Food Science & Nutrition,
Год журнала:
2024,
Номер
12(8), С. 5548 - 5560
Опубликована: Май 13, 2024
Abstract
In
the
present
study,
a
synbiotic
coating
of
flaxseed
mucilage,
defatted
rice
bran
carbohydrate,
and
Bifidobacterium
animalis
subsp.
Lactis
BB12
was
fabricated
for
dried
mango
slices
(M‐P‐C).
The
control
samples
contained
only
probiotic
bacteria
without
(M‐P).
Several
quality
parameters
(moisture,
weight
loss,
shrinkage
percentage,
pH,
firmness,
color)
were
assessed
on
specific
storage
circumstances
(25°C,
relative
humidity
(RH)
=
22%.).
addition,
survival
evaluated
under
simulated
gastrointestinal
(GI)
conditions.
According
to
results,
log
number
reached
8.1
6.2
coated
uncoated
samples,
respectively,
during
45
days
at
25°C
(>6
CFU
(log
colony‐forming
units)/g)
finished
stage
in
vitro
circumstances,
bacterial
count
6.8
4
respectively.
resulted
significantly
less
moisture
than
ones
(
p
<
.05).
growth
yeasts
molds
undetectable
both
samples.
results
acceptance
experiments
M‐P
M‐P‐C
showedthat
there
no
significant
differences
between
>.05),
indeed
case
purchase
intention
overall
acceptability.
After
reading
text
highlighting,
difference
all
attributes
pre
post
highlighting.
It
could
be
concluded
that
improved
characteristics
as
well
viability
time
Vaccines,
Год журнала:
2023,
Номер
11(4), С. 725 - 725
Опубликована: Март 24, 2023
Pathogens
found
in
food
are
believed
to
be
the
leading
cause
of
foodborne
illnesses;
and
they
considered
a
serious
problem
with
global
ramifications.
During
last
few
decades,
lot
attention
has
been
paid
determining
microorganisms
that
illnesses
developing
new
methods
identify
them.
Foodborne
pathogen
identification
technologies
have
evolved
rapidly
over
newer
focusing
on
immunoassays,
genome-wide
approaches,
biosensors,
mass
spectrometry
as
primary
identification.
Bacteriophages
(phages),
probiotics
prebiotics
were
known
ability
combat
bacterial
diseases
since
turn
20th
century.
A
focus
phage
use
was
development
medical
therapies;
however,
its
quickly
expanded
other
applications
biotechnology
industry.
similar
argument
can
made
regards
safety
industry,
directly
endanger
health
customers.
Recently,
bacteriophages,
most
likely
due
exhaustion
traditional
antibiotics.
Reviewing
variety
current
quick
techniques
is
purpose
this
study.
Using
these
techniques,
we
able
pathogenic
bacteria,
which
forms
basis
for
future
research
advances.
review
recent
studies
phages,
means
combating
significant
also
presented.
Furthermore,
discussed
advantages
using
phages
well
challenges
face,
especially
given
their
prevalent
application
safety.
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 1, 2024
Population
aging
has
become
a
primary
global
public
health
issue,
and
the
prevention
of
age-associated
diseases
prolonging
healthy
life
expectancies
are
particular
importance.
Gut
microbiota
emerged
as
novel
target
in
various
host
physiological
disorders
including
aging.
Comprehensive
understanding
on
changes
gut
during
aging,
characteristics
centenarians,
can
provide
us
possibility
to
achieving
or
intervene
pathological
through
microbiota-directed
strategies.
This
review
aims
summarize
associated
with
explore
potential
biomarkers
address
microbiota-associated
mechanisms
focusing
intestinal
barrier
immune
status.
By
summarizing
existing
effective
dietary
strategies
interventions,
probability
developing
diet
targeting
future
is
provided.
focused
three
key
notions:
Firstly,
new
for
regulating
status
lifespan,
its
closely
related
age.
Thus,
we
summarized
aging-associated
features
at
levels
genus/species
important
metabolites
comparing
differences
among
elderly
people
younger
people.
Secondly,
exploring
discussing
using
regime/components
targeted
aging-related
promote
human
lifespan.
