exercise. This emphasizes importance considering future endeavors optimize potential elucidate mechanisms.

Language: Английский

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