Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 512, P. 162672 - 162672
Published: April 17, 2025
Language: Английский
Journal of Neuroscience Research, Journal Year: 2023, Volume and Issue: 101(10), P. 1538 - 1554
Published: June 5, 2023
Abstract Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central nervous system; it imposes great psychological and economic burdens on affected patients their families. The dynamic balance between reactive oxygen species (ROS) antioxidants essential for maintaining normal cellular physiological functions. As important intracellular signaling molecules, ROS regulate numerous activities, including vascular reactivity neuronal function. However, excessive can cause damage macromolecules, DNA, lipids, proteins; this eventually leads cell death. This review discusses mechanisms of oxidative stress in SCI describes some pathways after injury, with aim providing guidance development novel treatment strategies.
Language: Английский
Citations
40
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35836 - e35836
Published: Aug. 1, 2024
Stem cell transplantation has emerged as a promising avenue in regenerative medicine, potentially facilitating tissue repair degenerative diseases and injuries. This review comprehensively examines recent developments challenges stem transplantation. It explores the identification isolation of various types, including embryonic, induced pluripotent, adult cells derived from multiple sources. Additionally, highlights tissue-specific applications these cells, focusing on bone cartilage regeneration, treatment neurological disorders, management hematological conditions. Future advancements effective resolution current will be crucial fully realizing potential medicine. With responsible ethical practices, field can transform disease injury treatment, ultimately improving quality life for countless individuals.
Language: Английский
Citations
12
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
Periodontal disease is a highly prevalent worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal can achieve good control inflammation, it difficult to regenerate supporting tissues satisfactory therapeutic effect. In recent years, due tissue regeneration ability, research on Mesenchymal stromal/stem cells (MSCs) MSC-derived exosomes has been gradually deepened, especially its ability interact with microenvironment body in complex immunoregulatory network, which led many new perspectives strategies for diseases. This paper systematically reviews immunomodulatory (including bone immunomodulation) properties MSCs their role inflammatory microenvironment, summarizes pathways mechanisms by MSC-EVs have promoted lists potential areas future research, describes issues should be considered basic direction development "cell-free therapies" regeneration.
Language: Английский
Citations
2
Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101942 - 101942
Published: Jan. 13, 2025
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11719 - 11719
Published: July 20, 2023
Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of central nervous system restore cells, myelin, and neural connections. Cell therapy, particularly with mesenchymal stem cells (MSCs), holds significant promise for TSCI treatment. This systematic review aims analyze efficacy, safety, therapeutic potential MSC-based cell therapies in TSCI. A comprehensive search PUBMED COCHRANE databases until February 2023 was conducted, combining terms such as “spinal injury,” “stem cells,” therapy,” “mesenchymal “traumatic injury”. Among 53 studies initially identified, 22 (21 clinical trials 1 case series) were included. Findings these consistently demonstrate improvements AIS (ASIA Impairment Scale) grades, sensory scores, and, lesser extent, motor scores. Meta-analyses further support positive outcomes. have shown short- medium-term indicated by absence adverse events within studied timeframe. However, caution required when drawing generalized recommendations scientific evidence available. Further research needed elucidate long-term safety implications advancements. Although progress has been made, therapies, additional exploring other future gene neurostimulation techniques, tissue engineering approaches are essential understanding evolving treatment landscape.
Language: Английский
Citations
23
Materials, Journal Year: 2023, Volume and Issue: 16(10), P. 3633 - 3633
Published: May 10, 2023
As the area and range of surgical treatments in orthopedic field have expanded, development biomaterials used for these has also advanced. Biomaterials osteobiologic properties, including osteogenicity, osteoconduction, osteoinduction. Natural polymers, synthetic ceramics, allograft-based substitutes can all be classified as biomaterials. Metallic implants are first-generation that continue to constantly evolving. made from pure metals, such cobalt, nickel, iron, or titanium, alloys, stainless steel, cobalt-based titanium-based alloys. This review describes fundamental characteristics metals new developments nanotechnology 3D-printing technology. overview discusses clinicians commonly use. A complementary relationship between doctors biomaterial scientists is likely necessary future.
Language: Английский
Citations
20
Theranostics, Journal Year: 2024, Volume and Issue: 14(2), P. 879 - 891
Published: Jan. 1, 2024
Spinal cord injury (SCI) is an acute damage to the central nervous system that results in severe morbidity and permanent disability. Locally implanted scaffold systems with immobilized mesenchymal stem cells (MSCs) have been widely proven promote locomotor function recovery SCI rats; however, underlying mechanism remains elusive.
Language: Английский
Citations
8
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Oct. 4, 2024
Mesenchymal stem cells (MSCs) have gained considerable attention in the field of regenerative medicine due to their ability secrete small extracellular vesicles (EVs) known as exosomes. This review delves into various biological activities MSCs and cell interactions enabled by these exosomes, with a focus on potential for neuronal regeneration treatment neurological disorders. We scrutinize findings from multiple studies that underscore neuroprotective neuro-regenerative effects exosomes derived MSCs, illuminating mechanisms action therapeutic applications. thoroughly investigates all related pathways, miRNAs, factors suggest strategies enhancing therapy disorders using boosting regeneration.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17317 - 17317
Published: Dec. 10, 2023
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular milieu. Within these nanovesicles reside a multitude of bioactive molecules, which orchestrate essential biological processes, including cell differentiation, proliferation, and survival, in the recipient cells. These properties exosomes render them promising choice for therapeutic use realm tissue regeneration repair. possess notable positive attributes, high bioavailability, inherent safety, stability, as well capacity to be functionalized so that drugs or agents can encapsulated within have surface modified with ligands receptors imbue selective targeting. Remarkably, small size receptor-mediated transcytosis enable cross blood-brain barrier (BBB) access central nervous system (CNS). Unlike cell-based therapies, present fewer ethical constraints collection direct approach human body. advantageous qualities underscore vast potential treatment option neurological injuries diseases, setting apart from other agents. Considering exosomes, current review seeks specifically examine an area investigation encompasses development Schwann (SC)-derived exosomal (SCEVs) spinal cord injury (SCI) protection SCs, myelinating glia peripheral system, long history demonstrated benefit repair injured nerves when transplanted, recent advancement clinical investigations feasibility safety humans. This delves utilizing SCEVs therapy SCI, explores engineering strategies customize specific actions, examines how may offer unique advantages over SC transplantation cord.
Language: Английский
Citations
15
Animals, Journal Year: 2024, Volume and Issue: 14(9), P. 1363 - 1363
Published: April 30, 2024
Mesenchymal stem cells (MSCs) are considered a very promising alternative tool in cell therapies and regenerative medicine due to their ease of obtaining from various tissues ability differentiate into different types. This manuscript provides review current knowledge on the use MSC-based as an for certain common pathologies dogs cats where conventional treatments ineffective. The aim this is assist clinical veterinarians making decisions about suitability each protocol perspective, rather than focusing solely research. have shown results pathologies, such spinal cord injuries, wounds, skin eye diseases. However, effectiveness these can be influenced by wide array factors, leading varying outcomes. Future research will focus designing protocols methodologies that allow more precise effective MSC case.
Language: Английский
Citations
6