Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease

Nutrients, Год журнала: 2023, Номер 15(20), С. 4466 - 4466

Опубликована: Окт. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Язык: Английский

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Microbial Biosurfactant as an Alternate to Chemical Surfactants for Application in Cosmetics Industries in Personal and Skin Care Products: A Critical Review

BioMed Research International, Год журнала: 2023, Номер 2023(1)

Опубликована: Янв. 1, 2023

Cosmetics and personal care items are used worldwide administered straight to the skin. The hazardous nature of chemical surfactant utilized in production cosmetics has caused alarm on a global scale. Therefore, bacterial biosurfactants (BS) becoming increasingly popular industrial product as biocompatible, low‐toxic alternative surfactant. Chemical surfactants can induce allergic responses skin irritations; thus, they should be replaced with less harmful substances for health. cosmetic industry seeks novel biological alternatives replace compounds improve qualities. Most these chemicals have origin obtained from plant, bacterial, fungal, algal sources. Various molecules intriguing capabilities, such biosurfactants, vitamins, antioxidants, pigments, enzymes, peptides. These safe, biodegradable, environmentally friendly than options. Plant‐based saponins, offer numerous advantages over synthetic surfactants, i.e., nontoxic, nature. Saponins promising source natural various academic applications. However, microbial glycolipids lipopeptides been biotechnology due their multifunctional character, including detergency, emulsifying, foaming, moisturizing capabilities. In addition, some them potential antibacterial agents. this review, we like enlighten application replacing existing skincare pharmaceutical formulations antibacterial, surface moisturizing, low toxicity characteristics.

Язык: Английский

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Effects of Probiotics on Gut Microbiota: An Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6022 - 6022

Опубликована: Май 30, 2024

The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent phenotypes. This comprehensive review provides firsthand information on their influence health, effects diet how alter function along with corresponding building healthy intestine. We also discuss implications some most important diseases. In summary, significant boosting overall immunity, increasing abundance beneficial bacteria, ameliorate symptoms multiple

Язык: Английский

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The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Сен. 16, 2024

Short-chain fatty acids (SCFAs) - acetate, propionate, and butyrate are important bacterial fermentation metabolites regulating many aspects of human physiology. Decreases in the concentrations any or multiple SCFAs associated with various detrimental effects to host. Previous research has broadly focused on gut microbiome produced as a group, minimal distinction between independently, each significantly different host effects. In this review, we comprehensively delineate roles these emphasis receptor affinity, signaling pathway involvement, net physiologic Butyrate is highlighted due its unique role gastrointestinal-associated functions, especially maintaining barrier integrity. functions by promoting epithelial tight junctions, serving fuel for colonocyte ATP production, modulating immune system. Interaction system occurs locally gastrointestinal tract systemically brain. Investigation into conducted production pathways specific players involved highlights risk use gram-positive targeted antibiotics. We review discuss evidence showing relationship butyrate-producing genus,

Язык: Английский

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Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review

Foods, Год журнала: 2024, Номер 13(1), С. 151 - 151

Опубликована: Янв. 2, 2024

Functional dyspepsia (FD) is a common functional gastrointestinal disorder. The pathophysiology remains poorly understood; however, alterations in the small intestinal microbiome have been observed. Current treatments for FD with drugs are limited, and there certain safety problems. A class of active probiotic bacteria can control homeostasis, nutritional digestion absorption, energy balance when taken dosages. Probiotics play many roles maintaining microecological balance, improving barrier function, regulating immune response. presence composition microorganisms vital role onset progression serve as critical factor both regulation potential intervention regarding management this condition. Thus, advantages to alleviating by flora using probiotics, targeting microorganisms. This review summarizes research progress probiotics provides reference basis improve FD.

Язык: Английский

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Antibiotics and the gut microbiome: Understanding the impact on human health

Medicine in Microecology, Год журнала: 2024, Номер 20, С. 100106 - 100106

Опубликована: Апрель 8, 2024

Antibiotic use has become problematic because it unintentionally upsets the delicate equilibrium of human gut microbiota. Antibiotics, especially broad-spectrum ones, that were once regarded as life-saving treatments for bacterial infections instead indiscriminately destroy good bacteria are essential preserving health in addition to their target pathogens. Antibiotic-induced dysbiosis, term this disturbance, sets off a series adverse reactions negatively impact microbiome, resulting decline microbial diversity and creation an environment is favourable establishment strains resistant antibiotics. exposure wide-ranging effects from prenatal adulthood; research shown long-term include increased risk antibiotic resistance, obesity, allergies, asthma, altered metabolic processes. This thorough investigation emphasises critical need more sophisticated knowledge therapy on microbiota necessity implementing all-encompassing solutions reduce its detrimental protect throughout life.

Язык: Английский

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Roles of microbiota in pancreatic cancer development and treatment

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 27, 2024

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This due to the fact that most cases are only diagnosed at advanced and palliative stage, there a high incidence of therapy resistance. Despite ongoing efforts, date, mechanisms underlying PDAC oncogenesis its responses treatment still largely unclear. As study microbiome in cancer progresses, growing evidence suggests bacteria or fungi might be key players both as well resistance chemo- immunotherapy, for instance through modulation tumor microenvironment reshaping host immune response. Here, we review how microbiota exerts these effects directly indirectly via microbial-derived metabolites. Finally, further discuss potential modulating composition PDAC.

Язык: Английский

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Update on the gut microbiome in health and diseases

World Journal of Methodology, Год журнала: 2024, Номер 14(1)

Опубликована: Март 7, 2024

The Human Microbiome Project, Earth and next-generation sequencing have advanced novel genome association, host genetic linkages, pathogen identification. microbiome is the sum of microbes, their information, ecological niche. This study will describe how millions bacteria in gut affect human body health disease. changes relation with age, an increase

Язык: Английский

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Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Язык: Английский

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Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 614 - 614

Опубликована: Янв. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Язык: Английский

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