Thirdly,
intervention
effectively
improve
imbalance
such
probiotics,
prebiotics,
postbiotics,
but
their
effects
vary
among.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 14, 2025
Chronic
kidney
disease
(CKD)
is
a
global
public
health
issue
characterized
by
progressive
loss
of
function,
which
end-stage
(ESKD)
the
last
stage.
The
increase
in
prevalence
CKD
linked
to
increasing
traditional
risk
factors,
including
obesity,
hypertension,
and
diabetes
mellitus,
as
well
metabolic
particularly
insulin
resistance,
dyslipidemia,
hyperuricemia.
Mortality
comorbidities,
such
cardiovascular
complications,
rise
steadily
function
deteriorates.
Patients
who
progress
ESKD
require
long-term
replacement
therapy,
transplantation
or
hemodialysis/peritoneal
dialysis.
It
currently
understood
that
crucial
aspect
involves
persistent,
low-grade
inflammation.
In
addition,
increased
oxidative
stress,
endothelial
dysfunction,
vascular
calcification
from
poor
calcium
phosphate
metabolism,
difficulties
with
coagulation
are
some
complex
molecular
pathways
underlying
CKD-related
ESKD-related
issues.
Novel
mechanisms,
microbiome
dysbiosis
apolipoprotein
L1
gene
mutation,
have
improved
our
understanding
mechanisms.
High
Africa
has
been
APOL1
high-risk
alleles.
3-fold
African
Americans
compared
European
mainly
attributed
variants
chromosome
22q12
locus.
Additionally,
role
new
therapies
SGLT2
inhibitors,
mineralocorticoid
receptor
antagonists,
channel
inhibitors
offers
therapeutic
targets
slowing
down
progression
chronic
disease.
This
review
describes
recent
mechanisms
emerging
targets.
Microorganisms,
Год журнала:
2024,
Номер
12(1), С. 194 - 194
Опубликована: Янв. 18, 2024
Probiotics
are
known
to
promote
human
health
either
precautionary
in
healthy
individuals
or
therapeutically
patients
suffering
from
certain
ailments.
Although
this
knowledge
was
empirical
past
tomes,
modern
science
has
already
verified
it
and
expanded
new
limits.
These
microorganisms
can
be
found
nature
various
foods
such
as
dairy
products
supplements
formulated
for
clinical
preventive
use.
The
current
review
examines
the
different
mechanisms
of
action
probiotic
strains
how
they
interact
with
organism
host.
Emphasis
is
put
on
therapeutic
use
these
beneficial
conditions
gastrointestinal
tract.
Diseases
tract
particularly
any
malfunction
inflammation
intestines
seriously
compromise
whole
organism.
interaction
between
host’s
microbiota
alleviate
signs
symptoms
while
some
cases,
due
course,
intervene
underlying
pathology.
Various
safety
issues
probiotics
also
discussed.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Апрель 19, 2024
All
microorganisms
like
bacteria,
viruses
and
fungi
that
reside
within
a
host
environment
are
considered
microbiome.
The
number
of
bacteria
almost
equal
human
cells,
however,
the
genome
these
may
be
100
times
larger
than
genome.
Every
aspect
physiology
health
can
influenced
by
microbiome
living
in
various
parts
our
body.
Any
imbalance
composition
or
function
is
seen
as
dysbiosis.
Different
types
dysbiosis
corresponding
symptoms
depend
on
site
microbial
imbalance.
contribution
intestinal
extra-intestinal
microbiota
to
influence
systemic
activities
through
interplay
between
different
axes.
Whole
body
complex
process
involving
gut
non-gut
related
It
still
at
stage
infancy
has
not
yet
been
fully
understood.
Dysbiosis
genetic
factors,
lifestyle
habits,
diet
including
ultra-processed
foods
food
additives,
well
medications.
associated
with
many
diseases
cannot
diagnosed
standard
blood
tests
investigations.
Microbiota
derived
metabolites
analyzed
useful
management
addressed
altering
proper
modulation.
effect
interventions
humans
depends
beneficial
alteration
mostly
based
animal
studies
evolving
evidence
from
studies.
