Long-span delivery of differentiable hybrid robots for restoration of neural connections

Matter, Год журнала: 2025, Номер 8(3), С. 101942 - 101942

Опубликована: Янв. 13, 2025

Язык: Английский

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Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

Journal of Neuroscience Research, Год журнала: 2023, Номер 101(10), С. 1538 - 1554

Опубликована: Июнь 5, 2023

Abstract Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central nervous system; it imposes great psychological and economic burdens on affected patients their families. The dynamic balance between reactive oxygen species (ROS) antioxidants essential for maintaining normal cellular physiological functions. As important intracellular signaling molecules, ROS regulate numerous activities, including vascular reactivity neuronal function. However, excessive can cause damage macromolecules, DNA, lipids, proteins; this eventually leads cell death. This review discusses mechanisms of oxidative stress in SCI describes some pathways after injury, with aim providing guidance development novel treatment strategies.

Язык: Английский

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Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury

Theranostics, Год журнала: 2024, Номер 14(2), С. 879 - 891

Опубликована: Янв. 1, 2024

Spinal cord injury (SCI) is an acute damage to the central nervous system that results in severe morbidity and permanent disability. Locally implanted scaffold systems with immobilized mesenchymal stem cells (MSCs) have been widely proven promote locomotor function recovery SCI rats; however, underlying mechanism remains elusive.

Язык: Английский

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Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine

Heliyon, Год журнала: 2024, Номер 10(16), С. e35836 - e35836

Опубликована: Авг. 1, 2024

Stem cell transplantation has emerged as a promising avenue in regenerative medicine, potentially facilitating tissue repair degenerative diseases and injuries. This review comprehensively examines recent developments challenges stem transplantation. It explores the identification isolation of various types, including embryonic, induced pluripotent, adult cells derived from multiple sources. Additionally, highlights tissue-specific applications these cells, focusing on bone cartilage regeneration, treatment neurological disorders, management hematological conditions. Future advancements effective resolution current will be crucial fully realizing potential medicine. With responsible ethical practices, field can transform disease injury treatment, ultimately improving quality life for countless individuals.

Язык: Английский

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Mesenchymal Stem Cell Therapy in Traumatic Spinal Cord Injury: A Systematic Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11719 - 11719

Опубликована: Июль 20, 2023

Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of central nervous system restore cells, myelin, and neural connections. Cell therapy, particularly with mesenchymal stem cells (MSCs), holds significant promise for TSCI treatment. This systematic review aims analyze efficacy, safety, therapeutic potential MSC-based cell therapies in TSCI. A comprehensive search PUBMED COCHRANE databases until February 2023 was conducted, combining terms such as “spinal injury,” “stem cells,” therapy,” “mesenchymal “traumatic injury”. Among 53 studies initially identified, 22 (21 clinical trials 1 case series) were included. Findings these consistently demonstrate improvements AIS (ASIA Impairment Scale) grades, sensory scores, and, lesser extent, motor scores. Meta-analyses further support positive outcomes. have shown short- medium-term indicated by absence adverse events within studied timeframe. However, caution required when drawing generalized recommendations scientific evidence available. Further research needed elucidate long-term safety implications advancements. Although progress has been made, therapies, additional exploring other future gene neurostimulation techniques, tissue engineering approaches are essential understanding evolving treatment landscape.

Язык: Английский

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The Clinical Use of Osteobiologic and Metallic Biomaterials in Orthopedic Surgery: The Present and the Future

Materials, Год журнала: 2023, Номер 16(10), С. 3633 - 3633

Опубликована: Май 10, 2023

As the area and range of surgical treatments in orthopedic field have expanded, development biomaterials used for these has also advanced. Biomaterials osteobiologic properties, including osteogenicity, osteoconduction, osteoinduction. Natural polymers, synthetic ceramics, allograft-based substitutes can all be classified as biomaterials. Metallic implants are first-generation that continue to constantly evolving. made from pure metals, such cobalt, nickel, iron, or titanium, alloys, stainless steel, cobalt-based titanium-based alloys. This review describes fundamental characteristics metals new developments nanotechnology 3D-printing technology. overview discusses clinicians commonly use. A complementary relationship between doctors biomaterial scientists is likely necessary future.

Язык: Английский

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Current Advances in Mesenchymal Stem Cell Therapies Applied to Wounds and Skin, Eye, and Neuromuscular Diseases in Companion Animals

Animals, Год журнала: 2024, Номер 14(9), С. 1363 - 1363

Опубликована: Апрель 30, 2024

Mesenchymal stem cells (MSCs) are considered a very promising alternative tool in cell therapies and regenerative medicine due to their ease of obtaining from various tissues ability differentiate into different types. This manuscript provides review current knowledge on the use MSC-based as an for certain common pathologies dogs cats where conventional treatments ineffective. The aim this is assist clinical veterinarians making decisions about suitability each protocol perspective, rather than focusing solely research. have shown results pathologies, such spinal cord injuries, wounds, skin eye diseases. However, effectiveness these can be influenced by wide array factors, leading varying outcomes. Future research will focus designing protocols methodologies that allow more precise effective MSC case.

Язык: Английский

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Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(24), С. 17317 - 17317

Опубликована: Дек. 10, 2023

Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular milieu. Within these nanovesicles reside a multitude of bioactive molecules, which orchestrate essential biological processes, including cell differentiation, proliferation, and survival, in the recipient cells. These properties exosomes render them promising choice for therapeutic use realm tissue regeneration repair. possess notable positive attributes, high bioavailability, inherent safety, stability, as well capacity to be functionalized so that drugs or agents can encapsulated within have surface modified with ligands receptors imbue selective targeting. Remarkably, small size receptor-mediated transcytosis enable cross blood-brain barrier (BBB) access central nervous system (CNS). Unlike cell-based therapies, present fewer ethical constraints collection direct approach human body. advantageous qualities underscore vast potential treatment option neurological injuries diseases, setting apart from other agents. Considering exosomes, current review seeks specifically examine an area investigation encompasses development Schwann (SC)-derived exosomal (SCEVs) spinal cord injury (SCI) protection SCs, myelinating glia peripheral system, long history demonstrated benefit repair injured nerves when transplanted, recent advancement clinical investigations feasibility safety humans. This delves utilizing SCEVs therapy SCI, explores engineering strategies customize specific actions, examines how may offer unique advantages over SC transplantation cord.

Язык: Английский

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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Nano Convergence, Год журнала: 2024, Номер 11(1)

Опубликована: Май 13, 2024

Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.

Язык: Английский

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Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 3, 2025

Periodontal disease is a highly prevalent worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal can achieve good control inflammation, it difficult to regenerate supporting tissues satisfactory therapeutic effect. In recent years, due tissue regeneration ability, research on Mesenchymal stromal/stem cells (MSCs) MSC-derived exosomes has been gradually deepened, especially its ability interact with microenvironment body in complex immunoregulatory network, which led many new perspectives strategies for diseases. This paper systematically reviews immunomodulatory (including bone immunomodulation) properties MSCs their role inflammatory microenvironment, summarizes pathways mechanisms by MSC-EVs have promoted lists potential areas future research, describes issues should be considered basic direction development "cell-free therapies" regeneration.

Язык: Английский

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