The
influenza
virus
(IFV)
imposes
a
considerable
health
and
economic
burden
globally,
requiring
comprehensive
understanding
of
its
pathogenic
mechanisms.
Ferroptosis,
an
iron-dependent
lipid
peroxidation
cell
death
pathway,
holds
unique
implications
for
the
antioxidant
defense
system,
with
possible
contributions
to
inflammation.
This
exploration
focuses
on
dynamic
interplay
between
ferroptosis
host
against
viruses,
emphasizing
influence
IFV
infections
activation
pathway.
causes
different
types
death,
including
apoptosis,
necrosis,
ferroptosis.
IFV-induced
ferroptotic
is
mediated
by
alterations
in
iron
homeostasis,
intensifying
accumulation
reactive
oxygen
species
promoting
peroxidation.
A
investigation
into
mechanism
viral
infections,
specifically
IFV,
has
great
potential
identify
therapeutic
strategies.
may
pave
way
development
drugs
using
inhibitors,
presenting
effective
approach
suppress
infections.
Medicine,
Год журнала:
2024,
Номер
103(9), С. e37360 - e37360
Опубликована: Март 1, 2024
Oxidative
stress,
a
condition
characterized
by
an
imbalance
between
reactive
oxygen
species
(ROS)
production
and
the
body's
ability
to
detoxify
them,
has
emerged
as
pivotal
factor
in
pathophysiology
of
various
diseases.
Red
blood
cells
(RBCs),
essential
components
circulatory
system,
are
particularly
susceptible
oxidative
damage
due
their
high
oxygen-carrying
capacity
abundance
vulnerable
biomolecules.
This
review
comprehensively
explores
intricate
mechanisms
underlying
stress-induced
red
subsequent
implications
for
overall
health
disease.
We
delve
into
sources
ROS
generation
within
RBCs,
including
metabolic
processes
external
factors,
shedding
light
on
delicate
redox
balance
that
governs
cellular
homeostasis.
The
impact
stress
extends
beyond
confines
primary
physiological
role,
these
actively
participate
immune
responses,
inflammation
modulation,
nitric
oxide
metabolism.
Consequently,
understanding
RBCs
provides
valuable
insights
broader
landscape
In
conclusion,
this
underscores
critical
role
influencing
cell
physiology
its
far-reaching
human
health.
Elucidating
molecular
intricacies
relationship
not
only
enhances
our
fundamental
biological
but
also
paves
way
development
targeted
therapeutic
interventions
mitigate
adverse
effects
and,
extension,
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 3, 2025
Diabetes
is
a
growing
health
concern,
accompanied
by
significant
complications
like
cardiovascular
disease,
kidney
and
retinopathy.
Metal
ions,
including
iron,
zinc,
copper,
play
crucial
role
in
maintaining
human
through
their
balance
within
the
body.
Disruptions
metal
ion
can
intensify
diabetic
conditions.
For
instance,
iron
overload
induces
oxidative
stress,
which
harms
islet
β
cells
impacts
vascular
of
diabetes.
Abnormal
copper
levels
heighten
insulin
resistance,
zinc
deficiency
has
strong
connection
with
type
1
Future
-
depth
exploration
association
between
metabolism
diabetes
holds
potential
to
uncover
novel
treatment
avenues,
enhancing
both
quality
life
prognosis
for
patients.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2024,
Номер
Volume 17, С. 1635 - 1649
Опубликована: Апрель 1, 2024
Diabetic
retinopathy
(DR)
can
cause
permanent
blindness
with
unstated
pathogenesis.
We
aim
to
find
novel
biomarkers
and
explore
the
mechanism
of
apoptotic
protease
activating
factor
1
(APAF1)
in
DR.
IUBMB Life,
Год журнала:
2024,
Номер
76(12), С. 1011 - 1034
Опубликована: Июль 25, 2024
Abstract
Within
the
last
decade,
scientific
community
has
witnessed
importance
of
ferroptosis
as
a
novel
cascade
molecular
events
leading
to
cellular
decisions
death
distinct
from
apoptosis
and
other
known
forms
cell
death.
Notably,
such
non‐
apoptotic
iron‐dependent
regulated
been
found
be
intricately
linked
several
physiological
processes
well
pathogenesis
various
diseases.
To
this
end,
recent
data
support
notion
that
potential
connection
between
inherited
bone
marrow
failure
(IBMF)
in
individuals
with
ribosomopathies
may
exist.
In
review,
we
suggest
ribosome‐related
IBMFs
identified
mutations
ribosomal
proteins
lead
changes
ribosome
composition
hematopoietic
progenitors,
seem
affect
function,
thus
enhancing
expression
some
mRNAs
subgroups
while
reducing
others.
These
an
imbalance
inside
pathways
are
promoted
others
inhibited.
This
disturbance
is
accompanied
by
ROS
production
lipid
peroxidation,
additional
finding
most
them
iron
accumulation.
Once
peroxidation
accumulation
two
main
characteristics
ferroptosis,
it
possible
mechanism
plays
key
role
manifestation
IBMF
type
disease.
If
further
confirmed,
new
pharmacological
targets
inhibitors
already
exploited
for
treatment
diseases,
could
utilized
improve
ribosomopathies.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Авг. 11, 2024
Ferrous
ion
accumulation
and
lethal
oxidative
stress
mediate
irreversible
retinal
pigment
epithelial
(RPE)
cell
ferroptosis
subsequent
photoreceptor
degeneration,
a
potential
key
pathogenic
factor
in
the
onset
of
dry
age-related
macular
degeneration
(dAMD),
causing
vision
loss
global
elderly
population.
However,
currently,
no
effective
interventional
treatment
strategy
exists
clinical
practice.
Herein,
lesion
site-targeted
melanin-like
nanoparticles,
named
ConA-MelNPs,
are
designed
as
novel
inhibitor
for
degenerative
diseases.
ConA-MelNPs
possessed
chelating
iron
characteristics,
alleviating
severe
mitochondrial
damage
caused
by
protecting
RPE
cells
from
induced
sodium
iodate
(NaIO