There
tremendous
potential
for
diagnosis,
treatment,
prognosis
diseases,
as,
monitoring
disease
humans.
system-based
approach
diagnosis
better
pure
taxonomic
approach.
could
new
therapeutic
target
conditions.
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
highly
aggressive
cancer
characterized
by
late
diagnosis,
rapid
progression,
and
high
mortality
rate.
Its
complex
biology,
dense,
stromal
tumor
environment
with
an
immunosuppressive
milieu,
contributes
to
resistance
against
standard
treatments
like
chemotherapy
radiation.
This
comprehensive
review
explores
the
dynamic
role
of
microbiome
in
modulating
efficacy
outcomes
PDAC.
It
delves
into
microbiome's
impact
on
drug
metabolism
resistance,
interaction
between
microbial
elements,
drugs,
human
biology.
We
also
highlight
significance
specific
bacterial
species
enzymes
influencing
action
immune
response
microenvironment.
Cutting-edge
methodologies,
including
artificial
intelligence,
low-biomass
analysis
patient-derived
organoid
models,
are
discussed,
offering
insights
nuanced
interactions
microbes
cells.
The
potential
microbiome-based
interventions
as
adjuncts
conventional
PDAC
paving
way
for
personalized
therapy
approaches.
synthesizes
recent
research
provide
in-depth
understanding
how
affects
efficacy.
focuses
elucidating
key
mechanisms
identifying
existing
knowledge
gaps.
Addressing
these
gaps
crucial
enhancing
medicine
refining
treatment
strategies,
ultimately
improving
patient
outcomes.
Microbiome Research Reports,
Год журнала:
2024,
Номер
3(2)
Опубликована: Март 18, 2024
Technological
advances
in
studying
the
human
microbiome
depth
have
enabled
identification
of
microbial
signatures
associated
with
health
and
disease.
This
confirms
crucial
role
microbiota
maintaining
homeostasis
host
status.
Nowadays,
there
are
several
ways
to
modulate
composition
effectively
improve
health;
therefore,
development
therapeutic
treatments
based
on
gut
is
experiencing
rapid
growth.
In
this
review,
we
summarize
influence
infectious
disease
cancer,
which
two
main
targets
microbiome-based
therapies
currently
being
developed.
We
analyze
two-way
interaction
between
traditional
drugs
order
emphasize
drug
effectivity
treatment
response.
explore
different
strategies
available
for
modulating
ecosystem
our
benefit,
ranging
from
1st
generation
intervention
more
complex
2nd
their
regulatory
framework.
Lastly,
finish
a
quick
overview
what
believe
future
these
strategies,
that
3rd
developed
use
artificial
intelligence
(AI)
algorithms.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(4), С. 2214 - 2228
Опубликована: Янв. 18, 2024
Previously,
Lactobacillus
paracasei
VL8,
a
lactobacillus
strain
isolated
from
the
traditional
Finnish
fermented
dairy
product
Viili,
demonstrated
immunomodulatory
and
antibacterial
effects.
The
prebiotic
mannan-oligosaccharide
(MOS)
further
promoted
its
activity
growth
performance,
holding
promise
for
maintaining
intestinal
health.
However,
this
has
not
been
verified
in
vivo.
In
study,
we
elucidated
process
by
which
L.
VL8
synbiotc
combination
(SYN)
with
MOS
repair
barrier
function
dextran
sodium
sulfate
(DSS)-induced
colitis
mice.
SYN
surpasses
or
alone
restoring
goblet
cells
improving
tight
junction
structure.
Omics
analysis
on
gut
microbiota
reveals
SYN's
ability
to
restore
spp.
abundance
promote
tryptophan
metabolism.
intervention
also
inhibits
DSS-induced
hyperactivation
of
Wnt/β-catenin
pathway.
Tryptophan
metabolites
induce
organoid
differentiation.
Co-housing
experiments
confirm
transferability,
replicating
repair.
conclusion,
our
study
highlights
potential
therapeutic
efficacy
synbiotic
damaged
offers
new
insights
into
complex
crosstalk
between
stem
cells.
