Российский физиологический журнал им И М Сеченова,
Год журнала:
2023,
Номер
109(12), С. 1780 - 1798
Опубликована: Дек. 1, 2023
The
development
of
coronavirus
infection
prevents
the
transport
oxygen
to
tissues
through
mechanism
impaired
hemoglobin
saturation
in
damaged
lung.
change
affinity
for
oxygen,
which
is
most
important
factor
compensating
deficiency
various
pathological
conditions,
underlies
processes
adaptation
hypoxia.
question
significance
shift
oxyhemoglobin
dissociation
curve
this
pathology
actively
discussed,
its
left
arterial
blood
and
right
venous
are
noted,
conditions
hypoxic
syndrome
reflects
a-ctivation
body’s
mechanisms
compensate
deficiency.
position
not
specific
pathology,
but
determined
by
severity
imbalance
cardiorespiratory
system,
as
well
peculiarities
status
patients
analyzed
sample.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 6, 2024
Abstract
This
innovative
work
aims
to
develop
highly
biocompatible
and
degradable
nanoparticles
by
encapsulating
haemoglobin
(Hb)
within
poly-ε-caprolactone
for
novel
biomedical
applications.
We
used
a
modified
double
emulsion
solvent
evaporation
method
fabricate
the
particles.
A
Scanning
electron
microscope
(SEM)
characterized
them
surface
morphology.
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
Ultraviolet–visible
spectroscopies
(UV–visible)
elucidated
preserved
chemical
biological
structure
of
encapsulated
haemoglobin.
The
airproof
equilibrium
apparatus
obtained
oxygen-carrying
capacity
P
50
values.
DPPH
assay
assessed
free
radical
scavenging
potential.
antibacterial
properties
were
observed
using
four
different
bacterial
strains
disk
diffusion
method.
MTT
investigates
cytotoxic
effects
on
mouse
fibroblast
cultured
cell
lines
(L-929).
showed
that
have
no
toxicity
over
large
concentrations.
well-preserved
Hb
particles,
toxicity,
high
oxygen
affinity,
value,
IC50
values
open
area
new
research,
which
may
be
as
artificial
carriers,
antioxidant,
agents,
potential
therapeutic
agents
well
drug
carrier
particles
treat
cancerous
cells.
novelty
this
is
antioxidant
developed
are
not
been
reported
yet.
Results
prepared
strong
Biomedical Journal,
Год журнала:
2024,
Номер
47(6), С. 100723 - 100723
Опубликована: Апрель 6, 2024
COVID-19
reduces
lung
functionality
causing
a
decrease
of
blood
oxygen
levels
(hypoxemia)
often
related
to
decreased
cellular
oxygenation
(hypoxia).
Besides
injury,
other
factors
are
implicated
in
the
regulation
availability
such
as
pH,
partial
arterial
carbon
dioxide
tension
(PaCO
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 6, 2025
COVID-19
severity
and
high
in-hospital
mortality
are
often
associated
with
severe
hypoxemia,
hyperlactatemia,
acidosis,
yet
the
key
players
driving
this
association
remain
unclear.
It
is
generally
assumed
that
organ
damage
causes
toxic
but
since
neutrophil
numbers
in
can
exceed
80%
of
total
circulating
leukocytes,
we
asked
if
metabolic
acidosis
mediated
by
glycolytic
neutrophils
lung
impaired
oxygen
delivery
critically
ill
patients.
Based
on
prospective
outcome,
patients
were
divided
into
ICU-
survivors
ICU-non-survivors.
Samples
analyzed
to
explore
correlations
exist
between
counts,
damage,
glycolysis,
blood
lactate,
pH,
hemoglobin
saturation,
outcome.
We
also
interrogated
isolated
neutrophils,
platelets,
PBMCs
for
activities.
Arterial
gas
analyses
showed
remarkable
hypoxemia
non-survivors
no
consistent
differences
PCO2
or
[HCO3
-].
The
dissociation
curve
revealed
a
right-shift,
lower
blood-pH
elevated
lactate
non-survivors.
Metabolic
analysis
different
cells
increased
activity
only
when
considering
number
neutrophils.
This
indicates
role
neutrophilia
hyperlactatemia
subsequently
contributing
outcomes
SARS-CoV-2
infection.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 874 - 874
Опубликована: Янв. 21, 2025
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
causes
COVID-19,
a
disease
that
can
range
in
presentation
from
mild
symptoms
to
severe
conditions
such
as
pneumonia
and
distress
syndrome.
