Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 3, 2025
Gastric
cancer
(GC)
remains
a
significant
global
health
concern
due
to
its
poor
prognosis
and
limited
therapeutic
options,
particularly
in
advanced
stages.
Tumor
microenvironment
(TME),
tumor-associated
macrophages
(TAMs),
plays
key
role
tumor
progression,
immune
evasion,
therapy
resistance.
TAMs
exhibit
plasticity,
shifting
between
pro-inflammatory
M1
immunosuppressive
M2
phenotypes,
with
the
latter
predominating
GC
contributing
outcomes.
Recent
advancements
focus
on
targeting
TAMs,
including
inhibiting
polarization,
reprogramming
combining
TAM-targeted
approaches
checkpoint
inhibitors.
Innovations
nanotechnology,
metabolic
reprogramming,
pathways
such
as
interleukin-6
C-C
motif
ligand
2/C-C
chemokine
receptor
2
further
enhance
these
strategies.
However,
challenges
remain,
spatial
functional
heterogeneity
of
within
TME
need
for
selective
avoid
disrupting
homeostasis.
Ongoing
research
TAM
origins,
functions,
interactions
is
crucial
developing
precise
effective
therapies.
These
advances
hold
promise
not
only
improving
outcomes
but
also
addressing
other
cancers
similarly
complex
microenvironments.
Язык: Английский
Single-cell RNA sequencing to map tumor heterogeneity in gastric carcinogenesis paving roads to individualized therapy
Cancer Immunology Immunotherapy,
Год журнала:
2024,
Номер
73(11)
Опубликована: Сен. 13, 2024
Gastric
cancer
(GC)
is
a
highly
heterogeneous
disease
with
complex
tumor
microenvironment
(TME)
that
encompasses
multiple
cell
types
including
cells,
immune
stromal
and
so
on.
Cancer-associated
cells
could
remodel
the
TME
influence
progression
of
GC
therapeutic
response.
Single-cell
RNA
sequencing
(scRNA-seq),
as
an
emerging
technology,
has
provided
unprecedented
insights
into
complicated
biological
composition
characteristics
at
molecular,
cellular,
immunological
resolutions,
offering
new
idea
for
studies.
In
this
review,
we
discuss
novel
findings
from
scRNA-seq
datasets
revealing
origin
evolution
GC,
powerful
tool
investigating
transcriptional
dynamics
intratumor
heterogeneity
(ITH)
in
GC.
Meanwhile,
demonstrate
vital
within
TME,
T
B
macrophages,
play
important
role
progression.
Additionally,
also
overview
how
facilitates
our
understanding
about
effects
on
individualized
therapy
patients.
Spatial
transcriptomes
(ST)
have
been
designed
to
determine
spatial
distribution
capture
local
intercellular
communication
networks,
enabling
further
relationship
between
background
particular
its
functions.
summary,
other
single-cell
technologies
provide
valuable
perspective
molecular
pathological
hold
promise
advancing
basic
research
clinical
practice
Язык: Английский
The Importance of Extracellular Vesicle Screening in Gastric Cancer: A 2024 Update
Cancers,
Год журнала:
2024,
Номер
16(14), С. 2574 - 2574
Опубликована: Июль 18, 2024
Extracellular
vesicles,
or
EVs,
are
membrane-bound
nanocompartments
produced
by
tumor
cells.
EVs
carry
proteins
and
nucleic
acids
from
host
cells
to
target
cells,
where
they
can
transfer
lipids,
proteomes,
genetic
material
change
the
function
of
serve
as
reservoirs
for
mobile
cellular
signals.
The
collection
using
less
invasive
processes
has
piqued
interest
many
researchers.
Exosomes
substances
that
suppress
immune
system.
If
results
exosome
screening
negative,
immunotherapy
will
be
beneficial
GC
patients.
In
this
study,
we
provide
an
update
on
based
ongoing
review
papers
clinical
trials.
Язык: Английский
SPP1‐SRD5A3 signaling axis regulated lymph node metastasis by activating Mucin type O glycan biosynthesis
The FASEB Journal,
Год журнала:
2025,
Номер
39(7)
Опубликована: Апрель 2, 2025
Lymph
node
metastasis
(LNM)
holds
substantial
implications
for
the
recurrence
and
survival
of
cancer
patients,
but
intricate
regulatory
mechanisms
underlying
LNM
remain
poorly
understood.
MTOGB
was
dominantly
increased
in
pan-cancer,
significantly
activated
epithelial
cells
enriched
LNM.
Subsequently,
we
identified
a
specific
cell
subpopulation,
EC4,
located
at
terminal
differentiation
trajectory
Lineage2.
By
intersecting
differentially
expressed
genes
cluster
2,
EC4
Lineage2,
six
crucial
genes.
Notably,
expression
Steroid
5α-reductase
3
(SRD5A3)
with
progression
stages.
Knockdown
SRD5A3
effectively
suppressed
MTOGB,
blocking
both
animal
models.
Nilotinib
screened
as
candidate
inhibitor
confirmed
to
remarkably
decrease
metastasis.
SOX4
potential
transcription
factor
SRD5A3,
modulated
by
dramatic
increase
communication
SPP1+
macrophages
immune
microenvironment.
The
supernatant
from
macrophage
enhanced
SOX4/SRD5A3
metastatic
ability
cells,
this
effect
reversed
deletion
SPP1.
Collectively,
our
findings
illuminate
SPP1-SRD5A3
signaling
driver
suggest
that
its
blockade
could
be
promising
option
overcoming
Язык: Английский
Harnessing Exosomes: From Tumor Immune Escape to Therapeutic Innovation in Gastric Cancer Immunotherapy
Cancer Letters,
Год журнала:
2025,
Номер
626, С. 217792 - 217792
Опубликована: Май 22, 2025
Язык: Английский
NK cell-derived artificial extracellular vesicles elicit potent anti-tumor efficacy and tumor microenvironment reprogramming capability
Cancer Nanotechnology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Май 30, 2025
IDO1 as a potential diagnostic biomarker for gastric cancer
Asian Journal of Surgery,
Год журнала:
2024,
Номер
47(10), С. 4351 - 4353
Опубликована: Июль 3, 2024
Язык: Английский
CD206 accelerates hepatocellular carcinoma progression by regulating the tumour immune microenvironment and increasing M2-type polarisation of tumour-associated macrophages and inflammation factor expression
Discover Oncology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Сен. 13, 2024
Язык: Английский