SARS-CoV-2,
single-stranded
RNA
virus,
spreads
through
aerosols
droplets.
It
enters
human
cells
by
binding
the
angiotensin-converting
enzyme
receptor,
leading
various
complications,
including
significant
alterations
red
blood
potential
disruptions
haemoglobin
function
oxygen
transport.
During
infection,
interaction
between
hypoxia,
inflammation,
haematopoiesis
affects
erythropoiesis
at
multiple
levels.
Hypoxia
resulting
lung
complications
reduced
cell
count,
influence
regulation
of
hepcidin,
key
regulator
iron
levels
blood.
Elevated
hepcidin
are
associated
with
hypoxia
suppression
erythroferrone,
hormone
normally
inhibits
production.
Despite
high
patients
intensive
care
units
often
exhibit
elevated
ferritin
levels,
which,
rather
than
indicating
low
suggest
disrupted
metabolism
development
anaemia.
Iron
is
kept
stores,
likely
due
paradoxically
which
explains
measurements.
An
increase
immature
decrease
CD71+
erythroid
observed.
The
highlight
their
dual
role
modulating
hyper-inflammation
immune
response
during
progression.
This
review
examines
pathway
SARS-CoV-2
production
haematopoietic
system
how
it
triggers
cytokine
storms
interleukins,
cells,
cells.
Understanding
these
processes
provides
novel
pathways
for
managing
haematological
manifestations
responses
COVID-19.
Balneo and PRM Research Journal,
Год журнала:
2023,
Номер
14(Vol.14, no.2), С. 565 - 565
Опубликована: Июнь 23, 2023
Abstract:
Oxygen
is
essential
for
cellular
respiration
and
energy
production.
Tissue
oxygenation
refers
to
delivering
oxygen
cells
throughout
the
body.
Microcirculation
brings
blood
through
small
sanguine
vessels
maintain
cells'
supply
of
nutrients
oxygen.
Optimal
tissue
ox-ygenation
microcirculation
are
maintaining
healthy
tissue.
Conversely,
poor
can
cause
damage,
impair
wound
healing,
increase
infection
risk.
Several
factors
affect
microcirculation,
including
age,
lifestyle
(such
as
smoking
stress),
underlying
medical
conditions
diabetes
high
pres-sure).
To
improve
individuals
engage
in
habits
such
regular
exercise,
eating,
stress
management,
avoiding
smoking.
also
be
looked
therapeutic,
given
that
topical
cosmetic
treatments
massage,
pelotherapy,
hydrotherapy,
moisturizers,
certain
skin
care
products
help
promote
at
somatic
level.
In
scientific
literature,
focus
on
hypoxia
rather
than
oxygenation.
This
article
proposes
a
paradigm
shift
emphasizes
homeostatic
importance
pathophysiological
therapeutic
circumstances.
The
systematic
review
data
from
last
2
years
(2021-2022)
meta-analysis
performed
will
contribute
practical
approach
pathology
circumscribed
Keywords:
oxygenation;
Hypoxia;
Microcirculation;
Homeostasis;
Microenvironment
Hematology Reports,
Год журнала:
2023,
Номер
15(4), С. 543 - 554
Опубликована: Окт. 10, 2023
Coronavirus
Disease
2019
(COVID-19)
was
described
to
affect
red
blood
cells
(RBC)
in
both
severe
and
mild
disease
courses.
The
aim
of
this
study
investigate
whether
hematological
hemorheological
changes
that
were
previously
for
COVID-19
patients
after
the
acute
infection
state
are
still
prominent
another
4
months
assess
potential
long-term
effects.Hematological
RBC
rheological
parameters,
including
deformability
aggregation,
measured
41
days
non-COVID
control
(T0)
later
(T1).The
data
confirm
alterations
mainly
related
cell
volume
hemoglobin
concentration,
but
also
reduced
increased
aggregation
at
T0
compared
control.
While
seems
have
recovered,
hemoglobin-related
parameters
impaired
T1.
thus
more
pronounced
male
patients.COVID-19-related
partly
consist
several
might
be
persistent
symptoms
reported
by
many
patients.
The
coronavirus
disease
2019
(COVID-19)
pandemic,
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
has
led
to
substantial
morbidity
and
mortality
worldwide.
Hematological
abnormalities
are
common
in
COVID-19
patients
play
a
significant
role
pathogenesis
prognosis.
